{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:34:00Z","timestamp":1785267240074,"version":"3.55.0"},"reference-count":57,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Sciatica is a common condition associated with significant pain and reduced quality of life (QoL). However, its impact and associated determinants remain underexplored in Saudi Arabia. Therefore, this study aimed to examine determinants of quality of life among Saudi adults with sciatica. Materials and Methods: A cross-sectional study was conducted in Saudi Arabia between February and March 2024 using an online Arabic questionnaire disseminated via social media. Participants (n = 927) aged \u226518 years completed a 50-item questionnaire covering sociodemographic characteristics, clinical history, lifestyle factors, and the Short Form-12 (SF-12) QoL scale. Results: Of the 927 adults (mean age 30 \u00b1 11 years), 76% (n = 706) were female and 24% (n = 221) male; 10% (n = 92) reported sciatica. Overall, 57% (n = 531) reported good QoL. Multivariate analysis revealed that increasing age (Odds ratio (OR) = 1.04; 95% CI: 1.01\u20131.07), urban residence (OR = 1.49; 95% CI: 1.11\u20132.00), and higher income (&gt;15,000 Saudi Arabia Riyal (SAR); OR = 1.53; 95% CI: 1.03\u20132.27) were associated with better QoL. Conversely, diabetes (OR = 0.42; 95% CI: 0.22\u20130.79), arthritis (OR = 0.52; 95% CI: 0.32\u20130.83), and sciatica duration &gt;1 year (OR = 0.29; 95% CI: 0.12\u20130.69) were associated with poorer QoL. Gender, body mass index (BMI), smoking, and physical activity showed no significant associations. Conclusions: Sciatica, prolonged symptom duration, and comorbidities such as diabetes and arthritis negatively affect QoL in Saudi adults, whereas socioeconomic and demographic factors contribute positively. The results underscore the importance of early intervention and tailored support for sciatica patients with long-standing symptoms or specific comorbidities to improve health outcomes. Longitudinal studies are warranted to assess causality and the impact of interventions.<\/jats:p>","DOI":"10.3390\/medicina61101824","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:13:27Z","timestamp":1760361207000},"page":"1824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Determinants of Quality of Life Among Saudi Adults with Sciatica: A Cross-Sectional Study"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-1191","authenticated-orcid":false,"given":"Mohammad A.","family":"Jareebi","sequence":"first","affiliation":[{"name":"Family and Community Medicine Department, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah J.","family":"Almalki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkarim Zain","family":"Suwaydi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6552-0768","authenticated-orcid":false,"given":"Ehab F.","family":"Hakami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3037-769X","authenticated-orcid":false,"given":"Mnar H.","family":"Moafa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saud N.","family":"Wadani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah N.","family":"Hakami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3319-7501","authenticated-orcid":false,"given":"Shatha K.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik I.","family":"Hakami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmajid E.","family":"Abuhadi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-3064","authenticated-orcid":false,"given":"Majed A.","family":"Ryani","sequence":"additional","affiliation":[{"name":"Family and Community Medicine Department, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Bahri","sequence":"additional","affiliation":[{"name":"Family and Community Medicine Department, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya H.","family":"Khormi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A.","family":"Hakami","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Dawadmi College of Medicine, Shaqra University, Shaqra 11911, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-6724","authenticated-orcid":false,"given":"Abdulwahab A.","family":"Aqeeli","sequence":"additional","affiliation":[{"name":"Family and Community Medicine Department, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00002517-200012000-00001","article-title":"Conservative Treatment of Sciatica: A Systematic Review","volume":"13","author":"Vroomen","year":"2000","journal-title":"J. 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