{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T16:58:56Z","timestamp":1766595536565,"version":"3.48.0"},"reference-count":52,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Autologous hematopoietic stem cell transplantation (AHSCT) offers life-saving treatment for hematologic malignancies but can result in persistent sexual dysfunction and relationship challenges. Attachment theory provides a valuable framework for understanding how enduring relational patterns influence sexual well-being. This study aimed to assess sexual function and attachment styles in AHSCT survivors and examine correlations between attachment and sexual health outcomes. Materials and Methods: A multicenter, cross-sectional study was conducted from December 2019 to March 2022 in five public hospitals in Athens, Greece. Participants were 127 adult survivors who had undergone AHSCT between 6 months and 5 years before enrollment. Sexual function was evaluated with the International Index of Erectile Function (IIEF) for men and the Female Sexual Function Index (FSFI) for women. Attachment style was measured using the Experience in Close Relationships Scale\u2013Short Form (ECRSHORT-FORMSCALE). Results: Men demonstrated high erectile function (IIEF total: 54.10 \u00b1 20.1), whereas women reported moderate sexual dysfunction (FSFI total: 22.51 \u00b1 8.95). Both genders showed average attachment levels, with anxiety scoring lowest and discomfort with closeness highest. Between-group comparisons revealed no significant difference in anxiety (p = 0.95), a near-significant difference in avoidance (p = 0.056), and a significant difference in discomfort with closeness (p &lt; 0.0001), with women scoring higher. In men, no significant correlations emerged between attachment and sexual function. In women, higher attachment anxiety correlated negatively with all FSFI domains except pain, avoidance correlated positively with lubrication, and discomfort with closeness correlated negatively with desire and pain. Conclusions: Findings reveal gender-specific patterns in attachment and their influence on sexual function of AHSCT survivors, highlighting the need for attachment-informed interventions to support intimacy, relationship satisfaction, and overall quality of life in survivorship care.<\/jats:p>","DOI":"10.3390\/medicina62010038","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T16:41:19Z","timestamp":1766594479000},"page":"38","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attachment Styles and Sexual Function Among Survivors of Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-3642","authenticated-orcid":false,"given":"Ioanna","family":"Tsatsou","sequence":"first","affiliation":[{"name":"One Day Clinic, Hellenic Airforce General Hospital, P. Kanellopoulou 3, 11525 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6990-2585","authenticated-orcid":false,"given":"Theocharis I.","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"Nursing Department, Hellenic Mediterranean University, 71004 Herakleion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyriaki","family":"Mystakidou","sequence":"additional","affiliation":[{"name":"Pain Relief and Palliative Care Unit, Department of Radiology, Areteion Hospital, School of Medicine, National & Kapodistrian University of Athens, Korinthias 27, 11526 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Nikoloudi","sequence":"additional","affiliation":[{"name":"Pain Relief and Palliative Care Unit, Department of Radiology, Areteion Hospital, School of Medicine, National & Kapodistrian University of Athens, Korinthias 27, 11526 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-4203","authenticated-orcid":false,"given":"Eleni","family":"Panagou","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Hellenic Army General Hospital, P. Kanellopoulou, 11525 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevi-Maria","family":"Prapa","sequence":"additional","affiliation":[{"name":"Oncology Department, Athens Hospital for Chest Diseases \u201cSotiria\u201d, Mesogeion 152, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Angelaki","sequence":"additional","affiliation":[{"name":"Psychiatric Department, Hellenic Airforce General Hospital, P. Kanellopoulou 3, 11523 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Bartzi","sequence":"additional","affiliation":[{"name":"Oncology Department, Hellenic Airforce General Hospital, P. Kanellopoulou 3, 11523 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9174-443X","authenticated-orcid":false,"given":"Ourania","family":"Govina","sequence":"additional","affiliation":[{"name":"Nursing Department, University of West Attica, Agiou Spiridonos 28, 12243 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13287-024-04126-z","article-title":"Hematopoietic stem cells: Understanding the mechanisms to unleash the therapeutic potential of hematopoietic stem cell transplantation","volume":"16","author":"Aljagthmi","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kenyon, M., and Babic, A. (2023). The European Blood and Marrow Transplantation Textbook for Nurses: Under the Auspices of EBMT, Springer Nature.","DOI":"10.1007\/978-3-031-23394-4"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbmt.2016.11.004","article-title":"Long-Term Survivorship after Hematopoietic Cell Transplantation: Roadmap for Research and Care","volume":"23","author":"Battiwalla","year":"2017","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11899-023-00694-8","article-title":"Managing Survivorship after Hematopoietic Cell Transplantation","volume":"18","author":"Khera","year":"2023","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1038\/s41598-025-88748-0","article-title":"Trajectories of quality of life during hematopoietic stem cell transplantation: Longitudinal cohort study","volume":"15","author":"Ilska","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_6","first-page":"1693","article-title":"Sexuality and quality of life of patients with hematologic malignancy and hematopoietic stem cell transplantation: A critical review","volume":"25","author":"Tsatsou","year":"2020","journal-title":"J. BUON"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1002\/cncr.29675","article-title":"Sexual health in hematopoietic stem cell transplant recipients","volume":"121","author":"Li","year":"2025","journal-title":"Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejon.2019.01.001","article-title":"Sexuality after hematopoietic stem cell transplantation: A mixed methods study","volume":"39","author":"Booker","year":"2019","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/PPO.0b013e318198c758","article-title":"Sexuality after hematopoietic stem cell transplantation","volume":"15","author":"Yi","year":"2009","journal-title":"Cancer J."},{"key":"ref_10","first-page":"11","article-title":"Sexuality After Cancer as an Unmet Need: Addressing Disparities, Achieving Equality","volume":"42","author":"Katz","year":"2020","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/07347332.2021.2004292","article-title":"Facilitators and obstacles to couples\u2019 intimacy after hematopoietic stem cell transplantation: A qualitative study","volume":"40","author":"Lupinacci","year":"2022","journal-title":"J. Psychosoc. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Bacalhau, L., and Pont\u00edfice-Sousa, P. (2025). Lived experience of comfort with sexuality and fertility for survivors of hematopoietic progenitor cell transplants: Phenomenological study. J. Cancer Surviv. Res. Pract., Advance online publication.","DOI":"10.1007\/s11764-025-01752-1"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/sj.bmt.1705613","article-title":"Sexual functioning in patients undergoing bone marrow transplantation: A longitudinal study","volume":"39","author":"Humphreys","year":"2007","journal-title":"Bone Marrow Transplant."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/pon.1542","article-title":"Marital adjustment, satisfaction and dissolution among hematopoietic stem cell transplant patients and spouses: A prospective, five-year longitudinal investigation","volume":"19","author":"Langer","year":"2010","journal-title":"Psycho-Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1037\/a0021367","article-title":"Attachment and the processing of social information across the life span: Theory and evidence","volume":"137","author":"Dykas","year":"2011","journal-title":"Psychol. Bull."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.copsyc.2016.04.006","article-title":"Adult Attachment, Stress, and Romantic Relationships","volume":"13","author":"Simpson","year":"2017","journal-title":"Curr. Opin. Psychol."},{"key":"ref_17","unstructured":"Bowlby, J. (1969). Attachment and Loss: Attachment, Basic Books."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bowlby, R. (2018). Fifty Years of Attachment Theory, Routledge.","DOI":"10.4324\/9780429474736"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the Eastern Cooperative Oncology Group","volume":"5","author":"Oken","year":"1982","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Michalos, A.C. (2014). Cognitive Function. Encyclopedia of Quality of Life and Well-Being Research, Springer.","DOI":"10.1007\/978-94-007-0753-5"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/pon.1417","article-title":"Measuring attachment security in patients with advanced cancer: Psychometric properties of a modified and brief Experiences in Close Relationships scale","volume":"18","author":"Lo","year":"2009","journal-title":"Psycho-Oncol."},{"key":"ref_22","unstructured":"Simpson, J.A., and Rholes, W.S. (1998). Self-report measurement of adult attachment: An integrative overview. Attachment Theory and Close Relationships, Guildford Press."},{"key":"ref_23","first-page":"1005","article-title":"Attachment orientations of Greek cancer patients in palliative care. A validation study of the Experiences in Close Relationships scale","volume":"21","author":"Tsilika","year":"2016","journal-title":"J. BUON"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","article-title":"The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction","volume":"49","author":"Rosen","year":"1997","journal-title":"Urology"},{"key":"ref_25","first-page":"313\u2013321","article-title":"Cultural and linguistic evaluation of the International Index of Erectile Function (IIEF) in the Greek language (\u03a7\u03b1\u03c4\u03b6\u03b7\u03bc\u03bf\u03c5\u03c1\u03b1\u03c4\u03af\u03b4\u03b7\u03c2, \u039a., \u03a4\u03c3\u03af\u03bc\u03c4\u03c3\u03b9\u03bf\u03c5, \u0396., \u039a\u03b1\u03c1\u03b1\u03bd\u03c4\u03b1\u03bd\u03ac, A., \u03a7\u03b1\u03c4\u03b6\u03b7\u03c7\u03c1\u03ae\u03c3\u03c4\u03bf\u03c5, \u0394. (2001). \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03c3\u03bc\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b3\u03bb\u03c9\u03c3\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u0394\u03b9\u03b5\u03b8\u03bd\u03ae \u0394\u03b5\u03af\u03ba\u03c4\u03b7 \u03a3\u03c4\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u039b\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 (\u0394\u0394\u03a3\u039b) \u03c3\u03c4\u03b7\u03bd \u03b5\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae \u03b3\u03bb\u03ce\u03c3\u03c3\u03b1. \u0395\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae O\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, 13: 313\u2013321.)","volume":"13","author":"Hatzimouratidis","year":"2001","journal-title":"Elliniki Ourologia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J. Sex Marital Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1002\/cncr.26739","article-title":"Psychometric validation of the Female Sexual Function Index (FSFI) in cancer survivors","volume":"118","author":"Baser","year":"2012","journal-title":"Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ijir.2017.18","article-title":"Translation and validation of the Greek version of the female sexual function index questionnaire","volume":"29","author":"Zachariou","year":"2017","journal-title":"Int. J. Impot. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0022-3999(02)00335-5","article-title":"Attachment and coping with chronic disease","volume":"53","author":"Schmidt","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1017\/S1478951507000466","article-title":"Marital therapy for couples facing advanced cancer: Case review","volume":"5","author":"McLean","year":"2007","journal-title":"Palliat. Support. Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1475-6811.2001.tb00026.x","article-title":"Attachment and spousal caregiving","volume":"8","author":"Feeney","year":"2001","journal-title":"Pers. Relatsh."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/14681994.2016.1158804","article-title":"Sexuality and romantic relationships: Investigating the relation between attachment style and sexual satisfaction","volume":"31","author":"Goldsmith","year":"2016","journal-title":"Sex. Relatsh. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/00224499.2013.838744","article-title":"Attachment insecurities and women\u2019s sexual function and satisfaction: The mediating roles of sexual self-esteem, sexual anxiety, and sexual assertiveness","volume":"52","author":"Brassard","year":"2015","journal-title":"J. Sex Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1111\/j.1743-6109.2012.02843.x","article-title":"Adult attachment and sexual functioning: A review of past research","volume":"9","author":"Stefanou","year":"2012","journal-title":"J. Sex. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1177\/02654075221108759","article-title":"Why do you have sex and does it make you feel better? Integrating attachment theory, sexual motives, and sexual well-being in long-term couples","volume":"39","author":"Beaulieu","year":"2022","journal-title":"J. Soc. Pers. Relatsh."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/ijir.2014.33","article-title":"Attachment styles and sexual dysfunctions: A case-control study of female and male sexuality","volume":"27","author":"Ciocca","year":"2015","journal-title":"Int. J. Impot. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/pon.5068","article-title":"Breast Cancer Network Australia Attachment styles, self-compassion, and psychological adjustment in long-term breast cancer survivors","volume":"28","author":"Arambasic","year":"2019","journal-title":"Psycho-Oncol."},{"key":"ref_38","first-page":"2459","article-title":"Attachment styles in patients with lung cancer and their spouses: Associations with patient and spouse adjustment","volume":"20","author":"Porter","year":"2012","journal-title":"Support. Care Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/pon.1186","article-title":"The contribution of attachment security and social support to depressive symptoms in patients with metastatic cancer","volume":"16","author":"Rodin","year":"2007","journal-title":"Psycho-Oncol."},{"key":"ref_40","first-page":"5813","article-title":"Attachment style and body image as mediators between marital adjustment and sexual satisfaction in women with cervical cancer","volume":"28","author":"Pedras","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/pon.3664","article-title":"The role of relationship attachment in psychological adjustment to cancer in patients and caregivers: A systematic review of the literature","volume":"23","author":"Nicholls","year":"2014","journal-title":"Psycho-Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1080\/00224499.2015.1063576","article-title":"A Structural Equation Modeling Analysis of the Relationships between Depression, Anxiety, and Sexual Problems over Time","volume":"53","author":"Forbes","year":"2016","journal-title":"J. Sex Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Eilert, D.W., and Buchheim, A. (2023). Attachment-Related Differences in Emotion Regulation in Adults: A Systematic Review on Attachment Representations. Brain Sci., 13.","DOI":"10.3390\/brainsci13060884"},{"key":"ref_44","first-page":"525","article-title":"Exploring the Association between Attachment Style, Psychological Well-Being, and Relationship Status in Young Adults and Adults-A Cross-Sectional Study","volume":"13","author":"Sagone","year":"2023","journal-title":"Eur. J. Investig. Health Psychol. Educ."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.3390\/curroncol30030223","article-title":"Sexual Function in Women Survivors of Hematologic Malignancy after Autologous Hematopoietic Stem Cell Transplantation","volume":"30","author":"Tsatsou","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_46","first-page":"793","article-title":"The association between psychosocial and medical factors with long-term sexual dysfunction after treatment for colorectal cancer","volume":"21","author":"Milbury","year":"2013","journal-title":"Support. Care Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2340\/1651-226X.2025.42110","article-title":"Exploring how attachment insecurities mediate the link between sexual and partnership satisfaction in adolescents and young adults with cancer","volume":"64","author":"Heyne","year":"2025","journal-title":"Acta Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/07347332.2021.1890306","article-title":"Body image, sexual activity, and side effects of treatments across the first year after surgery in women facing breast cancer: The influence of attachment insecurity","volume":"39","author":"Favez","year":"2021","journal-title":"J. Psychosoc. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kokka, I., Sotiropoulou, P., and Mourikis, I. (2025). The Attachment Type, Relationship Characteristics, and Sexual Function of Women: Insights from a Cross-Sectional Analysis. Int. J. Environ. Res. Public Health, 22.","DOI":"10.3390\/ijerph22050794"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"15347354241230956","DOI":"10.1177\/15347354241230956","article-title":"Evaluating the Feasibility and Acceptability of a Psychosexual Intervention for Couples Post-allogeneic Hematopoietic Stem Cell Transplantation","volume":"23","author":"Pillay","year":"2024","journal-title":"Integr. Cancer Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/S0140-6736(22)00306-3","article-title":"Improved models of care for cancer survivors","volume":"399","author":"Jefford","year":"2021","journal-title":"Lancet"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.copsyc.2018.02.005","article-title":"Evolved to be connected: The dynamics of attachment and sex over the course of romantic relationships","volume":"25","author":"Birnbaum","year":"2019","journal-title":"Curr. Opin. Psychol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/38\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T16:57:15Z","timestamp":1766595435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["medicina62010038"],"URL":"https:\/\/doi.org\/10.3390\/medicina62010038","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]}}}