{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:04:48Z","timestamp":1770087888948,"version":"3.49.0"},"reference-count":19,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Rheumatoid arthritis (RA) is a multisystem autoimmune disease that needs immunosuppressive treatment. Previously, studies have shown an increased risk of cancer in patients with RA compared with the general population. The purpose of this study was to explore the associations between RA and cancer risk, providing updated insights into the incidence of specific cancers in patients with RA. Materials and Methods: A total of 746 cancer cases were observed, with the most common types being nonmelanoma skin cancer (139 cases), breast cancer (87 cases), lung cancer (47 cases), and Hodgkin lymphoma (43 cases). Results: Compared with the general Lithuanian population, patients with RA had an increased overall cancer risk, with an SIR of 1.17 and 95% CI of 1.09\u20131.26. Hematological cancers and nonmelanoma skin cancers were the most common types of cancer in the RA population, and patients with RA had a significantly greater risk of site-specific cancers (non-Hodgkin lymphoma: SIR 4.19, 95% CI 1.57\u201311.18; Hodgkin lymphoma: SIR 3.03, 95% CI 2.11\u20134.36; myeloma: SIR 3.00, 95% CI 1.84\u20134.90; leukemia: SIR 2.39, 95% CI 1.62\u20133.54; and skin nonmelanoma: SIR 1.54, 95% CI 1.27\u20131.83). Male patients with RA had an increased risk of prostate and kidney cancer (SIR 1.40, 95% CI 1.12\u20131.75; SIR 1.85, 95% CI 1.11\u20133.06). Our study revealed a significantly lower risk of colorectal cancer among patients with RA. Additionally, we observed a statistically significant reduction in the risk of mouth and pharynx cancers; however, this finding was based on only three observed cases. Conclusions: Patients with RA remain particularly affected by an increased cancer risk. Knowing these risks, we need clear recommendations for specific screenings in patients with RA, which could allow for early diagnosis and better cancer treatment in the early stages.<\/jats:p>","DOI":"10.3390\/medicina62020290","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:49:44Z","timestamp":1770036584000},"page":"290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Cancer in Patients with Rheumatoid Arthritis Compared with the General Population: A Nationwide Cohort Study in Lithuania"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9300-6442","authenticated-orcid":false,"given":"Vaida","family":"Gedvilait\u0117","sequence":"first","affiliation":[{"name":"Chemotherapy Department, Medical Oncology Center, National Cancer Center, Vilnius University Hospital Santaros klinikos, 08660 Vilnius, Lithuania"},{"name":"Laboratory of Cancer Epidemiology, National Cancer Institute, 08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"August\u0117","family":"Ka\u010d\u0117nien\u0117","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Epidemiology, National Cancer Institute, 08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gintar\u0117","family":"Jonu\u0161ien\u0117","sequence":"additional","affiliation":[{"name":"Antakalnis Outpatient Clinic, 10207 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-4603","authenticated-orcid":false,"given":"Jolanta","family":"Dadonien\u0117","sequence":"additional","affiliation":[{"name":"Department of Public Health, Institute of Health Sciences, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania"},{"name":"Clinic of Rheumatology, Orthopaedic Traumatology and Reconstructive Surgery, Institute of Clinical Medicine, Vilnius University Faculty of Medicine, 03101 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-3761","authenticated-orcid":false,"given":"Dalia","family":"Miltinien\u0117","sequence":"additional","affiliation":[{"name":"Clinic of Rheumatology, Orthopaedic Traumatology and Reconstructive Surgery, Institute of Clinical Medicine, Vilnius University Faculty of Medicine, 03101 Vilnius, Lithuania"},{"name":"Innovative Medicine Center, 08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giedr\u0117","family":"Deresevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Innovative Medicine Center, 08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-543X","authenticated-orcid":false,"given":"Giedr\u0117","family":"Smailyt\u0117","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Epidemiology, National Cancer Institute, 08406 Vilnius, Lithuania"},{"name":"Department of Public Health, Institute of Health Sciences, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/ejhg.2008.163","article-title":"Meta-analysis of genome-wide linkage studies across autoimmune diseases","volume":"17","author":"Forabosco","year":"2009","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrg2489","article-title":"Detecting shared pathogenesis from the shared genetics of immune-related diseases","volume":"10","author":"Zhernakova","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1183\/09031936.00222911","article-title":"Effect of autoimmune diseases on risk and survival in histology-specific lung cancer","volume":"40","author":"Hemminki","year":"2012","journal-title":"Eur. Respir. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s13075-015-0728-9","article-title":"Incidence of malignancy in adult patients with rheumatoid arthritis: A meta-analysis","volume":"17","author":"Simon","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100768","DOI":"10.1016\/j.lanepe.2023.100768","article-title":"Risk of cancer for patients with rheumatoid arthritis versus general population: A national claims database cohort study","volume":"35","author":"Beydon","year":"2023","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_6","first-page":"e7870","article-title":"Prevalence of cancer in rheumatoid arthritis: Epidemiological study based on the national health and nutrition examination survey (NHANES)","volume":"12","author":"Bhandari","year":"2020","journal-title":"Cureus"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/ar2404","article-title":"A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis","volume":"10","author":"Smitten","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.rdc.2004.01.007","article-title":"Associations between rheumatoid arthritis and malignancy","volume":"30","author":"Chakravarty","year":"2004","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e001698","DOI":"10.1136\/rmdopen-2021-001698","article-title":"Lymphoma complicating rheumatoid arthritis: Results from a French case-control study","volume":"7","author":"Kedra","year":"2021","journal-title":"RMD Open"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/rheumatology\/keaa330","article-title":"Lymphoma risks in patients with rheumatoid arthritis treated with biological drugs-a Swedish cohort study of risks by time, drug and lymphoma subtype","volume":"60","author":"Hellgren","year":"2021","journal-title":"Rheumatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/jnci\/djj004","article-title":"Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype","volume":"98","author":"Smedby","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_12","first-page":"9746241","article-title":"A case of multiple myeloma misdiagnosed as seronegative rheumatoid arthritis and review of relevant literature","volume":"2018","author":"Schoninger","year":"2018","journal-title":"Case Rep. Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/1756-185X.12935","article-title":"Multiple myeloma masquerading as severe seropositive rheumatoid arthritis with subcutaneous nodules and mononeuritis multiplex","volume":"20","author":"Edavalath","year":"2017","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s10067-020-05396-7","article-title":"The risk of leukemia in patients with rheumatoid arthritis: A systematic review and meta-analysis","volume":"40","author":"Luo","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e18515","DOI":"10.1111\/jcmm.18515","article-title":"Rheumatoid arthritis reduces the risk of colorectal cancer through immune inflammation mediation","volume":"28","author":"Li","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"i262","DOI":"10.1136\/bmj.i262","article-title":"Rheumatoid arthritis, anti-tumour necrosis factor treatment, and risk of squamous cell and basal cell skin cancer: Cohort study based on nationwide prospectively recorded data from Sweden","volume":"352","author":"Raaschou","year":"2016","journal-title":"BMJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s10067-019-04865-y","article-title":"Risk of non-melanoma skin cancer for rheumatoid arthritis patients receiving TNF antagonist: A systematic review and meta-analysis","volume":"39","author":"Wang","year":"2020","journal-title":"Clin. Rheumatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/acr.24890","article-title":"Risk of prostate cancer in US veterans with rheumatoid arthritis","volume":"75","author":"Wheeler","year":"2023","journal-title":"Arthritis Care Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"dyae006","DOI":"10.1093\/ije\/dyae006","article-title":"Rheumatoid arthritis and cancer risk in the million women study","volume":"53","author":"Yang","year":"2024","journal-title":"Int. J. Epidemiol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/2\/290\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:23:46Z","timestamp":1770038626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/2\/290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["medicina62020290"],"URL":"https:\/\/doi.org\/10.3390\/medicina62020290","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]}}}