{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:12:18Z","timestamp":1775146338871,"version":"3.50.1"},"reference-count":78,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Rosacea is a chronic inflammatory dermatosis with a complex pathophysiology that continues to challenge effective long-term disease management. Rosacea is characterized by immune dysregulation, oxidative stress, neurovascular dysfunction, and impaired epidermal barrier integrity, while current therapeutic options remain limited. Hippophae rhamnoides (sea buckthorn) is a phytochemically rich medicinal plant with reported anti-inflammatory and dermo-reparative properties. Materials and Methods: A systematic literature review was conducted following PRISMA guidelines using the PubMed database. Studies published from 2020 onward evaluating sea buckthorn extracts, oils, or isolate bioactive compounds in the in vitro, in vivo, and limited clinical contexts were included, with emphasis on rosacea relevant mechanisms. Results: Twenty-six studies show that sea buckthorn compounds modulate inflammation, oxidative stress, vascular and immune responses, and barrier function in preclinical models. They consistently reduce pro-inflammatory mediators, improve barrier integrity, and attenuate immune or vascular activation, suggesting potential benefits for inflammatory skin disorders such as rosacea. Conclusions: Hippophae rhamnoides shows promising anti-inflammatory and skin-repairing effects that may benefit patients with rosacea. However, most evidence comes from preclinical studies, and clinical data specifically for rosacea are limited. Well-designed clinical trials are needed to confirm its effectiveness in treating this condition.<\/jats:p>","DOI":"10.3390\/medicina62040676","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:14:43Z","timestamp":1775142883000},"page":"676","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rosacea and Hippophae rhamnoides: A Phytonutrient Approach to Skin Repair (The Systematic Review)"],"prefix":"10.3390","volume":"62","author":[{"given":"Maria Andrada","family":"Hincu","sequence":"first","affiliation":[{"name":"Research Center of Morfofunctional Science, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doina Alina","family":"Nicoara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ovidius University of Constanta, 900002 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9249-5247","authenticated-orcid":false,"given":"Elena","family":"Niculet","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenuta","family":"Ambrose","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7068","authenticated-orcid":false,"given":"Alin Laurentiu","family":"Tatu","sequence":"additional","affiliation":[{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madalina Nicoleta","family":"Matei","sequence":"additional","affiliation":[{"name":"Department of Medical Dentistry, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Bujoreanu-Bezman","sequence":"additional","affiliation":[{"name":"Surgical Medical Department, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-464X","authenticated-orcid":false,"given":"Alin Codrut","family":"Nicolescu","sequence":"additional","affiliation":[{"name":"Medical Center \u201cRoma\u201d for Diagnosis and Treatment, 011773 Bucharest, Romania"},{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Egoclinic, District 1, 010235 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9254-1047","authenticated-orcid":false,"given":"Ticuta","family":"Negreanu-Pirjol","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Ovidius University of Constanta, 900470 Constanta, Romania"},{"name":"Academy of Romanian Scientists, 3 Ilfov Street, 050044 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin","family":"Tudorache","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cTitu Maiorescu\u201d University, 040441 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mei, D., Sun, J., Wang, X., Li, H., and Zhang, Y. 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