{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T02:02:20Z","timestamp":1768960940430,"version":"3.49.0"},"reference-count":64,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: Multiple sclerosis (MS) involves complex physical, cognitive and behavioral challenges that collectively affect quality of life. Integrating lifestyle components such as sleep optimization, dietary behaviors, stress management, and self-management strategies into rehabilitation may enhance outcomes beyond traditional approaches. This scoping review aimed to map rehabilitation interventions that combine psychomotor, cognitive, lifestyle-focused, or multimodal elements and assess quality of life in adults with MS. Methods: This scoping review was conducted in accordance with the PRISMA-ScR guidelines, which guided the identification, screening, and selection of studies. Screening and data extraction were conducted independently by two reviewers. From 135 records, nine primary studies and four secondary evidence sources were included. Results: Most studies involved adults with mild-to-moderate disability and predominantly relapsing\u2013remitting multiple sclerosis. Physical or motor rehabilitation interventions were examined in five studies, while two studies evaluated multimodal rehabilitation programs, one study focused on cognitive rehabilitation, and one study investigated lifestyle-oriented or self-management-integrated approaches. Quality of life was assessed in all included studies, with improvements reported across multiple domains. Fatigue-related outcomes were reported in four studies, sleep-related outcomes in three studies, and digitally delivered or hybrid rehabilitation interventions were implemented in three studies, indicating an emerging trend toward technology-supported rehabilitation approaches. Conclusions: Contemporary MS rehabilitation is moving toward multidimensional, holistic models that integrate lifestyle components. Standardized outcomes, inclusion of more diverse MS phenotypes, and rigorous evaluation of integrated frameworks are required to strengthen the evidence base and inform clinical practice.<\/jats:p>","DOI":"10.3390\/medicina62010215","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:02:07Z","timestamp":1768914127000},"page":"215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reconsidering Rehabilitation and Lifestyle Approaches to Improve Quality of Life in People with Multiple Sclerosis: A Scoping Review"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0543-1888","authenticated-orcid":false,"given":"Elena Bianca","family":"Basalic","sequence":"first","affiliation":[{"name":"Department of Fundamental, Preventive, and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania"},{"name":"Neurorehabilitation Department, Clinical Hospital of Psychiatry and Neurology, 500036 Brasov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4263-2589","authenticated-orcid":false,"given":"Nadinne Alexandra","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Fundamental, Preventive, and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania"},{"name":"Neurorehabilitation Department, Clinical Hospital of Psychiatry and Neurology, 500036 Brasov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Minzatanu","sequence":"additional","affiliation":[{"name":"Department of Fundamental, Preventive, and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania"},{"name":"Neurorehabilitation Department, Clinical Hospital of Psychiatry and Neurology, 500036 Brasov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina Ionelia","family":"Manaila","sequence":"additional","affiliation":[{"name":"Department of Fundamental, Preventive, and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania"},{"name":"Neurorehabilitation Department, Clinical Hospital of Psychiatry and Neurology, 500036 Brasov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ionut Cristian Cozmin","family":"Baseanu","sequence":"additional","affiliation":[{"name":"Department of Fundamental, Preventive, and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania"},{"name":"Neurorehabilitation Department, Clinical Hospital of Psychiatry and Neurology, 500036 Brasov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1796-1038","authenticated-orcid":false,"given":"Roxana Steliana","family":"Miclaus","sequence":"additional","affiliation":[{"name":"Department of Fundamental, Preventive, and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania"},{"name":"Neurorehabilitation Department, Clinical Hospital of Psychiatry and Neurology, 500036 Brasov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/157015910792246218","article-title":"Chronic Progressive Multiple Sclerosis\u2014Pathogenesis of Neurodegeneration and Therapeutic Strategies","volume":"8","author":"Fitzner","year":"2010","journal-title":"Curr. Neuropharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1212\/WNL.0000000000005345","article-title":"Comprehensive systematic review summary: Disease-modifying therapies for adults with multiple sclerosis","volume":"90","author":"Day","year":"2018","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17562864211066751","DOI":"10.1177\/17562864211066751","article-title":"Smouldering multiple sclerosis: The \u2018real MS\u2019","volume":"15","author":"Giovannoni","year":"2022","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nrneurol.2017.33","article-title":"Comorbidity in multiple sclerosis: Implications for patient care","volume":"13","author":"Marrie","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.msard.2018.07.013","article-title":"The disease burden of Multiple Sclerosis from the individual and population perspective: Which symptoms matter most?","volume":"25","author":"Barin","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ciubotaru, A., Grosu, C., Alexa, D., Covali, R., Ma\u0219taleru, A., Leon, M.M., Schreiner, T.G., Ghiciuc, C.M., Roman, E.M., and Azoic\u0103i, D. (2024). The Faces of \u201cToo Late\u201d\u2014A Surprisingly Progressive Cohort of \u201cStable\u201d Relapsing Remitting Multiple Sclerosis Patients. Medicina, 60.","DOI":"10.3390\/medicina60091401"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cium\u0103rnean, L., S\u00e2rb, O.-F., Dr\u0103ghici, N.-C., S\u0103l\u0103gean, O., Milaciu, M.-V., Or\u0103\u0219an, O.-H., Vlad, C.-V., Vlad, I.-M., Alexescu, T., and Para, I. (2024). Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252010909"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1369-6513.2001.00111.x","article-title":"What do people with MS want and expect from health-care services?","volume":"4","author":"Somerset","year":"2001","journal-title":"Health Expect."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e2017008","DOI":"10.4178\/epih.e2017008","article-title":"The impact of disease characteristics on multiple sclerosis patients\u2019 quality of life","volume":"39","author":"Rezapour","year":"2017","journal-title":"Epidemiol. Health"},{"key":"ref_10","unstructured":"North Carolina Health Statistics (2016). Health-Related Quality of Life and Well-Being, Healthy People 2020 Midcourse Review."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s41687-022-00415-4","article-title":"Health-Related Quality of Life in people with Multiple Sclerosis: How does this Population Compare to Population-based Norms in Different Health Domains?","volume":"6","author":"Faraclas","year":"2022","journal-title":"J. Patient-Rep. Outcomes"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ciubotaru, A., Ignat, E.B., Alexa, D., Grosu, C., P\u0103v\u0103leanu, I., Manole, A., Ma\u0219taleru, A., Leon, M.M., Matei, D.V., and Azoic\u0103i, D. (2024). Influence of Education, Cognition, and Physical Disability on Quality of Life of Romanian Patients with Multiple Sclerosis\u2014A Cohort Study. Medicina, 60.","DOI":"10.3390\/medicina60030386"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/1352458516687404","article-title":"Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities","volume":"24","author":"Motl","year":"2018","journal-title":"Mult. Scler. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1000461","DOI":"10.4172\/2329-9096.1000461","article-title":"Changing Lifestyle of Persons with Multiple Sclerosis: Development, Feasibility and Preliminary Results of a Novel High-Impact Collaborative Intervention in Leisure Environments","volume":"6","author":"Mendozzi","year":"2018","journal-title":"Int. J. Phys. Med. Rehabil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1249\/MSS.0000000000002228","article-title":"Exercise Effects on Multiple Sclerosis Quality of Life and Clinical-Motor Symptoms","volume":"52","author":"Nagy","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"104529","DOI":"10.1016\/j.msard.2023.104529","article-title":"Cognitive rehabilitation and mindfulness reduce cognitive complaints in multiple sclerosis (REMIND-MS): A randomized controlled trial","volume":"71","author":"Nauta","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.msard.2016.07.003","article-title":"Brain health: Time matters in multiple sclerosis","volume":"9","author":"Giovannoni","year":"2016","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1212\/WNL.0000000000002487","article-title":"Multiple sclerosis: A lifestyle disease?","volume":"86","author":"Grant","year":"2016","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.12680\/balneo.2024.737","article-title":"Complex case of multiple sclerosis with multiple demyelinating locations","volume":"15","author":"Lungu","year":"2024","journal-title":"Balneo PRM Res. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"104016","DOI":"10.1016\/j.msard.2022.104016","article-title":"Lifestyle factors in multiple sclerosis disability progression and silent brain damage: A cross-sectional study","volume":"65","author":"Loret","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Stoiloudis, P., Kesidou, E., Bakirtzis, C., Sintila, S.-A., Konstantinidou, N., Boziki, M., and Grigoriadis, N. (2022). The Role of Diet and Interventions on Multiple Sclerosis: A Review. Nutrients, 14.","DOI":"10.3390\/nu14061150"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s13311-017-0581-4","article-title":"Diet, Gut Microbiota, and Vitamins D + A in Multiple Sclerosis","volume":"15","author":"Riccio","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref_23","first-page":"e47058","article-title":"Unraveling the Gut-Brain Axis in Multiple Sclerosis: Exploring Dysbiosis, Oxidative Stress, and Therapeutic Insights","volume":"15","author":"Sharifa","year":"2023","journal-title":"Cureus"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Davis, B., Liu, Y.-H., Stampley, J., Wood, G.C., Mitchell, D.C., Jensen, G.L., Gao, X., Glynn, N.W., Still, C.D., and Irving, B.A. (2021). The Association between Poor Diet Quality, Physical Fatigability and Physical Function in the Oldest-Old from the Geisinger Rural Aging Study. Geriatrics, 6.","DOI":"10.3390\/geriatrics6020041"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"101921","DOI":"10.1016\/j.msard.2019.101921","article-title":"Is diet associated with physical capacity and fatigue in persons with multiple sclerosis? \u2013Results from a pilot study","volume":"40","author":"Albrechtsen","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1177\/1352458520969099","article-title":"Exercise and the brain in multiple sclerosis","volume":"28","author":"Lozinski","year":"2022","journal-title":"Mult. Scler. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"112539","DOI":"10.1016\/j.exger.2024.112539","article-title":"Beneficial effects of physical exercise on cognitive-behavioral impairments and brain-derived neurotrophic factor alteration in the limbic system induced by neurodegeneration","volume":"195","author":"Sanaeifar","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"14582","DOI":"10.1038\/s41598-023-41075-8","article-title":"Effectiveness of physical activity interventions on reducing perceived fatigue among adults with chronic conditions: A systematic review and meta-analysis of randomised controlled trials","volume":"13","author":"Barakou","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jns.2016.10.040","article-title":"Sleep and fatigue in multiple sclerosis: A questionnaire-based, cross-sectional, cohort study","volume":"372","author":"Nociti","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/abm\/kaaa102","article-title":"Early Treatment Improvements in Depression Are Associated with Overall Improvements in Fatigue Impact and Pain Interference in Adults with Multiple Sclerosis","volume":"55","author":"Knowles","year":"2021","journal-title":"Ann. Behav. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2217\/nmt-2020-0010","article-title":"Multiple Sclerosis and Related Challenges to Young women\u2019s Health: Canadian Expert Review","volume":"10","author":"Vorobeychik","year":"2020","journal-title":"Neurodegener. Dis. Manag."},{"key":"ref_32","first-page":"271321","article-title":"The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis","volume":"2011","author":"Tarrants","year":"2011","journal-title":"Mult. Scler. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/jamaneurol.2024.2920","article-title":"Comorbidity and Disease Activity in Multiple Sclerosis","volume":"81","author":"Salter","year":"2024","journal-title":"JAMA Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1177\/1352458520915629","article-title":"Exercise and lifestyle physical activity recommendations for people with multiple sclerosis throughout the disease course","volume":"26","author":"Kalb","year":"2020","journal-title":"Mult. Scler. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/PHM.0000000000000987","article-title":"A Controlled Clinical Trial on the Effects of Exercise on Cognition and Mobility in Adults with Multiple Sclerosis","volume":"98","author":"Felippe","year":"2019","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3390\/neurosci3030034","article-title":"Non-Pharmacological Treatments of Cognitive Impairment in Multiple Sclerosis: A Review","volume":"3","author":"Bossa","year":"2022","journal-title":"NeuroSci"},{"key":"ref_37","first-page":"55","article-title":"Interventions to Improve Quality of Life in Multiple Sclerosis: New Opportunities and Key Talking Points","volume":"13","author":"Faraclas","year":"2023","journal-title":"Degener. Neurol. Neuromuscul. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Aromataris, E., and Munn, Z. (2024). Scoping Reviews (2020). Joanna Briggs Institute Reviewer\u2019s Manua, JBI.","DOI":"10.46658\/JBIRM-20-02"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/ane.13540","article-title":"Efficacy of high-intensity aerobic exercise on common multiple sclerosis symptoms","volume":"145","author":"Hvid","year":"2022","journal-title":"Acta Neurol. Scand."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101985","DOI":"10.1016\/j.rehab.2025.101985","article-title":"Outdoor walking exercise therapy improves walking capacity and well-being in persons with multiple sclerosis: A randomized controlled trial","volume":"68","author":"Hvid","year":"2025","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1007\/s00415-024-12327-y","article-title":"Improved quality of life and psychological symptoms following mindfulness and cognitive rehabilitation in multiple sclerosis and their mediating role for cognition: A randomized controlled trial","volume":"271","author":"Nauta","year":"2024","journal-title":"J. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Meyer, B., Betz, L.T., Jacob, G.A., Krause, N., Riemann-Lorenz, K., Gold, S.M., P\u00f6ttgen, J., and Heesen, C. (2024). Effectiveness of a digital lifestyle management intervention (levidex) to improve quality of life in people with multiple sclerosis: Results of a randomized controlled trial. BMC Neurol., 24.","DOI":"10.1186\/s12883-024-03843-5"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Amato, A., Ragonese, P., Ingoglia, S., Schiera, G., Schir\u00f2, G., Di Liegro, C.M., Salemi, G., Di Liegro, I., and Proia, P. (2021). Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach. Nutrients, 13.","DOI":"10.3390\/nu13124284"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Yal\u00e7\u0131n, G.Y., Tulek, Z., and K\u00fcrt\u00fcnc\u00fc, M. (2025). Effect of a nurse-led online patient support program on fatigue, sleep and quality of life in patients with multiple sclerosis: A quasi-experimental study. BMC Neurol., 25.","DOI":"10.1186\/s12883-025-04248-8"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"108380","DOI":"10.1016\/j.clineuro.2024.108380","article-title":"Tango classes in people with Multiple Sclerosis (PwMS): Impact on motor and non-motor functions","volume":"243","author":"Trinchillo","year":"2024","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_47","first-page":"1","article-title":"Effects of a Remote Multimodal Intervention Involving Diet, Walking Program, and Breathing Exercise on Quality of Life Among Newly Diagnosed People with Multiple Sclerosis: A Quasi-Experimental Non-Inferiority Pilot Study","volume":"14","author":"Saxby","year":"2024","journal-title":"Degener. Neurol. Neuromuscul. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"d\u2019Arma, A., Saresella, M., Rossi, V., Marventano, I., Piancone, F., La Rosa, F., Clerici, M., and Mendozzi, L. (2022). Increased Levels of Beta-Endorphin and Noradrenaline after a Brief High-Impact Multidimensional Rehabilitation Program in Multiple Sclerosis. Life, 12.","DOI":"10.3390\/life12050755"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"104576","DOI":"10.1016\/j.msard.2023.104576","article-title":"The effectiveness of nontraditional or home-based programing on ADL performance of individuals living with multiple sclerosis: A systematic review","volume":"71","author":"Belveal","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12955-022-02046-1","article-title":"Understanding lifestyle self-management regimens that improve the life quality of people living with multiple sclerosis: A systematic review and meta-analysis","volume":"20","author":"Wills","year":"2022","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/bjsports-2019-101375","article-title":"Effectiveness of exercises by telerehabilitation on pain, physical function and quality of life in people with physical disabilities: A systematic review of randomised controlled trials with GRADE recommendations","volume":"55","author":"Dias","year":"2021","journal-title":"Br. J. Sports Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1177\/1352458521996002","article-title":"Which exercise and behavioural interventions show most promise for treating fatigue in multiple sclerosis? A network meta-analysis","volume":"27","author":"Harrison","year":"2021","journal-title":"Mult. Scler. J."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kidd, T., Carey, N., Mold, F., Westwood, S., Miklaucich, M., Konstantara, E., Sterr, A., and Cooke, D. (2017). A systematic review of the effectiveness of self-management interventions in people with multiple sclerosis at improving depression, anxiety and quality of life. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0185931"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e041249","DOI":"10.1136\/bmjopen-2020-041249","article-title":"Quality of life in adults with multiple sclerosis: A systematic review","volume":"10","author":"Conrad","year":"2020","journal-title":"BMJ Open"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"256","DOI":"10.7224\/1537-2073.2019-094","article-title":"Role of Rehabilitation in Promoting Engagement in Daily Life in Multiple Sclerosis","volume":"22","author":"Peeters","year":"2020","journal-title":"Int. J. MS Care"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Du, L., Xi, H., Zhang, S., Zhou, Y., Tao, X., Lv, Y., Hou, X., and Yu, L. (2024). Effects of exercise in people with multiple sclerosis: A systematic review and meta-analysis. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1387658"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s40001-023-01185-5","article-title":"A systematic review and meta-analysis of the effects of non-pharmacological interventions on quality of life in adults with multiple sclerosis","volume":"28","author":"Gitman","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Duan, H., Jing, Y., Li, Y., Lian, Y., Li, J., and Li, Z. (2023). Rehabilitation treatment of multiple sclerosis. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1168821"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"262","DOI":"10.17712\/nsj.2025.4.20250054","article-title":"A narrative review of clinical practice guidelines for the application of physical therapy and rehabilitation procedures in the management of multiple sclerosis","volume":"30","author":"Alhusayni","year":"2025","journal-title":"Neurosciences"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/emph\/eoac009","article-title":"Multiple sclerosis and the microbiota","volume":"10","author":"Engelenburg","year":"2022","journal-title":"Evol. Med. Public Health"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuroscience.2025.01.032","article-title":"Scoping review: The effects of diet, physical activity and sleep on motor and physical fatigue in people with multiple sclerosis","volume":"568","author":"Boda","year":"2025","journal-title":"Neuroscience"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Kasiak, P., Kowalski, T., R\u0119bi\u015b, K., Klusiewicz, A., Starczewski, M., \u0141adyga, M., Wiecha, S., Barylski, M., Poliwczak, A.R., and Wierzbi\u0144ski, P. (2024). Below or all the way to the peak? Oxygen uptake efficiency slope as the index of cardiorespiratory response to exercise\u2014The NOODLE study. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1348307"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s11910-016-0688-8","article-title":"Diagnostic Criteria, Classification and Treatment Goals in Multiple Sclerosis: The Chronicles of Time and Space","volume":"16","author":"Ntranos","year":"2016","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Bevens, W., Weiland, T.J., Gray, K., Neate, S.L., Nag, N., Simpson-Yap, S., Reece, J., Yu, M., and Jelinek, G.A. (2022). The Feasibility of a Web-Based Educational Lifestyle Program for People with Multiple Sclerosis: A Randomized Controlled Trial. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.852214"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/215\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:27:16Z","timestamp":1768915636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["medicina62010215"],"URL":"https:\/\/doi.org\/10.3390\/medicina62010215","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]}}}