{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:05:14Z","timestamp":1779879914467,"version":"3.53.1"},"reference-count":20,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To evaluate the impact of Holmium Laser Enucleation of the Prostate (HoLEP) versus Transurethral Resection of the Prostate (TURP) on cognitive function and psychological well-being three months post-surgery. Materials and Methods: This prospective observational cohort study involved 150 patients undergoing surgical treatment for BPH; 132 patients (66 HoLEP, 66 TURP) completed baseline and 3-month follow-up evaluations. The Montreal Cognitive Assessment (MoCA) served as the primary measure of cognitive function, while the Mini-Mental State Examination (MMSE) functioned as a secondary measure. The Beck Anxiety Inventory and Beck Depression Inventory were utilized to assess individuals\u2019 mental states. We employed repeated-measures General Linear Models, adjusted for age and educational attainment, to examine temporal variations. Results: Baseline demographic, clinical, cognitive, and psychological characteristics were comparable among the groups. The modified analysis revealed no significant interaction between time and surgical procedure for MoCA (p = 0.405), indicating that both groups exhibited comparable cognitive trajectories. No significant differences were seen between the groups in the adjusted MoCA scores (p = 0.162). A minor, statistically insignificant temporal effect was observed (p = 0.058; partial \u03b72 = 0.028). Educational attainment independently forecasted cognitive performance (p = 0.024). The MMSE demonstrated a slight temporal effect (p = 0.015) with no interaction of approaches. Anxiety and depressive symptoms persisted uniformly and comparably among the groups. Conclusions: Three months post-surgery, neither HoLEP nor TURP was associated with a notable deterioration in cognitive performance. The surgical modality did not independently influence cognitive trajectory after adjusting for demographic variables. Contemporary endoscopic BPH surgery appears to be neurocognitively safe during the medium-term postoperative period.<\/jats:p>","DOI":"10.3390\/medicina62050971","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:19:52Z","timestamp":1779877192000},"page":"971","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Neurocognitive Outcomes Following Holmium Laser Enucleation and Transurethral Resection of the Prostate: A Prospective Cohort Study"],"prefix":"10.3390","volume":"62","author":[{"given":"Orkunt","family":"\u00d6zkaptan","sequence":"first","affiliation":[{"name":"Department of Urology, Health Sciences University, Kartal Dr. Lutfi Kirdar City Hospital, 34890, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-1986","authenticated-orcid":false,"given":"Cengiz","family":"\u00c7anakc\u0131","sequence":"additional","affiliation":[{"name":"Department of Urology, Health Sciences University, Kartal Dr. Lutfi Kirdar City Hospital, 34890, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0644-8282","authenticated-orcid":false,"given":"Erdin\u00e7","family":"Din\u00e7er","sequence":"additional","affiliation":[{"name":"Department of Urology, Health Sciences University, Kartal Dr. Lutfi Kirdar City Hospital, 34890, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-023X","authenticated-orcid":false,"given":"Osman Murat","family":"\u0130pek","sequence":"additional","affiliation":[{"name":"Department of Urology, Health Sciences University, Kartal Dr. Lutfi Kirdar City Hospital, 34890, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Burak","family":"Do\u011frusever","sequence":"additional","affiliation":[{"name":"Department of Urology, Health Sciences University, Kartal Dr. Lutfi Kirdar City Hospital, 34890, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuz","family":"T\u00fcrky\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Urology, Health Sciences University, Kartal Dr. Lutfi Kirdar City Hospital, 34890, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-5160","authenticated-orcid":false,"given":"Alper","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"Department of Urology, Health Sciences University, Kartal Dr. Lutfi Kirdar City Hospital, 34890, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sare Dilek","family":"\u00d6zkaptan","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology, Kartal Dr. Lutfi Kirdar City Hospital, 34890 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1097\/01.ju.0000155709.37840.fe","article-title":"Urologic diseases in America project: Benign prostatic hyperplasia","volume":"173","author":"Wei","year":"2005","journal-title":"J. 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