{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:38:33Z","timestamp":1793306313247,"version":"4.5.0"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010623","name":"University of Thessaly","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010623","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/04v4g9h31","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Venous thromboembolic disease (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a major cause of morbidity and mortality worldwide and imposes a substantial financial burden on health systems due to both the direct and indirect costs of acute management and long-term complications. This systematic review aimed to assess patient satisfaction with anticoagulation therapy for VTE and to highlight potential differences according to the type of anticoagulant. The review focused on factors influencing the patient experience, such as perceived efficacy, ease of use, adverse effects, and health-related quality of life. Materials and Methods: A systematic review, without quantitative meta-analysis, was conducted in accordance with PRISMA 2020 guidelines. Articles were identified through searches in major databases (PubMed, Scopus, Cochrane Library and others) using keywords including \u201cpatient satisfaction\u201d, \u201canticoagulation\u201d, \u201cvenous thromboembolic disease\u201d, and \u201cquality of life\u201d. In total, 21 studies published between 2009 and 2025 met the inclusion criteria. The studies assessed patient satisfaction with different types of anticoagulation, including vitamin K antagonists (VKAs), direct oral anticoagulants (DOACs), and low-molecular-weight heparin (LMWH) injections. Results: Across the included studies, patients generally reported higher levels of treatment satisfaction with DOACs compared with VKAs, mainly due to the absence of routine laboratory monitoring and fewer dietary restrictions. However, satisfaction varied according to age, sex, and clinical status. In specific patient populations, such as those with cancer-associated thrombosis, factors including fewer drug\u2013drug interactions and perceptions of safety with LMWH appeared to influence treatment choice and satisfaction. Adverse effects, particularly bleeding, were identified as major drivers of dissatisfaction. Several studies suggested that higher treatment satisfaction was associated with better adherence, while quality of life appeared to improve in patients treated with DOACs in comparison with VKAs. Conclusions: Patient satisfaction is a critical component of successful VTE management. Overall, DOACs appear to be associated with higher treatment satisfaction than traditional therapies such as VKAs, although further high-quality research is needed to individualise anticoagulation strategies. Systematic incorporation of patient-reported satisfaction into clinical decision-making and into international guidelines may improve adherence, enhance quality of life, and ultimately increase the effectiveness of anticoagulation therapy.<\/jats:p>","DOI":"10.3390\/medicina62040783","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:30:36Z","timestamp":1776443436000},"page":"783","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient Satisfaction with Anticoagulation for Venous Thromboembolic Disease: A Systematic Review of Oral and Parenteral Regiments"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3735-7663","authenticated-orcid":false,"given":"Eleftheria Elmina","family":"Lefkou","sequence":"first","affiliation":[{"name":"Blood Transfusion and Haemostasis Unit, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41223 Larissa, Greece"},{"name":"Department of Public Administration, School of Economics, Administration and Computer Science, Neapolis University Pafos, 8042 Pafos, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Fragkaki","sequence":"additional","affiliation":[{"name":"Psychology Faculty, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Mirsini","family":"Miliori","sequence":"additional","affiliation":[{"name":"Blood Transfusion and Haemostasis Unit, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41223 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Latsou","sequence":"additional","affiliation":[{"name":"Department of Public Administration, School of Economics, Administration and Computer Science, Neapolis University Pafos, 8042 Pafos, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Panagiotopoulou","sequence":"additional","affiliation":[{"name":"Department of Public Administration, School of Economics, Administration and Computer Science, Neapolis University Pafos, 8042 Pafos, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3696-6731","authenticated-orcid":false,"given":"Paraskevi","family":"Kotsi","sequence":"additional","affiliation":[{"name":"Blood Transfusion and Haemostasis Unit, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41223 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2316-6348","authenticated-orcid":false,"given":"Grigorios","family":"Gerotziafas","sequence":"additional","affiliation":[{"name":"INSERM UMR_S_938, Saint-Antoine Research Center (CRSA), Sorbonne University, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Geitona","sequence":"additional","affiliation":[{"name":"Department of Public Administration, School of Economics, Administration and Computer Science, Neapolis University Pafos, 8042 Pafos, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1111\/jth.15491","article-title":"Long-term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and meta-analysis","volume":"19","author":"Khan","year":"2021","journal-title":"J. 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