{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:04:45Z","timestamp":1785243885935,"version":"3.55.0"},"reference-count":74,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Peri-implantitis, a biofilm-driven inflammatory disease that causes progressive loss of the bone supporting dental implants, is common and difficult to treat: mechanical debridement cannot fully decontaminate the implant surface, and antibiotic adjuncts act non-selectively while promoting resistance. Antimicrobial peptides (AMPs) have emerged as a promising preventive strategy. As cationic, membrane-disrupting molecules they kill a broad spectrum of organisms with a low propensity to select for resistance, and as host-defense peptides they additionally modulate inflammation and promote epithelial and connective-tissue repair. This review examines AMP-functionalized titanium as a prospective strategy against peri-implantitis through a dermatological lens, drawing on the established roles of the cathelicidin LL-37 and the \u03b2-defensins in cutaneous and oral wound healing. We argue that the peri-implant transmucosal interface behaves as a healing epithelial barrier, so that a single class of host-defense peptides can address two goals usually pursued separately\u2014suppressing the peri-implant biofilm and reinforcing the soft-tissue seal. Because peri-implant disease initiates at the transmucosal region, we give particular attention to the abutment or transmucosal collar as the primary sealing target, and we consider how the concept extends to zirconia and hybrid components. The evidence assembled here, however, is predominantly preclinical, derived from in vitro and animal studies, and does not yet demonstrate clinical prevention of peri-implantitis in patients. After surveying peri-implant epidemiology, microbiology, AMP biology, surface-engineering strategies, and the in vivo evidence, we appraise the translational barriers\u2014stability, cytotoxicity, cost, regulation, and the absence of human trials\u2014that remain. We conclude that biologically intelligent, multifunctional peptide coatings represent a rational direction for next-generation implant surfaces.<\/jats:p>","DOI":"10.3390\/medicina62081463","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:45:26Z","timestamp":1785239126000},"page":"1463","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual-Function Antimicrobial Peptides as a Prospective Strategy Against Peri-Implantitis: Bridging Cutaneous Wound Healing and the Peri-Implant Soft-Tissue Seal"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-8271","authenticated-orcid":false,"given":"Laura","family":"Maghiar","sequence":"first","affiliation":[{"name":"Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Str., No. 1, 410087 Oradea, Romania"},{"name":"Department of Dermatovenerology, Clinical County Emergency Hospital Bihor, Gheorghe Doja Str., No. 65, 410169 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrada","family":"Iftode","sequence":"additional","affiliation":[{"name":"Department of Toxicology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-5466","authenticated-orcid":false,"given":"Andreea-Adriana","family":"Neam\u021bu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, Clinical County Emergency Hospital of Arad, Andrenyi Karoly Str., No. 2\u20134, 310037 Arad, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d Clinical County Emergency Hospital Timi\u0219oara, Liviu Rebreanu Boulevard, No. 156, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodor-Andrei","family":"Maghiar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Str., No. 1, 410087 Oradea, Romania"},{"name":"Department of Surgery, Pelican Hospital, Corneliu Coposu Str., No. 2, 410450 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea Maria","family":"Cristea","sequence":"additional","affiliation":[{"name":"Department of Toxicology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-5261","authenticated-orcid":false,"given":"Alina","family":"Anton","sequence":"additional","affiliation":[{"name":"Department of Toxicology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4581-8487","authenticated-orcid":false,"given":"Andreea-Mihaela","family":"Kis","sequence":"additional","affiliation":[{"name":"Department of Management and Communication in Dental Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1552-7961","authenticated-orcid":false,"given":"Valentin-Cristian","family":"Iovin","sequence":"additional","affiliation":[{"name":"Doctoral School Department, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Department III Functional Sciences, Physiology Discipline, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Centre of Immuno-Physiology and Biotechnologies (CIFBIOTEH), Department of Functional Sciences, Physiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marge","family":"Cristian","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Str., No. 1, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1087-8522","authenticated-orcid":false,"given":"Gabriel","family":"Armencea","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Radiology, Faculty of Dental Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219 Str., No. 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra Florina","family":"Bodog","sequence":"additional","affiliation":[{"name":"Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410073 Oradea, Romania"},{"name":"Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Street, No. 1, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina-Adriana","family":"Dehelean","sequence":"additional","affiliation":[{"name":"Department of Toxicology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4766-5945","authenticated-orcid":false,"given":"Carmen","family":"Neam\u021bu","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, \u201cVasile Goldis\u201d Western University of Arad, Liviu Rebreanu Str., No. 86, 310045 Arad, Romania"},{"name":"Department of Surgery I, Clinical County Emergency Hospital of Arad, Andrenyi Karoly Str., No. 2\u20134, 310037 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-6162","authenticated-orcid":false,"given":"Andrei Paul","family":"Tent","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo-Facial Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Str., No. 1, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S286","DOI":"10.1111\/jcpe.12957","article-title":"Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and 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