{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:49:30Z","timestamp":1783118970561,"version":"3.54.6"},"reference-count":52,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Albuminuria is a key clinical marker for early detection of diabetic kidney disease (DKD) in individuals with type 2 diabetes mellitus (T2DM). The triglyceride-glucose (TyG) index, a simple surrogate of insulin resistance, has been increasingly investigated for its potential association with renal complications. This study aimed to evaluate the relationship between the TyG index and albuminuria in patients with T2DM and assess its clinical utility as an accessible metabolic marker reflecting early renal involvement. Materials and Methods: This retrospective cross-sectional study included 570 adult patients with confirmed T2DM who were followed at a tertiary internal medicine outpatient clinic between January and December 2024. Participants were classified as albuminuric or non-albuminuric based on spot urine albumin-to-creatinine ratio (ACR) values. Clinical and biochemical parameters were collected from medical records, and the TyG index was calculated as ln [fasting triglyceride (mg\/dL) \u00d7 fasting glucose (mg\/dL)\/2]. Logistic regression models were used to identify independent factors associated with albuminuria. ROC analysis was performed to evaluate the discriminatory accuracy of the TyG index. Results: The median TyG index was significantly higher in the albuminuric group compared to the non-albuminuric group (10.0 vs. 9.1; p &lt; 0.001) and increased progressively with albuminuria severity (p &lt; 0.001). In multivariate logistic regression analysis, elevated TyG index, hyperlipidemia, and reduced estimated glomerular filtration rate were independently associated with albuminuria. When evaluated as a continuous variable, the TyG index showed strong discriminatory ability (area under curve (AUC) = 0.949; 95% confidence interval (CI): 0.933\u20130.964). Using the optimal cut-off threshold of 9.6, the TyG index maintained high diagnostic performance (AUC = 0.870; 95% CI: 0.839\u20130.902; sensitivity 87.7%, specificity 86.3%). Subgroup analyses confirmed the robustness of this association across clinical and demographic variables. Conclusions: In this study, higher TyG index values were significantly associated with the presence and severity of albuminuria in individuals with T2DM. While causality cannot be inferred, the findings suggest that the TyG index may serve as a practical, cost-effective tool for identifying patients at increased risk for early diabetic kidney involvement. Prospective longitudinal studies are needed to confirm its predictive value and clinical applicability.<\/jats:p>","DOI":"10.3390\/medicina61101803","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:22:08Z","timestamp":1759911728000},"page":"1803","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Relationship Between Albuminuria and Triglyceride Glucose Index in Patients with Type 2 Diabetes Mellitus: A Retrospective Cross-Sectional Study"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4976-4771","authenticated-orcid":false,"given":"Ozgur","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Kanuni Sultan Suleyman Training and Research Hospital, Atakent Distr., Turgut Ozal Blvd., No: 46\/1, Kucukcekmece, 34303 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-0136","authenticated-orcid":false,"given":"Osman","family":"Erinc","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kanuni Sultan Suleyman Training and Research Hospital, Atakent Distr., Turgut Ozal Blvd., No: 46\/1, Kucukcekmece, 34303 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"ref_1","unstructured":"International Diabetes Federation (2021). IDF Diabetes Atlas, The International Diabetes Federation. [10th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic Kidney Disease: Challenges, Progress, and Possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15018","DOI":"10.1038\/nrdp.2015.18","article-title":"Diabetic kidney disease","volume":"1","author":"Thomas","year":"2015","journal-title":"Nat. Rev. Dis. Primers."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"A8","DOI":"10.1053\/j.ajkd.2022.12.001","article-title":"US Renal Data System 2022 Annual Data Report: Epidemiology of Kidney Disease in the United States","volume":"81","author":"Johansen","year":"2023","journal-title":"Am. J. Kidney Dis."},{"key":"ref_6","unstructured":"Centers for Disease Control and Prevention (CDC) (2024, May 15). Chronic Kidney Disease Surveillance System\u2014United States, Available online: https:\/\/nccd.cdc.gov\/CKD\/."},{"key":"ref_7","first-page":"49","article-title":"Diabetic kidney disease: Worldwide difference in prevalence and risk factors","volume":"4","author":"Gheith","year":"2015","journal-title":"J. Nephropharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2337\/dc20-1913","article-title":"Worldwide Epidemiology of Diabetes-Related End-Stage Renal Disease, 2000\u20132015","volume":"44","author":"Cheng","year":"2021","journal-title":"Diabetes Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.tem.2016.07.002","article-title":"Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms","volume":"27","author":"Gnudi","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10557-020-07035-4","article-title":"The Potential of Albuminuria as a Biomarker of Diabetic Complications","volume":"35","author":"Raja","year":"2021","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jacc.2022.10.028","article-title":"Albuminuria and Heart Failure: JACC State-of-the-Art Review","volume":"81","author":"Khan","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","unstructured":"Rout, P., and Jialal, I. (2024). Diabetic Nephropathy, StatPearls."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Cho, S., Huh, H., Park, S., Lee, S., Jung, S., Kim, M., Lee, K.-N., Paek, J.H., Park, W.Y., and Jin, K. (2023). Impact of albuminuria on the various causes of death in diabetic patients: A nationwide population-based study. Sci. Rep., 13.","DOI":"10.1038\/s41598-022-23352-0"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.17925\/EE.2022.18.2.102","article-title":"Non-albuminuric Diabetic Kidney Disease Phenotype: Beyond Albuminuria","volume":"18","author":"Viejo","year":"2022","journal-title":"touchREV Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Shi, S., Ni, L., Gao, L., and Wu, X. (2022). Comparison of Nonalbuminuric and Albuminuric Diabetic Kidney Disease Among Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.871272"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Jin, Q., Liu, T., Qiao, Y., Liu, D., Yang, L., Mao, H., Ma, F., Wang, Y., Peng, L., and Zhan, Y. (2023). Oxidative stress and inflammation in diabetic nephropathy: Role of polyphenols. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1185317"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"H135","DOI":"10.1152\/ajpheart.00908.2024","article-title":"Endothelial dysfunction in chronic kidney disease: A clinical perspective","volume":"329","author":"Cho","year":"2025","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/0026-0495(93)90148-H","article-title":"Insulin resistance is related to albuminuria in patients with type II (non-insulin-dependent) diabetes mellitus","volume":"42","author":"Niskanen","year":"1993","journal-title":"Metabolism"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"910","DOI":"10.2337\/diacare.28.4.910","article-title":"Increased urinary albumin excretion, insulin resistance, and related cardiovascular risk factors in patients with type 2 diabetes: Evidence of a sex-specific association","volume":"28","author":"Minenna","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0168-8227(01)00228-5","article-title":"Microalbuminuria is associated with the insulin resistance syndrome independent of hypertension and type 2 diabetes in the Korean population","volume":"52","author":"Kim","year":"2001","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Jiang, Y., and Lai, X. (2024). Association between the triglyceride glucose index, triglyceride-glucose body mass index and diabetic kidney disease in adults with newly diagnosed type 2 diabetes. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1328601"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Li, X., and Wang, Y. (2024). Associations of the TyG index with albuminuria and chronic kidney disease in patients with type 2 diabetes. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0312374"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Chang, W., Liu, C.-C., Huang, Y.-T., Wu, J.-Y., Tsai, W.-W., Hung, K., Chen, I., and Feng, P.-H. (2023). Diagnostic efficacy of the triglyceride-glucose index in the prediction of contrast-induced nephropathy following percutaneous coronary intervention. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1282675"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wu, Y., Liu, C., and Cao, J. (2025). Association between triglyceride-glucose index and its composite obesity indexes and cardio-renal disease: Analysis of the NHANES 2013\u20132018 cycle. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1505808"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Pei, H., Su, X., Wu, S., and Wang, Z. (2024). Evaluating the impact of chronic kidney disease and the triglyceride-glucose index on cardiovascular disease: Mediation analysis in the NHANES. BMC Public Health, 24.","DOI":"10.1186\/s12889-024-20243-z"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/met.2008.0034","article-title":"The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects","volume":"6","year":"2008","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1016\/j.diabres.2011.05.030","article-title":"TyG index performs better than HOMA in a Brazilian population: A hyperglycemic clamp validated study","volume":"93","author":"Vasques","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.numecd.2021.11.017","article-title":"Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome","volume":"32","author":"Son","year":"2022","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"109042","DOI":"10.1016\/j.diabres.2021.109042","article-title":"The triglyceride-glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance","volume":"180","author":"Park","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wang, Z., Qian, H., Zhong, S., Gu, T., Xu, M., and Yang, Q. (2023). The relationship between triglyceride-glucose index and albuminuria in United States adults. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1215055"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Li, W., Wang, Y., He, F., Liu, Z., Dong, J., Zhang, Y., Li, T., Liu, S., and Chen, E. (2022). Association between triglyceride-glucose index and nonalcoholic fatty liver disease in type 2 diabetes mellitus. BMC Endocr. Disord., 22.","DOI":"10.1186\/s12902-022-01172-7"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Yu, C., Shi, Y., Wang, T., Zhu, L., Zhou, W., Bao, H., and Cheng, X. (2024). Triglyceride-glucose index change and chronic kidney disease progression in a Chinese hypertensive population. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1342408"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13098-024-01439-0","article-title":"The prognostic value of triglyceride-glucose index to adverse renal outcomes in patients with type 2 diabetes mellitus: Results from the cohort study of ACCORD","volume":"16","author":"Yu","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e212612","DOI":"10.1001\/jamanetworkopen.2021.2612","article-title":"The Triglyceride-Glucose Index and Obesity-Related Risk of End-Stage Kidney Disease in Austrian Adults","volume":"4","author":"Fritz","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s40001-023-01134-2","article-title":"Comparison of insulin resistance indices in predicting albuminuria among patients with type 2 diabetes","volume":"28","author":"Nabipoorashrafi","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12944-018-0878-2","article-title":"Association of serum high-density lipoprotein cholesterol with microalbuminuria in type 2 diabetes patients","volume":"17","author":"Sun","year":"2018","journal-title":"Lipids Health Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.2147\/JIR.S491694","article-title":"A Population-Based Study of the Mediating Role of WBC, NEUT and PLT in the Relationship Between Triglyceride-Glucose Index and Urinary Albumin Excretion","volume":"17","author":"Sun","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2024). 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes\u20142024. Diabetes Care, 47, S219\u2013S230.","DOI":"10.2337\/dc24-S011"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1007\/s11357-023-01044-5","article-title":"Baseline and usual triglyceride-glucose index and the risk of chronic kidney disease: A prospective cohort study","volume":"46","author":"Kunutsor","year":"2024","journal-title":"Geroscience"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/jdi.13371","article-title":"Association between the triglyceride-glucose index and diabetic nephropathy in patients with type 2 diabetes: A cross-sectional study","volume":"12","author":"Liu","year":"2021","journal-title":"J. Diabetes Investig."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Tam, A.A., Altay, F.P., Demir, P., Ozdemir, D., Topaloglu, O., Ersoy, R., and Cak\u0131r, B. (2024). The Association Between Diabetic Nephropathy and Triglyceride\/Glucose Index and Triglyceride\/High-Density Lipoprotein Cholesterol Ratio in Patients with Type 2 Diabetes Mellitus. J. Clin. Med., 13.","DOI":"10.3390\/jcm13226954"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"14791641221113784","DOI":"10.1177\/14791641221113784","article-title":"Triglyceride-glucose index is prospectively associated with chronic kidney disease progression in Type 2 diabetes-mediation by pigment epithelium-derived factor","volume":"19","author":"Low","year":"2022","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12933-023-01965-7","article-title":"The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction","volume":"22","author":"An","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wang, N., and Zhang, C. (2024). Oxidative Stress: A Culprit in the Progression of Diabetic Kidney Disease. Antioxidants, 13.","DOI":"10.3390\/antiox13040455"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1523-1755.2005.00235.x","article-title":"Lipid abnormalities associated with urinary albumin excretion rate in Taiwanese type 2 diabetic patients","volume":"67","author":"Tseng","year":"2005","journal-title":"Kidney Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12933-024-02244-9","article-title":"Joint association of TyG index and high sensitivity C-reactive protein with cardiovascular disease: A national cohort study","volume":"23","author":"Cui","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13098-023-01009-w","article-title":"Association of triglyceride-glucose index with atherosclerotic cardiovascular disease and mortality among familial hypercholesterolemia patients","volume":"15","author":"Wen","year":"2023","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Li, Z., Fan, X., Liu, Y., Yu, L., He, Y., Li, L., Gao, S., Chen, W., Yang, R., and Yu, C. (2024). Triglyceride-glucose index is associated with heart failure with preserved ejection fraction in different metabolic states in patients with coronary heart disease. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1447072"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12933-019-0898-x","article-title":"Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: The Northern Shanghai Study","volume":"18","author":"Zhao","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e17995","DOI":"10.1097\/MD.0000000000017995","article-title":"The triglyceride glucose index can predict newly diagnosed biopsy-proven diabetic nephropathy in type 2 diabetes: A nested case control study","volume":"98","author":"Shang","year":"2019","journal-title":"Medicine"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.2147\/DMSO.S318255","article-title":"Chongqing Diabetes Registry Group. Relationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus","volume":"14","author":"Lv","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.numecd.2023.03.026","article-title":"Association between triglyceride-glucose index and chronic kidney disease: A cohort study and meta-analysis","volume":"33","author":"Ren","year":"2023","journal-title":"Nutr. Metab. Cardiovasc. Dis."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/10\/1803\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:50:17Z","timestamp":1760035817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/10\/1803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["medicina61101803"],"URL":"https:\/\/doi.org\/10.3390\/medicina61101803","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]}}}