{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:22:08Z","timestamp":1787566928384,"version":"build-2736575974"},"reference-count":25,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Stenting isolated Medina 0,0,1 ostial side-branch lesions can result in geographic miss or protrusion into the main vessel. Drug-coated balloon (DCB) angioplasty avoids a permanent implant, but lesion-specific outcome data remain limited. We assessed procedural performance, bailout stenting, and 6- and 12-month outcomes after an intended DCB-only strategy. Materials and Methods: In this retrospective, single-center observational cohort study, we screened 170 patients who underwent coronary DCB treatment at a single center between 1 January 2023 and 31 July 2025. Thirty-one patients with de novo isolated Medina 0,0,1 lesions were included. The primary endpoint was 12-month target lesion failure (TLF), defined as cardiovascular death, target-vessel myocardial infarction, or clinically driven target lesion revascularization (TLR). Results: DCB-only strategy success was achieved in 29\/31 patients (93.5%), post-DCB angiographic success in 29\/31 (93.5%), and study-defined overall procedural success in 31\/31 (100%). Final TIMI grade 3 flow after DCB was present in 30\/31 patients; no flow-limiting dissection occurred. Two patients required bailout stenting, one because of deterioration to TIMI grade 2 flow and one because of residual stenosis &gt;30% with recoil. Thirty patients were alive with documented follow-up at 12 months; one patient died from a non-cardiovascular cause at month 1. No TLF was recorded within 12 months. One clinically driven TLR for target-lesion restenosis occurred at month 20, outside the prespecified window. Conclusions: In this selected cohort, an intended DCB-only strategy avoided stent implantation in most patients and had a low bailout rate. The findings support procedural feasibility but do not establish comparative efficacy. Larger prospective studies are required.<\/jats:p>","DOI":"10.3390\/medicina62091620","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:03:41Z","timestamp":1787558621000},"page":"1620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug-Coated Balloon Angioplasty for Isolated Medina 0,0,1 Ostial Side-Branch Lesions: Procedural Outcomes, Bailout Stenting, and 12-Month Clinical Follow-Up"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2231-126X","authenticated-orcid":false,"given":"Ebru","family":"\u015eahin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Memorial Ankara Hospital, 06520 \u00c7ankaya, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansu","family":"Akdeniz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Memorial Ankara Hospital, 06520 \u00c7ankaya, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beg\u00fcm","family":"Say\u0131n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Memorial Ankara Hospital, 06520 \u00c7ankaya, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Memorial Ankara Hospital, 06520 \u00c7ankaya, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-6332","authenticated-orcid":false,"given":"Fehmi","family":"Ka\u00e7maz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Memorial Ankara Hospital, 06520 \u00c7ankaya, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Oto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Memorial Ankara Hospital, 06520 \u00c7ankaya, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e06","DOI":"10.15420\/icr.2020.30","article-title":"Contemporary management of isolated ostial side branch disease: An evidence-based approach to Medina 001 bifurcations","volume":"16","author":"Suleiman","year":"2021","journal-title":"Interv. 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