{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:17:33Z","timestamp":1779297453410,"version":"3.51.4"},"reference-count":23,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Peyronie\u2019s disease (PD) is a chronic fibrotic disorder of the tunica albuginea causing penile deformity and sexual dysfunction. Platelet-rich plasma (PRP) has been proposed as a regenerative therapy with potential disease-modifying properties, but evidence of its use in chronic PD is scarce. This study evaluated the efficacy and safety of intralesional PRP injections in men with stable PD. Materials and Methods: A single-center retrospective cohort study was conducted including men with chronic PD treated with three weekly intralesional PRP injections (April 2022\u2013April 2025). Inclusion required curvature stability for \u22656 months and absence of prior PD therapy. The primary outcome was a change in penile curvature at 4 weeks post-treatment. Secondary outcomes included plaque thickness (ultrasound), erectile function (IIEF-5), and safety (Clavien\u2013Dindo grading). Results: Thirty-six men (mean age 61.2 \u00b1 10.4 years) completed the treatment. Mean penile curvature decreased from 30.5 \u00b1 7.3\u00b0 to 24.2 \u00b1 8.3\u00b0 (\u0394 = \u22126.3\u00b0, 95% CI \u22127.7 to \u22125.3; p &lt; 0.001); 25% achieved a \u226510\u00b0 reduction. Mean plaque thickness declined from 3.25 \u00b1 0.69 mm to 2.91 \u00b1 0.76 mm (\u0394 = \u22120.34 mm; p &lt; 0.001). IIEF-5 increased modestly (+1.1; p = 0.142). Only mild, transient adverse events occurred (pain 5.6%, hematoma 2.8%). Conclusions: Intralesional PRP was safe and yielded statistically significant but modest reductions in penile curvature and plaque thickness in chronic PD. Clinically meaningful improvement occurred in a minority of patients. These findings support keeping PRP investigational pending well-designed randomized controlled trials with standardized protocols and longer follow-up.<\/jats:p>","DOI":"10.3390\/medicina62010221","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:11:17Z","timestamp":1768993877000},"page":"221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intralesional Platelet-Rich Plasma for Treating Chronic Peyronie\u2019s Disease: A Single-Center Retrospective Cohort Study"],"prefix":"10.3390","volume":"62","author":[{"given":"Luigi","family":"Pucci","sequence":"first","affiliation":[{"name":"Department of Urology, AORN Antonio Cardarelli, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9706-8516","authenticated-orcid":false,"given":"Celeste","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catello","family":"Sansone","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples \u201cFederico II\u201d, 80138 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9000-7534","authenticated-orcid":false,"given":"Simone","family":"Tammaro","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2102-7933","authenticated-orcid":false,"given":"Giorgio","family":"Stanziola","sequence":"additional","affiliation":[{"name":"Department of Urology, AORN Antonio Cardarelli, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunzio","family":"Langella","sequence":"additional","affiliation":[{"name":"Department of Urology, AORN Antonio Cardarelli, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Dachille","sequence":"additional","affiliation":[{"name":"Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area Urology, University of Bari, 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-2335","authenticated-orcid":false,"given":"Davide","family":"Arcaniolo","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"De Sio","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Carrino","sequence":"additional","affiliation":[{"name":"Department of Urology, AORN Antonio Cardarelli, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4103\/aja202460","article-title":"Intralesional and topical treatments for Peyronie\u2019s disease: A narrative review of current knowledge","volume":"27","author":"Minore","year":"2025","journal-title":"Asian J. Androl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00345-024-05065-3","article-title":"Platelet-rich plasma therapy in erectile dysfunction and Peyronie\u2019s disease: A systematic review of the literature","volume":"42","author":"Asmundo","year":"2024","journal-title":"World J. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1590\/s1677-5538.ibju.2024.9920","article-title":"Evidence of restorative therapies in the treatment of Peyronie disease: A narrative review","volume":"50","author":"Mesquita","year":"2024","journal-title":"Int. Braz. J. Urol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.purol.2022.05.004","article-title":"Tolerance and efficacy of platelet-rich plasma injections in Peyronie\u2019s disease: Pilot study","volume":"32","author":"Schirmann","year":"2022","journal-title":"Prog. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/2090598X.2022.2135284","article-title":"Platelet-rich plasma in patients affected with Peyronie\u2019s disease","volume":"21","author":"Achraf","year":"2023","journal-title":"Arab. J. Urol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s00345-025-05691-5","article-title":"Platelet-rich plasma intra-plaque injections rapidly reduce penile curvature and improve sexual function in Peyronie\u2019s disease patients: Results from a prospective large-cohort study","volume":"43","author":"Dachille","year":"2025","journal-title":"World J. Urol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.56434\/j.arch.esp.urol.20257802.23","article-title":"Low-intensity extracorporeal shock wave therapy and platelet-rich plasma: Effective combination treatment of chronic-phase Peyronie\u2019s disease","volume":"78","year":"2025","journal-title":"Arch. Esp. Urol."},{"key":"ref_8","unstructured":"European Association of Urology (2025). EAU Guidelines on Sexual and Reproductive Health 2025, EAU Guidelines Office. Peyronie\u2019s Disease Chapter."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA, 310, 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/0090-4295(83)90210-8","article-title":"Autophotography in evaluation of functional penile disorders","volume":"21","year":"1983","journal-title":"Urology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.ijir.3900472","article-title":"Development and evaluation of an abridged 5-item version of the International Index of Erectile Function as a diagnostic tool for erectile dysfunction","volume":"11","author":"Rosen","year":"1999","journal-title":"Int. J. Impot. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_13","first-page":"102526","article-title":"New protocol in the treatment of Peyronie\u2019s disease by combining platelet-rich plasma, percutaneous needle tunneling, and penile modeling: Preliminary results","volume":"34","author":"Alshuaibi","year":"2024","journal-title":"Prog. Urol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5812\/ijem.3505","article-title":"Normality tests for statistical analysis: A guide for non-statisticians","volume":"10","author":"Ghasemi","year":"2012","journal-title":"Int. J. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1017\/S1049023X25001517","article-title":"Analysis of paired data","volume":"40","author":"Franc","year":"2025","journal-title":"Prehosp. Disaster Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41592-019-0470-3","article-title":"Moving beyond P values: Data analysis with estimation graphics","volume":"16","author":"Ho","year":"2019","journal-title":"Nat. Methods"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41443-023-00744-y","article-title":"Safety and feasibility of percutaneous needle tunneling with platelet-rich plasma injections for Peyronie\u2019s disease in the outpatient setting: A pilot study","volume":"36","author":"Zugail","year":"2024","journal-title":"Int. J. Impot. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/s41443-024-00844-3","article-title":"A phase 2 randomized, placebo-controlled crossover trial to evaluate safety and efficacy of platelet-rich plasma injections for Peyronie\u2019s disease: Clinical trial update","volume":"36","author":"Ledesma","year":"2024","journal-title":"Int. J. Impot. Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Virag, R. (2017). Evaluation of the benefit of using a combination of autologous platelet rich-plasma and hyaluronic acid for the treatment of Peyronie\u2019s disease. Sex. Health Issues, 1\u20138.","DOI":"10.15761\/SHI.1000102"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.joms.2003.12.003","article-title":"Platelet-rich plasma: Evidence to support its use","volume":"62","author":"Marx","year":"2004","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Devereaux, J., Dargahi, N., Fraser, S., Nurgali, K., Kiatos, D., and Apostolopoulos, V. (2020). Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186519"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Chellini, F., Tani, A., Vallone, L., Nosi, D., Pavan, P., Bambi, F., Orlandini, S.Z., and Sassoli, C. (2018). Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-\u03b21-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A\/VEGF Receptor-1-Mediated Signaling. Cells, 7.","DOI":"10.3390\/cells7090142"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"qeaf051","DOI":"10.1093\/sxmrev\/qeaf051","article-title":"Virtual reality in the management of male sexual dysfunction: An updated narrative review of the literature","volume":"14","author":"Krishnappa","year":"2025","journal-title":"Sex. Med. Rev."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/221\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:58:40Z","timestamp":1768996720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/1\/221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["medicina62010221"],"URL":"https:\/\/doi.org\/10.3390\/medicina62010221","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]}}}