{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:45:05Z","timestamp":1792511105304,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This study aimed to evaluate the predictive value of the Aggregate Index of Systemic Inflammation (AISI) for contrast-induced nephropathy (CIN) development in elderly patients with acute coronary syndrome (ACS) undergoing PCI. Materials and Methods: The study included consecutive patients aged \u226565 years who underwent PCI for ACS between January 2022 and January 2024. The primary endpoint was the occurrence of CIN, defined as an increase in serum creatinine \u22650.5 mg\/dL or \u226525% from baseline within 48\u201372 h after PCI. The AISI was calculated for each patient. Results: A total of 437 patients (mean age 73.7 \u00b1 7.2 years, 64.5% male) were included. The overall incidence of CIN was 25.6%. Patients who developed CIN were older, more frequently female, and had lower left ventricular ejection fraction and albumin but higher SYNTAX I scores and baseline creatinine (all p &lt; 0.001). AISI demonstrated a significant predictive accuracy for CIN (AUC: 0.709, 95% CI: 0.647\u20130.771, p &lt; 0.001), which was statistically comparable to the Mehran score (AUC: 0.744, p = 0.095). In multivariable analysis, AISI emerged as a strong independent predictor of CIN (OR: 1.345, 95% CI: 1.123\u20131.437, p &lt; 0.001), alongside SYNTAX I scores, baseline creatinine, and serum albumin. Notably, AISI retained its independent predictive power even when adjusted for the Mehran score (OR: 1.276, p &lt; 0.001). Conclusions: AISI independently predicts CIN in elderly patients with ACS undergoing PCI. Its superior discriminative ability compared with single hematologic markers highlights the importance of systemic inflammatory burden in CIN pathogenesis. Incorporating AISI into pre-procedural assessment may improve risk stratification and preventive management in this high-risk population.<\/jats:p>","DOI":"10.3390\/medicina62020361","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:45:36Z","timestamp":1770831936000},"page":"361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive Performance of the Aggregate Index of Systemic Inflammation for Contrast-Induced Nephropathy After PCI in Elderly ACS Patients"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7055-8219","authenticated-orcid":false,"given":"\u00c7a\u011fatay","family":"\u00d6nal","sequence":"first","affiliation":[{"name":"Department of Cardiology, \u00d6zel Gazi Hospital, \u0130zmir 35230, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-3206","authenticated-orcid":false,"given":"Cennet","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bak\u0131rk\u00f6y Dr. Sadi Konuk Education and Research Hospital, \u0130stanbul 34147, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-5503","authenticated-orcid":false,"given":"Yasin","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Private Beylikd\u00fcz\u00fc Kolan Hospital, \u0130stanbul 34528, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Ay\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Private Medical Point Hospital, \u0130zmir 35575, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes: Developed by the Task Force on the management of acute coronary syndromes of the European Society of Cardiology (ESC)","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur. 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