{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:29:05Z","timestamp":1767677345299,"version":"3.48.0"},"reference-count":42,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UKM","award":["FF-2024-433"],"award-info":[{"award-number":["FF-2024-433"]}]},{"name":"Jiblah University for Medical and Health Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Type 2 diabetes mellitus (T2DM) is increasing in prevalence worldwide, placing a substantial burden on healthcare systems, particularly in resource-limited settings. In Yemen, limited screening and diagnostic capacity contribute to delayed detection and management. Prediabetes, a reversible state of dysglycemia, carries significant cardiovascular risk and frequently progresses to diabetes. Early identification of both conditions is vital for prevention and public health planning. Materials and Methods: This cross-sectional study, conducted from July 2024 to May 2025 in three medical centers in Ibb Governorate, Yemen, assessed 1045 adults aged 18\u201360 years without known diabetes or prediabetes. Glycaemic status was classified according to the 2025 American Diabetes Association criteria. Undiagnosed diabetes was defined using three diagnostic combinations: FBS + OGTT, FBS + HbA1c, and OGTT + HbA1c. Results: The prevalence of undiagnosed diabetes was 8.4% (FBS + OGTT) and 9.76% (FBS + HbA1c or OGTT + HbA1c). Prediabetes prevalence was 23.4%, 14.7% and 26.4% based on FBS, OGTT, and HbA1c, respectively. Females represented a higher proportion of undiagnosed diabetes and prediabetes cases. Age was significantly associated with glycemic status across all tests, while gender showed significant associations with FBS and HbA1c. Family history of chronic disease was significantly associated with HbA1c-based classification. Approximately 8\u201310% of adults in Ibb had undiagnosed diabetes, while up to one-quarter had prediabetes. Age and family history were key predictors of dysglycaemia. Conclusions: These findings highlight the need for targeted, multi-marker screening and early intervention strategies, particularly in relatively stable regions of conflict-affected settings, to prevent progression to diabetes and reduce long-term complications and healthcare burden.<\/jats:p>","DOI":"10.3390\/medicina62010087","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T17:24:58Z","timestamp":1767201898000},"page":"87","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Undiagnosed Diabetes and Prediabetes in Yemen: A Growing Public Health Crisis in the Shadow of Conflict"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3998-1324","authenticated-orcid":false,"given":"Mohammed A. M. Y.","family":"Al-Hetar","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia"},{"name":"Medical City Complex, The Specialised Clinic for Endocrinology and Diabetes, Ibb 6001196, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5187-4395","authenticated-orcid":false,"given":"Siti Liyana","family":"Saud Gany","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9719-6662","authenticated-orcid":false,"given":"Noradliyanti","family":"Rusli","sequence":"additional","affiliation":[{"name":"Faculty of Bioeconomics, Food & Health Sciences, University Geomatika Malaysia, Taman Setiawangsa, Kuala Lumpur 54200, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4163-2234","authenticated-orcid":false,"given":"Mohd Amir","family":"Kamaruzzaman","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-1650","authenticated-orcid":false,"given":"Wan Zurinah","family":"Wan Ngah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia"},{"name":"Medical Innovation Research Centre, Shiga Universiti of Medical Sciences, Otsu 520-2192, Shiga, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-1816","authenticated-orcid":false,"given":"Shamsul Azhar","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Almatary","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jiblah University for Medical and Health Sciences, Ibb 600196, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-217X","authenticated-orcid":false,"given":"Norasyikin","family":"A. Wahab","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia"},{"name":"Department of Medicine, Hospital Canselor Tuanku Mukhriz, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2337\/dc23-Srev","article-title":"Summary of Revisions: Standards of Care in Diabetes-2023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_2","unstructured":"Federation, I.D. (2025). IDF Diabetes Atlas 11th Edition\u2014Middle-East & North Africa (MENA) Fact Sheet, International Diabetes Federation."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lu, L., Bennett, D.A., Millwood, I.Y., Parish, S., McCarthy, M.I., Mahajan, A., Lin, X., Bragg, F., Guo, Y., and Holmes, M.V. (2018). Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults. PLoS Med., 15.","DOI":"10.1371\/journal.pmed.1002566"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00125-023-06085-1","article-title":"Feasibility of prevention of type 2 diabetes in low- and middle-income countries","volume":"67","author":"Kengne","year":"2024","journal-title":"Diabetologia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(13)62189-3","article-title":"The state of health in the Arab world, 1990\u20132010: An analysis of the burden of diseases, injuries, and risk factors","volume":"383","author":"Mokdad","year":"2014","journal-title":"Lancet"},{"key":"ref_6","first-page":"47","article-title":"Effect of Habitual Khat Chewing on Glycemic Control, Body Mass Index, and Age at Diagnosis of Diabetes in Patients with Type 2 Diabetes Mellitus in Yemen","volume":"8","author":"Gunaid","year":"2015","journal-title":"Clin. Med. Insights Endocrinol. Diabetes"},{"key":"ref_7","unstructured":"Federation, I.D. (2025, December 23). Diabetes Facts & Figures. Available online: https:\/\/idf.org\/about-diabetes\/diabetes-facts-figures\/."},{"key":"ref_8","unstructured":"Federation, I.D. (2025, December 23). Diabetes Prevalence in Saudi Arabia. Available online: https:\/\/idf.org\/our-network\/regions-and-members\/middle-east-and-north-africa\/members\/saudi-arabia\/."},{"key":"ref_9","unstructured":"World Health Organization (2023). HeRAMS Yemen Baseline Report 2023: Non-Communicable Disease and Mental Health Services: A Comprehensive Mapping of Availability of Essential Services and Barriers to Their Provision, World Health Organization."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/clinchem\/48.3.436","article-title":"Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus","volume":"48","author":"Sacks","year":"2002","journal-title":"Clin. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4137\/BMI.S38440","article-title":"Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients","volume":"11","author":"Sherwani","year":"2016","journal-title":"Biomark Insights"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1080\/03007995.2019.1601455","article-title":"Understanding prediabetes: Definition, prevalence, burden and treatment options for an emerging disease","volume":"35","author":"Rett","year":"2019","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.2337\/dc22-2376","article-title":"Global Prevalence of Prediabetes","volume":"46","author":"Rooney","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40842-019-0080-0","article-title":"Global epidemiology of prediabetes\u2014Present and future perspectives","volume":"5","author":"Hostalek","year":"2019","journal-title":"Clin. Diabetes Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1001\/jama.2015.10029","article-title":"Prevalence of and Trends in Diabetes Among Adults in the United States, 1988\u20132012","volume":"314","author":"Menke","year":"2015","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1210\/er.2015-1137","article-title":"Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus","volume":"37","author":"Harreiter","year":"2016","journal-title":"Endocr. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Hyzam, D., Zou, M., Boah, M., Saeed, A., Li, C., Pan, S., Zhai, J., and Wu, L.-J. (2020). Health information and health-seeking behaviour in Yemen: Perspectives of health leaders, midwives and mothers in two rural areas of Yemen. BMC Pregnancy Childbirth, 20.","DOI":"10.1186\/s12884-020-03101-9"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13031-025-00685-x","article-title":"Healthcare accessibility in Yemen\u2019s conflict zones: Comprehensive review focused on strategies and solutions","volume":"19","author":"Salem","year":"2025","journal-title":"Confl. Health"},{"key":"ref_20","unstructured":"Bank, T.W. (2021). Yemen Health Policy Note: Priorities for Restoring Health Services, World Bank Group."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ba-Haj, S., Bin-Briak, A., and Ba-Haj, A. (2025). Bridging the Knowledge Gap: A Study of Non-Communicable Disease Awareness and Risk Factors Among University Students in Yemen. Res. Sq.","DOI":"10.21203\/rs.3.rs-8158099\/v1"},{"key":"ref_22","unstructured":"Federation, I.D. (2025, December 23). Diabetes Data for Oman. Available online: https:\/\/diabetesatlas.org\/data-by-location\/country\/oman\/."},{"key":"ref_23","unstructured":"Magliano, D.J.B., and Edward, J. (2021). IDF Diabetes Atlas, International Diabetes Federation. [10th ed.]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/ejcn.2011.135","article-title":"Nutrition transition in the United Arab Emirates","volume":"65","author":"Ng","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_25","first-page":"694","article-title":"Dietary transition and obesity in selected Arabic-speaking countries: A review of the current evidence","volume":"22","author":"Bernstein","year":"2016","journal-title":"East. Mediterr. Health J."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Al-Hetar, M.A.M.Y., Rusli, N., Kamaruzzaman, M.A., Al-Goshae, H., Ngah, W.Z.W., Shah, S.A., Al-Matary, A.M., Al-Hetar, Q.M., Senan, D.A.M., and Wahab, N.A. (2025). Evaluating the Role of Vitamin D in Prediabetes Management, Insights from RCTs in the MENA Region: A Comprehensive Systematic Review. J. Clin. Med., 14.","DOI":"10.3390\/jcm14041239"},{"key":"ref_27","unstructured":"World Health Organization (2016). Global Report on Diabetes, World Health Organization."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ahmed, T., Kishore, J., Onamika, M., Goswami, S., Momo, I.R., Sumon, H., and Bowden, R.G. (2025). Comparing Glucometer-Based and Laboratory-Based OGTT for Diabetes Diagnosis: A Narrative Review. Endocrines, 6.","DOI":"10.3390\/endocrines6030048"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1210\/js.2017-00266","article-title":"Diabetic by HbA1c, Normal by OGTT: A Frequent Finding in the Mexico City Diabetes Study","volume":"1","year":"2017","journal-title":"J. Endocr. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9933219","DOI":"10.1155\/jdr\/9933219","article-title":"Comparison of HbA1c and OGTT Results in Obese and Morbidly Obese Patients: A Single-Center Evaluation From an Obesity Clinic","volume":"2025","year":"2025","journal-title":"J. Diabetes Res."},{"key":"ref_31","first-page":"127","article-title":"Discordance between Fasting Plasma Glucose (FPG) and HbA1c in Diagnosing Diabetes and Pre-diabetes in The Malaysian Cohort","volume":"36","author":"Abdullah","year":"2021","journal-title":"J. ASEAN Fed. Endocr. Soc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"E22","DOI":"10.5888\/pcd18.200365","article-title":"HbA(1c) Performance in African Descent Populations in the United States With Normal Glucose Tolerance, Prediabetes, or Diabetes: A Scoping Review","volume":"18","author":"Khosla","year":"2021","journal-title":"Prev. Chronic Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e095500","DOI":"10.1136\/bmjopen-2024-095500","article-title":"Inequities in diabetes prevention and control in fragile, conflict-affected and vulnerable settings: A mixed-methods study from the WHO Eastern Mediterranean Region","volume":"15","author":"Loffreda","year":"2025","journal-title":"BMJ Open"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.2337\/dc12-2290","article-title":"Evidence of reduced \u03b2-cell function in Asian Indians with mild dysglycemia","volume":"36","author":"Staimez","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1749-6632.2012.06838.x","article-title":"Type 2 diabetes in South Asians: Similarities and differences with white Caucasian and other populations","volume":"1281","author":"Gujral","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13098-019-0418-x","article-title":"Differential role of insulin resistance and \u03b2-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population","volume":"11","author":"Cai","year":"2019","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.2337\/dc13-0184","article-title":"Sex Disparities in the Quality of Diabetes Care: Biological and Cultural Factors May Play a Different Role for Different Outcomes: A cross-sectional observational study from the AMD Annals initiative","volume":"36","author":"Rossi","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_38","first-page":"e271","article-title":"Diabetes Mellitus Among Adults in Herat, Afghanistan: A Cross-Sectional Study","volume":"6","year":"2017","journal-title":"Cent. Asian J. Glob. Health"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.puhe.2016.03.025","article-title":"Increasing prevalence of diabetes in Bangladesh: A scoping review","volume":"138","author":"Biswas","year":"2016","journal-title":"Public Health"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.diabres.2013.11.001","article-title":"Global estimates of undiagnosed diabetes in adults","volume":"103","author":"Beagley","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/S0140-6736(10)60550-8","article-title":"Diabetes in sub-Saharan Africa","volume":"375","author":"Mbanya","year":"2010","journal-title":"Lancet"},{"key":"ref_42","unstructured":"World Health Organization (2011). Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus, World Health Organization."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/87\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:19:13Z","timestamp":1767676753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["medicina62010087"],"URL":"https:\/\/doi.org\/10.3390\/medicina62010087","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2025,12,31]]}}}