{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:49:31Z","timestamp":1793803771180,"version":"4.6.1"},"reference-count":198,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The concept of \u2018developmental hemostasis\u2019 from birth to infancy and onwards to childhood and adulthood was introduced in the 1980s and is used to indicate the fundamental discrepancies of hemostatic mechanism between children and adults. The underlying differentiations are more pronounced in term and even more in preterm neonates. Hemostatic alterations tend to improve throughout childhood and adolescence but still imply a great example of the basic concept that children do not simply represent small adults. Many neonatal coagulation disorders lead to severe morbidities, such as intraventricular hemorrhage and intracerebral infarct, with critical consequences on long-term neurodevelopmental outcome. As the limits of viability have decreased and many preterm and severely affected neonates survive and grow up, a broad understanding of hemorrhagic and thrombotic complications in neonates is very important, in order to provide prompt identification and treatment. Coagulation abnormalities are usually induced by specific pathophysiologic disorders, and neonatal sepsis is a significant trigger of hemostatic derangement. Despite the initial protective role of coagulation activation during the early stages of sepsis, ultimately hemostatic abnormalities exert a substantial impact on clinical outcome and prognosis. This review explores developmental aspects of coagulation, particularly in relation to neonatal sepsis.<\/jats:p>","DOI":"10.3390\/medicina62030584","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:49:58Z","timestamp":1774003798000},"page":"584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal Sepsis-Induced Coagulopathy in the Light of Developmental Hemostasis: Friend or Foe?"],"prefix":"10.3390","volume":"62","author":[{"given":"Paraskevi","family":"Papadogeorgou","sequence":"first","affiliation":[{"name":"Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"},{"name":"Department of Neonatology, General Hospital of Athens \u201cAlexandra\u201d, 11528\u00a0Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-8901","authenticated-orcid":false,"given":"Rozeta","family":"Sokou","sequence":"additional","affiliation":[{"name":"Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios P.","family":"Fortis","sequence":"additional","affiliation":[{"name":"Laboratory of Reliability and Quality Control in Laboratory Hematology (HemQcR), Department of Bio-Medical Sciences, School of Health & Caring Sciences, University of West Attica (UniWA), 12243 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1403-143X","authenticated-orcid":false,"given":"Vasiliki","family":"Mougiou","sequence":"additional","affiliation":[{"name":"Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Boutsikou","sequence":"additional","affiliation":[{"name":"Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-6191","authenticated-orcid":false,"given":"Nicoletta","family":"Iacovidou","sequence":"additional","affiliation":[{"name":"Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-6510","authenticated-orcid":false,"given":"Serena","family":"Valsami","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology and Blood Bank Unit, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"ref_1","first-page":"120","article-title":"Risk factors for venous and arterial thrombosis","volume":"9","author":"Previtali","year":"2011","journal-title":"Blood Transfus. = Trasfus. Del Sangue"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Papadogeorgou, P., Boutsikou, T., Boutsikou, M., Pergantou, E., Mantzou, A., Papassotiriou, I., Iliodromiti, Z., Sokou, R., Bouza, E., and Politou, M. (2023). A Global Assessment of Coagulation Profile and a Novel Insight into Adamts-13 Implication in Neonatal Sepsis. Biology, 12.","DOI":"10.3390\/biology12101281"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Papadogeorgou, P., Valsami, S., Boutsikou, M., Pergantou, E., Mantzou, A., Papassotiriou, I., Iliodromiti, Z., Sokou, R., Bouza, E., and Politou, M. (2024). Coagulation Profile in Neonates with Congenital Heart Disease: A Pilot Study. Medicina, 60.","DOI":"10.3390\/medicina60020268"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.4103\/0019-5049.144643","article-title":"Overview of the coagulation system","volume":"58","author":"Palta","year":"2014","journal-title":"Indian J. Anaesth."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.thromres.2004.07.020","article-title":"Platelet physiology and thrombosis","volume":"114","author":"Andrews","year":"2004","journal-title":"Thromb. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1055\/s-0037-1613209","article-title":"Platelet activation and blood coagulation","volume":"88","author":"Heemskerk","year":"2002","journal-title":"Thromb. Haemost."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Karim, F., Adil, S.N., Afaq, B., and Ul Haq, A. (2013). Deficiency of ADAMTS-13 in pediatric patients with severe sepsis and impact on in-hospital mortality. BMC Pediatr., 13.","DOI":"10.1186\/1471-2431-13-44"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/MOH.0000000000000884","article-title":"Targeting hemostatic enzymes: From mechanistic insights to therapeutic frontiers","volume":"32","author":"Zakar","year":"2025","journal-title":"Curr. Opin. Hematol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/0310057X1704500206","article-title":"Applying the cell-based coagulation model in the management of critical bleeding","volume":"45","author":"Ho","year":"2017","journal-title":"Anaesth. Intensive Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/bja\/aeh174","article-title":"Updates in perioperative coagulation: Physiology and management of thromboembolism and haemorrhage","volume":"93","author":"Bombeli","year":"2004","journal-title":"Br. J. Anaesth."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1007\/BF03022247","article-title":"From normal to pathological hemostasis","volume":"53","author":"Lasne","year":"2006","journal-title":"Can. J. Anaesth. = J. Can. D\u2019anesthesie"},{"key":"ref_12","first-page":"e191","article-title":"Hemostasis in the Neonate","volume":"9","year":"2008","journal-title":"Neoreviews"},{"key":"ref_13","first-page":"87","article-title":"Anticlotting mechanisms 1: Physiology and pathology","volume":"13","author":"Hutchinson","year":"2013","journal-title":"Contin. Educ. Anaesth. Crit. Care Pain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2141.2005.05444.x","article-title":"Molecular mechanisms of fibrinolysis","volume":"129","author":"Hajjar","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1182\/blood.V70.1.165.165","article-title":"Development of the human coagulation system in the full-term infant","volume":"70","author":"Andrew","year":"1987","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1160\/TH05-01-0047","article-title":"Developmental haemostasis. Impact for clinical haemostasis laboratories","volume":"95","author":"Monagle","year":"2006","journal-title":"Thromb. Haemost."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1542\/neo.19-1-e11","article-title":"Coagulation Disorders in the Newborn","volume":"19","author":"Davila","year":"2018","journal-title":"NeoReviews"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1182\/blood.V98.9.2730","article-title":"Changes in health and disease of the metalloprotease that cleaves von Willebrand factor","volume":"98","author":"Mannucci","year":"2001","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1111\/j.1538-7836.2012.04905.x","article-title":"Age dependency of coagulation parameters during childhood and puberty","volume":"10","author":"Appel","year":"2012","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1182\/asheducation.V2012.1.506.3798532","article-title":"Platelets in the neonatal period: Developmental differences in platelet production, function, and hemostasis and the potential impact of therapies","volume":"2012","year":"2012","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Caparr\u00f3s-P\u00e9rez, E., Teruel-Montoya, R., L\u00f3pez-Andreo, M.J., Llanos, M.C., Rivera, J., Palma-Barqueros, V., Blanco, J.E., Vicente, V., Mart\u00ednez, C., and Ferrer-Mar\u00edn, F. (2017). Comprehensive comparison of neonate and adult human platelet transcriptomes. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183042"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41390-019-0316-9","article-title":"Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: A novel approach to guide platelet transfusion","volume":"85","author":"Waller","year":"2019","journal-title":"Pediatr. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/09537100400016862","article-title":"Neonatal platelets from cord blood and peripheral blood","volume":"16","author":"Sitaru","year":"2005","journal-title":"Platelets"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.thromres.2008.10.004","article-title":"The platelet hyporeactivity of extremely low birth weight neonates is age-dependent","volume":"124","author":"Bednarek","year":"2009","journal-title":"Thromb. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1076029620929092","DOI":"10.1177\/1076029620929092","article-title":"The Developing Balance of Thrombosis and Hemorrhage in Pediatric Surgery: Clinical Implications of Age-Related Changes in Hemostasis","volume":"26","author":"Achey","year":"2020","journal-title":"Clin. Appl. Thromb. Hemost. Off. J. Int. Acad. Clin. Appl. Thromb. Hemost."},{"key":"ref_26","first-page":"427","article-title":"Template bleeding times of 240 neonates born at 24 to 41 weeks gestation","volume":"28","author":"Latini","year":"2008","journal-title":"J. Perinatol. Off. J. Calif. Perinat. Assoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/bja\/aeq258","article-title":"Thromboelastometry (ROTEM) in children: Age-related reference ranges and correlations with standard coagulation tests","volume":"105","author":"Oswald","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kollia, M., Iacovidou, N., Iliodromiti, Z., Pouliakis, A., Sokou, R., Mougiou, V., Boutsikou, M., Politou, M., Boutsikou, T., and Valsami, S. (2022). Primary hemostasis in fetal growth restricted neonates studied via PFA-100 in cord blood samples. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.946932"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/s-2007-996049","article-title":"Platelet function in the newborn","volume":"24","author":"Michelson","year":"1998","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1160\/TH14-05-0476","article-title":"Platelets in neonates: Central mediators in haemostasis, antimicrobial defence and inflammation","volume":"113","author":"Andres","year":"2015","journal-title":"Thromb. Haemost."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e12719","DOI":"10.1002\/rth2.12719","article-title":"Platelets in the neonate: Not just a small adult","volume":"6","author":"Davenport","year":"2022","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.siny.2011.07.007","article-title":"Developmental haemostasis: Secondary haemostasis","volume":"16","author":"Monagle","year":"2011","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1203\/00006450-199503000-00019","article-title":"Identification of a unique form of protein C in the ovine fetus: Developmentally linked transition to the adult form","volume":"37","author":"Spedale","year":"1995","journal-title":"Pediatr. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.pcl.2013.08.003","article-title":"Developmental hemostasis: Clinical implications from the fetus to the adolescent","volume":"60","author":"Jaffray","year":"2013","journal-title":"Pediatr. Clin. North Am."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1172\/JCI115579","article-title":"An anticoagulant dermatan sulfate proteoglycan circulates in the pregnant woman and her fetus","volume":"89","author":"Andrew","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0049-3848(98)00035-8","article-title":"Anticoagulant dermatan sulfate proteoglycan (decorin) in the term human placenta","volume":"90","author":"Delorme","year":"1998","journal-title":"Thromb. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1055\/s-2007-1004433","article-title":"Neonatal and maternal hemostasis: Value of molecular markers in the assessment of hemostatic status","volume":"10","author":"Suarez","year":"1984","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-2003-42585","article-title":"The fibrinolytic system in children","volume":"29","author":"Albisetti","year":"2003","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_39","first-page":"115","article-title":"The fibrinolytic system in newborns and children","volume":"52","author":"Parmar","year":"2006","journal-title":"Clin. Lab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1182\/blood.V80.8.1998.1998","article-title":"Maturation of the hemostatic system during childhood","volume":"80","author":"Andrew","year":"1992","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/ajh.2830320407","article-title":"Newborn\u2019s fibrinolytic mechanism: Components and plasmin generation","volume":"32","author":"Corrigan","year":"1989","journal-title":"Am. J. Hematol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101157","DOI":"10.1016\/j.blre.2023.101157","article-title":"Contemporary tools for evaluation of hemostasis in neonates. Where are we and where are we headed?","volume":"64","author":"Sokou","year":"2024","journal-title":"Blood Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2141.2002.03674.x","article-title":"The investigation and management of neonatal haemostasis and thrombosis","volume":"119","author":"Williams","year":"2002","journal-title":"Br. J. Haematol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1542\/pir.32.1.31","article-title":"Focus on diagnosis: A primer on D-dimer","volume":"32","author":"Camet","year":"2011","journal-title":"Pediatr. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/s-0030-1254050","article-title":"Disseminated intravascular coagulation in term and preterm neonates","volume":"36","author":"Veldman","year":"2010","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood.V72.5.1651.1651","article-title":"Development of the human coagulation system in the healthy premature infant","volume":"72","author":"Andrew","year":"1988","journal-title":"Blood"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1111\/jth.12372","article-title":"Developmental hemostasis: Age-specific differences in the levels of hemostatic proteins","volume":"11","author":"Attard","year":"2013","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"F319","DOI":"10.1136\/fn.88.4.F319","article-title":"Effects of gestational age and prenatal and perinatal events on the coagulation status in premature infants","volume":"88","author":"Salonvaara","year":"2003","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_49","first-page":"869","article-title":"The coagulation system of extremely preterm infants: Influence of perinatal risk factors on coagulation","volume":"32","author":"Poralla","year":"2012","journal-title":"J. Perinatol. Off. J. Calif. Perinat. Assoc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"F270","DOI":"10.1136\/archdischild-2014-306196","article-title":"Interpretation of clotting tests in the neonate","volume":"100","author":"Pal","year":"2015","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1111\/jth.13130","article-title":"Coagulation indices in very preterm infants from cord blood and postnatal samples","volume":"13","author":"Neary","year":"2015","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000353366","article-title":"Laboratory coagulation parameters in extremely premature infants born earlier than 27 gestational weeks upon admission to a neonatal intensive care unit","volume":"104","author":"Neary","year":"2013","journal-title":"Neonatology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/trf.12322","article-title":"Reference intervals for common coagulation tests of preterm infants (CME)","volume":"54","author":"Christensen","year":"2014","journal-title":"Transfusion"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.thromres.2023.03.005","article-title":"Platelet function in neonates and children","volume":"231","author":"McCafferty","year":"2023","journal-title":"Thromb. Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Gorio, C., Molinari, A.C., Martini, T., Ferretti, A., Albrici, G., Carracchia, G., Ierardi, A., Leotta, M., Portesi, N., and Sacco, M. (2025). Hemostasis Laboratory Diagnostics in Newborns. J. Clin. Med., 14.","DOI":"10.20944\/preprints202506.0076.v1"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Theodoraki, M., Palioura, A.E., Palioura, A.P., Pouliakis, A., Iliodromiti, Z., Boutsikou, T., Iacovidou, N., and Sokou, R. (2025). Unveiling the Hemostatic Signature of Prematurity: A Prospective Rotational Thromboelastometry-Based Analysis. Medicina, 61.","DOI":"10.3390\/medicina61091718"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1542\/neo.23-2-e82","article-title":"Developmental Hemostasis: The Evolution of our Coagulation System","volume":"23","author":"Guzzardo","year":"2022","journal-title":"NeoReviews"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1007\/s00431-021-04154-4","article-title":"The use of thromboelastography (TEG) and rotational thromboelastometry (ROTEM) in neonates: A systematic review","volume":"180","author":"Katsaras","year":"2021","journal-title":"Eur. J. Pediatr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1309\/LABNMY41RUD099J2","article-title":"Parameters of thromboelastography in healthy newborns","volume":"130","author":"Edwards","year":"2008","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1160\/TH09-05-0282","article-title":"Clot formation of neonates tested by thromboelastography correlates with gestational age","volume":"103","author":"Strauss","year":"2010","journal-title":"Thromb. Haemost."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"F79","DOI":"10.1136\/archdischild-2016-310545","article-title":"Thromboelastography in term neonates: An alternative approach to evaluating coagulopathy","volume":"102","author":"Sewell","year":"2017","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/pbc.25865","article-title":"Assessment of Functional Fibrinolysis in Cord Blood Using Modified Thromboelastography","volume":"63","author":"Sidlik","year":"2016","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MPH.0b013e318162bd2c","article-title":"Clot strength: A comparison between cord and adult blood by means of thrombelastometry","volume":"30","author":"Cvirn","year":"2008","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1515\/cclm-2016-0931","article-title":"Reference ranges of thromboelastometry in healthy full-term and pre-term neonates","volume":"55","author":"Sokou","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.earlhumdev.2017.09.014","article-title":"Reference intervals of citrated-native whole blood thromboelastography in premature neonates","volume":"115","author":"Motta","year":"2017","journal-title":"Early Hum. Dev."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ozolina, A., Sarkele, M., Sabelnikovs, O., Skesters, A., Jaunalksne, I., Serova, J., Ievins, T., Bjertnaes, L.J., and Vanags, I. (2016). Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: A Prospective Pilot Study. Front. Med., 3.","DOI":"10.3389\/fmed.2016.00064"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Katsaras, G.N., Sokou, R., Tsantes, A.G., Konstantinidi, A., Gialamprinou, D., Piovani, D., Bonovas, S., Kriebardis, A.G., Mitsiakos, G., and Kokoris, S. (2021). Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study. Diagnostics, 11.","DOI":"10.3390\/diagnostics11111995"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1136\/archdischild-2019-317860","article-title":"Thromboelastographic profiles of healthy very low birthweight infants serially during their first month","volume":"105","author":"Raffaeli","year":"2020","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s43856-023-00338-1","article-title":"The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern","volume":"3","author":"Zhong","year":"2023","journal-title":"Commun. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00281-020-00803-2","article-title":"Preterm birth and sustained inflammation: Consequences for the neonate","volume":"42","author":"Humberg","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/S0378-3782(14)70008-8","article-title":"Bi-directional activation of inflammation and coagulation in septic neonates","volume":"90","author":"Stronati","year":"2014","journal-title":"Early Hum. Dev."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Theodoraki, M., Sokou, R., Valsami, S., Iliodromiti, Z., Pouliakis, A., Parastatidou, S., Karavana, G., Ioakeimidis, G., Georgiadou, P., and Iacovidou, N. (2020). Reference Values of Thrombolastometry Parameters in Healthy Term Neonates. Children, 7.","DOI":"10.3390\/children7120259"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1016\/j.thromres.2013.07.006","article-title":"High haematocrit in cyanotic congenital heart disease affects how fibrinogen activity is determined by rotational thromboelastometry","volume":"132","author":"Westbury","year":"2013","journal-title":"Thromb. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/trf.15785","article-title":"Is placental blood a reliable source for the evaluation of neonatal hemostasis at birth?","volume":"60","author":"Raffaeli","year":"2020","journal-title":"Transfusion"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Cannata, G., Mariotti Zani, E., Argentiero, A., Caminiti, C., Perrone, S., and Esposito, S. (2021). TEG(\u00ae) and ROTEM(\u00ae) Traces: Clinical Applications of Viscoelastic Coagulation Monitoring in Neonatal Intensive Care Unit. Diagnostics, 11.","DOI":"10.3390\/diagnostics11091642"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"100031","DOI":"10.1016\/j.rpth.2022.100031","article-title":"Viscoelastic testing: An illustrated review of technology and clinical applications","volume":"7","author":"Hartmann","year":"2023","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"101610","DOI":"10.1016\/j.siny.2025.101610","article-title":"The value of thromboelastography to neonatology","volume":"30","author":"Manzoni","year":"2025","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1055\/s-0041-1729964","article-title":"Rotational Thromboelastometry in Neonates Admitted to a Neonatal Intensive Care Unit: A Large Cross-sectional Study","volume":"47","author":"Sokou","year":"2021","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00431-017-3072-z","article-title":"Thromboelastometry for diagnosis of neonatal sepsis-associated coagulopathy: An observational study","volume":"177","author":"Sokou","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Sokou, R., Ioakeimidis, G., Piovani, D., Parastatidou, S., Konstantinidi, A., Tsantes, A.G., Lampridou, M., Houhoula, D., Iacovidou, N., and Kokoris, S. (2022). Development and validation of a sepsis diagnostic scoring model for neonates with suspected sepsis. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.1004727"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.thromres.2020.05.028","article-title":"ROTEM diagnostic capacity for measuring fibrinolysis in neonatal sepsis","volume":"192","author":"Lampridou","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/ijlh.14165","article-title":"Thromboelastometry and prediction of in-hospital mortality in neonates with sepsis","volume":"46","author":"Sokou","year":"2024","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/ejh.13534","article-title":"The role of ROTEM variables based on clot elasticity and platelet component in predicting bleeding risk in thrombocytopenic critically ill neonates","volume":"106","author":"Parastatidou","year":"2021","journal-title":"Eur. J. Haematol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-0042-1753513","article-title":"The Utility of NATEM Assay in Predicting Bleeding Risk in Critically Ill Neonates","volume":"49","author":"Sokou","year":"2023","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0040-1715832","article-title":"A Risk Score for Predicting the Incidence of Hemorrhage in Critically Ill Neonates: Development and Validation Study","volume":"121","author":"Sokou","year":"2021","journal-title":"Thromb. Haemost."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1055\/s-0043-1777070","article-title":"Bleeding Scoring Systems in Neonates: A Systematic Review","volume":"50","author":"Sokou","year":"2024","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s00431-022-04427-6","article-title":"Optimizing fresh-frozen plasma transfusion in surgical neonates through thromboelastography: A quality improvement study","volume":"181","author":"Raffaeli","year":"2022","journal-title":"Eur. J. Pediatr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/hae.12115","article-title":"The effect of labour on the coagulation system in the term neonate","volume":"19","author":"Kulkarni","year":"2013","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1182\/blood-2009-08-236430","article-title":"Factor XII stimulates ERK1\/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis","volume":"115","author":"LaRusch","year":"2010","journal-title":"Blood"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.blre.2009.12.001","article-title":"Hemostasis in neonates and children: Pitfalls and dilemmas","volume":"24","author":"Monagle","year":"2010","journal-title":"Blood Rev."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"13610","DOI":"10.1021\/bi801656u","article-title":"Antiangiogenic forms of antithrombin specifically bind to the anticoagulant heparin sequence","volume":"47","author":"Richard","year":"2008","journal-title":"Biochemistry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1055\/s-0031-1297162","article-title":"The coagulation system in children: Developmental and pathophysiological considerations","volume":"37","author":"Ignjatovic","year":"2011","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1164\/ajrccm.158.2.9712116","article-title":"A placebo-controlled randomized trial of antithrombin therapy in neonatal respiratory distress syndrome","volume":"158","author":"Schmidt","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ignjatovic, V., Lai, C., Summerhayes, R., Mathesius, U., Tawfilis, S., Perugini, M.A., and Monagle, P. (2011). Age-related differences in plasma proteins: How plasma proteins change from neonates to adults. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017213"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1182\/blood-2010-08-300913","article-title":"The hemostatic status of pediatric recipients of adult liver grafts suggests that plasma levels of hemostatic proteins are not regulated by the liver","volume":"117","author":"Lisman","year":"2011","journal-title":"Blood"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00572765","article-title":"Plasma elimination of antithrombin III (heparin cofactor activity) is accelerated in term newborn infants","volume":"141","author":"Schmidt","year":"1984","journal-title":"Eur. J. Pediatr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1182\/blood.V78.9.2299.2299","article-title":"Alpha-2-macroglobulin may provide protection from thromboembolic events in antithrombin III-deficient children","volume":"78","author":"Mitchell","year":"1991","journal-title":"Blood"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"645s","DOI":"10.1378\/chest.126.3_suppl.645S","article-title":"Antithrombotic therapy in children: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Monagle","year":"2004","journal-title":"Chest"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1055\/s-0038-1642714","article-title":"Developmental hemostasis: Relevance to thromboembolic complications in pediatric patients","volume":"74","author":"Andrew","year":"1995","journal-title":"Thromb. Haemost."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Khizroeva, J., Makatsariya, A., Vorobev, A., Bitsadze, V., Elalamy, I., Lazarchuk, A., Salnikova, P., Einullaeva, S., Solopova, A., and Tretykova, M. (2023). The Hemostatic System in Newborns and the Risk of Neonatal Thrombosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241813864"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.4081\/pr.2011.e30","article-title":"The coagulopathy in sepsis: Significance and implications for treatment","volume":"3","author":"Saracco","year":"2011","journal-title":"Pediatr. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/09537104.2020.1817360","article-title":"Immunothrombosis and thromboinflammation in host defense and disease","volume":"32","author":"Martinod","year":"2021","journal-title":"Platelets"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/a-2178-6491","article-title":"The Concept of Thromboinflammation","volume":"44","author":"Schrottmaier","year":"2024","journal-title":"Hamostaseologie"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Chang, J.C. (2022). Molecular Pathogenesis of Endotheliopathy and Endotheliopathic Syndromes, Leading to Inflammation and Microthrombosis, and Various Hemostatic Clinical Phenotypes Based on \u201cTwo-Activation Theory of the Endothelium\u201d and \u201cTwo-Path Unifying Theory\u201d of Hemostasis. Medicina, 58.","DOI":"10.3390\/medicina58091311"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13054-021-03524-6","article-title":"Endotheliopathy in septic conditions: Mechanistic insight into intravascular coagulation","volume":"25","author":"Ito","year":"2021","journal-title":"Crit. Care"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41390-019-0343-6","article-title":"The emerging role of immunothrombosis in paediatric conditions","volume":"86","author":"Franchi","year":"2019","journal-title":"Pediatr. Res."},{"key":"ref_107","first-page":"52","article-title":"Study of protein C, protein S, and antithrombin III in newborns with sepsis","volume":"11","author":"Alaraby","year":"2010","journal-title":"Pediatr. Crit. Care Med. A J. Soc. Crit. Care Med. World Fed. Pediatr. Intensive Crit. Care Soc."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Bonetti, C., Silvestri, I., Caccioppola, A., Meli, A., Grasselli, G., and Panigada, M. (2025). Viscoelastic Hemostatic Assays in Sepsis: From Pathophysiology to Potential Clinical Implications. Semin. Thromb. Hemost., online ahead of print.","DOI":"10.1055\/s-0045-1809373"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1213\/ANE.0000000000006888","article-title":"Sepsis-Induced Coagulopathy: A Comprehensive Narrative Review of Pathophysiology, Clinical Presentation, Diagnosis, and Management Strategies","volume":"138","author":"Williams","year":"2024","journal-title":"Anesth. Analg."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Tsantes, A.G., Parastatidou, S., Tsantes, E.A., Bonova, E., Tsante, K.A., Mantzios, P.G., Vaiopoulos, A.G., Tsalas, S., Konstantinidi, A., and Houhoula, D. (2023). Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines. Life, 13.","DOI":"10.3390\/life13020350"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ajpath.2019.07.021","article-title":"Nanomechanics of the Endothelial Glycocalyx: From Structure to Function","volume":"190","author":"Cosgun","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Fatmi, A., Saadi, W., Beltr\u00e1n-Garc\u00eda, J., Garc\u00eda-Gim\u00e9nez, J.L., and Pallard\u00f3, F.V. (2022). The Endothelial Glycocalyx and Neonatal Sepsis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010364"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/bja\/aeh163","article-title":"Physiology of the endothelium","volume":"93","author":"Galley","year":"2004","journal-title":"Br. J. Anaesth."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.ajpath.2019.06.017","article-title":"Glycocalyx in Endotoxemia and Sepsis","volume":"190","author":"Goligorsky","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13613-024-01301-6","article-title":"Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: From the viewpoint of surviving sepsis campaign guidelines","volume":"14","author":"Iba","year":"2024","journal-title":"Ann. Intensive Care"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Bitsadze, V., Lazarchuk, A., Vorobev, A., Khizroeva, J., Tretyakova, M., Makatsariya, N., Gashimova, N., Grigoreva, K., Tatarintseva, A., and Karpova, A. (2025). Systemic Inflammatory Response Syndrome, Thromboinflammation, and Septic Shock in Fetuses and Neonates. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202502.0618.v1"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Sokou, R., Lianou, A., Gounari, E., Tsantes, A.G., Bonovas, S., Nikolopoulos, G., Tsantes, A.E., and Iacovidou, N. (2026). Neonatal Sepsis-Induced Coagulopathy: An Evolving Frontier at the Crossroads of Inflammation and Hemostasis. Semin. Thromb. Hemost., online ahead of print.","DOI":"10.1055\/a-2823-8395"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/CCM.0000000000004091","article-title":"Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis","volume":"48","author":"Whitney","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s40635-023-00582-8","article-title":"Capillary leak and endothelial permeability in critically ill patients: A current overview","volume":"11","author":"Saravi","year":"2023","journal-title":"Intensive Care Med. Exp."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1080\/09537104.2021.2019694","article-title":"Early recognition of sepsis-induced coagulopathy using the C2PAC index: A ratio of soluble type C lectin-like receptor 2 (sCLEC-2) level and platelet count","volume":"33","author":"Ishikura","year":"2022","journal-title":"Platelets"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jth.13911","article-title":"Inflammation and thrombosis: Roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis","volume":"16","author":"Iba","year":"2018","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Kim, S., and Lee, K. (2025). Emerging Roles of Megakaryocytes in Immune Regulation and Potential Therapeutic Prospects. Cells, 14.","DOI":"10.3390\/cells14211677"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Yan, C., Wu, H., Fang, X., He, J., and Zhu, F. (2023). Platelet, a key regulator of innate and adaptive immunity. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1074878"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/MOH.0000000000000551","article-title":"Platelets as key players in inflammation and infection","volume":"27","author":"Nicolai","year":"2020","journal-title":"Curr. Opin. Hematol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Sokou, R., Lianou, A., Tsantes, A.G., Petrou, E., Bonovas, S., Nikolopoulos, G., Tsantes, A.E., and Iacovidou, N. (2025). Platelets in Neonatal Sepsis: Beyond Clotting, From Silent Players to Immune Orchestrators. Semin. Thromb. Hemost., online ahead of print.","DOI":"10.1055\/a-2731-2399"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/09537104.2016.1252837","article-title":"Higher platelet reactivity and platelet-monocyte complex formation in Gram-positive sepsis compared to Gram-negative sepsis","volume":"28","author":"Tunjungputri","year":"2017","journal-title":"Platelets"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1055\/s-0039-1694995","article-title":"Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation","volume":"46","author":"Iba","year":"2020","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13054-017-1605-5","article-title":"Shock induced endotheliopathy (SHINE) in acute critical illness\u2014a unifying pathophysiologic mechanism","volume":"21","author":"Johansson","year":"2017","journal-title":"Crit. Care"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1160\/TH14-02-0126","article-title":"The role of platelets in sepsis","volume":"112","year":"2014","journal-title":"Thromb. Haemost."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1182\/blood-2013-11-540526","article-title":"Amplification of bacteria-induced platelet activation is triggered by Fc\u03b3RIIA, integrin \u03b1IIb\u03b23, and platelet factor 4","volume":"123","author":"Arman","year":"2014","journal-title":"Blood"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/09537104.2016.1148129","article-title":"Human platelet activation by Escherichia coli: Roles for Fc\u03b3RIIA and integrin \u03b1IIb\u03b23","volume":"27","author":"Watson","year":"2016","journal-title":"Platelets"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"741","DOI":"10.17305\/bb.2023.10135","article-title":"The role of platelets in sepsis: A review","volume":"24","author":"Xu","year":"2024","journal-title":"Biomol. Biomed."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.chom.2015.05.011","article-title":"Synergistic Action of Staphylococcus aureus \u03b1-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis","volume":"17","author":"Powers","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/rth2.12465","article-title":"The role of platelets in sepsis","volume":"5","author":"Shannon","year":"2021","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/rth2.12109","article-title":"The coagulation system in host defense","volume":"2","author":"Antoniak","year":"2018","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"gkae1262","DOI":"10.1093\/nar\/gkae1262","article-title":"Neutrophil extracellular traps have active DNAzymes that promote bactericidal activity","volume":"53","author":"Ku","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.2631","article-title":"Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance","volume":"14","author":"Wong","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Gialamprinou, D., Mitsiakos, G., Katsaras, G.N., Kontovazainitis, C.G., Karagianni, P., Roilides, E., and Kenet, G. (2022). Neonatal Sepsis and Hemostasis. Diagnostics, 12.","DOI":"10.3390\/diagnostics12020261"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"De Alarc\u00f3n, P.A., Werner, E.J., Christensen, R.D., and Sola-Visner, M.C. (2021). Acquired Thrombocytopenias. Neonatal Hematology, Cambridge University Press. [3rd ed.].","DOI":"10.1017\/9781108773584"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00431-002-0938-4","article-title":"Whole blood platelet deposition on extracellular matrix under flow conditions in preterm neonatal sepsis","volume":"161","author":"Finkelstein","year":"2002","journal-title":"Eur. J. Pediatr."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/09537104.2021.1962837","article-title":"Neonatal platelet physiology and implications for transfusion","volume":"33","year":"2022","journal-title":"Platelets"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Giraud, A., Guiraut, C., Chevin, M., Chabrier, S., and S\u00e9bire, G. (2017). Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke. Front. Neurol., 8.","DOI":"10.3389\/fneur.2017.00612"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1084\/jem.174.3.729","article-title":"Fibrinolytic response to tumor necrosis factor in healthy subjects","volume":"174","author":"Levi","year":"1991","journal-title":"J. Exp. Med."},{"key":"ref_146","first-page":"556","article-title":"4G\/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease","volume":"354","author":"Hermans","year":"1999","journal-title":"Meningococcal Research Group. Lancet"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.adnc.2004.07.003","article-title":"Linking the sepsis triad of inflammation, coagulation, and suppressed fibrinolysis to infants","volume":"4","author":"Short","year":"2004","journal-title":"Adv. Neonatal Care Off. J. Natl. Assoc. Neonatal Nurses"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1182\/blood.V95.5.1721.005k13_1721_1728","article-title":"A monoclonal antibody specific to the granulocyte-derived elastase-fragment D species of human fibrinogen and fibrin: Its application to the measurement of granulocyte-derived elastase digests in plasma","volume":"95","author":"Kohno","year":"2000","journal-title":"Blood"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13613-019-0499-6","article-title":"Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: Results of an observational pilot study","volume":"9","author":"Schmitt","year":"2019","journal-title":"Ann. Intensive Care"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Shaw, R.J., Abrams, S.T., Badu, S., Toh, C.H., and Dutt, T. (2024). The Highs and Lows of ADAMTS13 Activity. J. Clin. Med., 13.","DOI":"10.20944\/preprints202406.1832.v1"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Tiscia, G., Favuzzi, G., De Laurenzo, A., Cappucci, F., Fischetti, L., Colaizzo, D., Chinni, E., Florio, L., Miscio, G., and Piscitelli, A.P. (2021). The Prognostic Value of ADAMTS-13 and von Willebrand Factor in COVID-19 Patients: Prospective Evaluation by Care Setting. Diagnostics, 11.","DOI":"10.3390\/diagnostics11091648"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e3374","DOI":"10.1097\/MD.0000000000003374","article-title":"Decreased ADAMTS 13 Activity is Associated With Disease Severity and Outcome in Pediatric Severe Sepsis","volume":"95","author":"Lin","year":"2016","journal-title":"Medicine"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1574-695X.2008.00480.x","article-title":"Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax","volume":"54","author":"Chung","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ccc.2019.12.002","article-title":"Role of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis","volume":"36","author":"Sungurlu","year":"2020","journal-title":"Crit. Care Clin."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10354-009-0738-9","article-title":"Blood coagulation disorders in septic patients","volume":"160","author":"Knoebl","year":"2010","journal-title":"Wien. Med. Wochenschr. (1946)"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00431-006-0139-7","article-title":"Plasma antithrombin III and protein C levels in early recognition of late-onset sepsis in newborns","volume":"165","author":"Lauterbach","year":"2006","journal-title":"Eur. J. Pediatr."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/INF.0b013e3180f616f0","article-title":"Low plasma protein C values predict mortality in low birth weight neonates with septicemia","volume":"26","author":"Venkataseshan","year":"2007","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.4049\/jimmunol.2300333","article-title":"Diverse Functions of C4b-Binding Protein in Health and Disease","volume":"211","author":"Werner","year":"2023","journal-title":"J. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Eliwan, H., Omer, M., McKenna, E., Kelly, L.A., Nolan, B., Regan, I., and Molloy, E.J. (2021). Protein C Pathway in Paediatric and Neonatal Sepsis. Front. Pediatr., 9.","DOI":"10.3389\/fped.2021.562495"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1097\/00003246-200111000-00003","article-title":"Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis","volume":"29","author":"Bernard","year":"2001","journal-title":"Crit. Care Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1056\/NEJMoa1202290","article-title":"Drotrecogin alfa (activated) in adults with septic shock","volume":"366","author":"Ranieri","year":"2012","journal-title":"New Engl. J. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1160\/TH15-08-0687","article-title":"Antithrombin: Anti-inflammatory properties and clinical applications","volume":"115","author":"Levy","year":"2016","journal-title":"Thromb. Haemost."},{"key":"ref_163","first-page":"CD005385","article-title":"Recombinant human activated protein C for severe sepsis in neonates","volume":"2012","author":"Kylat","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1055\/s-2003-42586","article-title":"Protein C pathway in infants and children","volume":"29","year":"2003","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Schl\u00f6mmer, C., Brandtner, A., and Bachler, M. (2021). Antithrombin and Its Role in Host Defense and Inflammation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084283"},{"key":"ref_166","first-page":"974","article-title":"Disseminated intravascular coagulation: Old disease, new hope","volume":"327","author":"Toh","year":"2003","journal-title":"BMJ (Clin. Res. Ed.)"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0344-0338(82)80033-2","article-title":"Disseminated intravascular coagulation in newborn infants. Prevalence in autopsies and significance as a cause of death","volume":"174","author":"Dairaku","year":"1982","journal-title":"Pathol. Res. Pract."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/0885066618773679","article-title":"Newly Proposed Sepsis-Induced Coagulopathy Precedes International Society on Thrombosis and Haemostasis Overt-Disseminated Intravascular Coagulation and Predicts High Mortality","volume":"35","author":"Iba","year":"2020","journal-title":"J. Intensive Care Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s12185-021-03152-4","article-title":"Validation of sepsis-induced coagulopathy score in critically ill patients with septic shock: Post hoc analysis of a nationwide multicenter observational study in Japan","volume":"114","author":"Tanaka","year":"2021","journal-title":"Int. J. Hematol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1055\/s-0037-1616068","article-title":"Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation","volume":"86","author":"Taylor","year":"2001","journal-title":"Thromb. Haemost."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1532\/IJH97.05190","article-title":"Plasminogen activator inhibitor 1 promotes a poor prognosis in sepsis-induced disseminated intravascular coagulation","volume":"84","author":"Madoiwa","year":"2006","journal-title":"Int. J. Hematol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e017046","DOI":"10.1136\/bmjopen-2017-017046","article-title":"New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: A retrospective analysis of a nationwide survey","volume":"7","author":"Iba","year":"2017","journal-title":"BMJ Open"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1111\/jth.15500","article-title":"Clinical value of pediatric sepsis-induced coagulopathy score in diagnosis of sepsis-induced coagulopathy and prognosis in children","volume":"19","author":"Xiang","year":"2021","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1055\/s-0040-1718736","article-title":"Evaluation of Sepsis-Induced Coagulopathy in Critically Ill Pediatric Patients with Septic Shock","volume":"121","author":"Jhang","year":"2021","journal-title":"Thromb. Haemost."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00134-017-5021-8","article-title":"Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit","volume":"44","author":"Schlapbach","year":"2018","journal-title":"Intensive Care Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1001\/jamapediatrics.2022.1301","article-title":"Validation of the Pediatric Sequential Organ Failure Assessment Score and Evaluation of Third International Consensus Definitions for Sepsis and Septic Shock Definitions in the Pediatric Emergency Department","volume":"176","author":"Balamuth","year":"2022","journal-title":"JAMA Pediatr."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41390-019-0517-2","article-title":"A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants","volume":"88","author":"Wynn","year":"2020","journal-title":"Pediatr. Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/CCM.0000000000005294","article-title":"Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce","volume":"50","author":"Menon","year":"2022","journal-title":"Crit. Care Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41390-020-0850-5","article-title":"Neonatal sepsis: Need for consensus definition, collaboration and core outcomes","volume":"88","author":"Molloy","year":"2020","journal-title":"Pediatr. Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/jth.13235","article-title":"Contact system revisited: An interface between inflammation, coagulation, and innate immunity","volume":"14","author":"Long","year":"2016","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"109769","DOI":"10.1016\/j.intimp.2023.109769","article-title":"Clinical and laboratory findings to differentiate late-onset sepsis caused by Gram-negative vs Gram-positive bacteria among perterm neonates: A retrospective cohort study","volume":"116","author":"Zhang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0378-3782(12)70019-1","article-title":"Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units","volume":"88","author":"Hornik","year":"2012","journal-title":"Early Hum. Dev."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41390-021-01444-3","article-title":"Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in preterm neonates","volume":"91","author":"Cernada","year":"2022","journal-title":"Pediatr. Res."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Sokou, R., Gounari, E.A., Tsante, K.A., Konstantinidi, A., Lampridou, M., Theodoraki, M., Kriebardis, A.G., Fortis, S.P., Iacovidou, N., and Tsantes, A.G. (2025). Thromboelastometry-Based Profiling of Haemostatic Alterations in Neonatal Sepsis by Causative Pathogens. Antibiotics, 14.","DOI":"10.3390\/antibiotics14010101"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2141.1999.01154.x","article-title":"Plasma thrombopoietin concentrations in thrombocytopenic and non-thrombocytopenic patients in a neonatal intensive care unit","volume":"104","author":"Sola","year":"1999","journal-title":"Br. J. Haematol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"100100","DOI":"10.1016\/j.rpth.2023.100100","article-title":"Sepsis-induced coagulopathy in preterm neonates with Gram-positive sepsis presents with hypercoagulation and reduced platelet activation compared with healthy preterm neonates","volume":"7","author":"Gialamprinou","year":"2023","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Sokou, R., Palioura, A.E., Konstantinidi, A., Lianou, A., Lampridou, M., Theodoraki, M., Piovani, D., Bonovas, S., Tsante, K.A., and Ioannou, P. (2024). The Role of Rotational Thromboelastometry in Early Detection of the Hemostatic Derangements in Neonates with Systemic Candida Infection. J. Fungi, 11.","DOI":"10.3390\/jof11010017"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Hua, Y., Li, N., Lao, J., Chen, Z., Ma, S., and Li, X. (2024). Machine learning models for coagulation dysfunction risk in inpatients administered \u03b2-lactam antibiotics. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1503713"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.2018.19283","article-title":"Evaluation and Management of Penicillin Allergy: A Review","volume":"321","author":"Shenoy","year":"2019","journal-title":"JAMA"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Bai, H., Li, H., Nie, X., Yao, Y., Han, X., Wang, J., and Peng, L. (2023). Development and validation of a nomogram for predicting cefoperazone\/sulbactam-induced hypoprothrombinaemia in Hospitalized adult patients. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0291658"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1055\/a-2564-7613","article-title":"Hemostatic Manifestations of Invasive Fungal Infections: A Comprehensive Review of Pathophysiological Mechanisms in Sepsis-Induced Hemostatic Disturbances, with a Focus on the Neonatal Population","volume":"51","author":"Lianou","year":"2025","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12959-024-00641-4","article-title":"Coagulation dysfunction events associated with echinocandins: A real-world study from FDA adverse event reporting system (FAERS) database","volume":"22","author":"Cheng","year":"2024","journal-title":"Thromb. J."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF01372152","article-title":"Prediction of neonatal sepsis by thromboelastography","volume":"12","author":"Grant","year":"1997","journal-title":"Pediatr. Surg. Int."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1182\/blood-2003-06-1789","article-title":"Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia","volume":"102","author":"Kerlin","year":"2003","journal-title":"Blood"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/1574-6976.12080","article-title":"Bacteria under stress by complement and coagulation","volume":"38","author":"Berends","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1111\/jth.14942","article-title":"The protective rather than prothrombotic fibrinogen in COVID-19 and other inflammatory states","volume":"18","author":"Thachil","year":"2020","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Loof, T.G., Deicke, C., and Medina, E. (2014). The role of coagulation\/fibrinolysis during Streptococcus pyogenes infection. Front. Cell. Infect. Microbiol., 4.","DOI":"10.3389\/fcimb.2014.00128"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/3\/584\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:17:29Z","timestamp":1774005449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/3\/584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":198,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["medicina62030584"],"URL":"https:\/\/doi.org\/10.3390\/medicina62030584","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]}}}