{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:15:54Z","timestamp":1785417354103,"version":"3.56.0"},"reference-count":21,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["NSTC 113-2221-E-155-032"],"award-info":[{"award-number":["NSTC 113-2221-E-155-032"]}]},{"name":"National Science and Technology Council","award":["NSTC 114-2221-E-003-037"],"award-info":[{"award-number":["NSTC 114-2221-E-003-037"]}]},{"award":["NSTC 113-2221-E-155-032"],"award-info":[{"award-number":["NSTC 113-2221-E-155-032"]}],"id":[{"id":"https:\/\/ror.org\/00wnb9798","id-type":"ROR","asserted-by":"publisher"}]},{"award":["NSTC 114-2221-E-003-037"],"award-info":[{"award-number":["NSTC 114-2221-E-003-037"]}],"id":[{"id":"https:\/\/ror.org\/00wnb9798","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Myopic choroidal neovascularization (mCNV) is a vision-threatening complication of pathologic myopia. While anti-VEGF monotherapy is the current standard of care, recurrence and suboptimal responses remain challenges. Faricimab is a novel bispecific antibody that targets both vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) to improve vascular stability. This study aims to evaluate the short-term efficacy and safety of a single intravitreal faricimab injection in eyes with active mCNV. Materials and Methods: This retrospective, single-center study included 27 eyes from 24 patients with active mCNV, including both treatment-na\u00efve and previously treated cases. All eyes received a single intravitreal injection of faricimab (6.0 mg\/0.05 mL). Best-corrected visual acuity (BCVA) in logMAR and central retinal thickness (CRT) via spectral-domain optical coherence tomography were assessed at baseline and one month post injection. Statistical significance was determined using paired and independent t-tests (p &lt; 0.05). Results: The study population (mean age 55.5 \u00b1 13.9 years; mean axial length 29.3 \u00b1 1.6 mm) showed significant improvements at one month. Mean BCVA improved from 0.77 \u00b1 0.71 logMAR to 0.51 \u00b1 0.52 logMAR (p &lt; 0.005). Mean CRT decreased from 290.2 \u00b1 66.0 \u03bcm to 242.5 \u00b1 45.7 \u03bcm (p &lt; 0.005). No ocular adverse events, such as intraocular inflammation, retinal detachment, or endophthalmitis, were observed. Conclusions: A single intravitreal injection of faricimab provides significant short-term functional and anatomical improvement in this small retrospective series. Dual inhibition of VEGF-A and Ang-2 appears to be a safe and effective approach for stabilizing retinal vasculature in patients with high myopia. Larger, long-term prospective studies are needed to determine optimal treatment intervals for mCNV.<\/jats:p>","DOI":"10.3390\/medicina62050832","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:32:22Z","timestamp":1777469542000},"page":"832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Real-World Results of the Single Intravitreal Injection of Faricimab in Treatment-Na\u00efve Subfoveal Myopic Choroidal Neovascularization"],"prefix":"10.3390","volume":"62","author":[{"given":"Hao-Chun","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Medicine, National Yang Ming Chiao Tung University, Taipei City 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-4203","authenticated-orcid":false,"given":"Ling-Uei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Medicine, National Yang Ming Chiao Tung University, Taipei City 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Lun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan City 320, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan City 320, Taiwan"},{"name":"Department of Medicine, National Taiwan University, Taipei City 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ting","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Medicine, National Yang Ming Chiao Tung University, Taipei City 112, Taiwan"},{"name":"Department of Medicine, National Taiwan University, Taipei City 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Ray","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan City 320, Taiwan"},{"name":"Department of Medicine, National Taiwan University, Taipei City 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-7246","authenticated-orcid":false,"given":"Fang-Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Medicine, National Taiwan University, Taipei City 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Medicine, National Taiwan University, Taipei City 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8373-2271","authenticated-orcid":false,"given":"Cheng-Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan City 320, Taiwan"},{"name":"Department of Electrical Engineering, National Taiwan Normal University, Taipei City 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3157-3613","authenticated-orcid":false,"given":"Jia-Kang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Medicine, National Yang Ming Chiao Tung University, Taipei City 112, Taiwan"},{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan City 320, Taiwan"},{"name":"Department of Medicine, National Taiwan University, Taipei City 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.preteyeres.2017.10.005","article-title":"Diagnosis and treatment guideline for myopic choroidal neovascularization due to pathologic myopia","volume":"63","author":"Ikuno","year":"2018","journal-title":"Prog. 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