{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:53:16Z","timestamp":1785412396620,"version":"3.56.0"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020275","name":"Vilnius University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020275","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03nadee84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Premature ventricular contractions are among the most common arrhythmias encountered in clinical practice. However, this disorder can be associated with arrhythmia-induced cardiomyopathy or be the first sign of primary myocardial diseases. Certain morphologies of premature ventricular contractions are associated with a higher risk for sudden arrhythmia and cardiac dysfunction in the adult population. There is data on the clinical value and significance of the contraction morphology in adults, but there is a lack of such data for children. Materials and Methods: This observational prospective study of pediatric outpatients with premature ventricular contractions was conducted at Vilnius University Hospital Santaros Clinics. Inclusion criteria comprised children aged 3\u201317 years with more than 5% premature ventricular contractions over 24 h. Exclusion criteria included previously diagnosed congenital heart defects and cardiomyopathies, channelopathies, or the presence of any acute condition. The electrocardiographic morphology and measurements were assessed, analyzed, and described in this study. Results: The electrocardiograms of 80 patients were analyzed according to the ECG-estimated morphology of the arrhythmia complex, arrhythmic QRS complex duration, ratio with the normal QRS complex, and maximum deflection index in V5\u2013V6 derivations. Cardiac MRI abnormalities (8 of 30 MRI studies) was reliably associated with a PVC duration of &gt;150 ms and the maximal amount of extrasystoles per 24 h, with a median amount of 29.6%. A long postcoupling interval (&gt;0.9 s) was associated with PVC progression. Conclusions: In this exploratory pediatric cohort, wider PVC QRS duration and higher maximal PVC burden were associated with ventricular MRI abnormalities, while longer postcoupling interval was associated with PVC progression.<\/jats:p>","DOI":"10.3390\/medicina62061165","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:46:28Z","timestamp":1781588788000},"page":"1165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Clinical Role of Electrocardiographic Morphology of Premature Ventricular Contractions for Prognostic Outcomes in Children"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6139-6202","authenticated-orcid":false,"given":"Rita","family":"Kunigeliene","sequence":"first","affiliation":[{"name":"Clinic of Children\u2019s Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Universiteto St. 3, 01513 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7439-9478","authenticated-orcid":false,"given":"Germanas","family":"Marinskis","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Universiteto St. 3, 01513 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2703-3446","authenticated-orcid":false,"given":"Vytautas","family":"Usonis","sequence":"additional","affiliation":[{"name":"Clinic of Children\u2019s Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Universiteto St. 3, 01513 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2701-1669","authenticated-orcid":false,"given":"Odeta","family":"Kinciniene","sequence":"additional","affiliation":[{"name":"Clinic of Children\u2019s Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Universiteto St. 3, 01513 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.amjmed.2022.07.004","article-title":"Premature Ventricular Contractions (PVCs): A Narrative Review","volume":"135","author":"Klewer","year":"2022","journal-title":"Am. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00246-021-02556-7","article-title":"The Efficacy of Anti-Arrhythmic Drugs in Children with Idiopathic Frequent Symptomatic or Asymptomatic Premature Ventricular Complexes With or Without Asymptomatic Ventricular Tachycardia: A Retrospective Multi-Center Study","volume":"42","author":"Bertels","year":"2021","journal-title":"Pediatr. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00431-026-06750-8","article-title":"Spontaneous resolution of idiopathic ventricular arrhythmias in children: Clinical predictors and a probability-based scoring system","volume":"185","author":"Chueva","year":"2026","journal-title":"Eur. J. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"euaf167","DOI":"10.1093\/europace\/euaf167","article-title":"Premature ventricular contraction-induced ventricular dysfunction in children without structural heart disease: A systematic review and meta-analysis","volume":"27","author":"Flore","year":"2025","journal-title":"Europace"},{"key":"ref_5","first-page":"e6585","article-title":"The Ubiquitous Premature Ventricular Complex","volume":"12","author":"Koester","year":"2020","journal-title":"Cureus"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/clc.22697","article-title":"Assessment of subtle cardiac dysfunction in patients with frequent premature ventricular complexes by real-time three-dimensional speckle tracking echocardiography","volume":"40","author":"Ling","year":"2017","journal-title":"Clin. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/s00246-010-9740-7","article-title":"Frequent ventricular premature beats in children with a structurally normal heart: A cause for reversible left ventricular dysfunction?","volume":"31","author":"Kakavand","year":"2010","journal-title":"Pediatr. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Volpato, G., Falanga, U., Cipolletta, L., Conti, M.A., Grifoni, G., Ciliberti, G., Urbinati, A., Barbarossa, A., Stronati, G., and Fogante, M. (2021). Sports Activity and Arrhythmic Risk in Cardiomyopathies and Channelopathies: A Critical Review of European Guidelines on Sports Cardiology in Patients with Cardiovascular Diseases. Medicina, 57.","DOI":"10.3390\/medicina57040308"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e13067","DOI":"10.1111\/anec.13067","article-title":"Prognostic impact of morphology and duration of premature ventricular contractions in a population without structural heart disease","volume":"28","author":"Scorza","year":"2023","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.jacc.2014.08.003","article-title":"ACC\/AAP\/AHA\/ASE\/HRS\/SCAI\/SCCT\/SCMR\/SOPE 2014 Appropriate Use Criteria for Initial Transthoracic Echocardiography in Outpatient Pediatric Cardiology: A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Academy of Pediatrics, American Heart Association, American Society of Echocardiography, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Pediatric Echocardiography","volume":"64","author":"Campbell","year":"2014","journal-title":"JACC"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e014415","DOI":"10.1161\/CIRCIMAGING.122.014415","article-title":"Society for Cardiovascular Magnetic Resonance\/European Society of Cardiovascular Imaging\/American Society of Echocardiography\/Society for Pediatric Radiology\/North American Society for Cardiovascular Imaging Guidelines for the Use of Cardiac Magnetic Resonance in Pediatric Congenital and Acquired Heart Disease: Endorsed by The American Heart Association","volume":"15","author":"Fogel","year":"2022","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/ehjci\/jez164","article-title":"Multicentre reference values for cardiac magnetic resonance imaging derived ventricular size and function for children aged 0\u201318 years","volume":"21","author":"Sadighy","year":"2020","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1017\/S1047951115001110","article-title":"Premature ventricular contraction-induced cardiomyopathy in children","volume":"26","author":"Spector","year":"2016","journal-title":"Cardiol. Young"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/eurheartj\/ehv727","article-title":"Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: A position statement of the ESC working group on myocardial and pericardial diseases","volume":"37","author":"Pinto","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s00247-022-05521-5","article-title":"Ventricular function and tissue characterization by cardiac magnetic resonance imaging following hospitalization for multisystem inflammatory syndrome in children: A prospective study","volume":"53","author":"DiLorenzo","year":"2023","journal-title":"Pediatr. Radiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.3892\/etm.2017.4224","article-title":"Myocardial fibrosis in congenital and pediatric heart disease","volume":"13","author":"Tian","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/europace\/eur245","article-title":"HRS\/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA)","volume":"13","author":"Ackerman","year":"2011","journal-title":"Europace"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/HCO.0000000000000581","article-title":"Frequent premature ventricular beats in healthy children: When to ignore and when to treat?","volume":"34","author":"Cohen","year":"2019","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tcm.2018.09.014","article-title":"Treatment of ventricular arrhythmias: What\u2019s New?","volume":"29","author":"Markman","year":"2019","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Anderson, R.D., Kumar, S., Parameswaran, R., Wong, G., Voskoboinik, A., Sugumar, H., Watts, T., Sparks, P.B., Morton, J.B., and McLellan, A. (2019). Differentiating Right- and Left-Sided Outflow Tract Ventricular Arrhythmias: Classical ECG Signatures and Prediction Algorithms. Circ. Arrhythmia Electrophysiol., 12 .","DOI":"10.1161\/CIRCEP.119.007392"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1111\/jce.14152","article-title":"Twelve-lead electrocardiographic localization of idiopathic premature ventricular contraction origins","volume":"30","author":"Yamada","year":"2019","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_22","unstructured":"Ibarrola, M. (2019). Ventricular extrasystoles in athletes: What can be learned from the clinical history, clinical examination, the electrocardiogram and the initial approach?. E-J. Cardiol. Pract., 17."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.5152\/TurkArchPediatr.2024.24075","article-title":"The Prognosis of Idiopathic Premature Ventricular Beats in Children with Structurally Normal Hearts","volume":"59","author":"Ekici","year":"2024","journal-title":"Turk. Arch. Pediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"i23","DOI":"10.1093\/eurheartjsupp\/suae006","article-title":"Unlocking the enigma: Decoding premature ventricular complexes for effective clinical assessment and risk management","volume":"26","author":"Tatangelo","year":"2024","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Muser, D., Tritto, M., Mariani, M.V., Di Monaco, A., Compagnucci, P., Accogli, M., De Ponti, R., and Guarracini, F. (2021). Diagnosis and Treatment of Idiopathic Premature Ventricular Contractions: A Stepwise Approach Based on the Site of Origin. Diagnostics, 11.","DOI":"10.3390\/diagnostics11101840"},{"key":"ref_26","first-page":"17","article-title":"Frequent ventricular extrasystoles: Significance, prognosis and treatment","volume":"9","author":"Merino","year":"2011","journal-title":"ESC Counc. Cardiol. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/clc.23271","article-title":"Detection of concealed structural heart disease by imaging in patients with apparently idiopathic premature ventricular complexes: A review of current literature","volume":"42","author":"Sassone","year":"2019","journal-title":"Clin. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kunigeliene, R., Kinciniene, O., Marinskis, G., and Usonis, V. (2025). Predictors of Ventricular Abnormalities in Children with Idiopathic Ventricular Extrasystoles. Children, 12.","DOI":"10.3390\/children12020206"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1136\/heartjnl-2019-314922","article-title":"Outcomes of untreated frequent premature ventricular complexes with normal left ventricular function","volume":"105","author":"Lee","year":"2019","journal-title":"Heart"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/6\/1165\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:39:13Z","timestamp":1781843953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/6\/1165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["medicina62061165"],"URL":"https:\/\/doi.org\/10.3390\/medicina62061165","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}