{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:05:06Z","timestamp":1791381906827,"version":"4.3.3"},"reference-count":57,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This study is aimed at evaluating periodontal health in patients with psoriasis and investigating its impact on dermatology-specific and oral health-related quality of life. Materials and Methods: A total of 226 individuals were enrolled, including 113 patients with clinically diagnosed psoriasis and 113 age- and gender-matched healthy controls. The periodontal parameters recorded included plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (CAL). Oral health-related quality of life was assessed using the Oral Health Impact Profile-14 (OHIP-14), while dermatology-specific quality of life was evaluated with the Psoriasis Quality of Life Questionnaire (PQLQ). Psoriasis severity was measured by the Psoriasis Area and Severity Index (PASI). Results: Patients with psoriasis demonstrated significantly poorer periodontal parameters compared to controls, with higher PI (p = 0.006), PD (p = 0.001), and CAL (p = 0.041), as well as a lower number of teeth (p = 0.027). No significant differences in GI were observed (p = 0.331). Subdomain analysis of OHIP-14 indicated significantly greater functional limitation in the psoriasis group (p = 0.001), although no differences were detected in other domains. Positive and significant correlations were found among all the OHIP-14 subscales in both groups, and PQLQ scores were strongly correlated with OHIP-14 outcomes in the psoriasis group (p &lt; 0.05). PASI scores tended to be higher among patients with periodontitis than those with gingivitis or periodontal health, but this difference did not reach statistical significance (p = 0.257). Conclusions: Psoriasis patients exhibited poorer periodontal status and reduced oral health-related quality of life compared to healthy individuals. However, differences in oral hygiene habits may also have contributed to these findings. Our findings suggest an association between psoriasis and impaired periodontal health, but due to the cross-sectional design, a causal relationship cannot be established.<\/jats:p>","DOI":"10.3390\/medicina61101825","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:13:27Z","timestamp":1760361207000},"page":"1825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Periodontal Health and Quality of Life in Patients with Psoriasis: A Cross-Sectional Study"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4205-861X","authenticated-orcid":false,"given":"G\u00fclbahar","family":"Ustao\u011flu","sequence":"first","affiliation":[{"name":"Department of Periodontology, Gulhane Faculty of Dentistry, University of Health Sciences, Ankara 06010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7682-2498","authenticated-orcid":false,"given":"\u015eeyma","family":"\u00c7ardakc\u0131 Bahar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Gulhane Faculty of Dentistry, University of Health Sciences, Ankara 06010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-2125","authenticated-orcid":false,"given":"Ay\u015fenur","family":"Botsal\u0131","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara 06010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-8244","authenticated-orcid":false,"given":"\u00d6zlem","family":"Sara\u00e7 Atag\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Gulhane Faculty of Dentistry, University of Health Sciences, Ankara 06010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-7819","authenticated-orcid":false,"given":"Seval","family":"Ceylan \u015een","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Gulhane Faculty of Dentistry, University of Health Sciences, Ankara 06010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6301-0870","authenticated-orcid":false,"given":"Ahmet Tu\u011frul","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara 06010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6222-420X","authenticated-orcid":false,"given":"Zeynep Hazan","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Gulhane Faculty of Dentistry, University of Health Sciences, Ankara 06010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jaad.2004.07.045","article-title":"The prevalence of psoriasis in African Americans: Results from a population-based study","volume":"52","author":"Gelfand","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"ii18","DOI":"10.1136\/ard.2004.033217","article-title":"Psoriasis: Epidemiology, clinical features, and quality of life","volume":"64","author":"Langley","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jaad.2008.02.039","article-title":"Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics","volume":"58","author":"Menter","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.clindermatol.2007.08.007","article-title":"Psoriasis: Epidemiology","volume":"25","author":"Gudjonsson","year":"2007","journal-title":"Clin. Dermatol."},{"key":"ref_5","first-page":"e37702","article-title":"Psychological Well-Being of Adult Psoriasis Patients: A Narrative Review","volume":"15","author":"Hepat","year":"2023","journal-title":"Cureus"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/1346-8138.13806","article-title":"Critical role of environmental factors in the pathogenesis of psoriasis","volume":"44","author":"Zeng","year":"2017","journal-title":"J. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s13555-021-00483-2","article-title":"Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities","volume":"11","author":"Menter","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","article-title":"The pathogenesis of human periodontitis: An introduction","volume":"14","author":"Page","year":"1997","journal-title":"Periodontology 2000"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Sabine Elisabeth, G., Yuxi, Z., Jiawen, Y., Lei, W., Sabine, R., and Joerg, M. (J. Periodontal Res., 2025). Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis, J. Periodontal Res., ahead of print.","DOI":"10.1111\/jre.70003"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3390\/hygiene2020007","article-title":"Diabetes and Non-Surgical Periodontal Therapy: What Can We Hope for?","volume":"2","author":"Stoica","year":"2022","journal-title":"Hygiene"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/00016350903583678","article-title":"Periodontitis in psoriasis patients: A blinded, case-controlled study","volume":"68","author":"Preus","year":"2010","journal-title":"Acta Odontol. Scand."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/odi.12271","article-title":"Association of chronic periodontitis and psoriasis: Periodontal status with severity of psoriasis","volume":"21","author":"Sharma","year":"2015","journal-title":"Oral Dis."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Skudutyte-Rysstad, R., Slevolden, E.M., Hansen, B.F., Sandvik, L., and Preus, H.R. (2014). Association between moderate to severe psoriasis and periodontitis in a Scandinavian population. BMC Oral Health, 14.","DOI":"10.1186\/1472-6831-14-139"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1055\/s-0040-1713465","article-title":"Higher Prevalence of Periodontitis and Decayed, Missing and Filled Teeth in Patients with Psoriasis","volume":"14","author":"Barros","year":"2020","journal-title":"Eur. J. Dent."},{"key":"ref_15","first-page":"101","article-title":"Periodontitis: A newly identified comorbidity in psoriasis and psoriatic arthritis","volume":"16","author":"Antal","year":"2019","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2133.2001.144s58033.x","article-title":"The impact of psoriasis on quality of life","volume":"144","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1067\/mjd.2001.114592","article-title":"Physical and psychologic measures are necessary to assess overall psoriasis severity","volume":"45","author":"Kirby","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2133.1988.tb01774.x","article-title":"A survey of the social and psychological effects of psoriasis","volume":"118","author":"Ramsay","year":"1988","journal-title":"Br. J. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1365-2133.1997.tb01113.x","article-title":"Quality of life in patients with psoriasis: The contribution of clinical variables and psoriasis-specific stress","volume":"137","author":"Fortune","year":"1997","journal-title":"Br. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2340\/0001555575240243","article-title":"The Psoriasis Life Stress Inventory: A preliminary index of psoriasis-related stress","volume":"75","author":"Gupta","year":"1995","journal-title":"Acta Derm.-Venereol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1365-2133.1990.tb04192.x","article-title":"Validation of Sickness Impact Profile and Psoriasis Disability Index in Psoriasis","volume":"123","author":"Finlay","year":"1990","journal-title":"Br. J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1067\/mjd.2000.107501","article-title":"The burden of psoriasis: A study concerning health-related quality of life among Norwegian adult patients with psoriasis compared with general population norms","volume":"43","author":"Wahl","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1046\/j.1365-2133.1999.03112.x","article-title":"Measuring health-related quality of life in patients with mild to moderate eczema and psoriasis: Clinical validity, reliability and sensitivity to change of the DLQI. The Cavide Research Group","volume":"141","author":"Badia","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000246844","article-title":"The relationship between disease severity, disability and psychological distress in patients undergoing PUVA treatment for psoriasis","volume":"189","author":"Root","year":"1994","journal-title":"Dermatology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1046\/j.1365-2133.1999.03207.x","article-title":"Quality of life, health-state utilities and willingness to pay in patients with psoriasis and atopic eczema","volume":"141","author":"Lundberg","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"ref_26","first-page":"996","article-title":"A review of quality of life measurement in psoriasis","volume":"141","author":"Mombers","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"ref_27","first-page":"e14422","article-title":"Effects of disease severity on quality of life in patients with psoriasis","volume":"33","author":"Cadirci","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_28","first-page":"189","article-title":"Developing a quality of life questionnaire in patients with psoriasis","volume":"37","author":"Aydemir","year":"2003","journal-title":"Turkderm-Turk. Arch. Dermatol. Venereol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1600-0528.1997.tb00941.x","article-title":"Derivation and validation of a short-form oral health impact profile","volume":"25","author":"Slade","year":"1997","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000083509","article-title":"The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque-type psoriasis","volume":"210","author":"Schmitt","year":"2005","journal-title":"Dermatology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1365-4632.2005.02448.x","article-title":"Developing a quality of life instrument in patients with psoriasis: The Psoriasis Quality of Life Questionnaire (PQLQ)","volume":"45","author":"Inanir","year":"2006","journal-title":"Int. J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1902\/jop.1967.38.6.610","article-title":"The Gingival Index, the Plaque Index and the Retention Index Systems","volume":"38","year":"1967","journal-title":"J. Periodontol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal Disease in Pregnancy. II. Correlation Between Oral Hygiene and Periodontal Condtion","volume":"22","author":"Silness","year":"1964","journal-title":"Acta Odontol. Scand."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.hlpt.2016.03.004","article-title":"Quality of Life and Oral Health Impact Profile in Turkish Dental Patients","volume":"5","author":"Top","year":"2016","journal-title":"Health Policy Technol. (SSCI)"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav. Res. Methods"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/JPER.18-0394","article-title":"Periodontitis as another comorbidity associated with psoriasis: A case-control study","volume":"90","author":"Mendes","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/odi.13617","article-title":"Periodontitis in patients with psoriasis: A systematic review and meta-analysis","volume":"28","author":"Zhang","year":"2022","journal-title":"Oral Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/jdv.14051","article-title":"Periodontitis and risk of psoriasis: A systematic review and meta-analysis","volume":"31","author":"Ungprasert","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/jcpe.13996","article-title":"Are periodontitis and psoriasis associated? A pre-clinical murine model","volume":"51","author":"Marruganti","year":"2024","journal-title":"J. Clin. Periodontol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1159\/000518296","article-title":"Smoking and Periodontitis Can Play a Synergistic Role in the Development of Psoriasis: A Nationwide Cohort Study","volume":"238","author":"Han","year":"2022","journal-title":"Dermatology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/jdv.13814","article-title":"Risk of periodontitis in patients with psoriasis and psoriatic arthritis","volume":"31","author":"Egeberg","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jobcr.2024.06.008","article-title":"Association of psoriasis and periodontitis in the north Indian population","volume":"14","author":"Sachan","year":"2024","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/bjd.12631","article-title":"Bimodal immune activation in psoriasis","volume":"170","author":"Christophers","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3390\/epidemiologia5030033","article-title":"Periodontitis in Psoriatic Patients: Epidemiological Insights and Putative Etiopathogenic Links","volume":"5","author":"Rupe","year":"2024","journal-title":"Epidemiologia"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.5114\/ada.2022.118998","article-title":"Evaluation of the relationship between psoriasis, periodontitis, and markers of inflammation","volume":"39","author":"Majchrzycka","year":"2022","journal-title":"Postep. Dermatol. Alergol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/jcpe.13620","article-title":"Relationship between periodontitis and psoriasis: A two-sample Mendelian randomization study","volume":"49","author":"Baurecht","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1744-313X.2011.01068.x","article-title":"Genetic variants in IFIH1 play opposite roles in the pathogenesis of psoriasis and chronic periodontitis","volume":"39","author":"Chen","year":"2012","journal-title":"Int. J. Immunogenet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/jid.2013.508","article-title":"The prevalence and odds of depressive symptoms and clinical depression in psoriasis patients: A systematic review and meta-analysis","volume":"134","author":"Dowlatshahi","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1111\/jdv.14460","article-title":"Depression and suicidality in psoriasis: Review of the literature including the cytokine theory of depression","volume":"31","author":"Koo","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2165\/00128071-200506060-00005","article-title":"The psychosocial burden of psoriasis","volume":"6","author":"Kimball","year":"2005","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2147\/PTT.S519420","article-title":"Challenges Psoriasis and Its Impact on Quality of Life: Challenges in Treatment and Management","volume":"15","author":"Ponikowska","year":"2025","journal-title":"Psoriasis"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Costa, A.A., Cota, L.O.M., Esteves Lima, R.P., Oliveira, A., Cortelli, S.C., Cortelli, J.R., Cyrino, R.M., Mendes, V.S., Silva, T.A., and Costa, F.O. (2024). The association between periodontitis and the impact of oral health on the quality of life of individuals with psoriasis and psoriatic arthritis. PLoS ONE, 19.","DOI":"10.1101\/2024.03.13.24304243"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/scd.12938","article-title":"Impact of periodontitis on oral health-related quality of life of patients with psoriatic arthritis","volume":"44","author":"Mishra","year":"2024","journal-title":"Spec. Care Dent."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s00784-020-03600-1","article-title":"Periodontitis and the impact of oral health on the quality of life of psoriatic individuals: A case-control study","volume":"25","author":"Costa","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jid.2018.12.014","article-title":"Oral Health in Patients with Psoriasis-A Prospective Study","volume":"139","author":"Woeste","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"291","DOI":"10.25259\/IJDVL_331_2022","article-title":"The association of psoriasis and psoriatic arthritis with periodontitis: A hospital-based case-control study","volume":"90","author":"Polineni","year":"2023","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_57","first-page":"e156","article-title":"Oral health in patients with severe inflammatory dermatologic and rheumatologic disease","volume":"3","author":"Kiernan","year":"2023","journal-title":"Ski. Health Dis."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/10\/1825\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:23:32Z","timestamp":1760369012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/10\/1825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,12]]},"references-count":57,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["medicina61101825"],"URL":"https:\/\/doi.org\/10.3390\/medicina61101825","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,12]]}}}