{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T06:03:25Z","timestamp":1794377005142,"version":"4.9.0"},"reference-count":36,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTSs) can substantially impair health-related quality of life (HRQoL). We examined the relationship between LUTS severity, measured by the International Prostate Symptom Score (IPSS), and HRQoL assessed with the World Health Organization Quality of Life-BREF (WHOQOL-BREF) in men receiving pharmacological treatment for BPH. Materials and Methods: We conducted a cross-sectional study at the University Clinical Center of Vojvodina (May\u2013July 2024). Seventy men aged 50\u201380 years on \u22651 year of pharmacological therapy for BPH were enrolled. LUTS severity was categorized by IPSS (mild, moderate, severe). HRQoL was measured across WHOQOL-BREF domains (physical, psychological, social, environmental). Group differences were tested with one-way analysis of variance (ANOVA) and post hoc tests; associations were evaluated with Spearman\u2019s rank correlation; multivariable linear regression adjusted for age, socioeconomic status, and therapy type. Results: Severe LUTS were associated with significantly lower HRQoL in the physical (p = 0.002), social (p = 0.007), and environmental (p = 0.008) domains compared with mild or moderate symptoms, while psychological scores did not differ. IPSS correlated negatively with the physical (\u03c1 = \u22120.438, p &lt; 0.001), social (\u03c1 = \u22120.470, p &lt; 0.001), and environmental (\u03c1 = \u22120.449, p &lt; 0.001) domains. In multivariable regression, IPSS remained independently associated with lower physical HRQoL (\u03b2 = \u22120.768, p &lt; 0.001), independent of age, socioeconomic status, and therapy type. Conclusions: Greater LUTS severity is associated with poorer health-related quality of life in men receiving pharmacological treatment for BPH. Integrating comprehensive symptom assessment with HRQoL measures may enhance clinical evaluation and support more personalized management. Longitudinal studies are needed to determine whether symptom improvement translates into meaningful gains in quality of life.<\/jats:p>","DOI":"10.3390\/medicina61122244","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T16:42:05Z","timestamp":1766076125000},"page":"2244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors Associated with Health-Related Quality of Life in Patients with Benign Prostatic Hyperplasia Undergoing Pharmacological Treatment: A Cross-Sectional Study"],"prefix":"10.3390","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8076-6955","authenticated-orcid":false,"given":"Sr\u0111an","family":"Govedarica","sequence":"first","affiliation":[{"name":"Clinic of Urology, University Clinical Center of Vojvodina, Hajduk Veljkova 1-9, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Ra\u0161kovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-792X","authenticated-orcid":false,"given":"Sa\u0161a","family":"Vojinov","sequence":"additional","affiliation":[{"name":"Clinic of Urology, University Clinical Center of Vojvodina, Hajduk Veljkova 1-9, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Grbi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Urology, University Clinical Center of Vojvodina, Hajduk Veljkova 1-9, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-2170","authenticated-orcid":false,"given":"Mladen","family":"Popov","sequence":"additional","affiliation":[{"name":"Clinic of Urology, University Clinical Center of Vojvodina, Hajduk Veljkova 1-9, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-1219","authenticated-orcid":false,"given":"Biljana","family":"Vu\u010dkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Laboratory Medicine, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Ze\u010devi\u0107","sequence":"additional","affiliation":[{"name":"International Center for Cardiovascular Diseases, MC Medicor, Polje 40, 6310 Izola, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Strili\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8732-3170","authenticated-orcid":false,"given":"Dimitrije","family":"Jeremi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Urology, University Clinical Center of Vojvodina, Hajduk Veljkova 1-9, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/bju.15229","article-title":"Benign prostatic hyperplasia-what do we know?","volume":"127","author":"Devlin","year":"2021","journal-title":"BJU Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/bju.15286","article-title":"The rising worldwide impact of benign prostatic hyperplasia","volume":"127","author":"Launer","year":"2021","journal-title":"BJU Int."},{"key":"ref_3","first-page":"8","article-title":"The impact of the treatment of benign prostatic hyperplasia with lower urinary tract symptoms on quality of life: A scoping literature review aided by AI","volume":"20","author":"Faraon","year":"2024","journal-title":"J. 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