{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:12:24Z","timestamp":1788772344231,"version":"build-2803163510"},"reference-count":65,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: In this study, we investigate the relationship between the state of consciousness and the whole white matter integrity at the chronic stage in diffuse axonal injury (DAI) patients, using tract-based spatial statistics (TBSS). Materials and Methods: Twenty-seven chronic DAI patients and 22 healthy controls were enrolled. Patients were divided into a disorder of consciousness (DOC) group (n = 11, Coma Recovery Scale-Revised [CRS-R] score &lt; 23) and a non-DOC group (n = 16, CRS-R score = 23). Fractional anisotropy (FA) values across 48 subcortical white matter regions of interest (ROIs), defined by the Johns Hopkins University atlas, were analyzed using TBSS to evaluate group differences. Results: The groups significantly differed on FA values of 48 ROIs (Pillai\u2019s trace = 1.000, p &lt; 0.05). The Tukey\u2019s HSD test revealed that the FA values of 44 ROIs (except for the column and body of fornix, right corticospinal tract, left retrolenticular part of internal capsule, and left uncinate fasciculus) among the 48 ROIs of the DOC group were significantly lower than those of the non-DOC group, whereas the FA values of all 48ROIs of the DOC group were significantly lower than those of the control group (p &lt; 0.05). On the other hand, except for the bilateral corticospinal tract, the FA values of 46 ROIs among the 48 ROIs of the non-DOC group were significantly lower than those of the control group (p &lt; 0.05). Conclusions: In DAI patients, the state of consciousness was related to injury severity in most subcortical neural structures.<\/jats:p>","DOI":"10.3390\/medicina62091708","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:07:06Z","timestamp":1788768426000},"page":"1708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in the Subcortical White Matter Integrity Based on the Disorder of Consciousness at the Chronic Stage of Diffuse Axonal Injury: A Tract-Based Spatial Statistics Study"],"prefix":"10.3390","volume":"62","author":[{"given":"Sung Ho","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 170 Hyeonchung-ro, Namku, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Min Jye","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 170 Hyeonchung-ro, Namku, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-6813","authenticated-orcid":false,"given":"Dong Hyun","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Special Creative Convergence, College of Rehabilitation Sciences, Daegu University, 201 Daegu-Daero, Jillyang-eup, Gyeongsan-si 38453, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/0269905031000149542","article-title":"Acute confusion following traumatic brain injury","volume":"18","author":"Sherer","year":"2004","journal-title":"Brain Inj."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/02699059209034950","article-title":"Epidemiological findings in traumatic post-comatose unawareness","volume":"6","author":"Sazbon","year":"1992","journal-title":"Brain Inj."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1080\/026990596123918","article-title":"International Working Party on the Management of the Vegetative State: Summary report","volume":"10","author":"Andrews","year":"1996","journal-title":"Brain Inj."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1053\/apmr.2001.25137","article-title":"Current concepts: Diffuse axonal injury-associated traumatic brain injury","volume":"82","author":"Meythaler","year":"2001","journal-title":"Arch. 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