{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:36:29Z","timestamp":1793730989810,"version":"4.6.1"},"reference-count":162,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The liver is the primary site of synthesis for most coagulation factors and the central organ responsible for maintaining hemostatic equilibrium. In individuals with advanced liver disease, significant disruptions in coagulation homeostasis occur and consequently predispose patients to both thrombotic and bleeding complications. This review summarizes the pathophysiologic basics of liver cirrhosis-associated coagulopathies and discusses the diagnosis and treatment of common procoagulant conditions such as portal vein thrombosis and post-transplant hepatic artery thrombosis. The review also systematically addresses the most common bleeding complications, including spontaneous, portal hypertension-related, and periprocedural bleeding. The proper pre-procedural assessment of the bleeding risk is often required due to the great number of invasive procedures to which these patients are frequently subjected. The viscoelastic testing (thromboelastogram and thromboelastometry) seems to emerge as the most appropriate diagnostic method. Specific treatment recommendations for the correction of coagulation abnormalities and the management of severe thrombocytopenia are hereby presented.<\/jats:p>","DOI":"10.3390\/medicina62010104","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T11:11:46Z","timestamp":1767352306000},"page":"104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Coagulation Abnormalities in Liver Cirrhosis: Diagnostic and Therapeutic Approaches"],"prefix":"10.3390","volume":"62","author":[{"given":"Dorotea","family":"Bozic","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, University Hospital Split, Spin\u010di\u0107eva 1, 21 000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Babic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Split, Spin\u010di\u0107eva 1, 21 000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3777-7350","authenticated-orcid":false,"given":"Ivna","family":"Olic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Split, Spin\u010di\u0107eva 1, 21 000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Lalovac","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Clinical Hospital Merkur, Zaj\u010deva 19, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-1013","authenticated-orcid":false,"given":"Maja","family":"Mijic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Clinical Hospital Merkur, Zaj\u010deva 19, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5789-1869","authenticated-orcid":false,"given":"Anita","family":"Madir","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Clinical Nutrition, Clinical Hospital Dubrava, Avenija Gojka \u0160u\u0161ka 6, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8900-3045","authenticated-orcid":false,"given":"Kristian","family":"Podrug","sequence":"additional","affiliation":[{"name":"Private Clinic MedPoint, Ulica Petra Kre\u0161imira IV 104, 21 210 Solin, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-2748","authenticated-orcid":false,"given":"Antonio","family":"Mestrovic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Split, Spin\u010di\u0107eva 1, 21 000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1055\/s-0041-1733961","article-title":"New Insights in Coagulation and Fibrinolysis in Patients with Primary Brain Cancer: A Systematic Review","volume":"48","author":"Hvas","year":"2022","journal-title":"Semin. 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