{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:05:23Z","timestamp":1779725123001,"version":"3.53.1"},"reference-count":25,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: We aimed to determine whether preoperative systemic inflammatory markers derived from complete blood count differ between patients with intradural spinal tumors and healthy controls, and whether any such difference varies by pathological subtype or motor deficit status. Materials and Methods: Sixty-four patients who underwent surgery for histopathologically confirmed intradural spinal tumors between 2015 and 2023 were enrolled alongside 64 age- and sex-matched healthy controls. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and red cell distribution width (RDW) were calculated from preoperative complete blood count results. Comparisons were performed at the patient\u2013control level and stratified by pathological diagnosis (meningioma, schwannoma, ependymoma, other) and motor deficit status. Results: NLR (median 2.47 vs. 2.06; p &lt; 0.001), PLR (157.1 vs. 121.0; p &lt; 0.001), SII (706.1 vs. 595.0; p = 0.003), and PIV (404.2 vs. 287.0; p &lt; 0.001) were all significantly elevated in the tumor group, while LMR was significantly lower (3.66 vs. 4.34; p &lt; 0.001). RDW did not differ between groups (p = 0.420). Stratification by pathological subgroup and motor deficit status revealed no significant differences in any marker. Conclusion: Intradural spinal tumors\u2014including the predominantly benign cases that made up most of this cohort\u2014are accompanied by a detectable preoperative shift in systemic inflammatory markers, one that appears independent of tumor histology and neurological presentation. These findings demonstrate a measurable systemic inflammatory response in patients with intradural spinal tumors. However, the absence of differences across pathological subtypes and motor deficit status suggests that these markers reflect a generalized host response rather than tumor-specific characteristics, and their role in clinical decision-making remains to be clarified.<\/jats:p>","DOI":"10.3390\/medicina62050950","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:05:08Z","timestamp":1779721508000},"page":"950","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Systemic Inflammatory Marker Profile in Surgically Treated Intradural Spinal Tumors: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5971-3002","authenticated-orcid":false,"given":"Muhammet","family":"K\u0131rkge\u00e7it","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Megapoint Hospital, Kahramanmara\u015f 46100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6813-2064","authenticated-orcid":false,"given":"Hasan","family":"T\u00fcrko\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gaziantep City Hospital, Gaziantep 27470, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2816-6921","authenticated-orcid":false,"given":"Muharrem Furkan","family":"Y\u00fczba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University, Kahramanmara\u015f 46050, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3905-2206","authenticated-orcid":false,"given":"Emrullah Cem","family":"Kesilmez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University, Kahramanmara\u015f 46050, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u0131rat","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Aksaray Training and Research Hospital, Aksaray 68100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-2588","authenticated-orcid":false,"given":"Yusuf","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osmaniye Training and Research Hospital, Osmaniye 80010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9125-7316","authenticated-orcid":false,"given":"\u015eahin","family":"K\u0131rm\u0131z\u0131g\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gaziantep City Hospital, Gaziantep 27470, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9234-5908","authenticated-orcid":false,"given":"Kas\u0131m Zafer","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University, Kahramanmara\u015f 46050, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cupp, M.A., Cariolou, M., Tzoulaki, I., Aune, D., Evangelou, E., and Berlanga-Taylor, A.J. 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