{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:46:08Z","timestamp":1780929968523,"version":"3.54.1"},"reference-count":50,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vice Deanship of Scientific Research Chairs, King Saud University, Saudi Arabia; Research Chair of Epidemiology and Public Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Dysmenorrhea affects 50\u201390% of women worldwide and significantly impacts quality of life. This study aimed to determine the nationwide prevalence of dysmenorrhea among Saudi women and evaluate the independent associations between pain severity, associated symptoms, and mental health and quality of life outcomes. Materials and Methods: A cross-sectional study was conducted between May and August 2024 among women aged 18\u201355 years in Saudi Arabia. Data were collected through an online survey assessing sociodemographic characteristics, menstrual patterns, dysmenorrhea severity (Visual Analogue Scale, VAS 1\u201310), associated symptoms, mental health (DASS-21), and quality of life (MQLI). Univariate comparisons and multiple linear regression analyses were performed to identify independent predictors of depression, anxiety, stress, and quality of life (QoL). Results: Of 950 women (mean age 28 \u00b1 9.5 years, BMI 24 \u00b1 5.8 kg\/m2), 87% reported dysmenorrhea, with 50% experiencing pain every cycle and 55% reporting severe pain (VAS 7\u201310). Women with severe pain exhibited depression scores 47% higher than those with mild pain (21.8 vs. 14.8, p &lt; 0.001), with similar patterns for anxiety and stress. In multivariate analyses, severe pain (VAS 8\u201310) was associated with 7\u201311-point increases in DASS scores (all p &lt; 0.001). Constipation emerged as the strongest symptom-related predictor of depression (\u03b2 = 4.94, p &lt; 0.001), anxiety (\u03b2 = 4.79, p &lt; 0.001), stress (\u03b2 = 3.96, p &lt; 0.001), and reduced quality of life (\u03b2 = \u22120.45, p = 0.015). Risk factors included having children, higher BMI, and longer menstrual cycles, while higher income, later menarche, and greater education were protective. Conclusions: Pain severity, not dysmenorrhea presence alone, drives mental health burden. Constipation represents a novel therapeutic target. Integrated care addressing pain, gastrointestinal symptoms, and mental health is essential.<\/jats:p>","DOI":"10.3390\/medicina62010004","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T11:30:18Z","timestamp":1766489418000},"page":"4","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Dysmenorrhea Severity on Mental Wellbeing and Quality of Life Among Saudi Women: A Cross-Sectional Study"],"prefix":"10.3390","volume":"62","author":[{"given":"Ghadeer A.","family":"Alneel","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Women\u2019s Health Hospital, Riyadh 14611, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Jareebi","sequence":"additional","affiliation":[{"name":"Family and Community Medicine Department, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2333-2876","authenticated-orcid":false,"given":"Dhiyaa A. H.","family":"Otayf","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saja A.","family":"Almraysi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimaa A.","family":"Alhassan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej H.","family":"Zughaibi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Saudi Ministry of Health, Riyadh 11176, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seba Y.","family":"Muzaiiadi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altaf A.","family":"Abdulhaq","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha H.","family":"Alzubair","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Women\u2019s Health Hospital, Riyadh 14611, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda A.","family":"Alramadhan","sequence":"additional","affiliation":[{"name":"Dawadmi General Hospital, Dawadmi 17463, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid M.","family":"Akkour","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Faculty of Medicine, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8489-5997","authenticated-orcid":false,"given":"Adhari A.","family":"Alselmi","sequence":"additional","affiliation":[{"name":"Clinical Sciences Department, MBBS Program Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-6260","authenticated-orcid":false,"given":"Farjah H.","family":"Algahtani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Oncology Center, Chair of Epidemiology and Public Health Research, Faculty of Medicine, King Saud University\/King Saud Medical City, Riyadh 12373, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-8136","authenticated-orcid":false,"given":"Hani A.","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh 12373, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazi I.","family":"Al Jowf","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Applied Medical Sciences, University Medical Clinics Complex, King Faisal University, Al Hofuf, Al Ahsa 37912, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2147\/IJWH.S452210","article-title":"More than Cramps in Scrubs: Exploring Dysmenorrhea among Women Healthcare Workers","volume":"16","author":"Kiel","year":"2024","journal-title":"Int. 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