{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:58:05Z","timestamp":1785430685635,"version":"3.56.0"},"reference-count":81,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005289","name":"Provincial Secretariat for Higher Education and Scientific Research, AP Vojvodina, Republic of Serbia","doi-asserted-by":"publisher","award":["003794555 2025 09418 003 000 000 001 04 002"],"award-info":[{"award-number":["003794555 2025 09418 003 000 000 001 04 002"]}],"id":[{"id":"10.13039\/501100005289","id-type":"DOI","asserted-by":"publisher"}]},{"award":["003794555 2025 09418 003 000 000 001 04 002"],"award-info":[{"award-number":["003794555 2025 09418 003 000 000 001 04 002"]}],"id":[{"id":"https:\/\/ror.org\/0348qv851","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Environmental exposure to endocrine-disrupting chemicals (EDCs) is increasingly recognized as a potential contributor to cancer-related biological variability; however, human biomonitoring data in oncology populations remain limited. The present study aimed to assess urinary concentrations of selected phenolic EDCs and their associations with cardiometabolic, hematological, inflammatory, and survival-related parameters in patients with advanced lung cancer. Materials and Methods: A total of 190 patients diagnosed with stage IIIB\/IV lung cancer were included in this study. Urinary concentrations of bisphenol A (BPA), bisphenol S (BPS), triclosan (TCS), and resorcinol (RCO) were determined using validated analytical methods. Associations between exposure biomarkers and clinical laboratory parameters were evaluated using sex-stratified statistical analyses and regression models adjusted for age and body mass index. Results: TCS was the most frequently quantified compound (29.47%), followed by BPS (27.37%), RCO (11.58%), and BPA (7.89%). Higher odds of TCS quantification were observed in patients with lung adenocarcinoma and a higher probability of BPA quantification in patients with squamous-cell carcinoma. Sex-specific exposure patterns were observed, with higher BPA and BPS concentrations measured among female patients. Exposure to phenolic EDCs was associated with alterations in kidney function biomarkers, liver enzyme activity, inflammatory cell profiles, and anthropometric indicators. In particular, BPA and BPS showed associations with renal function markers and systemic inflammatory parameters, while TCS exposure was related to reduced leukocyte subpopulations. Survival analysis demonstrates borderline associations for BPA between exposure groups. Conclusions: These findings provide novel human biomonitoring evidence linking exposure to phenolic endocrine-disrupting chemicals with systemic metabolic and inflammatory variability in patients with advanced lung cancer. The observed associations support the biological plausibility that environmental endocrine disruptors may contribute to interindividual heterogeneity in cancer-related physiological responses.<\/jats:p>","DOI":"10.3390\/medicina62071409","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:14:27Z","timestamp":1784621667000},"page":"1409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenolic Endocrine-Disrupting Chemical Exposure and Systemic Biomarker Variability in Patients with Lung Cancer"],"prefix":"10.3390","volume":"62","author":[{"given":"Larisa","family":"\u0110uri\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacy, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5286-3858","authenticated-orcid":false,"given":"Nata\u0161a","family":"Milo\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacy, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-5480","authenticated-orcid":false,"given":"Maja","family":"Milanovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacy, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6639-4987","authenticated-orcid":false,"given":"Danica","family":"Sazdani\u0107-Veliki\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for Pulmonary Oncology, University of Novi Sad, 21204 Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2342-915X","authenticated-orcid":false,"given":"Jana","family":"Pavlovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Fo\u010da, University of East Sarajevo, 73300 Fo\u010da, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milorad","family":"\u0160panovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Public Health of Vojvodina, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-6065","authenticated-orcid":false,"given":"Nata\u0161a","family":"Mili\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacy, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dua, K., Gupta, G., MacLoughlin, R., Singh, S.C., and Bhat, A.A. (2025). Chemical substances linked to lung cancer. Lung Cancer and Environmental Toxicants, Academic Press.","DOI":"10.1016\/B978-0-443-30120-9.00004-0"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-025-09219-0","article-title":"The mutagenic forces shaping the genomes of lung cancer in never smokers","volume":"644","author":"Zhang","year":"2025","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lungcan.2022.01.015","article-title":"Time to diagnosis and treatment of lung cancer: A systematic overview of risk factors, interventions and impact on patient outcomes","volume":"166","author":"Zhang","year":"2022","journal-title":"Lung Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","article-title":"The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification","volume":"10","author":"Travis","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41572-024-00551-9","article-title":"Non-small-cell lung cancer","volume":"10","author":"Hendriks","year":"2024","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.5732\/cjc.011.10059","article-title":"Lung carcinoma signaling pathways activated by smoking","volume":"30","author":"Wen","year":"2011","journal-title":"Chin. J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.trecan.2024.07.008","article-title":"Small cell lung cancer profiling: An updated synthesis of subtypes, vulnerabilities, and plasticity","volume":"10","author":"Redin","year":"2024","journal-title":"Trends Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"118574","DOI":"10.1016\/j.ecoenv.2025.118574","article-title":"Endocrine disrupting chemicals exposure and health: An umbrella review","volume":"302","author":"Chen","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"117225","DOI":"10.1016\/j.cca.2023.117225","article-title":"The effects of phthalate exposure on metabolic parameters in polycystic ovary syndrome","volume":"540","author":"Milankov","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cca.2020.05.009","article-title":"Can environmental pollutant bisphenol A increase metabolic risk in polycystic ovary syndrome?","volume":"507","author":"Sudji","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Haruna, I., and Obeng-Gyasi, E. (2026). Combined Effect of Per- and Polyfluoroalkyl Substances, Toxic Metals, Phthalates and Volatile Organic Compounds on Reproductive Hormones. Pollutants, 6.","DOI":"10.3390\/pollutants6020031"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gherman-Lencu, C.-C., Alexescu, T.-G., Mure\u0219anu, C., Gerdanovics, C.A., Milaciu, M.-V., and Iancu, D.M. (2026). Implications of Endocrine-Disrupting Chemicals for Human Health and Effective Methods for Prevention and Reduction. Toxics, 14.","DOI":"10.3390\/toxics14060515"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mili\u0107, N., Milanovi\u0107, M., Drlja\u010da, J., Sudji, J., and Milo\u0161evi\u0107, N. (2023). Challenges in the Analytical Preparation of a Biological Matrix in Analyses of Endocrine-Disrupting Bisphenols. Separations, 10.","DOI":"10.3390\/separations10040226"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Al-Ani, M., Al-Ani, Y., Ibrahim, S.S., Ibrahim, R.S., Kubatka, P., and B\u00fcsselberg, D. (2025). Bisphenol A (BPA) Modifies Cancer Signaling Pathways: A Neglected Global Health Threat. J. Xenobiot., 15.","DOI":"10.3390\/jox15060207"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"118480","DOI":"10.1016\/j.ecoenv.2025.118480","article-title":"Molecular mechanism of bisphenols induction of breast cancer through PGR revealed by network toxicology and transcriptomics integration analysis","volume":"300","author":"Yuan","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"114889","DOI":"10.1016\/j.fct.2024.114889","article-title":"Evaluation of effects of bisphenol analogs AF, S, and F on viability, proliferation, production of selected cancer-related factors, and expression of selected transcripts in Caov-3 human ovarian epithelial cell line","volume":"191","author":"Scsukova","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105827","DOI":"10.1016\/j.tiv.2024.105827","article-title":"Bisphenol S enhances the cell proliferation ability of prostate cancer cells by regulating the expression of SDS","volume":"98","author":"Ju","year":"2024","journal-title":"Toxicol. Vitr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.biopha.2014.09.003","article-title":"Bisphenol A stimulates human lung cancer cell migration via upregulation of matrix metalloproteinases by GPER\/EGFR\/ERK1\/2 signal pathway","volume":"68","author":"Zhang","year":"2014","journal-title":"Biomed. Pharmacother."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chen, H., Jiang, T., Yang, Y., Cai, G., Jiang, Y., and Ouyang, W. (2025). Exploring the carcinogenic potential of bisphenol A in lung adenocarcinoma: Molecular mechanisms, key gene insights, and immune microenvironment impacts. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1647807"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"19643","DOI":"10.1007\/s11356-021-13071-w","article-title":"A comprehensive review on the carcinogenic potential of bisphenol A: Clues and evidence","volume":"28","author":"Khan","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tiv.2018.10.005","article-title":"Bisphenol S (BPS) triggers the migration of human non-small cell lung cancer cells via upregulation of TGF-\u03b2","volume":"54","author":"Song","year":"2019","journal-title":"Toxicol. Vitr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"111851","DOI":"10.1016\/j.toxlet.2026.111851","article-title":"Triclosan\u2019s interference with endocrine signalling: A mechanistic investigation","volume":"417","author":"Sharma","year":"2026","journal-title":"Toxicol. Lett."},{"key":"ref_23","first-page":"25119","article-title":"Comprehensive insight into triclosan-from widespread occurrence to health outcomes","volume":"30","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Cai, X., Ning, C., and Fan, L. (2023). Triclosan is associated with breast cancer via oxidative stress and relative telomere length. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1163965"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"119364","DOI":"10.1016\/j.ecoenv.2025.119364","article-title":"Association between triclosan\/triclocarban exposure and esophageal carcinoma development: A nested case-control study in a prospective cohort","volume":"306","author":"Song","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_26","first-page":"73","article-title":"Triclosan induces ROS-dependent cell death and autophagy in A375 melanoma cells","volume":"20","author":"Jin","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Winitthana, T., Lawanprasert, S., and Chanvorachote, P. (2014). Triclosan potentiates epithelial-to-mesenchymal transition in anoikis-resistant human lung cancer cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110851"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1021\/envhealth.5c00019","article-title":"Long-Term Maternal Exposure to Triclosan Provokes Pulmonary Fibrosis in Mouse Offspring","volume":"3","author":"Liu","year":"2025","journal-title":"Environ. Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"143009","DOI":"10.1016\/j.chemosphere.2024.143009","article-title":"Resorcinol as \u201cendocrine disrupting chemical\": Are thyroid-related adverse effects adequately documented in reptiles? In vivo experimentation in lizard Podarcis siculus","volume":"364","author":"Sciarrillo","year":"2024","journal-title":"Chemosphere"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/rtph.2002.1585","article-title":"Toxicology review and risk assessment of resorcinol: Thyroid effects","volume":"36","author":"Lynch","year":"2002","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.toxlet.2018.03.027","article-title":"Environmental and occupational exposure to resorcinol in Finland","volume":"298","author":"Porras","year":"2018","journal-title":"Toxicol. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3109\/13880209.2013.869231","article-title":"Ardisiphenol D, a resorcinol derivative identified from Ardisia brevicaulis, exerts antitumor effect through inducing apoptosis in human non-small-cell lung cancer A549 cells","volume":"52","author":"Zhao","year":"2014","journal-title":"Pharm. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2333767","DOI":"10.1155\/2023\/2333767","article-title":"Alkylresorcinols as a new type of gut microbiota regulators influencing immune therapy efficiency in lung cancer treatment","volume":"2023","author":"Shestopalov","year":"2023","journal-title":"Adv. Gut Microbiome Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.fct.2015.07.003","article-title":"Estimation of in vivo and in vitro exposure to bisphenol A as food contaminant","volume":"83","author":"Sudji","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Rodriguez-Lara, V., and Avila-Costa, M.R. (2021). An Overview of Lung Cancer in Women and the Impact of Estrogen in Lung Carcinogenesis and Lung Cancer Treatment. Front. Med., 8.","DOI":"10.3389\/fmed.2021.600121"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrendo.2010.87","article-title":"Environmental causes of cancer: Endocrine disruptors as carcinogens","volume":"6","author":"Soto","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11834","DOI":"10.1021\/acs.est.5b02135","article-title":"Urinary Concentrations of Bisphenol A and Three Other Bisphenols in Convenience Samples of U.S. Adults during 2000\u20132014","volume":"49","author":"Ye","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"114119","DOI":"10.1016\/j.ijheh.2023.114119","article-title":"Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014\u20132021)","volume":"249","author":"Govarts","year":"2023","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_39","unstructured":"European Environmental Agency (EEA) (2026, April 26). Human Exposure to Bisphenols (Signal). Available online: https:\/\/www.eea.europa.eu\/en\/european-zero-pollution-dashboards\/indicators\/human-exposure-to-bisphenol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"120323","DOI":"10.1016\/j.envpol.2022.120323","article-title":"Association between urinary bisphenol analogue concentrations and lung cancer in adults: A case-control study","volume":"315","author":"Qu","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2298\/JSC150721095M","article-title":"Seasonal variations of bisphenol A in the Danube River by the municipality of Novi Sad, Serbia","volume":"81","author":"Sudji","year":"2016","journal-title":"J. Serb. Chem. Soc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"114344","DOI":"10.1016\/j.envpol.2020.114344","article-title":"Occurrence and assessment of environmental risks of endocrine disrupting compounds in drinking, surface and wastewaters in Serbia","volume":"262","author":"Insa","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.envres.2017.09.021","article-title":"Urinary levels of triclosan and triclocarban in several Asian countries, Greece and the USA: Association with oxidative stress","volume":"160","author":"Iyer","year":"2018","journal-title":"Environ. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/cod.14236","article-title":"Systematic review on skin adverse effects of important hazardous hair cosmetic ingredients with a focus on hairdressers","volume":"88","author":"Uter","year":"2023","journal-title":"Contact Dermat."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Feraco, A., Armani, A., Gorini, S., Camajani, E., Quattrini, C., Filardi, T., Karav, S., Strollo, R., Caprio, M., and Lombardo, M. (2024). Gender Differences in Dietary Patterns and Eating Behaviours in Individuals with Obesity. Nutrients, 16.","DOI":"10.3390\/nu16234226"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Yuan, Y., Chen, Q., Ding, X., Zhong, Q., and Zhong, X. (2024). Endocrine disrupting chemical Bisphenol A and its association with cancer mortality: A prospective cohort study of NHANES. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1341789"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"28494","DOI":"10.1038\/s41598-024-79260-y","article-title":"The association between metabolic syndrome and lung cancer risk: A Mendelian randomization study","volume":"14","author":"Wei","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Cho, I.Y., Han, K., Shin, D.W., Cho, M.H., Yoo, J.E., and Cho, J.H. (2021). Associations of Variability in Metabolic Parameters with Lung Cancer: A Nationwide Population-Based Study. Cancers, 13.","DOI":"10.3390\/cancers13081982"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chest.2023.08.003","article-title":"Association of Metabolic Syndrome With Risk of Lung Cancer: A Population-Based Prospective Cohort Study","volume":"165","author":"Li","year":"2024","journal-title":"Chest"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jtho.2021.04.020","article-title":"Visceral Obesity Promotes Lung Cancer Progression-Toward Resolution of the Obesity Paradox in Lung Cancer","volume":"16","author":"Barbi","year":"2021","journal-title":"J. Thorac. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Jovi\u010di\u0107-Bata, J., Sazdani\u0107-Veliki\u0107, D., and \u0160evo, M. (2025). Lifestyle, Environmental, Occupational, and Dietary Risk Factors in Small-Cell vs. Non-Small-Cell Advanced Lung Cancer Patients: Is There a Connection?. Cancers, 17.","DOI":"10.3390\/cancers17050864"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/jnci\/djx286","article-title":"Overall and Central Obesity and Risk of Lung Cancer: A Pooled Analysis","volume":"110","author":"Yu","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3390\/jox13040049","article-title":"Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases","volume":"13","author":"Kang","year":"2023","journal-title":"J. Xenobiot."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kumar, M., Sarma, D.K., Shubham, S., Kumawat, M., Verma, V., Prakash, A., and Tiwari, R. (2020). Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases. Front. Public Health, 8.","DOI":"10.3389\/fpubh.2020.553850"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3988\/jcn.2024.0221","article-title":"Cardiovascular Autonomic Dysfunction Before and After Chemotherapy in Cancer Patients","volume":"20","author":"Yoon","year":"2024","journal-title":"J. Clin. Neurol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Palacios-Valladares, J.R., Martinez-Jimenez, Y.I., Morillon-Torres, V., Rivera-Maya, O.B., G\u00f3mez, R., and Calderon-Aranda, E.S. (2024). Bisphenol A and Its Emergent Substitutes: State of the Art of the Impact of These Plasticizers on Oxidative Stress and Its Role in Vascular Dysfunction. Antioxidants, 13.","DOI":"10.3390\/antiox13121468"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Hawryszko, M., S\u0142awi\u0144ski, G., Tomasik, B., and Lewicka, E. (2023). Cardiac Arrhythmias in Patients Treated for Lung Cancer: A Review. Cancers, 15.","DOI":"10.3390\/cancers15245723"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Aryan, L., Younessi, D., Zargari, M., Banerjee, S., Agopian, J., Rahman, S., Borna, R., Ruffenach, G., Umar, S., and Eghbali, M. (2020). The Role of Estrogen Receptors in Cardiovascular Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124314"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12940-024-01114-x","article-title":"Association of same-day urinary phenol levels and cardiac electrical alterations: Analysis of the Fernald Community Cohort","volume":"23","author":"Rubinstein","year":"2024","journal-title":"Environ. Health"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e00336","DOI":"10.1016\/j.plabm.2023.e00336","article-title":"Evaluation of creatine kinase (CK)-MB to total CK ratio as a diagnostic biomarker for primary tumors and metastasis screening","volume":"37","author":"Li","year":"2023","journal-title":"Pract. Lab Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12302-021-00586-9","article-title":"The bisphenol F and bisphenol S and cardiovascular disease: Results from NHANES 2013\u20132016","volume":"34","author":"Wang","year":"2022","journal-title":"Environ. Sci. Eur."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"102804","DOI":"10.1016\/j.eclinm.2024.102804","article-title":"Global, regional, and national burden of tracheal, bronchus, and lung cancer and its risk factors from 1990 to 2021: Findings from the global burden of disease study 2021","volume":"75","author":"Kuang","year":"2024","journal-title":"EClinicalMedicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41572-020-00235-0","article-title":"Small-cell lung cancer","volume":"7","author":"Rudin","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Sladi\u010d, M., Smrkolj, \u0160., Kav\u0161ek, G., Imamovic-Kumalic, S., Verdenik, I., and Virant-Klun, I. (2025). Bisphenol A in the Urine: Association with Urinary Creatinine, Impaired Kidney Function, Use of Plastic Food and Beverage Storage Products but Not with Serum Anti-M\u00fcllerian Hormone in Ovarian Malignancies. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26104811"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Guo, T.L., Eldefrawy, F., and Guo, K.M. (2025). Liver Toxicity Induced by Exposure to Bisphenol Analogs at Environmentally Relevant Levels: Insights from a Literature Review on Multiple Species. Livers, 5.","DOI":"10.3390\/livers5020024"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.toxrep.2017.10.006","article-title":"Bisphenol S impairs blood functions and induces cardiovascular risks in rats","volume":"4","author":"Pal","year":"2017","journal-title":"Toxicol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"100351","DOI":"10.1016\/j.emcon.2024.100351","article-title":"Exposure of Bisphenols (BPs) to hepatocellular carcinoma (HCC) patients and non-HCC patients: Association with liver function biomarkers","volume":"10","author":"Li","year":"2024","journal-title":"Emerg. Contam."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"120251","DOI":"10.1016\/j.envres.2024.120251","article-title":"Insights into the accumulation and hepatobiliary transport of bisphenols (BPs) in liver and bile","volume":"263","author":"Ding","year":"2024","journal-title":"Environ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Allegrini, S., Garcia-Gil, M., Pesi, R., Camici, M., and Tozzi, M.G. (2022). The Good, the Bad and the New about Uric Acid in Cancer. Cancers, 14.","DOI":"10.3390\/cancers14194959"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Jiang, S., Wang, Y., Wang, Z., Xu, Y., Li, X., Sun, M., and Li, B. (2024). Bisphenol A and its alternatives bisphenol S and F exposure with serum uric acid levels, hyperuricemia, and gout prevalence among US adults: A nationally representative cross-sectional study. BMC Public Health, 24.","DOI":"10.1186\/s12889-024-17883-6"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"109104","DOI":"10.1016\/j.envres.2019.109104","article-title":"Urinary bisphenol A and its analogues and haemato-biochemical alterations of pregnant women in Korea","volume":"182","author":"Kang","year":"2020","journal-title":"Environ. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8279789","DOI":"10.1155\/2019\/8279789","article-title":"Prevalence of Anemia and Associated Factors among Newly Diagnosed Patients with Solid Malignancy at Tikur Anbessa Specialized Hospital, Radiotherapy Center, Addis Ababa, Ethiopia","volume":"2019","author":"Kifle","year":"2019","journal-title":"Adv. Hematol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"171701","DOI":"10.1016\/j.scitotenv.2024.171701","article-title":"Dynamic alterations in physiological and biochemical indicators of Cirrhinus mrigala hatchlings: A sublethal exposure of triclosan","volume":"924","author":"Dar","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/15376516.2020.1836102","article-title":"Effects of bisphenol A and S on blood coagulation: In vivo, in vitro and in silico approaches in toxicodynamic","volume":"31","author":"Chagas","year":"2021","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Aguilar-Cazares, D., Chavez-Dominguez, R., Marroquin-Muci\u00f1o, M., Perez-Medina, M., Benito-Lopez, J.J., Camarena, A., Rumbo-Nava, U., and Lopez-Gonzalez, J.S. (2022). The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.929572"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.critrevonc.2017.06.002","article-title":"The role of the systemic inflammatory response in predicting outcomes in patients with advanced inoperable cancer: Systematic review and meta-analysis","volume":"116","author":"Dolan","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Moik, F., Z\u00f6chbauer-M\u00fcller, S., Posch, F., Pabinger, I., and Ay, C. (2020). Systemic Inflammation and Activation of Haemostasis Predict Poor Prognosis and Response to Chemotherapy in Patients with Advanced Lung Cancer. Cancers, 12.","DOI":"10.3390\/cancers12061619"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Liao, S., Sun, H., Lu, H., Wu, J., Wu, J., Wu, Z., Xi, J., Liao, W., and Wang, Y. (2025). Neutrophil-to-lymphocyte ratio-based prognostic score can predict outcomes in patients with advanced non-small cell lung cancer treated with immunotherapy plus chemotherapy. BMC Cancer, 25.","DOI":"10.1186\/s12885-025-13811-y"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2147\/OTT.S153290","article-title":"Prognostic utility of baseline neutrophil-to-lymphocyte ratio in patients receiving immune checkpoint inhibitors: A review and meta-analysis","volume":"11","author":"Sacdalan","year":"2018","journal-title":"Onco Targets Ther."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Chennamadhavuni, A., Abushahin, L., Jin, N., Presley, C.J., and Manne, A. (2022). Risk Factors and Biomarkers for Immune-Related Adverse Events: A Practical Guide to Identifying High-Risk Patients and Rechallenging Immune Checkpoint Inhibitors. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.779691"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"19596","DOI":"10.1038\/s41598-024-70214-y","article-title":"Derived neutrophil-to-lymphocyte ratio has the potential to predict safety and outcomes of durvalumab after chemoradiation in non-small cell lung cancer","volume":"14","author":"Sugimoto","year":"2024","journal-title":"Sci. Rep."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/7\/1409\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:11:38Z","timestamp":1784625098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/62\/7\/1409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":81,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["medicina62071409"],"URL":"https:\/\/doi.org\/10.3390\/medicina62071409","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]}}}