{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:37:05Z","timestamp":1789425425340,"version":"build-2803163510"},"reference-count":20,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Bicuspid aortic valve (BAV) is a common congenital cardiac abnormality frequently associated with aortopathy and progressive aortic dilatation. The 2021 International consensus statement introduced standardized phenotypic definitions for BAV and BAV-associated aortopathy. The aim of this study was to determine the distribution of BAV and BAV-associated aortopathy phenotypes according to the 2021 consensus statement and to assess statistical differences between imaging modalities (magnetic resonance imaging (MRI) and transthoracic echocardiography (TTE)) in aortic diameter measurements. Materials and Methods: This single-center retrospective study included 47 patients with BAV between 2014 and 2018. Aortic root and ascending aorta diameters were measured using MRI white-blood and black-blood sequences and TTE. BAV morphology and aortopathy phenotypes were classified according to the 2021 International consensus recommendations, and agreement between modalities was assessed using correlation and Bland\u2013Altman analysis. Results: The study population had a mean age of 30 \u00b1 11.05 years, with a male-to-female ratio of approximately 3.3:1. The fused BAV phenotype was the most prevalent (53.2%), followed by the partial-fusion (38.3%) and two-sinus (8.5%) phenotypes (p &lt; 0.001). Aortopathy phenotypes assessed by MRI and TTE demonstrated similar distribution patterns, with the extended phenotype being the most frequent, followed by ascending and root phenotypes, with no significant difference between modalities (p = 0.74). Strong correlations were observed across all imaging techniques for both ascending aorta and aortic root measurements; however, small but statistically significant differences were identified between selected modality pairs\u2014a mean difference of 1.59 mm between MRI black-blood and TTE ascending aorta diameters and 1.26 mm between MRI white-blood and TTE aortic root diameters. Conclusions: Multimodality imaging demonstrates strong agreement in the assessment of aortic diameters and yields comparable aortopathy phenotype distributions when applying the 2021 International Consensus Classification. Nevertheless, small systematic measurement differences between MRI and TTE may be clinically relevant in patients approaching diagnostic or therapeutic thresholds, highlighting the importance of consistent imaging methodology in longitudinal follow-up of BAV-associated aortopathy.<\/jats:p>","DOI":"10.3390\/medicina62040790","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:22:47Z","timestamp":1776691367000},"page":"790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Imaging-Based Phenotyping in Bicuspid Aortic Valve and Associated Aortopathy: A Retrospective Single-Center Study"],"prefix":"10.3390","volume":"62","author":[{"given":"Laurynas","family":"\u0160arkinas","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nomeda Rima","family":"Valevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine and Medical Physics, Institute of Biomedical Sciences, Vilnius University, LT-08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigita","family":"Glaveckait\u0117","sequence":"additional","affiliation":[{"name":"Clinic of Heart and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3342-6070","authenticated-orcid":false,"given":"Darius","family":"Palionis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine and Medical Physics, Institute of Biomedical Sciences, Vilnius University, LT-08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.31083\/j.rcm2406178","article-title":"Implications of Bicuspid Aortic Valve Disease and Aortic Stenosis\/Insufficiency as Risk Factors for Thoracic Aortic Aneurysm","volume":"24","author":"Jabagi","year":"2023","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/HCO.0000000000001020","article-title":"Bicuspid Aortic Valve Associated Aortopathy: 2022 Guideline Update","volume":"38","author":"Verma","year":"2023","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Katsaros, O., Ktenopoulos, N., Korovesis, T., Benetos, G., Apostolos, A., Koliastasis, L., Sagris, M., Milaras, N., Latsios, G., and Synetos, A. (2024). Bicuspid Aortic Valve Disease: From Pathophysiology to Treatment. J. Clin. Med., 13.","DOI":"10.3390\/jcm13174970"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wulffeld, S., Schmiegelow, M.D.S., Oksjoki, R., Nielsen, D.G., Schmiegelow, S.S., Ngo, A.T., Rauns\u00f8, J., Larsen, M.K., Bruun, N.E., and Procida, K. (2025). Valve Morphology and Timing of Surgery in Bicuspid Aortic Valve Disease. Clin. Res. Cardiol, Online ahead of print.","DOI":"10.1007\/s00392-025-02725-1"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/ejcts\/ezab038","article-title":"International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes","volume":"60","author":"Michelena","year":"2021","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.33963\/v.phj.104988","article-title":"Bicuspid Aortic Valves (BAV) Registry (RE-BAV): Clinical and Echocardiographic Characteristics of Patients with BAV According to Novel Classification of Bicuspid Aortic Valves","volume":"83","author":"Komar","year":"2025","journal-title":"Kardiol. Pol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nappi, F., Giacinto, O., Lusini, M., Garo, M., Caponio, C., Nenna, A., Nappi, P., Rousseau, J., Spadaccio, C., and Chello, M. (2022). Patients with Bicuspid Aortopathy and Aortic Dilatation. J. Clin. Med., 11.","DOI":"10.3390\/jcm11206002"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Valevi\u010dien\u0117, N., Palionis, D., Glaveckaite, S., Gumbiene, L., and Petrulioniene, Z. (2021). Routine Unenhanced 2D MRI for Maximal Segmental Diameters of Thoracic Aorta, Research Square.","DOI":"10.21203\/rs.3.rs-491009\/v1"},{"key":"ref_9","unstructured":"(2026, January 27). BCH Z-Score Calculator\u2014Home. Available online: https:\/\/zscore.chboston.org\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"ezaf109","DOI":"10.1093\/ejcts\/ezaf109","article-title":"Prevalence, Clinical Characterization, Management and Evolution of Bicuspid Aortic Valve Classified According to the 2021 International Consensus Statement in a Tertiary Care Hospital","volume":"67","author":"Rizza","year":"2025","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/echo.15405","article-title":"Gender differences in bicuspid aortic valve Sievers types, valvulopathy, aortopathy, and outcome of aortic valve replacement","volume":"39","author":"Li","year":"2022","journal-title":"Echocardiography"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3348\/kjr.2023.0312","article-title":"Computed Tomography and Magnetic Resonance Imaging Findings of Bicuspid Aortic Valve and Related Abnormalities of the Heart and Thoracic Aorta","volume":"24","author":"You","year":"2023","journal-title":"Korean J. Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.21037\/cdt.2017.05.03","article-title":"Diagnostic accuracy study of routine echocardiography for bicuspid aortic valve: A retrospective study and meta-analysis","volume":"7","author":"Hillebrand","year":"2017","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1093\/eurheartj\/ehae179","article-title":"2024 ESC Guidelines for the management of peripheral arterial and aortic diseases: Developed by the task force on the management of peripheral arterial and aortic diseases of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS), the European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN), and the European Society of Vascular Medicine (ESVM)","volume":"45","author":"Mazzolai","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e334\u2013482","DOI":"10.1161\/CIR.0000000000001106","article-title":"2022 ACC\/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"146","author":"Isselbacher","year":"2022","journal-title":"Circulation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/heartjnl-2012-301773","article-title":"Bicuspid aortic valve and associated aortic dilation in the young","volume":"98","author":"Fernandes","year":"2012","journal-title":"Heart"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijcard.2021.03.041","article-title":"Adolescents with bicuspid aortic valve: Which criteria should we use for aortic dilatation?","volume":"333","author":"Siurana","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_18","unstructured":"(2026, March 04). 2020 ACC\/AHA Guideline for the Management of Patients with Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Available online: https:\/\/www.ahajournals.org\/doi\/10.1161\/CIR.0000000000000923."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/jmri.27183","article-title":"How to Measure the Aorta Using MRI: A Practical Guide","volume":"52","author":"Scholte","year":"2020","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.echo.2014.11.015","article-title":"Multimodality Imaging of Diseases of the Thoracic Aorta in Adults: From the American Society of Echocardiography and the European Association of Cardiovascular Imaging: Endorsed by the Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance","volume":"28","author":"Goldstein","year":"2015","journal-title":"J. Am. Soc. Echocardiogr."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/4\/790\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T14:20:32Z","timestamp":1776694832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/4\/790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["medicina62040790"],"URL":"https:\/\/doi.org\/10.3390\/medicina62040790","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}