{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T09:08:23Z","timestamp":1779700103073,"version":"3.53.1"},"reference-count":23,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To evaluate maternal characteristics associated with placenta previa in comparison with breech cesarean controls, as well as maternal and neonatal outcomes. Materials and Methods: A retrospective case\u2013control study was conducted at the Hospital of Lithuanian University of Health Sciences, Kaunas Clinics (2015\u20132022). A total of 150 cases of placenta previa were compared with a control group of participants who underwent cesarean delivery due to fetal breech presentation without placenta previa. Results: In multivariable analysis, higher parity, prior cesarean delivery, in vitro fertilization, prior surgical termination of pregnancy, and prior uterine surgery were independently associated with placenta previa compared with breech cesarean controls. Maternal complications were significantly more frequent in the placenta previa group and included placenta accreta spectrum disorders, second- and third-trimester hemorrhage, postpartum hemorrhage, and increased need for blood transfusion. The most severe outcomes, including cesarean hysterectomy, occurred exclusively in cases complicated by placenta accreta spectrum disorders. Neonatal outcomes in the placenta previa group were characterized by higher rates of preterm birth, low Apgar scores, and birth weight &lt; 2500 g. Adverse neonatal outcomes were partly associated with earlier gestational age at delivery. However, placenta previa remained associated with low Apgar score after adjustment. Conclusions: Compared with breech cesarean controls, placenta previa was associated with multiple maternal characteristics, including higher parity, prior cesarean delivery, in vitro fertilization, prior surgical termination of pregnancy, and prior uterine surgery. The condition is linked to increased maternal hemorrhagic morbidity, particularly in cases complicated by placenta accreta spectrum disorders, as well as adverse neonatal outcomes mainly related to prematurity. These findings highlight the importance of careful antenatal monitoring and delivery planning in specialized centers.<\/jats:p>","DOI":"10.3390\/medicina62050931","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:06:26Z","timestamp":1779696386000},"page":"931","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics, Maternal and Neonatal Outcomes in Women with Placenta Previa Compared with Breech Cesarean Controls: A Retrospective Case-Control Study from a Single Tertiary Center in Lithuania"],"prefix":"10.3390","volume":"62","author":[{"given":"Vytaute","family":"Rimdzeviciute","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, LT-50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Leipuviene","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-0738","authenticated-orcid":false,"given":"Egle","family":"Savukyne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laima","family":"Maleckiene","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitana","family":"Ramoniene","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotryna","family":"Bajeruniene","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Republican Panevezys Hospital, LT-35144 Panevezys, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindaugas","family":"Kliucinskas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Landsverk, E., Westvik-Johari, K., Wennerholm, U.-B., Bergh, C., Kyhl, F., Spangmose, A.L., Vassard, D., Pinborg, A., R\u00f6n\u00f6, K., and Gissler, M. (2025). Risk of placenta previa in assisted reproductive technology: A Nordic population study with sibling analyses. PLoS Med., 22.","DOI":"10.1371\/journal.pmed.1004536"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00404-010-1598-7","article-title":"Critical Analysis of Risk Factors and Outcome of Placenta Previa","volume":"284","author":"Rosenberg","year":"2011","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2018.05.025","article-title":"The Effect of Advanced Maternal Age on Maternal and Neonatal Outcomes of Placenta Previa: A Register-Based Cohort Study","volume":"227","author":"Roustaei","year":"2018","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"04013","DOI":"10.7189\/jogh.14.04013","article-title":"Factors and Outcomes for Placental Anomalies: An Umbrella Review of Systematic Reviews and Meta-Analyses","volume":"14","author":"Fan","year":"2024","journal-title":"J. Glob. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e031193","DOI":"10.1136\/bmjopen-2019-031193","article-title":"Epidemiology of Placenta Previa Accreta: A Systematic Review and Meta-Analysis","volume":"9","author":"Jauniaux","year":"2019","journal-title":"BMJ Open"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/tmi.12100","article-title":"Prevalence of Placenta Praevia by World Region: A Systematic Review and Meta-Analysis","volume":"18","author":"Cresswell","year":"2013","journal-title":"Trop. Med. Int. Health TM IH"},{"key":"ref_7","first-page":"e59737","article-title":"Maternal and Perinatal Outcomes in Placenta Previa: A Comprehensive Review of Evidence","volume":"16","author":"Sahu","year":"2024","journal-title":"Cureus"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/01.AOG.0000206182.63788.80","article-title":"Previous Cesarean Delivery and Risks of Placenta Previa and Placental Abruption","volume":"107","author":"Getahun","year":"2006","journal-title":"Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.placenta.2021.10.009","article-title":"The Risk Factors Associated with Placenta Previa: An Umbrella Review","volume":"117","author":"Jenabi","year":"2022","journal-title":"Placenta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5630296","DOI":"10.1155\/2020\/5630296","article-title":"Neonatal and Maternal Complications of Placenta Praevia and Its Risk Factors in Tikur Anbessa Specialized and Gandhi Memorial Hospitals: Unmatched Case-Control Study","volume":"2020","author":"Adere","year":"2020","journal-title":"J. Pregnancy"},{"key":"ref_11","first-page":"1395","article-title":"Placenta Praevia: Incidence, Risk Factors and Outcome","volume":"29","author":"Kollmann","year":"2016","journal-title":"J. Matern.-Fetal Neonatal Med. Off. J. Eur. Assoc. Perinat. Med. Fed. Asia Ocean. Perinat. Soc. Int. Soc. Perinat. Obstet."},{"key":"ref_12","first-page":"494","article-title":"Placenta Previa and Maternal Hemorrhagic Morbidity","volume":"31","author":"Gibbins","year":"2018","journal-title":"J. Matern.-Fetal Neonatal Med. Off. J. Eur. Assoc. Perinat. Med. Fed. Asia Ocean. Perinat. Soc. Int. Soc. Perinat. Obstet."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Fan, D., Xia, Q., Liu, L., Wu, S., Tian, G., Wang, W., Wu, S., Guo, X., and Liu, Z. (2017). The Incidence of Postpartum Hemorrhage in Pregnant Women with Placenta Previa: A Systematic Review and Meta-Analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170194"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1007\/s43032-023-01191-2","article-title":"Risk Factors and Pregnancy Outcomes of Antepartum Hemorrhage in Women with Placenta Previa","volume":"30","author":"Im","year":"2023","journal-title":"Reprod. Sci. Thousand Oaks Calif."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/AOG.0000000000001005","article-title":"Abnormal Placentation: Placenta Previa, Vasa Previa, and Placenta Accreta","volume":"126","author":"Silver","year":"2015","journal-title":"Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1067\/mob.2003.76","article-title":"The Effect of Placenta Previa on Neonatal Mortality: A Population-Based Study in the United States, 1989 through 1997","volume":"188","author":"Ananth","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.placenta.2020.12.005","article-title":"Predictors of Adverse Neonatal Outcome in Pregnancies Complicated by Placenta Previa","volume":"104","author":"Levin","year":"2021","journal-title":"Placenta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1600-0412.2012.01375.x","article-title":"A Danish National Cohort Study on Neonatal Outcome in Singleton Pregnancies with Placenta Previa","volume":"91","author":"Pinborg","year":"2012","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_19","first-page":"541","article-title":"Neonatal Outcomes with Placenta Previa","volume":"93","author":"Crane","year":"1999","journal-title":"Obstet. Gynecol."},{"key":"ref_20","first-page":"2985","article-title":"Smoking and Placenta Previa: A Meta-Analysis","volume":"30","author":"Shobeiri","year":"2017","journal-title":"J. Matern.-Fetal Neonatal Med. Off. J. Eur. Assoc. Perinat. Med. Fed. Asia Ocean. Perinat. Soc. Int. Soc. Perinat. Obstet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12958-021-00722-3","article-title":"The Effect Prophylactic Internal Iliac Artery Balloon Occlusion in Patients with Placenta Previa or Placental Accreta Spectrum: A Systematic Review and Meta-Analysis","volume":"19","author":"Nankali","year":"2021","journal-title":"Reprod. Biol. Endocrinol. RBE"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"16206","DOI":"10.1038\/s41598-024-67300-6","article-title":"Evaluating the predictive efficacy of first trimester biochemical markers (PAPP-A, f\u03b2-hCG) in forecasting preterm delivery incidences","volume":"14","author":"Swiercz","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Swiercz, G., Zmelonek-Znamirowska, A., Szwabowicz, K., Armanska, J., Detka, K., Mlodawska, M., and Mlodawski, J. (2024). Navigating Uncertain Waters: First-Trimester Screening\u2019s Role in Identifying Neonatal Complications. J. Clin. Med., 13.","DOI":"10.3390\/jcm13071982"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/5\/931\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:51:44Z","timestamp":1779699104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/5\/931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,10]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["medicina62050931"],"URL":"https:\/\/doi.org\/10.3390\/medicina62050931","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,10]]}}}