{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:05:13Z","timestamp":1779725113813,"version":"3.53.1"},"reference-count":54,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn\u2019s disease (CD), represents a chronic immune-mediated disorder frequently associated with extraintestinal manifestations. While musculoskeletal, dermatologic, and ocular complications are well recognized, ear, nose, and throat (ENT) involvement remains underrecognized despite its potential morbidity. Objective: To systematically evaluate the spectrum of ENT manifestations in IBD, focusing on clinical presentation, diagnostic approaches, and outcomes. Methods: A systematic literature search was conducted in PubMed and Scopus in accordance with PRISMA 2020 guidelines. Eligible studies included English-language human studies (2015\u20132026) reporting ENT manifestations in UC or CD. Following screening, 23 studies were included in the qualitative synthesis. Extracted data comprised study design, IBD subtype, patient demographics, ENT manifestations, diagnostic methods, and clinical outcomes. Results: The majority of studies consisted of case reports and small observational series. Sensorineural hearing loss (SNHL) was the most frequently reported manifestation in both adult and pediatric populations, with evidence suggesting immune-mediated mechanisms and variable responsiveness to corticosteroids. Nasal involvement included pyoderma gangrenosum, pyoderma vegetans, and aseptic nasal septal abscess, occasionally resulting in severe structural complications such as saddle-nose deformity. Laryngeal and airway involvement included dysphonia, tracheitis, and rare but potentially life-threatening inflammatory airway disease. Additional findings included associations with chronic rhinosinusitis. Diagnosis relied on audiometry, imaging, endoscopy, and histopathology. Systemic corticosteroids were frequently effective; however, delayed recognition may lead to irreversible sequelae. Conclusions: ENT manifestations in IBD constitute a clinically heterogeneous but important group of extraintestinal complications. Increased awareness of ENT manifestations may support earlier diagnosis and multidisciplinary management of IBD, potentially reducing irreversible complications.<\/jats:p>","DOI":"10.3390\/medicina62050943","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:05:08Z","timestamp":1779721508000},"page":"943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ear, Nose, and Throat Manifestations in Inflammatory Bowel Diseases: A Systematic Review of the Clinical Spectrum"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-5227","authenticated-orcid":false,"given":"Eleni","family":"Litsou","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Ioannina, 45500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Psychogios","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Ioannina, 45500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-8091","authenticated-orcid":false,"given":"Maria","family":"Saridi","sequence":"additional","affiliation":[{"name":"Department of Nursing, University of Thessaly, 41500 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos H.","family":"Katsanos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Ioannina, 45500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios","family":"Fousekis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Ioannina, 45500 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Saez, A., Herrero-Fernandez, B., Gomez-Bris, R., S\u00e1nchez-Martinez, H., and Gonzalez-Granado, J.M. (2023). Pathophysiology of inflammatory bowel disease: Innate immune system. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021526"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.jfma.2018.07.005","article-title":"Inflammatory bowel disease and its treatment in 2018: Global and Taiwanese status updates","volume":"118","author":"Su","year":"2019","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Silva, I., and da Silva, M.T.B. (2025). Inflammatory bowel disease: Clinical diagnosis and treatment. J. Clin. Med., 14.","DOI":"10.3390\/books978-3-7258-5706-7"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5217\/ir.2017.15.3.338","article-title":"Impact of inflammatory bowel disease on daily life: An online survey by the Korean Association for the Study of Intestinal Diseases","volume":"15","author":"Kim","year":"2017","journal-title":"Intest. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","article-title":"ECCO-ESGAR guideline for diagnostic assessment in inflammatory bowel disease part 1: Initial diagnosis, monitoring of known IBD, detection of complications","volume":"13","author":"Maaser","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17562848221115312","DOI":"10.1177\/17562848221115312","article-title":"Inflammatory bowel disease and immune-mediated inflammatory diseases: Looking at the less frequent associations","volume":"15","author":"Bezzio","year":"2022","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000454712","article-title":"How does the epidemiology of inflammatory bowel disease differ between East and West?","volume":"2","author":"Yang","year":"2017","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5217\/ir.2018.16.2.168","article-title":"Predicting outcomes to optimize disease management in inflammatory bowel disease in Japan","volume":"16","author":"Kobayashi","year":"2018","journal-title":"Intest. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1055\/s-0044-1791571","article-title":"Clinical manifestation of sensorineural hearing loss as an extraintestinal complication of inflammatory bowel disease","volume":"7","author":"Kinoshita","year":"2024","journal-title":"Int. J. Pract. Otolaryngol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"362","DOI":"10.5152\/iao.2020.6035","article-title":"Assessment of hearing function in children with inflammatory bowel disease","volume":"16","author":"Polat","year":"2020","journal-title":"J. Int. Adv. Otol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1007\/s10620-016-4074-9","article-title":"Hearing loss in patients with inflammatory bowel disease","volume":"61","author":"Wengrower","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1017\/S0022215115002583","article-title":"Cochlear involvement in patients with ulcerative colitis","volume":"130","author":"Sagit","year":"2016","journal-title":"J. Laryngol. Otol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.amjoto.2015.02.013","article-title":"Sudden hearing loss and Crohn disease: When Cogan syndrome must be suspected","volume":"36","author":"Tirelli","year":"2015","journal-title":"Am. J. Otolaryngol."},{"key":"ref_15","first-page":"104","article-title":"Nasal mucosa pyoderma vegetans in a patient with ulcerative colitis","volume":"7","author":"Vahedi","year":"2015","journal-title":"Middle East J. Dig. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4103\/0976-3147.143205","article-title":"Sensorineural hearing loss and status epilepticus associated with ulcerative colitis","volume":"6","author":"Yazici","year":"2015","journal-title":"J. Neurosci. Rural. Pract."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1093\/ibd\/izab272","article-title":"A rare case of hearing loss in a patient with ulcerative colitis","volume":"28","author":"Birda","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/ecco-jcc\/jjv128","article-title":"Cogan\u2019s syndrome in patients with inflammatory bowel disease: A case series","volume":"9","author":"Vavricka","year":"2015","journal-title":"J. Crohns Colitis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.anl.2018.04.004","article-title":"Pyoderma gangrenosum on the nose","volume":"45","author":"Tomioka","year":"2018","journal-title":"Auris Nasus Larynx"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.12998\/wjcc.v8.i20.4953","article-title":"Nasal mucosa pyoderma vegetans associated with ulcerative colitis: A case report","volume":"8","author":"Yu","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1620\/tjem.2022.J053","article-title":"Presence of phlebitis in aseptic nasal septal abscess complicated with ulcerative colitis","volume":"258","author":"Ishikawa","year":"2022","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zaseeva, T., Havazelet, S., Vainer, I., Matmon, E., Shouval, D., Avishai, G., Hod, R., and Gilony, D. (2025). Crohn\u2019s disease manifestation as an intranasal space-occupying lesion. Ear Nose Throat J., 01455613241310581.","DOI":"10.1177\/01455613241310581"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000495985","article-title":"Subclinical nasal and lung lymphocytosis in ulcerative colitis","volume":"3","author":"Marvisi","year":"2019","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/wjo2.17","article-title":"Chronic rhinosinusitis associated with inflammatory bowel disease: A pilot prospective prevalence study","volume":"8","author":"Dhillon","year":"2022","journal-title":"World J. Otorhinolaryngol. Head Neck Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5693\/djo.01.2014.08.001","article-title":"External dacryocystorhinostomy outcomes in patients with a history of dacryocystitis","volume":"21","author":"Lefebvre","year":"2015","journal-title":"Digit. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jpge.2016.03.002","article-title":"Tracheitis: A rare extra-intestinal manifestation of ulcerative colitis in children","volume":"23","author":"Nunes","year":"2016","journal-title":"GE Port. J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"NP375","DOI":"10.1177\/0145561320973772","article-title":"Granulomatous inflammation causing severe supraglottic edema and airway obstruction in a pediatric patient","volume":"101","author":"Colevas","year":"2020","journal-title":"Ear Nose Throat J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/jgf2.356","article-title":"Refractory aphthae in the epiglottis and supraglottic area due to Crohn\u2019s disease","volume":"21","author":"Hori","year":"2020","journal-title":"J. Gen. Fam. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.asjsur.2022.08.101","article-title":"Laryngeal involvement in a patient with Crohn\u2019s disease: A case report","volume":"46","author":"Yin","year":"2023","journal-title":"Asian J. Surg."},{"key":"ref_30","first-page":"101918","article-title":"Tracheobronchitis and laryngitis associated with Crohn\u2019s disease","volume":"46","author":"Nakai","year":"2023","journal-title":"Respir. Med. Case Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5223\/pghn.2018.21.3.214","article-title":"Lemierre syndrome in adolescent with active ulcerative colitis","volume":"21","author":"Grmoja","year":"2018","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1007\/s10620-017-4781-x","article-title":"Ocular, auricular, and oral manifestations of inflammatory bowel disease","volume":"62","author":"Fine","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/j.gastro.2018.04.012","article-title":"Risk of serious and opportunistic infections associated with treatment of inflammatory bowel diseases","volume":"155","author":"Kirchgesner","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jvoice.2017.09.021","article-title":"Laryngeal manifestations of inflammatory bowel disease","volume":"33","author":"Loos","year":"2019","journal-title":"J. Voice"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/ibd\/izz210","article-title":"Laryngeal carcinoma in patients with inflammatory bowel disease: Clinical outcomes and risk factors","volume":"26","author":"Ven","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/lary.70106","article-title":"Sterile nasal septal abscess in ulcerative colitis with crypt abscess-like neutrophilic infiltration","volume":"136","author":"Murayama","year":"2026","journal-title":"Laryngoscope"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"17463","DOI":"10.3748\/wjg.v20.i46.17463","article-title":"Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients","volume":"20","author":"Zippi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_38","first-page":"8764","article-title":"Neurological disorders and inflammatory bowel diseases","volume":"20","author":"Casella","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11894-019-0698-1","article-title":"Extraintestinal manifestations of inflammatory bowel disease: Epidemiology, etiopathogenesis, and management","volume":"21","author":"Garber","year":"2019","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ecco-jcc\/jjv213","article-title":"The first European evidence-based consensus on extraintestinal manifestations in inflammatory bowel disease","volume":"10","author":"Harbord","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"ref_41","first-page":"265","article-title":"Ear-nose-throat manifestations in inflammatory bowel diseases","volume":"20","author":"Zois","year":"2007","journal-title":"Ann. Gastroenterol."},{"key":"ref_42","first-page":"235","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"7","author":"Levine","year":"2011","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"609","DOI":"10.14740\/jocmr3465w","article-title":"Ear involvement in inflammatory bowel disease: A review of the literature","volume":"10","author":"Fousekis","year":"2018","journal-title":"J. Clin. Med. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1468-3083.2009.03304.x","article-title":"Oral manifestations of inflammatory bowel disease","volume":"24","author":"Hussein","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Vattier, A., Chapuis, J., Orliaguet, M., Bourhis, A., Cholet, F., Misery, L., and Boisram\u00e9, S. (2026). When Crohn\u2019s disease is confined to the mouth: A diagnostic challenge. J. Clin. Med., 15.","DOI":"10.3390\/jcm15010004"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3121\/cmr.2015.1307","article-title":"Oral manifestations of inflammatory bowel diseases: Two case reports","volume":"14","author":"Pereira","year":"2016","journal-title":"Clin. Med. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12664-021-01216-1","article-title":"Sensorineural hearing loss and ulcerative colitis in remission","volume":"41","author":"Bodh","year":"2022","journal-title":"Indian J. Gastroenterol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"630","DOI":"10.5455\/2320-6012.ijrms20150319","article-title":"A clinical study on association between hearing loss and inflammatory bowel disease in a population attending a hospital","volume":"3","author":"Akhter","year":"2017","journal-title":"Int. J. Res. Med. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10151-015-1349-7","article-title":"Symptomatic sensorineural hearing loss in patients with ulcerative colitis","volume":"19","author":"Casella","year":"2015","journal-title":"Tech. Coloproctol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.amjoto.2008.04.009","article-title":"Sensorineural hearing loss in patients with inflammatory bowel disease","volume":"30","author":"Karmody","year":"2009","journal-title":"Am. J. Otolaryngol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e44402","DOI":"10.1097\/MD.0000000000044402","article-title":"The causality between chronic rhinosinusitis and inflammatory bowel disease: A bidirectional Mendelian randomization analysis","volume":"104","author":"Liu","year":"2025","journal-title":"Medicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1378\/chest.06-1074","article-title":"Thoracic manifestations of inflammatory bowel disease","volume":"131","author":"Black","year":"2007","journal-title":"Chest"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Frumento, D., and Talu, S. (2025). Immunological linkages between inflammatory bowel diseases and type 2 diabetes. Biomedicines, 13.","DOI":"10.3390\/biomedicines13092224"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/5\/943\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:31:49Z","timestamp":1779723109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/5\/943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["medicina62050943"],"URL":"https:\/\/doi.org\/10.3390\/medicina62050943","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]}}}