{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:09:10Z","timestamp":1775560150854,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Acute colicky abdominal pain, involving visceral spasms and inflammatory mechanisms, is a common complaint in everyday medical practice. Despite its widespread use, clinical evidence on the fixed-dose combination of pargeverine 10 mg plus lysine clonixinate 125 mg remains limited. The objective of this study was to describe real-world clinical outcomes, safety, and patient-reported experience associated with this combination in routine practice. Materials and methods: This multicenter, observational, non-comparative, real-world study included adult patients with acute colicky abdominal pain of gastrointestinal, urological, or gynecological origin. Pain intensity was assessed using a visual analog scale (VAS) at baseline and at 5 \u00b1 3 days. Secondary outcomes included time to pain relief, satisfaction with treatment, and safety. Associations between pain reduction and patient-reported outcomes were explored. Results: A total of 202 patients were analyzed. Significant pain reduction was observed across all etiologies (p &lt; 0.001), with median VAS reductions ranging from 6 to 9 points (approximately 70% to 90% from baseline). More than 95% of patients reported early improvement, and sustained relief was maintained in more than 96% throughout the study period, regardless of the pain\u2019s origin. Adverse events were infrequent (3%), mild in intensity (primarily transient gastrointestinal symptoms), and did not lead to treatment discontinuation. Conclusions: In real-world clinical practice, the fixed-dose combination of pargeverine and lysine clonixinate was associated with early and sustained, clinically meaningful pain reduction across multiple forms of acute visceral colicky pain, with a favorable safety and tolerability profile, supporting its relevance as a short-term therapeutic option in mild to severe acute pain.<\/jats:p>","DOI":"10.3390\/medicina62040706","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:40:31Z","timestamp":1775554831000},"page":"706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter Real-World Observational Study of Pargeverine\/Lysine Clonixinate in Acute Visceral Colicky Pain"],"prefix":"10.3390","volume":"62","author":[{"given":"Gerardo E.","family":"Espinosa-Estrada","sequence":"first","affiliation":[{"name":"Kuatro Gastroenterology Medical Specialties Tower, Metepec 52177, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-2920","authenticated-orcid":false,"given":"Samuel","family":"Sevilla-Fuentes","sequence":"additional","affiliation":[{"name":"Hospital General de Zona 1 \u201cEmilio Varela Luj\u00e1n\u201d, Zacatecas 98000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-6724","authenticated-orcid":false,"given":"Brandon","family":"Bautista-Becerril","sequence":"additional","affiliation":[{"name":"Laboratorio de Neumogen\u00f3mica, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-8124","authenticated-orcid":false,"given":"Ramc\u00e9s","family":"Falf\u00e1n-Valencia","sequence":"additional","affiliation":[{"name":"Laboratorio de Neumogen\u00f3mica, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis \u00c1ngel","family":"Mendoza-Vargas","sequence":"additional","affiliation":[{"name":"Hospital General de Zacatecas \u201cLuz Gonz\u00e1lez Cos\u00edo\u201d, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Francisco","family":"Araiza-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital \u201cGrupo \u00c1ngeles, M\u00e9xico\u201d, General Surgery, Mexico City 10700, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Moreno-Chavez","sequence":"additional","affiliation":[{"name":"Hospital General de Zona 1 \u201cEmilio Varela Luj\u00e1n\u201d, Zacatecas 98000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4236\/ijcm.2016.77052","article-title":"Clinical Assessment of the Use of Propinox Hydrochloride and Scopolamine Hydrochloride in the Treatment of Abdominal Colic: A Retrospective, Comparative Study","volume":"7","author":"Rzetelna","year":"2016","journal-title":"Int. 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