{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:56:46Z","timestamp":1768957006262,"version":"3.49.0"},"reference-count":58,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Long COVID-19 (LC) is a multifaceted condition characterized by persistent fatigue and impaired health-related quality of life (HRQoL). Exercise intolerance and post-exertional symptom exacerbation (PESE) pose challenges for rehabilitation. This study aimed to evaluate the effects of a 12-week core-focused plank exercise program on fatigue and HRQoL in women with LC, using validated patient-reported measures. Materials and Methods: A pilot quasi-experimental design was implemented, with non-randomized group allocation. Thirty-nine women with LC were recruited from the Madrid Long COVID Association. Participants were assigned to either an intervention group (n = 20), which completed a supervised plank-based motor control program, or a control group (n = 19), which maintained usual activity. Fatigue was assessed using the Modified Fatigue Impact Scale (MFIS), and HRQoL was measured using the EQ-5D-5L and EQ Visual Analog Scale (EQ-VAS). Body composition was evaluated via bioelectrical impedance analysis. Results: The intervention group showed significant reductions after intervention in the MFIS total scores compared to the control group, particularly in the physical (21.26 \u00b1 6.76 vs. 25.21 \u00b1 6.06; p &lt; 0.001) and psychosocial domains (4.51 \u00b1 0.41 vs. 5.21 \u00b1 0.38; p &lt; 0.001), without triggering PESE. EQ-VAS scores improved significantly (63.94 \u00b1 15.33 vs. 46.31 \u00b1 14.74; p = 0.034). No significant changes were found in body composition parameters, suggesting that benefits were driven by neuromuscular adaptations rather than morphological changes. Conclusions: A core-focused, non-aerobic exercise program effectively reduced fatigue and improved perceived health status in women with LC. These findings support the use of motor control-based interventions as a safe and feasible strategy for LC rehabilitation, particularly in populations vulnerable to PESE, suggesting clinical applicability for the rehabilitation of women with LC. Further randomized trials are warranted to confirm these results and explore long-term outcomes.<\/jats:p>","DOI":"10.3390\/medicina62010210","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:27:58Z","timestamp":1768908478000},"page":"210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Exhaustion to Empowerment: A Pilot Study on Motor Control-Based Exercise for Fatigue and Quality of Life in Long COVID-19 Patients"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-8884","authenticated-orcid":false,"given":"Carmen","family":"Jim\u00e9nez-Antona","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Faculty of Health Sciences, Universidad Rey Juan Carlos (URJC), 28922 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5779-9826","authenticated-orcid":false,"given":"Ricardo","family":"Moreta-Fuentes","sequence":"additional","affiliation":[{"name":"Fisyos Center, M\u00e9todo Moreta, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-2701","authenticated-orcid":false,"given":"David","family":"Varillas-Delgado","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science, Faculty of Health Sciences, Universidad Francisco de Vitoria, Pozuelo, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Moreta-Fuentes","sequence":"additional","affiliation":[{"name":"Fisyos Center, M\u00e9todo Moreta, 28027 Madrid, Spain"},{"name":"FREMAP Care Center, 28946 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-7135","authenticated-orcid":false,"given":"Sof\u00eda","family":"Laguarta-Val","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Faculty of Health Sciences, Universidad Rey Juan Carlos (URJC), 28922 Madrid, Spain"},{"name":"Cognitive Neuroscience, Pain, and Rehabilitation Research Group (NECODOR), Faculty of Health Sciences, Universidad Rey Juan Carlos (URJC), 28922 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Elboraay, T., Ebada, M.A., Elsayed, M., Aboeldahab, H.A., Salamah, H.M., Rageh, O., Elmallahy, M., AboElfarh, H.E., Mansour, L.S., and Nabil, Y. (2025). Long-Term Neurological and Cognitive Impact of COVID-19: A Systematic Review and Meta-Analysis in over 4 Million Patients. BMC Neurol., 25.","DOI":"10.1186\/s12883-025-04174-9"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0140-6736(24)01136-X","article-title":"Long COVID: A Clinical Update","volume":"404","author":"Greenhalgh","year":"2024","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1001\/jama.2022.18931","article-title":"Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021","volume":"328","author":"Vos","year":"2022","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1007\/s10072-024-07566-w","article-title":"Intervention Modalities for Brain Fog Caused by Long-COVID: Systematic Review of the Literature","volume":"45","author":"Gorenshtein","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1038\/s41598-024-54613-9","article-title":"Insights into Attention and Memory Difficulties in Post-COVID Syndrome Using Standardized Neuropsychological Tests and Experimental Cognitive Tasks","volume":"14","author":"Arbula","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jpsychires.2022.03.033","article-title":"Cognitive Dysfunction Associated with COVID-19: A Comprehensive Neuropsychological Study","volume":"150","author":"Yus","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e16084","DOI":"10.1111\/ene.16084","article-title":"Unraveling Brain Fog in Post-COVID Syndrome: Relationship between Subjective Cognitive Complaints and Cognitive Function, Fatigue, and Neuropsychiatric Symptoms","volume":"32","author":"Yus","year":"2025","journal-title":"Eur. J. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1111\/ene.16027","article-title":"What Do We Mean by Long COVID? A Scoping Review of the Cognitive Sequelae of SARS-CoV-2 Infection","volume":"30","author":"Nicotra","year":"2023","journal-title":"Eur. J. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Marchi, M., Grenzi, P., Serafini, V., Capoccia, F., Rossi, F., Marrino, P., Pingani, L., Galeazzi, G.M., and Ferrari, S. (2023). Psychiatric Symptoms in Long-COVID Patients: A Systematic Review. Front. Psychiatry, 14.","DOI":"10.3389\/fpsyt.2023.1138389"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/joim.13720","article-title":"Cognitive Dysfunction in Post-COVID-19 Condition: Mechanisms, Management, and Rehabilitation","volume":"294","author":"Borg","year":"2023","journal-title":"J. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/MCP.0000000000000863","article-title":"A Clinical Review of Long-COVID with a Focus on the Respiratory System","volume":"28","author":"Daines","year":"2022","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_12","first-page":"e177518","article-title":"Characteristics and Determinants of Pulmonary Long COVID","volume":"9","author":"Patton","year":"2024","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"106709","DOI":"10.1016\/j.rmed.2021.106709","article-title":"Severity of Respiratory Failure and Computed Chest Tomography in Acute COVID-19 Correlates with Pulmonary Function and Respiratory Symptoms after Infection with SARS-CoV-2: An Observational Longitudinal Study over 12 Months","volume":"191","author":"Steinbeis","year":"2022","journal-title":"Respir. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jennings, G., Monaghan, A., Xue, F., Mockler, D., and Romero-Ortu\u00f1o, R. (2021). A Systematic Review of Persistent Symptoms and Residual Abnormal Functioning Following Acute COVID-19: Ongoing Symptomatic Phase vs. Post-COVID-19 Syndrome. J. Clin. Med., 10.","DOI":"10.1101\/2021.06.25.21259372"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"ofab440","DOI":"10.1093\/ofid\/ofab440","article-title":"Long COVID and Post-Infective Fatigue Syndrome: A Review","volume":"8","author":"Sandler","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.amjmed.2024.01.025","article-title":"Clinical and Laboratory Characteristics of Fatigue-Dominant Long-COVID Subjects: A Cross-Sectional Study","volume":"138","author":"Lee","year":"2025","journal-title":"Am. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbi.2021.12.020","article-title":"Fatigue and Cognitive Impairment in Post-COVID-19 Syndrome: A Systematic Review and Meta-Analysis","volume":"101","author":"Ceban","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1093\/cid\/ciac283","article-title":"Risk Factors and Multidimensional Assessment of Long Coronavirus Disease Fatigue: A Nested Case-Control Study","volume":"75","author":"Margalit","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","first-page":"25","article-title":"Immunopathology and Therapeutic Strategies for Long COVID: Mechanisms, Manifestations, and Clinical Implications","volume":"27","author":"Junainah","year":"2025","journal-title":"AIDS Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e70019","DOI":"10.1002\/cph4.70019","article-title":"Mechanistic Insights Into Long Covid: Viral Persistence, Immune Dysregulation, and Multi-Organ Dysfunction","volume":"15","author":"Gupta","year":"2025","journal-title":"Compr. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Constantinescu-Bercu, A., Lobiuc, A., C\u0103liman-Sturdza, O.A., Oi\u0163\u0103, R.C., Iavorschi, M., Pav\u0103l, N.E., \u0218old\u0103nescu, I., Dimian, M., and Covasa, M. (2023). Long COVID: Molecular Mechanisms and Detection Techniques. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010408"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1249\/MSS.0000000000003280","article-title":"Effect of Physical Exercise-Based Rehabilitation on Long COVID: A Systematic Review and Meta-Analysis","volume":"56","author":"Zheng","year":"2024","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Godfrey, B., Shardha, J., Witton, S., Bodey, R., Tarrant, R., Greenwood, D.C., and Sivan, M. (2024). A Personalised Pacing and Active Rest Rehabilitation Programme for Post-Exertional Symptom Exacerbation and Health Status in Long COVID (PACELOC): A Prospective Cohort Study. J. Clin. Med., 14.","DOI":"10.20944\/preprints202412.0230.v1"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"00089","DOI":"10.1183\/23120541.00089-2024","article-title":"Changes in Fatigue Symptoms Following an Exercise-Based Rehabilitation Programme for Patients with Long COVID","volume":"10","author":"Daynes","year":"2024","journal-title":"ERJ Open Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"12605","DOI":"10.1038\/s41598-022-17033-1","article-title":"Psychometric Properties of the Spanish Version of the EuroQol-5D-5L in Previously Hospitalized COVID-19 Survivors with Long COVID","volume":"12","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"del Corral, T., Fabero-Garrido, R., Plaza-Manzano, G., Navarro-Santana, M.J., Fern\u00e1ndez-de-las-Pe\u00f1as, C., and L\u00f3pez-de-Uralde-Villanueva, I. (2023). Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a Respiratory Muscle Training Program in Individuals Experiencing Long-Term Post-COVID-19 Symptoms. Biomedicines, 11.","DOI":"10.3390\/biomedicines11092522"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4236\/ojtr.2025.133013","article-title":"Post-COVID Rehabilitation Service: COVID-19 Yorkshire Rehabilitation Scale (C-19 YRS) and Health-Related Quality of Life EuroQol Five-Dimensional Five-Level Questionnaire (EQ-5D-5L) Outcomes","volume":"13","author":"Griffiths","year":"2025","journal-title":"Open J. Ther. Rehabil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"afae084","DOI":"10.1093\/ageing\/afae084","article-title":"Post-COVID-19 Patients in Geriatric Rehabilitation Substantially Recover in Daily Functioning and Quality of Life","volume":"53","author":"Haaksma","year":"2024","journal-title":"Age Ageing"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Smith, J.L., Deighton, K., Innes, A.Q., Holl, M., Mould, L., Liao, Z., Doherty, P., Whyte, G., King, J.A., and Deniszczyc, D. (2023). Improved Clinical Outcomes in Response to a 12-Week Blended Digital and Community-Based Long-COVID-19 Rehabilitation Programme. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1149922"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/13854046.2025.2476798","article-title":"The Relationship between Performance Validity Test Failure, Fatigue, and Psychological Functioning in Long COVID","volume":"40","author":"Minor","year":"2025","journal-title":"Clin. Neuropsychol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Miana, M., Moreta-Fuentes, R., Jim\u00e9nez-Antona, C., Moreta-Fuentes, C., and Laguarta-Val, S. (2025). Improvement of Fatigue and Body Composition in Women with Long COVID After Non-Aerobic Therapeutic Exercise Program. J. Pers. Med., 15.","DOI":"10.3390\/jpm15060217"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e082441","DOI":"10.1136\/bmjopen-2023-082441","article-title":"Effectiveness and Tolerance of Exercise Interventions for Long COVID: A Systematic Review of Randomised Controlled Trials","volume":"15","author":"McDowell","year":"2025","journal-title":"BMJ Open"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40798-024-00695-8","article-title":"Practical Recommendations for Exercise Training in Patients with Long COVID with or without Post-Exertional Malaise: A Best Practice Proposal","volume":"10","author":"Gloeckl","year":"2024","journal-title":"Sports Med. Open"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e083405","DOI":"10.1136\/bmj-2024-083405","article-title":"Determining Sample Size for Pilot Trials: A Tutorial","volume":"390","author":"Ying","year":"2025","journal-title":"BMJ"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/pst.185","article-title":"Sample Size of 12 per Group Rule of Thumb for a Pilot Study","volume":"4","author":"Julious","year":"2005","journal-title":"Pharm. Stat."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"i5239","DOI":"10.1136\/bmj.i5239","article-title":"CONSORT 2010 Statement: Extension to Randomised Pilot and Feasibility Trials","volume":"355","author":"Eldridge","year":"2016","journal-title":"BMJ"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Milanese, C., Itani, L., Cavedon, V., Saadeddine, D., Raggi, S., Berri, E., and El Ghoch, M. (2025). Revising BMI Cut-Off Points for Overweight and Obesity in Male Athletes: An Analysis Based on Multivariable Model-Building. Nutrients, 17.","DOI":"10.3390\/nu17050908"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/ajcn\/72.3.694","article-title":"Healthy Percentage Body Fat Ranges: An Approach for Developing Guidelines Based on Body Mass Index","volume":"72","author":"Gallagher","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e222092","DOI":"10.1001\/jamanetworkopen.2022.2092","article-title":"Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk: A Systematic Review and Meta-Analysis","volume":"5","author":"McGlynn","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Varillas-Delgado, D. (2024). Association of Genetic Profile with Muscle Mass Gain and Muscle Injury Prevention in Professional Football Players after Creatine Supplementation. Nutrients, 16.","DOI":"10.3390\/nu16152511"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e1083","DOI":"10.23938\/ASSN.1083","article-title":"Effects of a Plank-Based Strength Training Programme on Muscle Activation in Patients with Long COVID: A Case Series","volume":"47","year":"2024","journal-title":"An. Sist. Sanit. Navar."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"103412","DOI":"10.1016\/j.eclinm.2025.103412","article-title":"Effects of Therapeutic Interventions on Long COVID: A Meta-Analysis of Randomized Controlled Trials","volume":"87","author":"Tan","year":"2025","journal-title":"eClinicalMedicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.7224\/1537-2073.2012-019","article-title":"Psychometric Properties of the Modified Fatigue Impact Scale","volume":"15","author":"Larson","year":"2013","journal-title":"Int. J. MS Care"},{"key":"ref_44","unstructured":"(2025, November 27). Modified Fatigue Impact Scale MFIS. Available online: https:\/\/www.nationalmssociety.org\/es\/for-professionals\/for-researchers\/researcher-resources\/research-tools\/clinical-study-measures\/mfis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s11136-013-0569-4","article-title":"Validation and Comparison of 15-D and EQ-5D-5L Instruments in a Spanish Parkinson\u2019s Disease Population Sample","volume":"23","author":"Adsuar","year":"2014","journal-title":"Qual. Life Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/JSM.0000000000000366","article-title":"Reliability and Practicality of the Core Score: Four Dynamic Core Stability Tests Performed in a Physician Office Setting","volume":"27","author":"Friedrich","year":"2017","journal-title":"Clin. J. Sport Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.23736\/S1973-9087.18.04778-0","article-title":"The Effects of 10-Week Core Stability Training on Balance in Women with Multiple Sclerosis According to Expanded Disability Status Scale: A Single-Blinded Randomized Controlled Trial","volume":"55","author":"Amiri","year":"2019","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.jacc.2022.02.003","article-title":"2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocarditis and Other Myocardial Involvement, Post-Acute Sequelae of SARS-CoV-2 Infection, and Return to Play: A Report of the American College of Cardiology Solution Set Oversight Committee","volume":"79","author":"Gluckman","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/wvn.12743","article-title":"The Effectiveness of Exercise in Alleviating Long COVID Symptoms: A Systematic Review and Meta-Analysis","volume":"21","author":"Cheng","year":"2024","journal-title":"Worldviews Evid. Based Nurs."},{"key":"ref_50","first-page":"800","article-title":"Rehabilitation and COVID-19: Systematic Review by Cochrane Rehabilitation","volume":"59","author":"Arienti","year":"2023","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e2333838","DOI":"10.1001\/jamanetworkopen.2023.33838","article-title":"Rehabilitation Interventions for Physical Capacity and Quality of Life in Adults With Post-COVID-19 Condition: A Systematic Review and Meta-Analysis","volume":"6","author":"Pouliopoulou","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Mustonen, T., Kanerva, M., Luukkonen, R., Lantto, H., Uusitalo, A., and Piiril\u00e4, P. (2024). Cardiopulmonary Exercise Testing in Long Covid Shows the Presence of Dysautonomia or Chronotropic Incompetence Independent of Subjective Exercise Intolerance and Fatigue. BMC Cardiovasc. Disord., 24.","DOI":"10.1186\/s12872-024-04081-w"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e2236057","DOI":"10.1001\/jamanetworkopen.2022.36057","article-title":"Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-Analysis","volume":"5","author":"Durstenfeld","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Cozma, A., Sitar-T\u0103ut, A.V., Or\u0103\u0219an, O.H., Leucu\u021ba, D.C., Pocol, T.C., S\u0103l\u0103gean, O., Cri\u0219an, C., Spori\u0219, N.D., Lazar, A.L., and M\u0103linescu, T.V. (2024). The Impact of Long COVID on the Quality of Life. Medicina, 60.","DOI":"10.3390\/medicina60081359"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.dsx.2021.04.007","article-title":"Long COVID: An Overview","volume":"15","author":"Raveendran","year":"2021","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Rudroff, T. (2025). Diagnosis of Long COVID Fatigue. Long COVID Fatigue, Springer.","DOI":"10.1007\/978-3-031-89474-9"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jmv.27309","article-title":"Post-Acute COVID-19 Syndrome (PCS) and Health-Related Quality of Life (HRQoL)-A Systematic Review and Meta-Analysis","volume":"94","author":"Malik","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2147\/PROM.S490870","article-title":"Health-Related Quality of Life in Long COVID: Mapping the Condition-Specific C19-YRSm Measure Onto the EQ-5D-5L","volume":"16","author":"Smith","year":"2025","journal-title":"Patient Relat. Outcome Meas."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:06:19Z","timestamp":1768910779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["medicina62010210"],"URL":"https:\/\/doi.org\/10.3390\/medicina62010210","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]}}}