{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T09:29:21Z","timestamp":1786958961053,"version":"build-2736575974"},"reference-count":26,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Sinonasal inverted papilloma (IP) is a benign yet locally aggressive tumour associated with a clinically relevant risk of recurrence and malignant transformation. While surgical outcomes are well documented, data on long-term patient-reported quality of life (QoL) remain limited and are often based on short-term or single time-point assessments using disease-specific instruments alone. Materials and Methods: We conducted a single-centre observational cohort study of adults with histologically confirmed IP treated endoscopically. Patients were followed in a university-affiliated otorhinolaryngology outpatient clinic and completed the Sino-Nasal Outcome Test-22 (SNOT-22) at each visit; from 2022 onwards, the generic WHOQOL-BREF questionnaire was additionally administered. Longitudinal SNOT-22 trajectories were analysed using generalised additive models and linear mixed-effects models. In a subgroup of patients, retrospectively recalled preoperative SNOT-22 and WHOQOL-BREF scores were used only for exploratory paired pre\u2013post comparisons. Results: Sixty-nine patients were included. Mean follow-up was 63.1 \u00b1 27.8 months, and recurrence occurred in 21 of 69 patients (30%). A total of 461 postoperative SNOT-22 assessments with complete follow-up time data were included in the longitudinal analysis, with a median of six assessments per patient. Mean postoperative SNOT-22 score was 25.4 \u00b1 19.8, and longitudinal postoperative trajectories showed a largely stable course over time. In the paired exploratory subgroup (n = 34), retrospectively recalled preoperative SNOT-22 scores were higher than postoperative scores, although these exploratory findings should be interpreted cautiously because baseline PROMs were not collected prospectively. Exploratory paired comparisons of WHOQOL-BREF showed higher postoperative scores in the physical, psychological and environmental domains. Conclusions: Patients with sinonasal IP treated endoscopically can achieve favourable and largely stable long-term disease-specific and generic QoL. No single baseline clinical factor showed a clear association with postoperative SNOT-22 scores in the longitudinal models. Combining disease-specific and generic patient-reported outcome measures with longitudinal modelling may support more informed postoperative counselling in this rare, recurrent condition, while structured surveillance remains essential.<\/jats:p>","DOI":"10.3390\/medicina62081567","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:05:41Z","timestamp":1786953941000},"page":"1567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Postoperative Patient-Reported Quality of Life After Endoscopic Surgery for Sinonasal Inverted Papilloma: A Longitudinal Cohort Study"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4507-5113","authenticated-orcid":false,"given":"Marcelina","family":"Niemiec-Urba\u0144czyk","sequence":"first","affiliation":[{"name":"Department of Laryngology and Laryngological Oncology, Upper-Silesian Medical Centre,\u00a0Medical University of Silesia, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Humeniuk-Arasiewicz","sequence":"additional","affiliation":[{"name":"Department of Laryngology and Laryngological Oncology, Upper-Silesian Medical Centre,\u00a0Medical University of Silesia, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-4920","authenticated-orcid":false,"given":"Karolina","family":"Goroszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Laryngology and Laryngological Oncology, Upper-Silesian Medical Centre,\u00a0Medical University of Silesia, 40-635 Katowice, Poland"},{"name":"Department of Otorhinolaryngology and Laryngological Oncology in Zabrze, Medical University of Silesia, 41-800 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u017cyna","family":"Stryjewska-Makuch","sequence":"additional","affiliation":[{"name":"Department of Laryngology and Laryngological Oncology, Upper-Silesian Medical Centre,\u00a0Medical University of Silesia, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Gl\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Allergology and Clinical Immunology in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.anorl.2016.03.006","article-title":"Sinonasal inverted papilloma: From diagnosis to treatment","volume":"133","author":"Lisan","year":"2016","journal-title":"Eur. 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