{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:20:23Z","timestamp":1777425623436,"version":"3.51.4"},"reference-count":61,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003356","name":"Gazi University","doi-asserted-by":"publisher","award":["47\/2020-06"],"award-info":[{"award-number":["47\/2020-06"]}],"id":[{"id":"10.13039\/501100003356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Evidence on the impact of adherence to the Mediterranean diet alone\u2014without supplementation\u2014on serum and follicular fluid fatty acid profiles and assisted reproduction outcomes remains limited. This study evaluated the effects of a pre-treatment Mediterranean diet intervention on these parameters. Materials and Methods: In this prospective, non-randomized controlled trial, 32 women undergoing infertility treatment were allocated to a Mediterranean diet intervention group (n = 16) or a control group (n = 16). The intervention lasted 12 weeks, and adherence was assessed using validated dietary indices. Serum and follicular fluid fatty acid profiles were analyzed, and implantation and pregnancy outcomes were recorded. Results: The diet group showed increased \u03c9-6 and \u03c9-3 intake with decreased LA\/ALA and \u03c9-6\/\u03c9-3 ratios. In the control group, serum EPA + DHA levels declined, whereas in the diet group serum LA\/ALA decreased. Follicular fluid in the intervention group had lower EPA + DHA and \u03c9-6 ratios. Diet adherence correlated positively with MII oocytes (r = 0.797) and pronuclei (r = 0.741). No significant associations were found between follicular fluid fatty acids and IVF outcomes. A total of four implantation events were observed (intervention: n = 3; control: n = 1). Two of the implantations in the intervention group resulted in live births, while the remaining implantation events did not result in live birth. Conclusions: A Mediterranean diet-aligned dietary intervention may induce favorable changes in blood and follicular fluid parameters; however, the underlying metabolic mechanisms warrant further investigation. Three implantations were observed in the intervention group and one in the control group; given the low number of events, comparisons of live birth outcomes should be interpreted with caution. Overall, the findings regarding ART outcomes and clinical translation remain exploratory due to the limited sample size. Well-designed randomized controlled trials in which ART and clinical endpoints are defined as primary outcomes are needed.<\/jats:p>","DOI":"10.3390\/medicina62030539","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:59:44Z","timestamp":1773406784000},"page":"539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mediterranean Diet Adherence, Fatty Acid Profiles, and Early Assisted Reproduction Outcomes: Findings from a 12-Week Dietary Intervention"],"prefix":"10.3390","volume":"62","author":[{"given":"\u00d6zge","family":"Cemali","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics,  Faculty of Health Science, Trakya University, 22020 Edirne, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Akdevelio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Science, Gazi University, 06500  Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysel","family":"Berkkan","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur Kenan","family":"Uluta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Gazi University, 06330 Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep Onur","family":"Karabacak","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Faculty of Medicine, Surgical Medical Sciences, Gazi University, 06500 Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130smail","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Faculty of Medicine, Surgical Medical Sciences, Gazi University, 06500 Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyhan","family":"G\u00fcm\u00fc\u015fl\u00fc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine,  IVF Center, Gazi University, 06500 Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1017\/S1368980011002515","article-title":"Mediterranean Diet Foundation Expert Group. Mediterranean diet pyramid today. Science and cultural updates","volume":"14","author":"Berry","year":"2011","journal-title":"Public Health Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Serra-Majem, L., Tomaino, L., Dernini, S., Berry, E.M., Lairon, D., Ngo de la Cruz, J., Bach-Faig, A., Donini, L.M., Medina, F.-X., and Belahsen, R. (2020). Updating the mediterranean diet pyramid towards sustainability: Focus on environmental concerns. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17238758"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/humrep\/dey003","article-title":"Adherence to the Mediterranean diet and IVF success rate among non-obese women attempting fertility","volume":"33","author":"Karayiannis","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.fertnstert.2009.12.079","article-title":"The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization\/intracytoplasmic sperm injection treatment increases the chance of pregnancy","volume":"94","author":"Vujkovic","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_5","unstructured":"Practice Committee of the American Society for Reproductive Medicine, and Practice Committee of the Society for Reproductive Endocrinology and Infertility (2022). Optimizing natural fertility: A committee opinion. Fertil. Steril., 117, 53\u201363. Available online: https:\/\/www.asrm.org\/practice-guidance\/practice-committee-documents\/optimizing-natural-fertility-a-committee-opinion-2021\/."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Baroutis, D., Kalampokas, T., Katsianou, E., Psarris, A., Daskalakis, G., Panoulis, K., and Eleftheriades, M. (2024). The Role of the Mediterranean Diet in Assisted Reproduction: A Literature Review. Nutrients, 16.","DOI":"10.20944\/preprints202406.1924.v1"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1093\/eurpub\/ckaf100","article-title":"Associations between adherence to a Mediterranean diet and assisted reproductive techniques outcomes: A systematic review","volume":"35","author":"Tuells","year":"2025","journal-title":"Eur. J. Public Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1001\/jama.2015.17296","article-title":"Live-birth rate associated with repeat in vitro fertilization treatment cycles","volume":"314","author":"Smith","year":"2015","journal-title":"JAMA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4103\/jhrs.jhrs_90_21","article-title":"Impact of the vegan diet on sperm quality and sperm oxidative stress values: A preliminary study","volume":"14","author":"Kljajic","year":"2021","journal-title":"J. Hum. Reprod. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"\u0141akoma, K., Kukharuk, O., and \u015ali\u017c, D. (2023). The influence of metabolic factors and diet on fertility. Nutrients, 15.","DOI":"10.3390\/nu15051180"},{"key":"ref_11","first-page":"497","article-title":"The role of alpha lipoic acid in female and male infertility: A systematic review","volume":"37","author":"Galati","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.fertnstert.2010.11.021","article-title":"Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology","volume":"95","author":"Hammiche","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12958-019-0520-9","article-title":"Mediterranean diet improves embryo yield in IVF: A prospective cohort study","volume":"17","author":"Sun","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.fertnstert.2011.08.034","article-title":"Dietary patterns and difficulty conceiving: A nested case\u2013control study","volume":"96","author":"Toledo","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tjog.2016.11.005","article-title":"Does different BMI influence oocyte and embryo quality by inducing fatty acid in follicular fluid?","volume":"56","author":"Mirabi","year":"2017","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/humrep\/dex335","article-title":"Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction","volume":"33","author":"Chiu","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/lipd.12288","article-title":"The Fatty Acid Composition of Human Follicular Fluid Is Altered by a 6-Week Dietary Intervention That Includes Marine Omega-3 Fatty Acids","volume":"56","author":"Kermack","year":"2021","journal-title":"Lipids"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.fertnstert.2019.09.041","article-title":"Effect of a 6-week \u201cMediterranean\u201d dietary intervention on in vitro human embryo development: The Preconception Dietary Supplements in Assisted Reproduction double-blinded randomized controlled trial","volume":"113","author":"Kermack","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Herlambang, H., Puspasari, A., Maharani, C., Enis, R.N., Tarawifa, S., Fitri, A.D., Harahap, H., Harahap, A.H., Kusdiyah, E., and Syamsunarno, M.R.A.A. (2022). Comprehensive fatty acid fractionation profilling in preeclampsia: A case control study with multivariable analysis. BMC Pregnancy Childbirth, 22.","DOI":"10.1186\/s12884-021-04313-3"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2466\/06.08.PMS.111.4.278-284","article-title":"International physical activity questionnaire: Reliability and validity of the Turkish version","volume":"111","author":"Saglam","year":"2010","journal-title":"Percept. Mot. Ski."},{"key":"ref_21","first-page":"67","article-title":"Beslenme durumunun saptanmasi","volume":"726","author":"Pekcan","year":"2008","journal-title":"Diyet El Kitabi"},{"key":"ref_22","unstructured":"Lohman, T.G., Roche, A.F., and Martorell, R. (1988). Anthropometric Standardization Reference Manual, Human Kinetics Books."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/07315724.1998.10718771","article-title":"Comparison of several equations and derivation of a new equation for calculating basal metabolic rate in obese children","volume":"17","author":"Tverskaya","year":"1998","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1017\/S1368980014001360","article-title":"Design and development of an instrument to measure overall lifestyle habits for epidemiological research: The Mediterranean Lifestyle (MEDLIFE) index","volume":"18","author":"Casasnovas","year":"2015","journal-title":"Public Health Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"194","DOI":"10.12968\/hmed.2018.79.4.194","article-title":"Controlled ovarian stimulation for in-vitro fertilization","volume":"79","author":"Howie","year":"2018","journal-title":"Br. J. Hosp. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"hoz025","DOI":"10.1093\/hropen\/hoz025","article-title":"Recommendations for good practice in ultrasound: Oocyte pick up","volume":"2019","author":"Panayotidis","year":"2019","journal-title":"Hum. Reprod. Open"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/humrep\/16.2.313","article-title":"Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates: Indications for aneuploidy and multinucleation","volume":"16","author":"Hardarson","year":"2001","journal-title":"Hum. Reprod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s10815-017-1032-1","article-title":"The association between fatty acid index and in vitro fertilization outcomes","volume":"34","author":"Eskew","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jfma.2017.08.006","article-title":"Preimplantation genetic diagnosis and screening: Current status and future challenges","volume":"117","author":"Chen","year":"2018","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Practice Committee of the American Society for Reproductive Medicine (2020). Definitions of infertility and recurrent pregnancy loss: A committee opinion. Fertil. Steril., 113, 533\u2013535.","DOI":"10.1016\/j.fertnstert.2019.11.025"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Jarman, M., Mathe, N., Ramazani, F., Pakseresht, M., Robson, P.J., Johnson, S.T., and Bell, R.C. (2018). Dietary patterns prior to pregnancy and associations with pregnancy complications. Nutrients, 10.","DOI":"10.3390\/nu10070914"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"567.E1","DOI":"10.1016\/j.ajog.2019.02.004","article-title":"Dietary patterns and outcomes of assisted reproduction","volume":"220","author":"Gaskins","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"627.e1","DOI":"10.1016\/j.ajog.2019.07.011","article-title":"Mediterranean diet and outcomes of assisted reproduction: An Italian cohort study","volume":"221","author":"Ricci","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"154229","DOI":"10.1016\/j.metabol.2020.154229","article-title":"The effect of underweight on female and male reproduction","volume":"107","author":"Boutari","year":"2020","journal-title":"Metabolism"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Assaf-Balut, C., de la Torre, N.G., Fuentes, M., Dur\u00e1n, A., Bordi\u00fa, E., Del Valle, L., Valerio, J., Jim\u00e9nez, I., Herraiz, M.A., and Izquierdo, N. (2019). A high adherence to six food targets of the Mediterranean diet in the late first trimester is associated with a reduction in the risk of materno-foetal outcomes: The St. Carlos Gestational Diabetes Mellitus Prevention Study. Nutrients, 11.","DOI":"10.3390\/nu11010066"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/09513590.2019.1630609","article-title":"Body fat distribution influences ART outcomes","volume":"36","author":"Christofolini","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/ajcn\/nqab364","article-title":"Male waist circumference in relation to semen quality and partner infertility treatment outcomes among couples undergoing infertility treatment with assisted reproductive technologies","volume":"115","author":"Bian","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa025039","article-title":"Adherence to a Mediterranean diet and survival in a Greek population","volume":"348","author":"Trichopoulou","year":"2003","journal-title":"New Engl. J. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3945\/jn.110.135566","article-title":"A short screener is valid for assessing Mediterranean diet adherence among older Spanish men and women","volume":"141","author":"Estruch","year":"2011","journal-title":"J. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"112121","DOI":"10.1016\/j.exger.2023.112121","article-title":"Mediterranean diet in the management and prevention of obesity","volume":"174","author":"Dominguez","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.advnut.2023.04.011","article-title":"Mediterranean diet-based interventions to improve anthropometric and obesity indicators in children and adolescents: A systematic review with meta-analysis of randomized controlled trials","volume":"14","author":"Kales","year":"2023","journal-title":"Adv. Nutr. Int. Rev. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.3945\/jn.111.142240","article-title":"Low-and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome","volume":"141","author":"Dewell","year":"2011","journal-title":"J. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nutres.2019.09.001","article-title":"Cross-sectional study of the combined associations of dietary and supplemental eicosapentaenoic acid+ docosahexaenoic acid on Omega-3 Index","volume":"71","author":"McDonnell","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.plefa.2019.01.002","article-title":"Association of reported fish intake and supplementation status with the omega-3 index","volume":"142","author":"Jackson","year":"2019","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.plefa.2011.01.001","article-title":"Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women","volume":"84","author":"Kawabata","year":"2011","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_46","unstructured":"Haytowitz, D., Ahuja, J., Wu, X., Khan, M., Somanchi, M., Nickle, M., Nguyen, Q., Roseland, J., Williams, J., and Patterson, K. (2018). USDA National Nutrient Database for Standard Reference, Legacy, USDA FoodData Central."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.atherosclerosis.2007.11.008","article-title":"Omega-3 fatty acids and coronary heart disease risk: Clinical and mechanistic perspectives","volume":"197","author":"Harris","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12944-016-0396-z","article-title":"The role of fatty acids on ICSI outcomes: A prospective cohort study","volume":"16","author":"Mirabi","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/jcp.27101","article-title":"Action mechanisms of n-3 polyunsaturated fatty acids on the oocyte maturation and developmental competence: Potential advantages and disadvantages","volume":"234","author":"Zarezadeh","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.theriogenology.2016.01.019","article-title":"N-3 polyunsaturated fatty acid DHA during IVM affected oocyte developmental competence in cattle","volume":"85","author":"Oseikria","year":"2016","journal-title":"Theriogenology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/cbin.10746","article-title":"Effect of eicosapentaenoic acid on bovine cumulus\u2013oocyte complex in vitro","volume":"41","author":"Nikoloff","year":"2017","journal-title":"Cell Biol. Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.theriogenology.2012.03.009","article-title":"Oocyte and embryo production and quality after OPU-IVF in dairy heifers given diets varying in their n-6\/n-3 fatty acid ratio","volume":"78","author":"Ponter","year":"2012","journal-title":"Theriogenology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E1364","DOI":"10.1210\/jc.2012-4115","article-title":"Relationship between serum polyunsaturated fatty acids and pregnancy in women undergoing in vitro fertilization","volume":"98","author":"Jungheim","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ciepiela, P., B\u0105czkowski, T., Drozd, A., Kazienko, A., Stachowska, E., and Kurzawa, R. (2015). Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization\u2013a prospective analysis of follicular fluid and a matched oocyte in a \u2018one follicle\u2013one retrieved oocyte\u2013one resulting embryo\u2019investigational setting. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119087"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.fertnstert.2019.08.059","article-title":"Oocytes of women who are obese or overweight have lower levels of n-3 polyunsaturated fatty acids compared with oocytes of women with normal weight","volume":"113","author":"Matorras","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_56","first-page":"162","article-title":"Fatty acid composition of human follicular fluid phospholipids and fertilization rate in assisted reproductive techniques","volume":"16","author":"Shaaker","year":"2012","journal-title":"Iran. Biomed. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/j.fertnstert.2011.01.154","article-title":"Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization","volume":"95","author":"Jungheim","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1093\/humrep\/des350","article-title":"BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality","volume":"27","author":"Valckx","year":"2012","journal-title":"Hum. Reprod."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"E2269","DOI":"10.1210\/jc.2013-3942","article-title":"Associations between insulin resistance, free fatty acids, and oocyte quality in polycystic ovary syndrome during in vitro fertilization","volume":"99","author":"Niu","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.3168\/jds.2014-7970","article-title":"Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress","volume":"98","author":"Aardema","year":"2015","journal-title":"J. Dairy Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3945\/an.114.007732","article-title":"Advances in our understanding of oxylipins derived from dietary PUFAs","volume":"6","author":"Gabbs","year":"2015","journal-title":"Adv. Nutr."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/3\/539\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:15:46Z","timestamp":1773407746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/3\/539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["medicina62030539"],"URL":"https:\/\/doi.org\/10.3390\/medicina62030539","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]}}}