{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:57:35Z","timestamp":1781060255488,"version":"3.54.1"},"reference-count":93,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The cribriform plate (CP) functions as a dynamic neuroimmune interface through which olfactory nerve bundles exit the brain within a specialized perineural microenvironment (cpPME). While traditionally viewed as a passive structural barrier, emerging evidence positions the CP as a central hub for cerebrospinal fluid (CSF) drainage, glymphatic\u2013lymphatic clearance, and antigen presentation. This review provides a comprehensive understanding of recent advances in cpPME research, highlighting the adaptive remodeling of the immune landscape in response to neuroinflammation and aging. We critically evaluate the translational gap between rodent models and human physiology, discussing the implications for neurodegenerative diagnostics, neuroinflammatory conditions, infectious diseases and \u201cnose-to-brain\u201d therapeutic delivery. By integrating anatomical, physiological, and immunological perspectives, we offer a comprehensive framework for understanding the CP\u2019s role in CNS homeostasis and its potential as a transformative diagnostic and therapeutic target.<\/jats:p>","DOI":"10.3390\/medicina62061125","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:58:12Z","timestamp":1781053092000},"page":"1125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Cribriform Plate: A Multifaceted Neuroimmune Hub in CNS Health and Disease"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2486-4631","authenticated-orcid":false,"given":"Kad\u0131r","family":"Cet\u0131nkaya","sequence":"first","affiliation":[{"name":"Neurosurgery Department, Hitit Un\u0131vers\u0131ty Corum Erol Olcok Training and Research Hospital, 19000 Corum, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-8366","authenticated-orcid":false,"given":"Oktay","family":"Alg\u0131n","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Faculty, Ankara University, 06230 Ankara, T\u00fcrkiye"},{"name":"Interventional MR Clinical R&D Institute, Ankara University, 06100 Ankara, T\u00fcrkiye"},{"name":"National MR Research Center, Bilkent University, 06800 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104558","DOI":"10.1016\/j.ebiom.2023.104558","article-title":"Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves","volume":"91","author":"Spera","year":"2023","journal-title":"eBioMedicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s00018-020-03706-5","article-title":"Cerebrospinal fluid outflow: A review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics","volume":"78","author":"Proulx","year":"2021","journal-title":"Cell. 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