{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:51:56Z","timestamp":1794009116224,"version":"4.8.0"},"reference-count":193,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Oskar Fischer Project"},{"DOI":"10.13039\/100032958","name":"Elhapa Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032958","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Attention-deficit\/hyperactivity disorder (ADHD) is increasingly recognized as a lifespan neurodevelopmental condition with far-reaching consequences for functioning and health that extend well beyond its core signs and symptoms. This narrative review synthesizes evidence on the real-world impact of ADHD across the lifespan, with a focus on academic and occupational outcomes, interpersonal and family functioning, risk-taking and behavioral outcomes, accidental and sport-related injuries, physical and medical health burdens, substance use disorders, sexual health risks, and mortality. Materials and Methods: A structured search of PubMed, Scopus, and Web of Science supplemented by reference-list screening was conducted to identify relevant clinical studies, epidemiological studies, longitudinal investigations, systematic reviews, and meta-analyses published between 2000 and 2025. Evidence was synthesized narratively, with greater interpretive weight given to systematic reviews and meta-analyses, large epidemiological datasets, longitudinal studies, and investigations accounting for important potential confounding factors. Results: Findings indicate that ADHD is associated with substantial impairments across functional, behavioral, and health domains. However, the strength and magnitude of these associations vary and may be influenced by symptom presentation, neurocognitive characteristics, psychiatric comorbidities, lifestyle behaviors, and broader clinical and contextual factors, with evidence of bidirectional relationships for some outcomes. These findings caution against uniformly interpreting adverse outcomes as direct causal consequences of ADHD and support interconnected neurocognitive, reward\/motivational, emotional, and environmental pathways linking ADHD features with downstream impairment. Clinically, the evidence underscores the importance of assessing functional impairment alongside ADHD signs and symptoms. Conclusions: Overall, ADHD is associated with substantial and heterogeneous burdens across the lifespan, highlighting the need for multidimensional assessment, further longitudinal and mechanistic research, and timely access to evidence-based interventions.<\/jats:p>","DOI":"10.3390\/medicina62091661","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:08:58Z","timestamp":1788142138000},"page":"1661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional Impairments and Adverse Outcomes Associated with ADHD: A Literature Review"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7070-8835","authenticated-orcid":false,"given":"Farzad","family":"Salehpour","sequence":"first","affiliation":[{"name":"Texas Consortium in Behavioral Neuroscience, Department of Psychology, The University of Texas at Austin, 108 E. Dean Keeton Stop A8000, Austin, TX 78712, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-0775","authenticated-orcid":false,"given":"Francisco","family":"Gonzalez-Lima","sequence":"additional","affiliation":[{"name":"Texas Consortium in Behavioral Neuroscience, Department of Psychology, The University of Texas at Austin, 108 E. Dean Keeton Stop A8000, Austin, TX 78712, USA"},{"name":"Interdisciplinary Neuroscience Program, Department of Psychiatry and Behavioral Sciences, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1038\/nrdp.2015.20","article-title":"Attention-deficit\/hyperactivity disorder","volume":"6","author":"Faraone","year":"2015","journal-title":"Nat. Rev. Dis. 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