{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:37:20Z","timestamp":1785418640622,"version":"3.56.0"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["190144075"],"award-info":[{"award-number":["190144075"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"award":["190144075"],"award-info":[{"award-number":["190144075"]}],"id":[{"id":"https:\/\/ror.org\/00k4n6c32","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Basque Government and the European Regional Development Fund","award":["ZE-2022\/00027"],"award-info":[{"award-number":["ZE-2022\/00027"]}]},{"name":"Junta de Andaluc\u00eda, Consejer\u00eda de Universidad, Investigaci\u00f3n e Innovaci\u00f3n","award":["P21.00182"],"award-info":[{"award-number":["P21.00182"]}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["PID2020-115372RB-I00"],"award-info":[{"award-number":["PID2020-115372RB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["PYC20 RE 072 UGR"],"award-info":[{"award-number":["PYC20 RE 072 UGR"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"award":["PID2020-115372RB-I00"],"award-info":[{"award-number":["PID2020-115372RB-I00"]}],"id":[{"id":"https:\/\/ror.org\/05r0vyz12","id-type":"ROR","asserted-by":"publisher"}]},{"award":["PYC20 RE 072 UGR"],"award-info":[{"award-number":["PYC20 RE 072 UGR"]}],"id":[{"id":"https:\/\/ror.org\/05r0vyz12","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Innitius S.L."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Risk stratification in symptomatic threatened preterm labor (TPTL) remains challenging, particularly for clinically actionable time horizons. We evaluated whether quantitative cervical stiffness measured with the Cervisense Intravaginal Probe discriminates between women who will and will not deliver within 7, 10, or 14 days after presentation and assessed its discriminative performance alone and in combination with transvaginal cervical length. Materials and Methods: We conducted a multicenter, non-interventional study across 10 obstetric emergency units in Spain. Eligible participants were women aged \u2265 18 years with a live singleton pregnancy at 28+0 to 36+6 weeks, regular uterine contractions, intact membranes, and cervical dilatation &lt; 2 cm on speculum examination. Cervical stiffness was measured at presentation using torsional wave elastography with the Cervisense Intravaginal Probe. Cervical length was measured by transvaginal ultrasonography following international standards. Outcomes were delivery within 7, 10, and 14 days after presentation. Discrimination was quantified using the area under the receiver operating characteristic curve (AUC). An explanatory multivariable logistic regression model for delivery within 14 days included cervical stiffness, cervical length, and covariates selected as potential confounders. Results: Among 305 participants, 17 (5.6%) delivered within 7 days, 19 (6.2%) within 10 days, and 24 (7.9%) within 14 days. Mean cervical stiffness was lower among women who delivered within 14 days than among those who did not (8.63 vs. 14.82 kPa; p = 0.048). Cervical length was shorter among women who delivered within 7, 10, and 14 days (all p &lt; 0.001). Discrimination for cervical stiffness was moderate (AUC, 0.66, 0.64, and 0.73 for \u22647, \u226410, and \u226414 days) and higher for cervical length (AUC, 0.80, 0.77, and 0.78). The combined model achieved the highest discrimination (AUC, 0.85, 0.85, and 0.86). In the \u226414-day explanatory model, higher log-transformed cervical stiffness was associated with lower odds of delivery (OR, 0.907; 95% CI, 0.828 to 0.995; p = 0.039), as was longer cervical length (OR per 1 mm, 0.910; 95% CI, 0.876 to 0.946; p &lt; 0.001). Conclusions: In symptomatic TPTL, Cervisense-derived cervical stiffness showed moderate discrimination for short-term delivery and provided complementary information to cervical length, with improved discrimination when both measures were combined. These findings support future studies developing multivariable prediction models that incorporate quantitative cervical consistency.<\/jats:p>","DOI":"10.3390\/medicina62050830","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:32:22Z","timestamp":1777469542000},"page":"830","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cervical Stiffness Measured by the Cervisense Intravaginal Probe for Identification of Imminent Delivery in Symptomatic Threatened Preterm Labor"],"prefix":"10.3390","volume":"62","author":[{"given":"Andrea","family":"Samper-Girona","sequence":"first","affiliation":[{"name":"Hospital Universitario Cl\u00ednico San Cecilio, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaia","family":"Aiartzaguena","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cruces, 48903 Barakaldo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-9403","authenticated-orcid":false,"given":"Jorge","family":"Burgos","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cruces, 48903 Barakaldo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4501-7361","authenticated-orcid":false,"given":"Mar\u00eda D.","family":"Mu\u00f1oz-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Torrej\u00f3n, 28850 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"Gil","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Torrej\u00f3n, 28850 Madrid, Spain"},{"name":"School of Medicine, Universidad Francisco de Vitoria, 28223 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1566-7185","authenticated-orcid":false,"given":"Amelia","family":"Valladolid","sequence":"additional","affiliation":[{"name":"Hospital Universitario Basurto, 48013 Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Urones","sequence":"additional","affiliation":[{"name":"Hospital Universitario Basurto, 48013 Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Cobo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"},{"name":"Hospital Sant Joan de D\u00e9u, 08950 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"},{"name":"Hospital Sant Joan de D\u00e9u, 08950 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4001-2017","authenticated-orcid":false,"given":"Mar\u00eda","family":"Goya","sequence":"additional","affiliation":[{"name":"Hospital Universitario Vall d`Hebron, 08035 Barcelona, Spain"},{"name":"School of Medicine, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Del Barco Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Vall d`Hebron, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-3533","authenticated-orcid":false,"given":"Jos\u00e9 E.","family":"Blanco-Carnero","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9216-9118","authenticated-orcid":false,"given":"Pilar","family":"Prats Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital Universitari Dexeus, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca S.","family":"Molina","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cl\u00ednico San Cecilio, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0140-6736(21)01207-1","article-title":"Global, Regional, and National Progress towards Sustainable Development Goal 3.2 for Neonatal and Child Health: All-Cause and Cause-Specific Mortality 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