{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:15:54Z","timestamp":1788671754761,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007033","name":"Eisai Korea Inc.","doi-asserted-by":"crossref","award":["4-2024-0700"],"award-info":[{"award-number":["4-2024-0700"]}],"id":[{"id":"10.13039\/501100007033","id-type":"DOI","asserted-by":"crossref"}]},{"award":["4-2024-0700"],"award-info":[{"award-number":["4-2024-0700"]}],"id":[{"id":"https:\/\/ror.org\/02z4faz68","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019265","name":"Yuhan Corporation","doi-asserted-by":"crossref","award":["4-2025-0044"],"award-info":[{"award-number":["4-2025-0044"]}],"id":[{"id":"10.13039\/100019265","id-type":"DOI","asserted-by":"crossref"}]},{"award":["4-2025-0044"],"award-info":[{"award-number":["4-2025-0044"]}],"id":[{"id":"https:\/\/ror.org\/00bv1jr75","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032301","name":"Samsung Bioepis Co., Ltd.","doi-asserted-by":"crossref","award":["4-2025-1066"],"award-info":[{"award-number":["4-2025-1066"]}],"id":[{"id":"10.13039\/100032301","id-type":"DOI","asserted-by":"crossref"}]},{"award":["4-2025-1066"],"award-info":[{"award-number":["4-2025-1066"]}],"id":[{"id":"https:\/\/ror.org\/02a6d4p26","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Samil Pharmaceutical Co., Ltd.","award":["4-2025-1087"],"award-info":[{"award-number":["4-2025-1087"]}]},{"name":"Samil Pharmaceutical Co., Ltd.","award":["LFN-26-I01"],"award-info":[{"award-number":["LFN-26-I01"]}]},{"award":["4-2025-1087"],"award-info":[{"award-number":["4-2025-1087"]}],"id":[{"id":"https:\/\/ror.org\/05ke98p93","id-type":"ROR","asserted-by":"publisher"}]},{"award":["LFN-26-I01"],"award-info":[{"award-number":["LFN-26-I01"]}],"id":[{"id":"https:\/\/ror.org\/05ke98p93","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This study examined whether positivity for any antineutrophil cytoplasmic antibody (ANCA) at diagnosis was associated with subsequent advanced systemic complications during follow-up in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). Materials and Methods: We retrospectively reviewed the medical records of 271 patients with MPA or GPA enrolled in the ANCA-associated vasculitis cohort at a tertiary hospital. Any ANCA positivity was defined as the presence of any of the following: myeloperoxidase-ANCA, proteinase 3-ANCA, perinuclear ANCA, or cytoplasmic ANCA. Subsequent advanced systemic complications during follow-up, such as all-cause mortality and end-stage kidney disease (ESKD), were evaluated. Results: The median age of the 271 patients with MPA or GPA was 62.0 years, and 239 and 32 were identified as ANCA-positive and ANCA-negative vasculitis, respectively. During follow-up, 47 patients (17.3%) died, and 52 (19.2%) progressed to ESKD. In a cross-sectional comparative analysis, ESKD occurred significantly more frequently in ANCA-positive patients than in ANCA-negative patients. Among the five subsequent advanced systemic complications of MPA and GPA, ANCA-negative patients exhibited a significantly higher cumulative ESKD-free survival rate than ANCA-positive patients. However, in multivariable Cox proportional hazards analysis adjusted for age, sex, AAV subtype, and baseline serum creatinine, ANCA positivity was not independently associated with subsequent ESKD. Conclusions: Any ANCA positivity at diagnosis was associated with subsequent ESKD in unadjusted analyses but was not an independent predictor after adjustment for baseline renal function and other clinically relevant covariates.<\/jats:p>","DOI":"10.3390\/medicina62091699","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:07:32Z","timestamp":1788538052000},"page":"1699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Any Circulating ANCA Positivity at Diagnosis and Subsequent End-Stage Kidney Disease in Microscopic Polyangiitis and Granulomatosis with Polyangiitis"],"prefix":"10.3390","volume":"62","author":[{"given":"Jang Woo","family":"Ha","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Yeop","family":"Whang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-3697","authenticated-orcid":false,"given":"Oh Chan","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Beom","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-3341","authenticated-orcid":false,"given":"Sang-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/ard.2006.054593","article-title":"Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies","volume":"66","author":"Watts","year":"2007","journal-title":"Ann. 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