{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:33:34Z","timestamp":1761006814610,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:00:00Z","timestamp":1760832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"VHS Medical Center Research Grant from the Republic of Korea","award":["VHSMC:24012"],"award-info":[{"award-number":["VHSMC:24012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Some cancer patients in palliative care need to access intravenous administration of medications to relieve symptoms. Few studies have explicitly assessed the safety and feasibility of peripherally inserted central catheter (PICC) insertion at bedside in palliative care settings. In this study, we suggest the usefulness, safety, and feasibility of bedside ultrasound-guided PICC placement as a tool for improvement in the quality of life for patients in palliative and hospice care settings. Materials and Methods: The study population, with terminal cancer and admitted to a palliative and hospice care unit in the Veterans Health Service Medical Center, was evaluated (N = 150). The patients were divided into two groups based on the methods of PICC insertion: Group 1 (PICC at bedside, N = 75) and Group 2 (PICC in intervention room, N = 75). The two groups were matched for age, sex, the level of Eastern Cooperative Oncology Group (ECOG) performance status, and types of primary cancer. Results: The success rates of the PICC procedure for Groups 1 and 2 were 89.33% and 97.33%, respectively, with no significant difference between the groups (p = 0.102). The mean duration (days) of catheter use was longer in Group 1 (23.31 \u00b1 16.36) compared to that in Group 2 (21.90 \u00b1 18.95), with no statistically significant difference (p = 0.639). Multivariable logistic regression analyses confirmed that Group 1 was not inferior to Group 2 regarding procedural success (Model 2, p = 0.21) and catheter dwell time (Model 2, p = 0.66). The most common cause of catheter removal in both groups was death, followed by self-removal and hospital discharge (p = 0.386). Conclusions: This study suggests that ultrasound-guided PICC insertion at bedside may have comparable procedural outcomes with potentially reducing the risks associated with intra-hospital patient transport compared with fluoroscopy-guided placement. We suggest this bedside approach can be considered a feasible and safe method for improving the quality of life of patients in palliative care settings.<\/jats:p>","DOI":"10.3390\/medicina61101876","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:23:34Z","timestamp":1760952214000},"page":"1876","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of Bedside Ultrasound-Guided Peripherally Inserted Central Catheter Placement in Cancer Patients in Palliative Care: A Single-Center Retrospective Study"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-1015","authenticated-orcid":false,"given":"Hak Ryeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9467-9277","authenticated-orcid":false,"given":"Junyong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-9254","authenticated-orcid":false,"given":"Jang Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Vascular and Transplant Surgery, Department of Surgery, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8900-079X","authenticated-orcid":false,"given":"Hwa Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20210405","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: An overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_2","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_4","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_5","unstructured":"Ferlay, J., Em, L.F., Laversanne, M., Colombet, M., Mery, L., Pi\u00f1eros, M., Znaor, A., Soerjomataram, I., and Bray, F. (2024, August 18). Global Cancer Observatory: Cancer Today. Available online: https:\/\/gco.iarc.who.int\/today."},{"key":"ref_6","unstructured":"Knaul, F., Radbruch, L., Connor, S., de Lima, L., Arreola-Ornelas, H., Mendez Carniado, O., Jiang Kwete, X., Bhadelia, A., Downing, J., and Krakauer, E.L. (2020). How Many Adults and Children are in Need of Palliative Care Worldwide, Global Atlas of Palliative Care."},{"key":"ref_7","unstructured":"National Hospice and Palliative Care Organization (2024, September 25). NHPCO Facts and Figures, 2024 Edition. Available online: https:\/\/allianceforcareathome.org\/facts-and-figures-report-2024-edition\/."},{"key":"ref_8","unstructured":"Statistics Korea, and Ministry of Health and Welfare (2024, March 18). 2007\u20132021. Cancer Registration Statistics. Prevalence of 24 Cancer Types by Gender and 5-Year Age Intervals. Available online: https:\/\/kosis.kr\/statHtml\/statHtml.do?orgId=117&tblId=DT_117N_A00124&conn_path=I2."},{"key":"ref_9","unstructured":"National Hospice Center, and Ministry of Health and Welfare (2024). Hospice & Palliative Care in Korea: Facts & Figures 2023."},{"key":"ref_10","first-page":"348","article-title":"The role of palliative care at the end of life","volume":"11","author":"Rome","year":"2011","journal-title":"Ochsner J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0885-3924(01)00281-0","article-title":"Symptom burden at the end of life: Hospice providers\u2018 perceptions","volume":"21","author":"Kutner","year":"2001","journal-title":"J. Pain. Symptom Manag."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/srao.2000.6590","article-title":"Cancer-related symptoms","volume":"10","author":"Cleeland","year":"2000","journal-title":"Semin. Radiat. Oncol."},{"key":"ref_13","first-page":"923","article-title":"The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection","volume":"9","author":"Jin","year":"2015","journal-title":"Patient Prefer. Adherence"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"881","DOI":"10.4143\/crt.2020.1008","article-title":"Safety, efficacy, and patient satisfaction with initial peripherally inserted central catheters compared with usual intravenous access in terminally ill cancer patients: A randomized Phase II study","volume":"53","author":"Park","year":"2021","journal-title":"Cancer Res. Treat."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jpainsymman.2005.04.004","article-title":"Patients\u2018 and relatives\u2018 perceptions about intravenous and subcutaneous hydration","volume":"30","author":"Mercadante","year":"2005","journal-title":"J. Pain. Symptom Manag."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.3346\/jkms.2010.25.12.1748","article-title":"Safety and effectiveness of central venous catheterization in patients with cancer: Prospective observational study","volume":"25","author":"Kim","year":"2010","journal-title":"J. Korean Med. Sci."},{"key":"ref_17","first-page":"494","article-title":"Venous access: A practical review for 2009","volume":"55","author":"Cheung","year":"2009","journal-title":"Can. Fam. Physician"},{"key":"ref_18","unstructured":"Montanarella, M.J., Agarwal, A., and Moon, B. (2024, September 29). Peripherally inserted central catheter (PICC) line placement, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK573064\/."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/0148607112457422","article-title":"Role of peripherally inserted central catheters in home parenteral nutrition: A 5-year prospective study","volume":"37","author":"Carrero","year":"2013","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/(SICI)1097-0142(20000201)88:3<653::AID-CNCR24>3.0.CO;2-1","article-title":"Cancer and comorbidity: Redefining chronic diseases","volume":"88","author":"Ogle","year":"2000","journal-title":"Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000100450","article-title":"Symptoms in the lives of terminal cancer patients: Which is the most important?","volume":"71","author":"Kwon","year":"2006","journal-title":"Oncology"},{"key":"ref_22","first-page":"4987","article-title":"Safety, efficacy, and patient-perceived satisfaction of peripherally inserted central catheters in terminally ill cancer patients: A prospective multicenter observational study","volume":"24","author":"Park","year":"2016","journal-title":"Support. Care Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/EJA.0000000000001180","article-title":"European Society of Anaesthesiology guidelines on perioperative use of ultra-sound-guided for vascular access (PERSEUS vascular access)","volume":"37","author":"Lamperti","year":"2020","journal-title":"Eur J Anaesthesiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1111\/jth.13794","article-title":"The Michigan Risk Score to predict peripherally inserted central catheter-associated thrombosis","volume":"15","author":"Chopra","year":"2017","journal-title":"J. Thromb. Haemost."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/cc362","article-title":"Intrahospital transport of critically ill patients","volume":"3","author":"Waydhas","year":"1999","journal-title":"Crit. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/cc9018","article-title":"Recommendations for the intra-hospital transport of critically ill patients","volume":"14","author":"Fanara","year":"2010","journal-title":"Crit. Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1097\/CCM.0b013e31828a3bbd","article-title":"Safety of intrahospital transport in ventilated critically ill patients: A multicenter cohort study*","volume":"41","author":"Schwebel","year":"2013","journal-title":"Crit. Care Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0964-3397(96)80554-4","article-title":"Intrahospital transportation: Monitoring and risks","volume":"12","author":"Brokalaki","year":"1996","journal-title":"Intensive Crit. Care Nurs."},{"key":"ref_29","first-page":"4561","article-title":"The health care cost of palliative care for cancer patients: A systematic review","volume":"28","author":"Yadav","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2309\/java.15-1-3","article-title":"Electrocardiogram (EKG) guided peripherally inserted central catheter placement and tip position: Results of a trial to replace radiological confirmation","volume":"15","author":"Moureau","year":"2010","journal-title":"J. Assoc. Vasc. Access"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Gullo, G., and Qanadli, S.D. (2022). ECG-based techniques to optimize peripherally inserted central catheters: Rationale for tip positioning and practical use. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.765935"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s40258-015-0192-3","article-title":"Sherlock 3CG(\u00ae) tip confirmation system for placement of peripherally inserted central catheters: A NICE medical technology guidance","volume":"14","author":"Dale","year":"2016","journal-title":"Appl. Health Econ. Health Policy"},{"key":"ref_33","unstructured":"Stephen Connor, C.M., and Brennen, F. (2024, September 05). What is Palliative Care for Adults, for Children? WHO Definition of Palliative Care. Available online: https:\/\/thewhpca.org\/resources\/global-atlas-of-palliative-care-2nd-ed-2020\/."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/10\/1876\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:10:04Z","timestamp":1760955004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/10\/1876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,19]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["medicina61101876"],"URL":"https:\/\/doi.org\/10.3390\/medicina61101876","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,19]]}}}