{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:20:45Z","timestamp":1764998445417,"version":"3.46.0"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031734","name":"Asociaci\u00f3n Espa\u00f1ola de Gastroenterolog\u00eda","doi-asserted-by":"crossref","award":["49\/2015"],"award-info":[{"award-number":["49\/2015"]}],"id":[{"id":"10.13039\/100031734","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Grupo Espa\u00f1ol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU) and Instituto de Salud Carlos III","award":["PI12\/02557","PI13\/00041"],"award-info":[{"award-number":["PI12\/02557","PI13\/00041"]}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"crossref","award":["MITIC-CM-2022"],"award-info":[{"award-number":["MITIC-CM-2022"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Crohn\u2019s Disease (CD) is a chronic inflammatory condition often treated with anti-TNF agents such as infliximab (IFX) and adalimumab (ADA). This study compares the efficacy, immunogenicity, and pharmacokinetics of IFX and ADA over a 54-week period. Materials and Methods: A prospective, multicentre cohort study was conducted involving 72 patients with active CD (Crohn\u2019s disease activity index, CDAI &gt; 150), who received treatment with either IFX (n = 42) or ADA (n = 30). Results: By week 54, treatment discontinuation occurred in 31% of IFX-treated patients (13\/42) and 37% of ADA-treated patients (11\/30), with no significant difference between groups (p = 0.612). Among those who completed the study, clinical remission (CDAI \u2264 150) was achieved in 65% of the IFX group and 95% of the ADA group (OR = 8.10; 95% CI = 1.10\u201320.11; p = 0.049). Loss of clinical response was more frequent in the IFX group (31%) than in the ADA group (10%), with an OR of 0.25 (95% CI: 0.06\u20130.97; p = 0.045). Fibrinogen levels declined in both groups, with a greater reduction observed in ADA-treated patients. The area under the ROC curve (AUC) for fibrinogen in distinguishing remission from active disease was 0.608 for IFX and 0.711 for ADA. Anti-drug antibodies were detected more frequently in IFX-treated patients (16.7%, 7\/42) compared to those receiving ADA (6.7%, 2\/30). Conclusions: Treatment with ADA demonstrated superior efficacy compared to IFX in maintaining clinical remission in CD, which was paralleled by a more effective normalization of fibrinogen levels (Clinical trial: GET-CRO-2010-01).<\/jats:p>","DOI":"10.3390\/medicina61122165","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T10:50:38Z","timestamp":1764931838000},"page":"2165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy and Immunogenicity of Infliximab and Adalimumab in Crohn\u2019s Disease: A Prospective Cohort Study"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-2136","authenticated-orcid":false,"given":"Luis G.","family":"Guijarro","sequence":"first","affiliation":[{"name":"Department of System Biology, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), 28029 Madrid, Spain"},{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8591-6116","authenticated-orcid":false,"given":"Patricia","family":"de Castro-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"},{"name":"Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-4242","authenticated-orcid":false,"given":"Mar\u00eda","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), 28029 Madrid, Spain"},{"name":"Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-1368","authenticated-orcid":false,"given":"Julio","family":"Acero-Sanz","sequence":"additional","affiliation":[{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"},{"name":"Department of Oral and Maxillofacial Surgery, Hospital Universitario Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"de Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-2515","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Guerra","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Universitario de Fuenlabrada, 28942 Fuenlabrada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-7581","authenticated-orcid":false,"given":"Marisa","family":"Iborra","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de La Fe, 46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3068-5659","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Cabriada","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de Galdakano, 48960 Galdakano, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4353-9968","authenticated-orcid":false,"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de Donostia, 20014 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Alba","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Cl\u00ednico San Carlos and IdISSC, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valle","family":"Garc\u00eda-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Reina Sof\u00eda\/Universidad de C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Mar\u00edn-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Gregorio Mara\u00f1\u00f3n e IiSGM, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-1477","authenticated-orcid":false,"given":"Manuel","family":"Barreiro-de Acosta","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Cl\u00ednico de Santiago, 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Vera","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-0917","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"Mart\u00edn-Arranz","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario La Paz, Instituto de Investigaci\u00f3n Hospital Universitario La Paz (IdiPaz), Universidad Aut\u00f3noma de Madrid, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-8187","authenticated-orcid":false,"given":"Francisco","family":"Mesonero","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-6250","authenticated-orcid":false,"given":"Laura","family":"Sempere","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Alicante, 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-3529","authenticated-orcid":false,"given":"Fernando","family":"Gomoll\u00f3n","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Cl\u00ednico Universitario, Lozano Blesa, IIS Arag\u00f3n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Hinojosa","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Vithas Virgen del Consuelo, 46007 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Hern\u00e1ndez-Breijo","sequence":"additional","affiliation":[{"name":"Department of System Biology, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1309-7510","authenticated-orcid":false,"given":"Melchor","family":"Alvarez-Mon","sequence":"additional","affiliation":[{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"},{"name":"Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"Javier P.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), 28029 Madrid, Spain"},{"name":"Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2588-1708","authenticated-orcid":false,"given":"Miguel A.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"},{"name":"Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0140-6736(23)02586-2","article-title":"Crohn\u2019s disease","volume":"403","author":"Dolinger","year":"2024","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chaparro, M., Garre, A., N\u00fa\u00f1ez Ortiz, A., Palomares, M.T.D.-L., Rodr\u00edguez, C., Riestra, S., Vela, M., Ben\u00edtez, J.M., Salgado, E.F., and Rodr\u00edguez, E.S. (2021). Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132885"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Petagna, L., Antonelli, A., Ganini, C., Bellato, V., Campanelli, M., Divizia, A., Efrati, C., Franceschilli, M., Guida, A.M., and Ingallinella, S. (2020). Pathophysiology of Crohn\u2019s disease inflammation and recurrence. Biol. Direct, 15.","DOI":"10.1186\/s13062-020-00280-5"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.immuni.2023.01.002","article-title":"The landscape of immune dysregulation in Crohn\u2019s disease revealed through single-cell transcriptomic profiling in the ileum and colon","volume":"56","author":"Kong","year":"2023","journal-title":"Immunity"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41435-024-00276-5","article-title":"Integrated analyses reveal the diagnostic and predictive values of COL5A2 and association with immune environment in Crohn\u2019s disease","volume":"25","author":"Zhong","year":"2024","journal-title":"Genes Immun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17562848221078456","DOI":"10.1177\/17562848221078456","article-title":"A review of the therapeutic management of Crohn\u2019s disease","volume":"15","author":"Kumar","year":"2022","journal-title":"Therap. Adv. 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