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While extensive literature documents vasculogenic ED as an early warning sign of coronary artery disease (CAD) and other atherosclerotic manifestations, the evidence for analogous phenomena in women is emerging but less mature. This perspective explores epidemiologic associations, shared pathophysiologic mechanisms, clinical implications, and screening paradigms for ED and FSAD as cardiovascular (CV) risk-enhancing conditions. This perspective endorses that clinicians should incorporate genital vasculogenic SD into CV risk stratification and that multidisciplinary care (primary care, cardiology, urology\/gynecology) is warranted. A summary table outlines key features and actionable steps.<\/jats:p>","DOI":"10.3390\/medicina62020416","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:39:10Z","timestamp":1771846750000},"page":"416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Erectile and Clitoral Dysfunction as Harbingers of Cardiovascular Disease: A Perspective"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-2081","authenticated-orcid":false,"given":"Fernanda","family":"Priviero","sequence":"first","affiliation":[{"name":"Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC 29208, USA"},{"name":"Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC 29208, USA"},{"name":"Department of Biomedical Engineering, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6559-5736","authenticated-orcid":false,"given":"Fiona","family":"Hollis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Physiology and Neuroscience, University of South Carolina, Columbia, SC 29208, USA"},{"name":"William Jennings Bryan (WJB) Dorn Veterans Administration Medical Center, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-3335","authenticated-orcid":false,"given":"Susan K.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Physiology and Neuroscience, University of South Carolina, Columbia, SC 29208, USA"},{"name":"William Jennings Bryan (WJB) Dorn Veterans Administration Medical Center, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3533-871X","authenticated-orcid":false,"given":"Mark","family":"Uline","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-3486","authenticated-orcid":false,"given":"Karl-Erik","family":"Andersson","sequence":"additional","affiliation":[{"name":"Division of Clinical Chemistry and Pharmacology, Lund University, 221 00 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9403-305X","authenticated-orcid":false,"given":"R. 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Sin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.mayocp.2024.06.002","article-title":"The Princeton IV Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease","volume":"99","author":"Kohler","year":"2024","journal-title":"Mayo Clin. Proc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0025-6196(11)62632-3","article-title":"Erectile dysfunction and cardiovascular disease","volume":"79","author":"Russell","year":"2004","journal-title":"Mayo Clin. Proc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjcard.2005.07.006","article-title":"The artery size hypothesis: A macrovascular link between erectile dysfunction and coronary artery disease","volume":"96","author":"Montorsi","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.5489\/cuaj.2311","article-title":"Diagnosing erectile dysfunction could save your patient\u2019s life","volume":"8","author":"Brock","year":"2014","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/eurjpc\/zwae051","article-title":"Impact of female sexual dysfunction on cardiovascular diseases","volume":"31","author":"Fukumoto","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/eurjpc\/zwae042","article-title":"Association between cardiovascular disease and risk of female sexual dysfunction: A systematic review and meta-analysis","volume":"31","author":"Dilixiati","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/heartjnl-2016-310762","article-title":"Sexual function and cardiovascular disease: What the general cardiologist needs to know","volume":"105","author":"Roushias","year":"2019","journal-title":"Heart"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/jsm.12041","article-title":"Erectile dysfunction precedes and is associated with severity of coronary artery disease among Asian Indians","volume":"10","author":"Kumar","year":"2013","journal-title":"J. Sex. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/sxmrev\/qeaf014","article-title":"Understanding the erectile dysfunction-cardiovascular disease connection: Clinical and pathophysiological insights","volume":"13","author":"An","year":"2025","journal-title":"Sex. Med. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1093\/eurheartj\/ehl341","article-title":"Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease","volume":"27","author":"Vlachopoulos","year":"2006","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1743-6109.2012.02820.x","article-title":"Female sexual arousal disorders","volume":"10","author":"Giraldi","year":"2013","journal-title":"J. Sex. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.sxmr.2021.05.001","article-title":"Persistent Genital Arousal Disorder (PGAD): A Clinical Review and Case Series in Support of Multidisciplinary Management","volume":"10","author":"Pease","year":"2022","journal-title":"Sex. Med. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1743-6109.2012.02990.x","article-title":"Persistent genital arousal disorder: Characterization, etiology, and management","volume":"10","author":"Facelle","year":"2013","journal-title":"J. Sex. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.ijir.3901530","article-title":"Sexual function in women with coronary artery disease: A preliminary study","volume":"19","author":"Kaya","year":"2007","journal-title":"Int. J. Impot. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.jsxm.2016.09.009","article-title":"Cardiometabolic Risk and Female Sexuality: Focus on Clitoral Vascular Resistance","volume":"13","author":"Maseroli","year":"2016","journal-title":"J. Sex. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1046\/j.1469-0705.1994.04060476.x","article-title":"The interpretation of uterine artery pulsatility index in normal and hypertensive pregnancy","volume":"4","author":"Grunewald","year":"1994","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/2631831820919581","article-title":"Assessment Scales for Sexual Disorders\u2014A Review","volume":"2","author":"Grover","year":"2020","journal-title":"J. Psychosex. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/postgradmedj-2017-135233","article-title":"Effect of prescription medications on erectile dysfunction","volume":"94","author":"Razdan","year":"2018","journal-title":"Postgrad. Med. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41443-022-00539-7","article-title":"Prevalence of sexual dysfunction in depressive and persistent depressive disorders: A systematic review and meta-analysis","volume":"35","author":"Goncalves","year":"2023","journal-title":"Int. J. Impot. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1161\/CIR.0000000000000019","article-title":"Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: Systematic review and recommendations: A scientific statement from the American Heart Association","volume":"129","author":"Lichtman","year":"2014","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gan, Y., Gong, Y., Tong, X., Sun, H., Cong, Y., Dong, X., Wang, Y., Xu, X., Yin, X., and Deng, J. (2014). Depression and the risk of coronary heart disease: A meta-analysis of prospective cohort studies. BMC Psychiatry, 14.","DOI":"10.1186\/s12888-014-0371-z"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/j.1743-6109.2012.02709.x","article-title":"Bidirectional association between depression and sexual dysfunction: A systematic review and meta-analysis","volume":"9","author":"Atlantis","year":"2012","journal-title":"J. Sex. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF01541402","article-title":"Male sexual dysfunction associated with coronary heart disease","volume":"9","author":"Wabrek","year":"1980","journal-title":"Arch. Sex. Behav."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0147-9563(96)80061-6","article-title":"Sexual function in patients with advanced heart failure","volume":"25","author":"Jaarsma","year":"1996","journal-title":"Heart Lung"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.ijir.3900282","article-title":"Does severity of ischemic coronary disease correlate with erectile function?","volume":"9","author":"Greenstein","year":"1997","journal-title":"Int. J. Impot. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000006845","article-title":"Sexual activity after first acute myocardial infarction in middle-aged men: Demographic, psychological and medical predictors","volume":"90","author":"Drory","year":"1998","journal-title":"Cardiology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1053\/ejvs.1998.0770","article-title":"Sexual function in women suffering from aortoiliac occlusive disease","volume":"17","author":"Hultgren","year":"1999","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/sj.ijir.3900725","article-title":"Erectile dysfunction is a marker for cardiovascular complications and psychological functioning in men with hypertension","volume":"13","author":"Burchardt","year":"2001","journal-title":"Int. J. Impot. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0302-2838(03)00305-1","article-title":"Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease","volume":"44","author":"Montorsi","year":"2003","journal-title":"Eur. Urol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/01.AOG.0000165276.85777.fb","article-title":"Sexual activity and function in postmenopausal women with heart disease","volume":"106","author":"Addis","year":"2005","journal-title":"Obstet. Gynecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1439-0272.2006.00753.x","article-title":"Incidence of changes and predictive factors for sexual function after coronary stenting","volume":"39","author":"Shi","year":"2007","journal-title":"Andrologia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1743-6109.2007.00473.x","article-title":"Sexual function in female patients with unstable angina or non-ST-elevation myocardial infarction","volume":"4","author":"Eyada","year":"2007","journal-title":"J. Sex. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.amjcard.2008.08.017","article-title":"Erectile dysfunction in men with congenital heart disease","volume":"102","author":"Cook","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/sj.ijir.3901613","article-title":"The prevalence and clinical relevance of sexual dysfunction in women and men with chronic heart failure","volume":"20","author":"Schwarz","year":"2008","journal-title":"Int. J. Impot. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/ijir.2009.43","article-title":"Cardiovascular disease risk, vascular health and erectile dysfunction among middle-aged, clinically depressed men","volume":"22","author":"Hoffman","year":"2010","journal-title":"Int. J. Impot. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijcard.2008.08.017","article-title":"Erectile dysfunction and depressive mood in men with coronary heart disease","volume":"138","author":"Lemogne","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1111\/j.1743-6109.2010.01761.x","article-title":"Effect of sexual function on health-related quality of life mediated by depressive symptoms in cardiac rehabilitation. findings of the SPARK project in 493 patients","volume":"7","author":"Kriston","year":"2010","journal-title":"J. Sex. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/eurheartj\/eht112","article-title":"Erectile dysfunction in the cardiovascular patient","volume":"34","author":"Vlachopoulos","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Rinkuniene, E., Gimzauskaite, S., Badariene, J., Dzenkeviciute, V., Kovaite, M., and Cypiene, A. (2021). The Prevalence of Erectile Dysfunction and Its Association with Cardiovascular Risk Factors in Patients after Myocardial Infarction. Medicina, 57.","DOI":"10.3390\/medicina57101103"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bju.15313","article-title":"Association of erectile dysfunction and cardiovascular disease: An umbrella review of systematic reviews and meta-analyses","volume":"128","author":"Mostafaei","year":"2021","journal-title":"BJU Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/jsxmed\/qdae056","article-title":"Nitric oxide in the penis: Still the key erection player?","volume":"21","author":"Burnett","year":"2024","journal-title":"J. Sex. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1743-6109.2010.02045.x","article-title":"Vascular modifications of the clitoris induced by topic nitric oxide donor gel--preliminary study","volume":"8","author":"Souto","year":"2011","journal-title":"J. Sex. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"117384","DOI":"10.1016\/j.bcp.2025.117384","article-title":"Tissue-specific regulation of NO-GC isoforms in the cardiovascular system","volume":"242","author":"Giesen","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.sxmr.2019.05.005","article-title":"Impact of Immune System Activation and Vascular Impairment on Male and Female Sexual Dysfunction","volume":"7","author":"Calmasini","year":"2019","journal-title":"Sex. Med. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.3390\/cimb46080521","article-title":"Oxidative Stress and Erectile Dysfunction: Pathophysiology, Impacts, and Potential Treatments","volume":"46","author":"Kaltsas","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0002-9149(00)00887-0","article-title":"Penile erection and cardiac risk: Pathophysiologic and pharmacologic mechanisms","volume":"86","author":"Andersson","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1310\/sci2301-1","article-title":"Neural Control and Physiology of Sexual Function: Effect of Spinal Cord Injury","volume":"23","author":"Krassioukov","year":"2017","journal-title":"Top. Spinal Cord. Inj. Rehabil."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1097\/01.ju.0000075352.03144.15","article-title":"A review of the physiology and pharmacology of peripheral (vaginal and clitoral) female genital arousal in the animal model","volume":"170","author":"Munarriz","year":"2003","journal-title":"J. Urol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0031-6997(24)01503-5","article-title":"Pharmacology of penile erection","volume":"53","author":"Andersson","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10484-015-9286-9","article-title":"Heart Rate Variability: A Risk Factor for Female Sexual Dysfunction","volume":"40","author":"Stanton","year":"2015","journal-title":"Appl. Psychophysiol. Biofeedback"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5213\/inj.2011.15.2.87","article-title":"Heart Rate Variability in Men with Erectile dysfunction","volume":"15","author":"Lee","year":"2011","journal-title":"Int. Neurourol. J."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhao, D., Wang, M., Sun, J.Y., Liu, J., Qi, Y., Hao, Y.C., Deng, Q.J., Liu, J., and Liu, J. (2021). Combined effect of menopause and cardiovascular risk factors on death and cardiovascular disease: A cohort study. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-01919-5"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"qfaf019","DOI":"10.1093\/sexmed\/qfaf019","article-title":"Menopause is associated with a decrease in sexual function among women with endometriosis","volume":"13","author":"Vallee","year":"2025","journal-title":"Sex. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/GME.0000000000000952","article-title":"Is the age at menopause a cause of sexual dysfunction? A Brazilian population-based study","volume":"25","author":"Lett","year":"2018","journal-title":"Menopause"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3109\/13697137.2016.1145206","article-title":"Impact of endo- and exogenous estrogens on heart rate variability in women: A review","volume":"19","author":"Capaldo","year":"2016","journal-title":"Climacteric"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/gme.0b013e3182337166","article-title":"Hot flashes and cardiac vagal control during women\u2019s daily lives","volume":"19","author":"Thurston","year":"2012","journal-title":"Menopause"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/gme.0b013e3181c7dea7","article-title":"Hot flashes and cardiac vagal control: A link to cardiovascular risk?","volume":"17","author":"Thurston","year":"2010","journal-title":"Menopause"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/13697137.2023.2196001","article-title":"Vasomotor symptoms and cardiovascular health: Findings from the SWAN and the MsHeart\/MsBrain studies","volume":"27","author":"Thurston","year":"2024","journal-title":"Climacteric"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"211","DOI":"10.5489\/cuaj.4907","article-title":"A practical guide to female sexual dysfunction: An evidence-based review for physicians in Canada","volume":"12","author":"Krakowsky","year":"2018","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"101332","DOI":"10.1016\/j.ajpc.2025.101332","article-title":"Erectile Dysfunction and Cardiovascular-Kidney-Metabolic Syndrome: Insights from the All of Us Research Program","volume":"24","author":"Blazoski","year":"2025","journal-title":"Am. J. Prev. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/jsxmed\/qdad140","article-title":"Clitoris color Doppler ultrasound: A 2023 update","volume":"20","author":"Maseroli","year":"2023","journal-title":"J. Sex. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"108381","DOI":"10.1016\/j.maturitas.2025.108381","article-title":"Cardiovascular disease and female sexual health across the life span: A bidirectional link","volume":"198","author":"Armeni","year":"2025","journal-title":"Maturitas"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/sxmrev\/qeaf035","article-title":"Evolving medical management of erectile dysfunction: Recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024)","volume":"13","author":"Stern","year":"2025","journal-title":"Sex. Med. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1001\/archinternmed.2011.440","article-title":"The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: A systematic review and meta-analysis","volume":"171","author":"Gupta","year":"2011","journal-title":"Arch. Intern. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.esxm.2018.02.001","article-title":"Physical Activity to Improve Erectile Function: A Systematic Review of Intervention Studies","volume":"6","author":"Gerbild","year":"2018","journal-title":"Sex. Med."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Wekker, V., Karsten, M.D.A., Painter, R.C., van de Beek, C., Groen, H., Mol, B.W.J., Hoek, A., Laan, E., and Roseboom, T.J. (2018). A lifestyle intervention improves sexual function of women with obesity and infertility: A 5 year follow-up of a RCT. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0205934"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/jsxmed\/qdad163","article-title":"Princeton IV consensus guidelines: PDE5 inhibitors and cardiac health","volume":"21","author":"Kloner","year":"2024","journal-title":"J. Sex. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/152460902317586001","article-title":"Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with female sexual arousal disorder","volume":"11","author":"Basson","year":"2002","journal-title":"J. Womens Health Gend. Based Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1743-6109.2012.02702.x","article-title":"What we don\u2019t talk about when we don\u2019t talk about sex: Results of a national survey of U.S. obstetrician\/gynecologists","volume":"9","author":"Sobecki","year":"2012","journal-title":"J. Sex. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/jsxmed\/qdae050","article-title":"Should experts in male sexual health learn about female sexual function?","volume":"21","author":"Parish","year":"2024","journal-title":"J. Sex. Med."},{"key":"ref_72","first-page":"9","article-title":"Erectile dysfunction in primary care: Sexual health inquiry and cardiovascular risk factors among patients with no previous cardiovascular events","volume":"34","author":"Dias","year":"2016","journal-title":"Rev. Port. Sa\u00fade P\u00fablica"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/sxmrev\/qeaf021","article-title":"Infection, inflammation, and sexual function in male and female patients-recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024)","volume":"13","author":"Facio","year":"2025","journal-title":"Sex. Med. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"100086","DOI":"10.1016\/j.cpnec.2021.100086","article-title":"Inflammation Predicts Sexual Arousability in Healthy Women","volume":"8","author":"Clephane","year":"2021","journal-title":"Compr. Psychoneuroendocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/jsxmed\/qdad037","article-title":"The efficacy of systemic inflammatory response and oxidative stress in erectile dysfunction through multi-inflammatory index: A prospective cross-sectional analysis","volume":"20","author":"Taskiran","year":"2023","journal-title":"J. Sex. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1038\/s41598-019-42342-3","article-title":"Association between serum high-sensitivity C-reactive protein levels and erectile dysfunction: A cross-sectional study of Chinese male population","volume":"9","author":"Li","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e38151","DOI":"10.1097\/MD.0000000000038151","article-title":"Systemic immune-inflammatory index and its association with female sexual dysfunction, specifically low sexual frequency, in depressive patients: Results from NHANES 2005 to 2016","volume":"103","author":"Qing","year":"2024","journal-title":"Medicine"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/andr.12961","article-title":"Periodontitis, erectile dysfunction, reproductive hormones, and semen quality: A systematic review","volume":"9","author":"Lecaplain","year":"2021","journal-title":"Andrology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/1557988316639050","article-title":"Association Between Periodontal Disease and Erectile Dysfunction: A Systematic Review","volume":"12","author":"Kellesarian","year":"2018","journal-title":"Am. J. Mens Health"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41415-019-0724-6","article-title":"The link between periodontitis and erectile dysfunction: A review","volume":"227","author":"Bizzarro","year":"2019","journal-title":"Br. Dent. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/odi.13815","article-title":"Is sexual dysfunction associated with periodontal status in perimenopausal women? A pilot study","volume":"28","author":"Gurlek","year":"2022","journal-title":"Oral Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1161\/CIR.0b013e31825719f3","article-title":"Periodontal disease and atherosclerotic vascular disease: Does the evidence support an independent association? A scientific statement from the American Heart Association","volume":"125","author":"Lockhart","year":"2012","journal-title":"Circulation"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.1016\/j.jacc.2018.11.003","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"73","author":"Grundy","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1016\/j.jacc.2019.03.010","article-title":"2019 ACC\/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"74","author":"Arnett","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/sj.ijir.3900258","article-title":"Vasculogenic female sexual dysfunction: The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency","volume":"9","author":"Park","year":"1997","journal-title":"Int. J. Impot. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s11883-025-01343-6","article-title":"Cardiovascular Risk Associated with Menopause and Menopause Hormone Therapy: A Review and Contemporary Approach to Risk Assessment","volume":"27","author":"Spertus","year":"2025","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jsxm.2021.01.172","article-title":"International Society for the Study of Women\u2019s Sexual Health (ISSWSH) Review of Epidemiology and Pathophysiology, and a Consensus Nomenclature and Process of Care for the Management of Persistent Genital Arousal Disorder\/Genito-Pelvic Dysesthesia (PGAD\/GPD)","volume":"18","author":"Goldstein","year":"2021","journal-title":"J. Sex. Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/2\/416\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:12:15Z","timestamp":1771909935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/2\/416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,22]]},"references-count":87,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["medicina62020416"],"URL":"https:\/\/doi.org\/10.3390\/medicina62020416","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,22]]}}}