{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:18:25Z","timestamp":1787944705025,"version":"build-2784847793"},"reference-count":15,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Autoimmune liver diseases (AILD), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), frequently lead to end-stage liver disease requiring transplantation. The factors associated with post-transplant mortality in recipients with autoimmune liver diseases (AILDs) remain incompletely characterized. We aimed to evaluate the clinical, laboratory, disease-related, and comorbidity factors associated with post-transplant mortality in this population. Materials and Methods: This retrospective cohort study included 94 AILD recipients (26 AIH, 28 PBC, 40 PSC) transplanted between 2004 and 2025. We analyzed clinical, laboratory, transplant-related variables, and comorbidities (Charlson Comorbidity Index [CCI]). We assessed survival using Kaplan\u2013Meier and Cox regression analyses. Early mortality was defined as death within 90 days after transplantation. Results: Overall mortality was 17.0% (16\/94). Mortality rates were 28.6%, 15.4%, and 10.0% in PBC, AIH, and PSC, respectively, without a statistically significant between-group difference (p = 0.313). Among 93 recipients with ascertainable follow-up, 8 deaths occurred within 90 days (8.6%). In the exploratory Cox regression analysis, preoperative creatinine showed the strongest association with mortality (HR = 8.67 per 1 mg\/dL increase, p &lt; 0.001). Transplant age (HR = 1.06 per year, p = 0.010) and disease duration (HR = 1.09 per year, p = 0.004) were also associated with mortality. These associations remained statistically significant in the exploratory multivariable model. MELD, MELD-Na, and MELD 3.0 were not significantly associated with post-transplant mortality in this cohort. Because of the limited number of deaths, the multivariable findings should be regarded as hypothesis-generating. Documented and treated acute rejection was recorded in 32.2% of recipients. In an exploratory analysis, higher BMI was associated with increased odds of this outcome; however, histopathological confirmation was not systematically available. Conclusions: In this single-center AILD cohort, preoperative serum creatinine, disease duration, age at transplantation, and comorbidity burden showed associations with post-transplant mortality, whereas the evaluated liver severity scores were not significantly associated with mortality. These exploratory findings require confirmation in larger multicenter cohorts before they can be incorporated into post-transplant risk-stratification models.<\/jats:p>","DOI":"10.3390\/medicina62091650","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:33:52Z","timestamp":1787942032000},"page":"1650","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the Factors That Predict Post-Transplant Mortality in Autoimmune Liver Disease Recipients"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-0956","authenticated-orcid":false,"given":"Sencan","family":"Acar","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Istanbul Florence Nightingale Hospital, Istanbul 34381, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Yildiray","family":"Yuzer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gayrettepe Florence Nightingale Hospital, Istanbul 34349, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Yaman","family":"Tokat","sequence":"additional","affiliation":[{"name":"Department of Surgery, Acibadem Hospital Group, Istanbul 34758, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101546","DOI":"10.1016\/j.jhepr.2025.101546","article-title":"Epidemiology, comorbidities, treatment and outcomes of autoimmune liver diseases: A French nationwide study","volume":"7","author":"Corpechot","year":"2025","journal-title":"JHEP Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/LVT.0000000000000419","article-title":"Recurrence of autoimmune liver diseases after transplantation: Review and expert opinion statement","volume":"31","author":"Corpechot","year":"2025","journal-title":"Liver Transpl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/LVT.0000000000000374","article-title":"Pursuing living donor liver transplantation improves outcomes of patients with autoimmune liver diseases: An intention-to-treat analysis","volume":"30","author":"Jones","year":"2024","journal-title":"Liver Transpl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/ajt.16864","article-title":"Long-term outcome after living donor liver transplantation. 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