{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:21:31Z","timestamp":1793650891186,"version":"4.5.1"},"reference-count":64,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Background: The intraovarian administration of autologous platelet-rich plasma (PRP) acts beneficially for the stimulation of follicle production in women presenting different forms of ovarian dysfunction. This pilot study aimed to evaluate and provide significant data regarding the efficacy of PRP to rejuvenate the ovaries. Methods: A total of 253 women aged 22\u201356 years, were divided into five groups, based on their status. All participants signed for informed consent for the current study. Blood sampling, preparation of PRP and intraovarian infusion of the latter were performed on all participants. The evaluation of PRP efficacy, a two-month follow-up detecting the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and anti-mullerian hormone (AMH), was performed for all participants. For women with advanced ages (&gt;48 years), the restoration and regularity of the menstrual cycle were additionally evaluated. Results: After the two-month follow-up, the majority of the participants presented improvement in their hormonal profiles. Additionally, 17% of the women in this pilot study successfully conceived. The restoration of the menstrual cycle was detected in 15% of the women with advanced ages. Conclusions: Intraovarian infusion of autologous PRP exhibited remarkable evidence and promising results to restore ovarian insufficiency.<\/jats:p>","DOI":"10.3390\/medicines10030019","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T04:28:41Z","timestamp":1677558521000},"page":"19","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical Benefit of Autologous Platelet-Rich Plasma Infusion in Ovarian Function Rejuvenation: Evidence from a Before-After Prospective Pilot Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9940-308X","authenticated-orcid":false,"given":"Athanasios","family":"Garavelas","sequence":"first","affiliation":[{"name":"Institute of Life, IASO Maternity Hospital, 37-39, Kifissias Avenue, 151 23 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-190X","authenticated-orcid":false,"given":"Panagiotis","family":"Mallis","sequence":"additional","affiliation":[{"name":"Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 Soranou Efessiou Street, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-6294","authenticated-orcid":false,"given":"Efstathios","family":"Michalopoulos","sequence":"additional","affiliation":[{"name":"Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 Soranou Efessiou Street, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eros","family":"Nikitos","sequence":"additional","affiliation":[{"name":"Institute of Life, IASO Maternity Hospital, 37-39, Kifissias Avenue, 151 23 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5114\/pm.2018.78550","article-title":"Premature ovarian insufficiency\u2014Aetiopathology, epidemiology, and diagnostic evaluation","volume":"17","author":"Rudnicka","year":"2018","journal-title":"Menopause Rev."},{"key":"ref_2","first-page":"360","article-title":"Premature ovarian insufficiency in general practice: Meeting the needs of women","volume":"46","author":"Nguyen","year":"2017","journal-title":"Aust. 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