{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:59:22Z","timestamp":1776160762559,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Prostate cancer is the second most common cancer in men worldwide, with 1,466,680 new cases and 396,792 deaths reported in 2022. Accurate preoperative grading is critical, as the grade assessed on biopsy cores may be underestimated compared to radical prostatectomy specimens. The aim of this study was to assess the ability of quantitative diffusion parameters derived by the standard monoexponential model (ADC\u2014apparent diffusion coefficient) and kurtosis model (Dapp\u2014apparent diffusion coefficient corrected for non-Gausion behavior and K-kurtosis) to predict Gleason Grade Group (GG) upgrading from transrectal ultrasound-guided (TRUS) biopsy to radical prostatectomy within each GG. Materials and Methods: This retrospective study included 128 patients with prostate cancer who underwent systematic TRUS biopsies and multiparametric magnetic resonance imaging (mpMRI) at 3T before prostatectomies between 2017 and 2021. Mean values of quantitative diffusion parameters (ADC, Dapp, K) were compared between upgraded and non-upgraded cohorts within each Grade Group obtained at biopsy. Results: Significant differences in ADC and K values were found between upgraded and non-upgraded lesions in GG1 and GG2 cohorts at biopsy, with lower ADCs and higher K values indicating a higher likelihood of upgrading. In GG1, ADC demonstrated an AUC of 0.762 (p &lt; 0.05) and K an AUC of 0.846 (p &lt; 0.05). In GG2, ADC showed an AUC of 0.814 (p &lt; 0.001) and K an AUC of 0.755 (p &lt; 0.001). No significant differences were observed in GG3 and GG4 cohorts. Conclusions: Quantitative diffusion parameters\u2014particularly ADC and kurtosis (K)\u2014demonstrated significant predictive value for Grade Group upgrading in patients with biopsy-proven GG1 (AUC: K = 0.846, ADC = 0.762) and GG2 (AUC: ADC = 0.814, K = 0.755, D = 0.810) prostate cancer. These findings suggest that incorporating quantitative DWI parameters into preoperative assessments may improve risk stratification and support clinical decision-making, particularly regarding the selection of patients for active surveillance. Validation in larger, multicenter cohorts is warranted.<\/jats:p>","DOI":"10.3390\/medicina62040750","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:14:17Z","timestamp":1776154457000},"page":"750","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Possible Role of Diffusion-Weighted Imaging in Prediction of Prostate Cancer Grade Group Upgrading: Insights from Biopsy to Radical Prostatectomy"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-6821","authenticated-orcid":false,"given":"Anna","family":"\u017burowska","sequence":"first","affiliation":[{"name":"Second Department of Radiology, Medical University of Gdansk, 80-214 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-9037","authenticated-orcid":false,"given":"Katarzyna","family":"Skrobisz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical University of Gdansk, 80-214 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Sowa","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University of Gdansk, 80-214 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4904-7059","authenticated-orcid":false,"given":"Rafa\u0142","family":"P\u0119ksa","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology, Medical University of Gdansk, 80-214 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-2414","authenticated-orcid":false,"given":"Damian","family":"Panas","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, 10-748 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6533-5774","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Grzywi\u0144ska","sequence":"additional","affiliation":[{"name":"Neuroinformatics and Artificial Intelligence Lab, Department of Neurophysiology, Neuropsychology and Neuroinformatics, Medical University of Gdansk, 80-210 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Matuszewski","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University of Gdansk, 80-214 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-4381","authenticated-orcid":false,"given":"Edyta","family":"Szurowska","sequence":"additional","affiliation":[{"name":"Second Department of Radiology, Medical University of Gdansk, 80-214 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref_1","first-page":"e70043","article-title":"Cancer statistics, 2026","volume":"76","author":"Siegel","year":"2026","journal-title":"CA Cancer J. 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