{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T05:21:24Z","timestamp":1767072084276,"version":"3.48.0"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To evaluate the significance of serum CA-125 level on the live birth rate of in vitro fertilization (IVF) in women with endometriosis. Materials and Methods: This retrospective observational study included women with endometriosis who underwent one stimulated IVF cycle. Serum CA-125 levels were measured in archived serum samples collected prior to ovarian stimulation, on the day of ovulation trigger, and during frozen embryo transfer. Serum CA-125 levels were compared between cycles with and without a live birth in both stimulated IVF and frozen embryo transfer cycles, with a subgroup analysis using a cut-off of 35 IU\/L. Results: Within the same patient undergoing the same IVF cycle, serum CA-125 level on the trigger day of the stimulated cycle was significantly lower than the baseline level before stimulation started (35.1 IU\/L [21.0\u201364.5 IU\/L] vs. 46.8 IU\/L [25.9\u2013104.0 IU\/L], p &lt; 0.001), but was higher than that in the frozen embryo transfer cycles (31.7 IU\/L [19.9\u201358.7 IU\/L] vs. 27.3 IU\/L [18.1\u201359.9 IU\/L], p = 0.041). Serum CA-125 levels were not associated with the live birth rate in the stimulated IVF cycle and frozen embryo transfer cycles. In subgroup analysis, women with serum CA-125 level \u2265 35 IU\/L on the trigger day had a significantly higher pregnancy rate from the fresh embryo transfer cycle than those with level &lt; 35 IU\/L (adjusted odds ratio 4.126, 95% CI 1.241\u201313.720, p = 0.021). The cut-off of 35 IU\/L did not show significant differences in live birth rate for either stimulated or frozen embryo transfer cycles. Conclusions: In women with endometriosis, no significant differences in serum CA-125 levels were found between those with and without a live birth in fresh and frozen embryo transfer cycles. In fresh embryo transfer cycles, those with serum CA-125 \u2265 35 IU\/L had significantly higher pregnancy rates.<\/jats:p>","DOI":"10.3390\/medicina62010053","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:25:51Z","timestamp":1766989551000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Significance of Serum CA-125 Level on the Live Birth Rates of In Vitro Fertilisation in Women with Endometriosis"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6836-5351","authenticated-orcid":false,"given":"Hoi Ki","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shui Fan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Kwong Wah Hospital, Hong Kong"},{"name":"Department of Obstetrics and Gynaecology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1279-5878","authenticated-orcid":false,"given":"Rebecca Siu Fan","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Ka Yee","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7688-4557","authenticated-orcid":false,"given":"Ernest Hung Yu","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-7798","authenticated-orcid":false,"given":"Raymond Hang Wun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/tog.12911","article-title":"Endometriosis and subfertility","volume":"26","author":"Morris","year":"2024","journal-title":"Obstet. 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