{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T02:02:07Z","timestamp":1784512927081,"version":"3.55.0"},"reference-count":16,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To identify factors associated with hospital admission decisions among hematologic patients presenting to the emergency department (ED) and to evaluate the incremental contribution of clinical, laboratory, and process-related variables using a hierarchical modeling framework. Materials and Methods: Single-center, retrospective observational cohort study conducted between January 2016 and December 2018. Adult patients for whom a hematology consultation was requested at ED presentation were included. Hierarchical block modeling was used as a sequential multivariable logistic regression approach in which clinical, laboratory, and process-related variables were entered in separate blocks. Process-related variables were defined as ED workflow-related factors, including mode of arrival, timing of presentation, and transfusion requirement. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), Hosmer\u2013Lemeshow goodness-of-fit test, calibration plot, calibration slope\/intercept, and nested bootstrap internal validation. Results: Of 428 patients included, 297 (69.4%) were hospitalized. In the updated final model, impaired mental status (aOR 2.682; 95% CI 1.393\u20135.161), ambulance arrival (aOR 2.607; 95% CI 1.532\u20134.434), body temperature (aOR 1.399 per \u00b0C; 95% CI 1.049\u20131.866), respiratory rate (aOR 1.105 per breath\/min; 95% CI 1.019\u20131.197), and heart rate (aOR 1.023 per bpm; 95% CI 1.007\u20131.040) were independently associated with hospital admission. Transfusion requirement showed an inverse association with admission (aOR 0.397; 95% CI 0.244\u20130.644), whereas platelet count showed the same direction of association but did not reach statistical significance in the updated final model. The final model demonstrated moderate apparent discrimination (AUC 0.771; 95% CI 0.725\u20130.818), with no statistically significant lack of fit on the Hosmer\u2013Lemeshow test (p = 0.188). After nested bootstrap internal validation, the optimism-corrected AUC was 0.729. Conclusions: In hematologic patients presenting to the ED, admission decisions were associated mainly with acute physiological instability\u2014particularly impaired mental status and abnormal vital signs\u2014rather than by age or sex. These findings should be interpreted as exploratory associations with real-world disposition decisions, not as a validated tool for predicting objective outcomes such as mortality, ICU transfer, or 30-day adverse events.<\/jats:p>","DOI":"10.3390\/medicina62071385","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:47:32Z","timestamp":1784508452000},"page":"1385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated with Hospital Admission Decisions in Hematologic Emergency Department Patients: A Hierarchical Modeling Study"],"prefix":"10.3390","volume":"62","author":[{"given":"Osman","family":"Kuncan","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Burak","family":"Sayhan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Salt","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-6511","authenticated-orcid":false,"given":"Eray","family":"\u00c7elikt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.mayocp.2017.02.008","article-title":"Emergencies in Hematology and Oncology","volume":"92","author":"Halfdanarson","year":"2017","journal-title":"Mayo Clin. 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