{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:15:02Z","timestamp":1764998102299,"version":"3.46.0"},"reference-count":20,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005289","name":"Provincial Secretariat for Science and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005289","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005289","name":"Medical Faculty, University of Novi Sad","doi-asserted-by":"publisher","award":["142-451-2619\/2021"],"award-info":[{"award-number":["142-451-2619\/2021"]}],"id":[{"id":"10.13039\/501100005289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The aim of this study was to identify clinical features and laboratory findings that correlate with and predict pathological echocardiographic findings in children diagnosed with Multisystem Inflammatory Syndrome. Materials and Methods: Retrospective study included all patients aged 0\u201318 diagnosed with Multisystem Inflammatory Syndrome and hospitalized at our clinic from July 2020 to December 2022. The clinical and laboratory data of 61 patients were studied and compared between two subgroups (normal\/abnormal echocardiography). Results: Elevated values of high-sensitivity troponin I were observed in 65.57% patients with MIS-C. The mean high-sensitivity troponin I value in the whole sample was 400.89 \u00b1 1989.31 pg\/mL. In patients with pathological echocardiographic findings, the mean value was 1240.24 \u00b1 3609 pg\/mL, while in patients with normal echocardiographic findings, it was 52.87 \u00b1 71.86 pg\/mL. Even though mean value was higher in the group of patients with abnormal echocardiography, no statistically significant difference was observed between high-sensitivity troponin I values in patients with and without pathological echocardiographic findings. Troponin levels were not in good correlation with pathological echocardiographic findings (point-biserial correlation; rpb = 0.25, p = 0.054) and were not good predictors of pathological echocardiographic findings (logistic regression; Chi2 = 3.77, p = 0.052). Logistic regression showed significant positive correlation of blood urea nitrogen levels and the degree of fever with abnormal echocardiographic findings (Chi2 = 10.04, p 0.002\/Chi2 = 6.10, p = 0.013, respectively). Conclusions: Only blood urea nitrogen levels and high fever showed statistically significant correlation and predictive value for abnormal echocardiographic findings in children with Multisystem Inflammatory Syndrome. High sensitive troponin I had no significant power to discriminate between normal and abnormal echocardiographic findings.<\/jats:p>","DOI":"10.3390\/medicina61122158","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T15:14:06Z","timestamp":1764861246000},"page":"2158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of Clinical and Laboratory Features of Multisystem Inflammatory Syndrome in Children with Echocardiographic Findings"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-7856","authenticated-orcid":false,"given":"Nenad","family":"Bari\u0161i\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"},{"name":"Institute for Child and Youth Healthcare of Vojvodina, Hajduk Veljkova 10, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Vijatov-\u0110uri\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"},{"name":"Institute for Child and Youth Healthcare of Vojvodina, Hajduk Veljkova 10, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borko","family":"Milanovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"},{"name":"Institute for Child and Youth Healthcare of Vojvodina, Hajduk Veljkova 10, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Vorgu\u010din","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"},{"name":"Institute for Child and Youth Healthcare of Vojvodina, Hajduk Veljkova 10, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Kopriv\u0161ek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"},{"name":"Institute for Child and Youth Healthcare of Vojvodina, Hajduk Veljkova 10, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Milojkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"},{"name":"Institute for Child and Youth Healthcare of Vojvodina, Hajduk Veljkova 10, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ognjen","family":"Le\u017eakov","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"},{"name":"Institute for Child and Youth Healthcare of Vojvodina, Hajduk Veljkova 10, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4917-8961","authenticated-orcid":false,"given":"Vesna","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"},{"name":"Institute for Child and Youth Healthcare of Vojvodina, Hajduk Veljkova 10, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e145347","DOI":"10.5812\/ijp-145347","article-title":"Comparison of Clinical Features and Outcomes of Shocks in Multisystem Inflammatory Syndrome in Children Associated with COVID-19 (MIS-C), Septic Shock, and Cardiogenic Shock","volume":"34","author":"Sitthikool","year":"2024","journal-title":"Iran. J. Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00246-022-03020-w","article-title":"Long-Term Cardiovascular Outcomes of Multisystem Inflammatory Syndrome in Children Associated with COVID-19 Using an Institution Based Algorithm","volume":"44","author":"Chakraborty","year":"2022","journal-title":"Pediatr. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12969-021-00632-z","article-title":"Proceedings of the 27th European Paediatric Rheumatology Congress (PReS 2021)","volume":"19","author":"Brix","year":"2021","journal-title":"Pediatr. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s00246-022-03021-9","article-title":"Clinical Predictors of Subacute Myocardial Dysfunction in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19","volume":"45","author":"McAree","year":"2022","journal-title":"Pediatr. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.32641\/andespediatr.v93i6.3807","article-title":"Compromiso cardiol\u00f3gico y marcadores inflamatorios en ni\u00f1os con S\u00edndrome Inflamatorio Multisist\u00e9mico relacionado a la infecci\u00f3n por COVID-19","volume":"93","author":"Diaz","year":"2022","journal-title":"Andes Pediatr."},{"key":"ref_6","first-page":"102","article-title":"Cardiac Involvement in Multisystem Inflammatory Syndrome in Children","volume":"202","author":"Maaloul","year":"2023","journal-title":"Indian J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jamapediatrics.2024.5466","article-title":"Six-Month Outcomes in the Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children Study","volume":"179","author":"Truong","year":"2025","journal-title":"JAMA Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1017\/S1047951124026283","article-title":"Short- and medium-term longitudinal outcomes of children diagnosed with multisystem inflammatory syndrome in children\u2014Report from a single centre in Pakistan","volume":"34","author":"Abbas","year":"2024","journal-title":"Cardiol. Young"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1007\/s12098-022-04385-9","article-title":"Multisystem Inflammatory Syndrome in Children (MIS-C) Related to SARS-CoV-2 and 1-Year Follow-up","volume":"90","author":"Kapoor","year":"2022","journal-title":"Indian J. Pediatr."},{"key":"ref_10","unstructured":"World Health Organization (2025, June 09). Multisystem Inflammatory Syndrome in Children and Adolescents with COVID-19. Available online: https:\/\/www.who.int\/publications\/i\/item\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00246-021-02738-3","article-title":"Echocardiographic Findings and Correlation with Laboratory Values in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19","volume":"43","author":"Kavurt","year":"2021","journal-title":"Pediatr. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/CIRCULATIONAHA.120.048360","article-title":"Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic","volume":"142","author":"Belhadjer","year":"2020","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.jacc.2020.08.056","article-title":"Echocardiographic findings in MIS-C","volume":"76","author":"Matsubara","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40124-022-00264-1","article-title":"Epidemiology, clinical features, and outcomes of multisystem inflammatory syndrome in children (MIS-C) and adolescents\u2014A live systematic review and meta-analysis","volume":"10","author":"Jiang","year":"2022","journal-title":"Curr. Pediatr. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ccc.2022.01.005","article-title":"Severe COVID-19 and multisystem inflammatory syndrome in children in children and adolescents","volume":"38","author":"Blatz","year":"2022","journal-title":"Crit. Care Clin."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ajem.2021.05.044","article-title":"Cardiac markers of multisystem inflammatory syndrome in children (MIS-C) in COVID-19 patients: A meta-analysis","volume":"49","author":"Zhao","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.CIR.102.2.203","article-title":"Renal function, neurohormonal activation, and survival in patients with chronic heart failure","volume":"102","author":"Hillege","year":"2000","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1584","DOI":"10.1097\/PEC.0000000000002804","article-title":"Diagnostic Yield of Cardiac Biomarker Testing in Predicting Cardiac Disease and Multisystem Inflammatory Syndrome in Children in the Pandemic Era","volume":"38","author":"Kelly","year":"2022","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1001\/jama.2022.8025","article-title":"Severity and incidence of multisystem inflammatory syndrome in children during 3 SARS-CoV-2 pandemic waves in Israel","volume":"327","author":"Levy","year":"2022","journal-title":"JAMA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e2116420","DOI":"10.1001\/jamanetworkopen.2021.16420","article-title":"Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected with SARS-CoV-2","volume":"4","author":"Payne","year":"2021","journal-title":"JAMA Netw Open."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/12\/2158\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:10:35Z","timestamp":1764997835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/61\/12\/2158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["medicina61122158"],"URL":"https:\/\/doi.org\/10.3390\/medicina61122158","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2025,12,4]]}}}