{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:05:12Z","timestamp":1779879912169,"version":"3.53.1"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To evaluate ocular findings in women with cervical HPV positivity undergoing loop electrosurgical excision procedure (LEEP) for cervical dysplasia and to assess conjunctival\/eyelid papilloma and other ocular findings in this cohort. Materials and Methods: This single-center, prospective, cross-sectional observational study was conducted at a tertiary referral hospital between September 2021 and October 2023. Women in whom LEEP was planned because of cervical dysplasia were eligible for inclusion. Patients who consented to ophthalmologic evaluation underwent preoperative eye examination and were included in the study. For the final analysis, women with cervical HPV negativity were excluded. Demographic characteristics, cervical HPV status and subtype, colposcopic biopsy histopathology, final LEEP histopathology, and ophthalmologic findings were recorded prospectively. Ocular findings were classified as normal ocular findings, conjunctival\/eyelid papilloma, or other ocular findings. Results: A total of 75 women were included in the final analysis. Normal ocular findings were observed in 66 women (88.0%), conjunctival\/eyelid papilloma lesions were identified in 3\/75 (4.0%), and other ocular findings were identified in six (8.0%). There were no significant differences among the ocular finding groups in age, gravida, or parity. Alcohol use differed across ocular finding groups (p = 0.039), although this finding was based on only three patients in the papilloma group and should be regarded as exploratory. Ocular findings were associated with colposcopic biopsy histopathology (p = 0.016) but not with final LEEP histopathology. In exploratory adjusted analyses, no independent predictor of conjunctival\/eyelid papilloma or any other ocular pathology was identified. Conclusions: In this cohort, the majority of patients had normal ocular findings, and conjunctival\/eyelid papilloma lesions were identified in only three patients. The observed ocular findings did not support a clinically meaningful cervical\u2013ocular association in this cohort. Further studies with ocular tissue-based HPV testing are needed to investigate whether HPV is present in ocular lesions and whether these findings correspond to cervical HPV results.<\/jats:p>","DOI":"10.3390\/medicina62050969","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:19:52Z","timestamp":1779877192000},"page":"969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ocular Findings in Women with Cervical HPV Positivity and Cervical Dysplasia Undergoing Loop Electrosurgical Excision Procedure: A Prospective Cross-Sectional Study"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0493-5439","authenticated-orcid":false,"given":"Nazl\u0131 Aylin","family":"Vural","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Yozgat State Hospital, Yozgat 66100, Turkey"},{"name":"Molecular Oncology, Graduate School of Education, Istinye University, Istanbul 34396, Turkey"},{"name":"Department of Gynecologic Oncology, Basaksehir Cam and Sakura State Hospital, Health Sciences University, Istanbul 34668, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Mergen","sequence":"additional","affiliation":[{"name":"Care Vision Freiburg, 79098 Freiburg im Breisgau, Germany"},{"name":"Department of Ophthalmology, Basaksehir Cam and Sakura City Hospital, Health Sciences University, Istanbul 34668, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-4220","authenticated-orcid":false,"given":"Serkan","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Basaksehir Cam and Sakura City Hospital, Health Sciences University, Istanbul 34668, Turkey"},{"name":"Department of Ophthalmology, \u00c7orlu State Hospital, Tekirda\u011f 59850, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2859-5220","authenticated-orcid":false,"given":"Cafer","family":"Yelkenci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Basaksehir Cam and Sakura State Hospital, Health Sciences University, Istanbul 34668, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-472X","authenticated-orcid":false,"given":"Ecem Esma","family":"Ye\u011fin","sequence":"additional","affiliation":[{"name":"Biostatistics and Medical Informatics, Istinye University, Istanbul 34396, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-3558","authenticated-orcid":false,"given":"Nil\u00fcfer","family":"\u00c7etinkaya Kocadal","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Basaksehir Cam and Sakura State Hospital, Health Sciences University, Istanbul 34668, Turkey"},{"name":"Gynecologic Oncology, Department of Obstetrics and Gynecology, Yeditepe University, Istanbul 34755, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/01443615.2019.1634030","article-title":"Human papillomavirus and cervical cancer","volume":"40","author":"Okunade","year":"2020","journal-title":"J. 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