{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:40:22Z","timestamp":1776339622116,"version":"3.51.2"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Placental vascular lesions are significant histopathological findings that indicate disruptions in uteroplacental and fetoplacental circulations and are associated with adverse pregnancy outcomes such as preeclampsia, intrauterine growth restriction (IUGR), and perinatal morbidity. This study aimed to re-examine the frequency and distribution of placental vascular lesions in placentas submitted for histopathological analysis at our center, based on criteria established by the Amsterdam Placental Workshop Group Consensus Statement. Materials and Methods: In this retrospective study, placental samples examined in the Department of Pathology at Akdeniz University Faculty of Medicine from 2016 to 2019 were analyzed. A total of 571 cases with at least one placental vascular lesion identified on histopathology were included. Hematoxylin\u2013eosin-stained sections from all cases were re-evaluated, and maternal vascular malperfusion (MVM), fetal vascular malperfusion (FVM), and other placental vascular pathologies were assessed according to the Amsterdam consensus criteria. Statistical analyses were performed using IBM SPSS Statistics for Windows, Version 25 (IBM Corp., Armonk, NY, USA). Categorical variables were compared using the chi-square or Fisher\u2019s exact test, while continuous variables were analyzed with the Mann\u2013Whitney U test. Results: MVM and FVM were considered the primary outcomes of the study. MVM was identified in 95.1% of cases, whereas FVM was present in 1.9%. Among individual lesions, chorangiosis (97.2%) and villous\/perivillous fibrinoid deposition (88.3%) were the most frequent findings, followed by mucinous cystic degeneration of the umbilical cord (61.5%) and dystrophic calcification (58.1%). Retroplacental hematoma was observed in 38.4% of cases. Although no significant association was found between MVM and placental weight or size, umbilical cord length was significantly shorter in MVM-positive cases (p = 0.032). In contrast, FVM showed significant associations with chorangiosis (p = 0.035) and placentomegaly (p = 0.003). The high frequency of chorangiosis may reflect a compensatory angiogenic response to chronic intrauterine hypoxia, potentially mediated by vascular growth factors, with variable effectiveness depending on the severity of the underlying condition. Conclusions: These findings suggest that placental vascular lesions are not only markers of obstetric complications but also serve as morphological indicators of fetoplacental adaptive responses.<\/jats:p>","DOI":"10.3390\/medicina62040773","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:14:46Z","timestamp":1776334486000},"page":"773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histopathologic Reassessment of Placental Vascular Lesions Based on the Amsterdam Consensus Criteria: A Retrospective Analysis of 571 Placental Cases"],"prefix":"10.3390","volume":"62","author":[{"given":"B\u00fc\u015fra","family":"Altunay \u00dcnal","sequence":"first","affiliation":[{"name":"Department of Pathology, K\u00fctahya City Hospital, 43100 K\u00fctahya, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"\u00c7obankent Aytekin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Konya Numune Hospital, 42060 Konya, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4438-0434","authenticated-orcid":false,"given":"Havva Serap","family":"Toru","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Akdeniz University, 07058 Antalya, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \u201cGreat Obstetrical Syndromes\u201d are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/apm.12833","article-title":"Maternal vascular malperfusion of the placental bed","volume":"126","author":"Ernst","year":"2018","journal-title":"Apmis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: Amsterdam placental workshop group consensus statement","volume":"140","author":"Khong","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/apm.12849","article-title":"Fetal vascular malperfusion, an update","volume":"126","author":"Redline","year":"2018","journal-title":"Apmis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.path.2012.10.001","article-title":"Fetal Thrombotic Vasculopathy: Perinatal Stroke, Growth Restriction, and Other Sequelae","volume":"6","author":"Kraus","year":"2013","journal-title":"Surg. Pathol. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/hupa.2000.9036","article-title":"Villous capillary lesions of the placenta: Distinctions between chorangioma, chorangiomatosis, and chorangiosis","volume":"31","author":"Ogino","year":"2000","journal-title":"Hum. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/00006254-198408000-00008","article-title":"Chorangiosis. An important placental sign of neonatal morbidity and mortality","volume":"39","author":"Altshuler","year":"1984","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ma, H., Liu, Z., and Ruan, J. (2023). Placental chorioangioma and pregnancy outcome: A ten-year retrospective study in a tertiary referral centre. BMC Pregnancy Childbirth, 23.","DOI":"10.1186\/s12884-023-05719-x"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0344-0338(11)80791-0","article-title":"Placental vascular anomaly with diffuse mesenchymal stei villuos hyperplasia: A new clinico-pathological entity?","volume":"187","author":"Moscoso","year":"1991","journal-title":"Pathol.-Res. Pract."},{"key":"ref_10","first-page":"611","article-title":"Diagnosis and management of placental mesenchymal disease. A review of the literature","volume":"74","author":"Colpaert","year":"2019","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4322\/acr.2014.039","article-title":"Placental mesenchymal dysplasia: Case report with gross and histological findings","volume":"4","author":"Toscano","year":"2014","journal-title":"Autops. Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/15513810802545350","article-title":"Immunohistochemical expression of p57 in placental vascular proliferative disorders of preterm and term placentas","volume":"28","author":"Allias","year":"2009","journal-title":"Fetal Pediatr. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/PAS.0000000000000334","article-title":"Fetal thrombotic vasculopathy: Significance in liveborn children using proposed society for pediatric pathology diagnostic criteria","volume":"39","author":"Chisholm","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.placenta.2007.09.003","article-title":"Placental pathology: A systematic approach with clinical correlations","volume":"29","author":"Redline","year":"2008","journal-title":"Placenta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","article-title":"Pathophysiology of placental-derived fetal growth restriction","volume":"218","author":"Burton","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","article-title":"The two-stage placental model of preeclampsia: An update","volume":"134","author":"Staff","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.5858\/arpa.2017-0212-RA","article-title":"Fetal vascular malperfusion","volume":"141","author":"Heider","year":"2017","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s40556-017-0133-3","article-title":"Placental Pathology and Stillbirth: A review of the literature and guidelines for the less experienced","volume":"4","author":"Kulkarni","year":"2017","journal-title":"J. Fetal Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Yaguchi, C., Ueda, M., Mizuno, Y., Fukuchi, C., Matsumoto, M., Furuta-Isomura, N., and Itoh, H. (2024). Association of placental pathology with physical and neuronal development of infants: A narrative review and reclassification of the literature by the consensus statement of the Amsterdam placental workshop group. Nutrients, 16.","DOI":"10.3390\/nu16111786"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-3016.2008.00935.x","article-title":"Placental characteristics and birthweight","volume":"22","author":"Salafia","year":"2008","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1469-7580.2008.00994.x","article-title":"A stereological perspective on placental morphology in normal and complicated pregnancies","volume":"215","author":"Mayhew","year":"2009","journal-title":"J. Anat."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/01.AOG.0000102706.84063.C7","article-title":"Risk factors and outcomes associated with a short umbilical cord","volume":"103","author":"Krakowiak","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1203\/00006450-198202000-00006","article-title":"Umbilical cord length as an index of fetal activity: Experimental study and clinical implications","volume":"16","author":"Moessinger","year":"1982","journal-title":"Pediatr. Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kingdom, J.C., and Kaufmann, P. (1999). Oxygen and placental vascular development. Hypoxia into the Next Millennium, Springer.","DOI":"10.1007\/978-1-4615-4711-2_20"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1177\/1093526619830866","article-title":"Focal Chorangiosis: Does It Have Clinical and Pathologic Significance?","volume":"22","author":"Sung","year":"2019","journal-title":"Pediatr. Dev. Pathol. Off. J. Soc. Pediatr. Pathol. Paediatr. Pathol. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.5858\/arpa.2024-0274-OA","article-title":"Machine Learning Assessment of Gestational Age in Accelerated Maturation, Delayed Maturation, Villous Edema, Chorangiosis, and Intrauterine Fetal Demise","volume":"149","author":"Goldstein","year":"2025","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Mehedintu, C., Frincu, F., Ionescu, O.M., Cirstoiu, M.M., Sajin, M., Olinca, M., Bratila, E., Petca, A., and Carp-Veliscu, A. (2022). A Challenging Diagnosis: Placental Mesenchymal Dysplasia-Literature Review and Case Report. Diagnostics, 12.","DOI":"10.3390\/diagnostics12020293"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/0971-3026.202949","article-title":"Placental mesenchymal dysplasia: What every radiologist needs to know","volume":"27","author":"Mittal","year":"2017","journal-title":"Indian J. Radiol. 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