{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:22:08Z","timestamp":1787566928859,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Conduction disorders (CDs) and permanent pacemaker implantation (PPI) remain among the most common complications after transcatheter aortic valve implantation (TAVI). Given their potential impact on long-term outcomes, improved preprocedural identification of patients at high risk for new-onset CDs is increasingly important. We investigated whether selected preprocedural inflammatory and fibrotic biomarkers, along with echocardiographic indices of regional myocardial remodeling, were associated with new-onset CDs after TAVI. Materials and Methods: This single-center prospective observational study included 112 patients with severe aortic stenosis undergoing TAVI. Peripheral blood samples were obtained within 24 h before TAVI for measurement of inflammatory and fibrotic biomarkers, including interleukin-6 (IL-6), C-reactive protein (CRP), CRP-to-albumin ratio (CAR), procalcitonin, ferritin, lactate dehydrogenase, and transforming growth factor-\u03b21. The primary outcome was the occurrence of new-onset CDs during the index hospitalization or within three months after TAVI. Results: New-onset CDs occurred in 58 patients (51.8%). IL-6 showed the strongest association with the outcome in univariable analysis (OR per 1-SD increase, 9.55; 95% CI 3.00\u201330.40; p &lt; 0.001), remained associated after adjustment for selected clinical and procedural predictors in exploratory models (adjusted OR 10.70; 95% CI 2.43\u201347.07; p = 0.002), and demonstrated the highest, although moderate, discriminatory performance among the evaluated biomarkers (AUC 0.730; 95% CI 0.637\u20130.823). CRP and CAR were higher in patients with CDs and were significant in univariable analysis, but showed weaker and less consistent adjusted associations. Among echocardiographic markers, AB strain ratio \u2265 2 was the most consistent imaging correlate in exploratory biomarker\u2013echocardiographic models. Conclusions: Elevated preprocedural IL-6 was the biomarker most consistently associated with new-onset CDs after TAVI. These findings suggest that higher preprocedural IL-6 levels may reflect patient-specific susceptibility to new-onset CDs after TAVI and could have potential value as an adjunctive biomarker, alongside echocardiographic assessment, for preprocedural risk evaluation, with further validation required in larger prospective studies.<\/jats:p>","DOI":"10.3390\/medicina62091623","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:03:41Z","timestamp":1787558621000},"page":"1623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preprocedural Biomarkers of Inflammation and Fibrosis and Echocardiographic Markers of Myocardial Remodeling in New-Onset Conduction Disorders After Transcatheter Aortic Valve Implantation"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5314","authenticated-orcid":false,"given":"Gordana","family":"Ba\u010di\u0107","sequence":"first","affiliation":[{"name":"Clinic for Cardiovascular Diseases, Clinical Hospital Centre Rijeka, Tome Stri\u017ei\u0107a 3, 51000 Rijeka, Croatia"},{"name":"Department of Internal Medicine, Faculty of Medicine, University of Rijeka, Bra\u0107e Branchetta 20, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8937-437X","authenticated-orcid":false,"given":"Davorka","family":"Luli\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Cardiovascular Diseases, Clinical Hospital Centre Rijeka, Tome Stri\u017ei\u0107a 3, 51000 Rijeka, Croatia"},{"name":"Department of Internal Medicine, Faculty of Medicine, University of Rijeka, Bra\u0107e Branchetta 20, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4525-9103","authenticated-orcid":false,"given":"Fabio","family":"Kadum","sequence":"additional","affiliation":[{"name":"Clinic for Cardiovascular Diseases, Clinical Hospital Centre Rijeka, Tome Stri\u017ei\u0107a 3, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snje\u017eana Hrabri\u0107","family":"Vlah","sequence":"additional","affiliation":[{"name":"Clinical Department of Laboratory Diagnostics, Clinical Hospital Centre Rijeka, Tome Stri\u017ei\u0107a 3, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9668-291X","authenticated-orcid":false,"given":"Ivana","family":"Smoljan","sequence":"additional","affiliation":[{"name":"Clinic for Cardiovascular Diseases, Clinical Hospital Centre Rijeka, Tome Stri\u017ei\u0107a 3, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-5559","authenticated-orcid":false,"given":"Vjekoslav","family":"Tomuli\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Cardiovascular Diseases, Clinical Hospital Centre Rijeka, Tome Stri\u017ei\u0107a 3, 51000 Rijeka, Croatia"},{"name":"Department of Internal Medicine, Faculty of Medicine, University of Rijeka, Bra\u0107e Branchetta 20, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-5944","authenticated-orcid":false,"given":"Sun\u010dica","family":"Buljevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Rijeka, Bra\u0107e Branchetta 20, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5031-2975","authenticated-orcid":false,"given":"Alen","family":"Ru\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Cardiovascular Diseases, Clinical Hospital Centre Rijeka, Tome Stri\u017ei\u0107a 3, 51000 Rijeka, Croatia"},{"name":"Department of Internal Medicine, Faculty of Medicine, University of Rijeka, Bra\u0107e Branchetta 20, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2582938","DOI":"10.1155\/2020\/2582938","article-title":"TAVR: A review of current practices and considerations in low-risk patients","volume":"2020","author":"Spears","year":"2020","journal-title":"J. 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