{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:56:00Z","timestamp":1784667360642,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This study aimed to investigate the influence of continuous positive airway pressure in patients with obstructive sleep apnoea on hearing and the possibility of recovering cochlear receptor cells. Materials and Methods: Forty-two patients with obstructive sleep apnoea (OSA) were assigned to the study group. Patients underwent pure-tone audiometry and transient-evoked (TEOAE) and distortion-product (DPOAE) otoacoustic emissions before starting continuous positive airway pressure (CPAP) therapy and six months after CPAP therapy. Subjects were further divided into the following two groups: those who adequately used the therapy and those who did not adhere to treatment recommendations. Results: There is no significant difference in hearing thresholds for specific frequencies after six months of CPAP therapy. There is no significant difference in TEOAE and DPOAE SNR values at any frequency after 6 months of CPAP therapy. There is no significant difference in hearing threshold results for specific frequencies as a function of subject co-operation with treatment. After therapy, there is a significant difference in the SNR values in TEOAEs at 2 kHz and 4 kHz in subjects of the OSA target group, depending on co-operation, being higher in co-operative subjects, while there are no significant differences at other frequencies. There is a significant difference in the SNR results in DPOAEs, where they are higher in co-operative subjects at 1000, 6000, 7000 and 8000 Hz. Conclusions: The use of continuous positive airway pressure as a therapy for OSA has no effect on hearing and cochlear receptor cell recovery. Co-operation with CPAP treatment does not affect hearing threshold, but does affect cochlear receptor cell function, which is better at mid and higher frequencies in those who co-operate. These findings underscore the clinical significance of treatment adherence. Consistent adherence is associated with measurable improvements in hearing, particularly at higher frequencies, which cannot typically be evaluated in routine clinical practice using standard pure-tone audiometry. Our results emphasise the importance of promoting compliance with CPAP therapy not only for cardiovascular and neurological protection, but also for maintaining hearing health.<\/jats:p>","DOI":"10.3390\/medicina61101833","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:51:28Z","timestamp":1760428288000},"page":"1833","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Continuous Positive Airway Pressure Treatment on Hearing and Inner Ear Function in Patients with Obstructive Sleep Apnoea\u2014Original Research"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-0529","authenticated-orcid":false,"given":"Mirjana","family":"Grebenar \u010cerkez","sequence":"first","affiliation":[{"name":"Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u017deljko","family":"Zub\u010di\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stjepan","family":"Juri\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Department of Neurology, University Hospital Center Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-7993","authenticated-orcid":false,"given":"Jelena","family":"\u0160ari\u0107 Juri\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Department of Neurology, University Hospital Center Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Kova\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-0649","authenticated-orcid":false,"given":"\u017deljka","family":"Laksar Klari\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1661-7147","authenticated-orcid":false,"given":"Darija","family":"Birti\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1001\/jama.2020.3514","article-title":"Diagnosis and Management of Obstructive Sleep Apnea: A Review","volume":"323","author":"Gottlieb","year":"2020","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chi, J.C., Lee, S.D., Huang, R.J., Lai, C.H., Liu, S.Y., Tsai, Y.J., Fu, P.H., and Ting, H. (2021). CPAP Treatment Improves Pure Tone Audiometry Threshold in Sensorineural Hearing Loss Patients with Sleep-Disordered Breathing. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18136768"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/B978-0-444-64032-1.00025-4","article-title":"Polysomnography","volume":"160","author":"Rundo","year":"2019","journal-title":"Handb. Clin. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline","volume":"13","author":"Kapur","year":"2017","journal-title":"J. Clin. Sleep Med."},{"key":"ref_5","first-page":"7215258","article-title":"Practical Aspects of Interface Application in CPAP Treatment","volume":"2019","author":"Bachour","year":"2019","journal-title":"Can. Respir. J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Saiphoklang, N., Leelasittikul, K., and Pugongchai, A. (2021). Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-93554-5"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.2147\/NSS.S310257","article-title":"The COVID-19 Lockdown and CPAP Adherence: The More Vulnerable Ones Less Likely to Improve Adherence?","volume":"13","author":"Demirovic","year":"2021","journal-title":"Nat. Sci. Sleep"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.5664\/jcsm.7640","article-title":"Treatment of Adult Obstructive Sleep Apnea with Positive Airway Pressure: An American Academy of Sleep Medicine Clinical Practice Guideline","volume":"15","author":"Patil","year":"2019","journal-title":"J. Clin. Sleep Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"119356","DOI":"10.1016\/j.gep.2024.119356","article-title":"Gene expression analysis of oxidative stress-related genes in the apical, middle, and basal turns of the cochlea","volume":"51","author":"Yang","year":"2024","journal-title":"Gene Expr. Patterns"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"108783","DOI":"10.1016\/j.heares.2023.108783","article-title":"Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss","volume":"434","author":"Tan","year":"2023","journal-title":"Hear. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pak, J.H., Kim, Y., Yi, J., and Chung, J.W. (2020). Antioxidant Therapy against Oxidative Damage of the Inner Ear: Protection and Preconditioning. Antioxidants, 9.","DOI":"10.3390\/antiox9111076"},{"key":"ref_12","unstructured":"Grebenar Cerkez, M., Zubcic, Z., Juric, S., Saric Juric, J., and Birti\u0107, D. (2024). Audiologic Profile of OSA Patients: The Effect of Chronic Nocturnal Intermittent Hypoxia on Auditory Function; A Pilot Study. Acta Clin. Croat., accepted."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lu, C.T., Lee, L.A., Lee, G.S., and Li, H.Y. (2022). Obstructive Sleep Apnea and Auditory Dysfunction-Does Snoring Sound Play a Role?. Diagnostics, 12.","DOI":"10.3390\/diagnostics12102374"},{"key":"ref_14","unstructured":"Katz, J., Chasin, M., English, K., Hood, L.J., and Tillery, K.L. (2015). Handbook of Clinical Audiology, Wolters Kluwer Health. [7th ed.]."},{"key":"ref_15","first-page":"104","article-title":"Transitory evoked otoacoustic emission (TEOAE) and distortion product otoacoustic emission (DPOAE) outcomes from a three-stage newborn hearing screening protocol","volume":"20","author":"Tzanakakis","year":"2016","journal-title":"Hippokratia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/clockssleep5020025","article-title":"The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP","volume":"5","author":"Sircu","year":"2023","journal-title":"Clocks Sleep"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00405-019-05468-8","article-title":"The association between obstructive sleep apnea and hearing loss: A cross-sectional analysis","volume":"276","author":"Kayabasi","year":"2019","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1196\/annals.1444.003","article-title":"Neurological aspects of obstructive sleep apnea","volume":"1142","author":"Broderick","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S1808-8694(15)31004-1","article-title":"Idiopathic sudden sensorineural hearing loss: Etiopathogenic aspects","volume":"72","author":"Lazarini","year":"2006","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00224-6","article-title":"Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals","volume":"155","author":"Sha","year":"2001","journal-title":"Hear. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3906\/sag-1705-66","article-title":"The effect of obstructive sleep apnea syndrome on the central auditory system","volume":"48","author":"Karamert","year":"2018","journal-title":"Turk. J. Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"zsx106","DOI":"10.1093\/sleep\/zsx106","article-title":"Damage of Inner Ear Sensory Hair Cells via Mitochondrial Loss in a Murine Model of Sleep Apnea With Chronic Intermittent Hypoxia","volume":"40","author":"Seo","year":"2017","journal-title":"Sleep"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s11325-011-0517-x","article-title":"Is obstructive sleep apnea syndrome a risk factor for auditory pathway?","volume":"16","author":"Casale","year":"2012","journal-title":"Sleep Breath."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11325-017-1530-5","article-title":"Severe obstructive sleep apnea is associated with cochlear function impairment","volume":"22","author":"Matsumura","year":"2018","journal-title":"Sleep Breath."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11325-019-01891-7","article-title":"Inner ear function in patients with obstructive sleep apnea","volume":"24","author":"Li","year":"2020","journal-title":"Sleep Breath."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.sleep.2022.04.005","article-title":"The relationship between obstructive sleep apnea with hearing and balance: A scoping review","volume":"95","author":"Cheung","year":"2022","journal-title":"Sleep Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1080\/08869634.2020.1783050","article-title":"Evaluation of the changes in the hearing system over the years among patients with OSAS using a CPAP device","volume":"40","author":"Deniz","year":"2022","journal-title":"Cranio"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/01945998221120777","article-title":"Obstructive Sleep Apnea and Sensorineural Hearing Loss: A Systematic Review and Meta-analysis","volume":"169","author":"Kasemsuk","year":"2023","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mastino, P., Rosati, D., de Soccio, G., Romeo, M., Pentangelo, D., Venarubea, S., Fiore, M., Meliante, P.G., Petrella, C., and Barbato, C. (2023). Oxidative Stress in Obstructive Sleep Apnea Syndrome: Putative Pathways to Hearing System Impairment. Antioxidants, 12.","DOI":"10.3390\/antiox12071430"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e281","DOI":"10.1055\/s-0045-1809060","article-title":"Effects of Continuous Positive Airway Pressure on the Degree of Sleepiness, Functional Quality of Sleep, and Electrophysiological Hearing Responses in Individuals with Obstructive Sleep Apnea","volume":"18","author":"Farber","year":"2025","journal-title":"Sleep Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1164\/rccm.200311-1571OC","article-title":"Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea","volume":"170","author":"Barnes","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.sleep.2022.11.037","article-title":"Investigating changes in cognition associated with the use of CPAP in cognitive impairment and dementia: A retrospective study","volume":"101","author":"Costa","year":"2023","journal-title":"Sleep Med."},{"key":"ref_33","first-page":"Doc09","article-title":"Current audiological diagnostics","volume":"16","author":"Hoth","year":"2017","journal-title":"GMS Curr. Top. Otorhinolaryngol. Head Neck Surg."},{"key":"ref_34","first-page":"164","article-title":"Distortion Product Oto-Acoustic Emission: A Superior Tool for Hearing Assessment Than Pure Tone Audiometry","volume":"21","author":"Kapoor","year":"2019","journal-title":"Noise Health"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Pawlaczyk-\u0142uszczy\u0144ska, M., Zamojska-Daniszewska, M., Dudarewicz, A., and Zaborowski, K. (2021). Pure-Tone Hearing Thresholds and Otoacoustic Emissions in Students of Music Academies. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18031313"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-0038-1641743","article-title":"Early Intervention of Adult Hearing Loss: Effectiveness of Auditory Measures for Detecting Hidden Hearing Loss and\/or Cochlear Synaptopathy: A Systematic Review","volume":"39","author":"Barbee","year":"2018","journal-title":"Semin. Hear."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.5664\/jcsm.9176","article-title":"CPAP adherence is associated with reduced risk for stroke among older adult Medicare beneficiaries with obstructive sleep apnea","volume":"17","author":"Wickwire","year":"2021","journal-title":"J. Clin. Sleep Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e060166","DOI":"10.1136\/bmjopen-2021-060166","article-title":"Effect of CPAP on cognitive function in stroke patients with obstructive sleep apnoea: A meta-analysis of randomised controlled trials","volume":"13","author":"Yang","year":"2023","journal-title":"BMJ Open"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/10\/1833\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T08:56:37Z","timestamp":1760432197000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/10\/1833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["medicina61101833"],"URL":"https:\/\/doi.org\/10.3390\/medicina61101833","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]}}}