{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:46:54Z","timestamp":1789962414664,"version":"4.0.1"},"reference-count":144,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Background: Gabapentin (GBP)-induced movement disorders (MDs) are under-recognized adverse drug reactions. They are commonly not discussed with patients, and their sudden occurrence can lead to misdiagnosis. This literature review aims to evaluate the clinical\u2013epidemiological profile, pathological mechanisms, and management of GBP-associated MD. Methods: Two reviewers identified and assessed relevant reports in six databases without language restriction between 1990 and 2023. Results: A total of 99 reports of 204 individuals who developed a MD associated with GBP were identified. The MDs encountered were 135 myoclonus, 22 dyskinesias, 7 dystonia, 3 akathisia, 3 stutterings, 1 myokymia, and 1 parkinsonism. The mean and median ages were 54.54 (SD: 17.79) and 57 years (age range: 10\u201389), respectively. Subjects were predominantly male (53.57%). The mean and median doses of GBP when the MD occurred were 1324.66 (SD: 1117.66) and 1033 mg\/daily (GBP dose range: 100\u20139600), respectively. The mean time from GBP-onset to GBP-associated MD was 4.58 weeks (SD: 8.08). The mean recovery time after MD treatment was 4.17 days (SD: 4.87). The MD management involved GBP discontinuation. A total of 82.5% of the individuals had a full recovery in the follow-up period. Conclusions: Myoclonus (GRADE A) and dyskinesia (GRADE C) were the most common movement disorders associated with GBP.<\/jats:p>","DOI":"10.3390\/medicines10090052","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:23:42Z","timestamp":1693995822000},"page":"52","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gabapentin-Associated Movement Disorders: A Literature Review"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6179-2177","authenticated-orcid":false,"given":"Jamir Pitton","family":"Rissardo","sequence":"first","affiliation":[{"name":"Neurology Department, Cooper University Hospital, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Medeiros Araujo de Matos","sequence":"additional","affiliation":[{"name":"Medicine Department, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-853, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8024-2354","authenticated-orcid":false,"given":"Ana Let\u00edcia","family":"Fornari Caprara","sequence":"additional","affiliation":[{"name":"Medicine Department, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.seizure.2021.06.028","article-title":"Brain Concentrations of Glutamate and GABA in Human Epilepsy: A Review","volume":"91","author":"Sarlo","year":"2021","journal-title":"Seizure"},{"key":"ref_2","unstructured":"Johnson, D.S., and Li, J.J. (2013). The Art of Drug Synthesis, John Wiley & Sons."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1046\/j.1471-4159.1995.64052125.x","article-title":"Transport of Gabapentin, a Gamma-Amino Acid Drug, by System l Alpha-Amino Acid Transporters: A Comparative Study in Astrocytes, Synaptosomes, and CHO Cells","volume":"64","author":"Su","year":"1995","journal-title":"J. Neurochem."},{"key":"ref_4","unstructured":"Meldrum, B.S., and Porter, R.J. (1986). Current Problems in Epilepsy: New Anticonvulsant Drugs, John Libbey & Company."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1136\/jnnp.50.6.682","article-title":"Gabapentin as an Antiepileptic Drug in Man","volume":"50","author":"Crawford","year":"1987","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0920-1211(94)90034-5","article-title":"The Long-Term Safety and Efficacy of Gabapentin (Neurontin\u00ae) as Add-on Therapy in Drug-Resistant Partial Epilepsy","volume":"18","author":"Group","year":"1994","journal-title":"Epilepsy Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40265-022-01810-3","article-title":"Gabapentinoids for Pain: A Review of Published Comparative Effectiveness Trials and Data Submitted to the FDA for Approval","volume":"83","author":"Williams","year":"2023","journal-title":"Drugs"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/WNF.0000000000000334","article-title":"Gabapentin-Associated Urinary Incontinence: A Case Verified by Rechallenge","volume":"42","author":"Rissardo","year":"2019","journal-title":"Clin. Neuropharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0304-3959(02)00255-5","article-title":"Gabapentin in Neuropathic Pain Syndromes: A Randomised, Double-Blind, Placebo-Controlled Trial","volume":"99","author":"Serpell","year":"2002","journal-title":"Pain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12856","DOI":"10.1523\/JNEUROSCI.2700-10.2010","article-title":"The A2\u03b4 Ligand Gabapentin Inhibits the Rab11-Dependent Recycling of the Calcium Channel Subunit A2\u03b4-2","volume":"30","author":"Dolphin","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ebiom.2019.03.008","article-title":"Gabapentin Increases Expression of \u03b4 Subunit-Containing GABAA Receptors","volume":"42","author":"Yu","year":"2019","journal-title":"eBioMedicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0149-2918(95)80067-0","article-title":"Efficacy and Tolerability of Gabapentin in Clinical Practice","volume":"17","year":"1995","journal-title":"Clin. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1017\/pan.2018.26","article-title":"No Longer Lost in Translation: Evidence That Google Translate Works for Comparative Bag-of-Words Text Applications","volume":"26","author":"Schoonvelde","year":"2018","journal-title":"Political Anal."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jankovic, J., Hallett, M., Okun, M.S., Comella, C.L., and Fahn, S. (2021). Principles and Practice of Movement Disorders E-Book, Elsevier Health Sciences.","DOI":"10.1016\/B978-0-323-31071-0.00026-3"},{"key":"ref_15","unstructured":"Ma, F. (2022). Encyclopedia of Gerontology and Population Aging, Springer."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A Method for Estimating the Probability of Adverse Drug Reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Rissardo, J.P., and Caprara, A.L.F. (2023). Fluoroquinolone-Associated Movement Disorder: A Literature Review. Medicines, 10.","DOI":"10.3390\/medicines10060033"},{"key":"ref_18","first-page":"A249","article-title":"Gabapentin-Associated Myoclonus","volume":"45","year":"1995","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/j.1528-1157.1996.tb00537.x","article-title":"Movement Disorders Associated with the Use of Gabapentin","volume":"37","author":"Reeves","year":"1996","journal-title":"Epilepsia"},{"key":"ref_20","first-page":"203","article-title":"Gabapentin Related Myoclonus","volume":"37","author":"Scheyer","year":"1996","journal-title":"Epilepsia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0920-1211(97)00078-8","article-title":"High Dose Gabapentin in Refractory Partial Epilepsy: Clinical Observations in 50 Patients","volume":"29","author":"Wilson","year":"1998","journal-title":"Epilepsy Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1528-1157.2000.tb00192.x","article-title":"Myoclonus Associated with the Use of Gabapentin","volume":"41","author":"Diedrich","year":"2000","journal-title":"Epilepsia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00002826-200001000-00010","article-title":"Asterixis Induced by Gabapentin","volume":"23","author":"Jacob","year":"2000","journal-title":"Clin. Neuropharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1046\/j.1528-1157.2001.44000.x","article-title":"Myoclonus in Epilepsy Patients with Anticonvulsive Add-on Therapy with Pregabalin","volume":"42","author":"Huppertz","year":"2001","journal-title":"Epilepsia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1191\/0269216303Pm772cr","article-title":"Myoclonic Jerks Associated with Gabapentin","volume":"17","author":"Scullin","year":"2003","journal-title":"Palliat. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0278-5846(03)00166-0","article-title":"Asterixis and Toxic Encephalopathy Induced by Gabapentin","volume":"28","author":"Sechi","year":"2004","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/01.PHM.0000151943.06257.64","article-title":"Asterixis Related to Gabapentin as a Cause of Falls","volume":"84","author":"Babiy","year":"2005","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1592\/phco.2005.25.12.1817","article-title":"Gabapentin-Induced Neurologic Toxicities","volume":"25","author":"Bookwalter","year":"2005","journal-title":"Pharmacotherapy"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.0013-9580.2005.20804.x","article-title":"Gabapentin-Induced Myoclonus in End-Stage Renal Disease","volume":"46","author":"Zhang","year":"2005","journal-title":"Epilepsia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neucli.2006.12.003","article-title":"Drug-Induced Myoclonus: A French Pharmacovigilance Database Study","volume":"36","author":"Gardette","year":"2006","journal-title":"Neurophysiol. Clin."},{"key":"ref_31","first-page":"495","article-title":"Gabapentin-Induced Myoclonus in a Patient with End-Stage Renal Disease","volume":"24","author":"Han","year":"2006","journal-title":"J. Korean Neurol. Assoc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s00415-005-0970-1","article-title":"Gabapentin-Induced Severe Myoclonus in a Patient with Impaired Renal Function","volume":"253","author":"Holtkamp","year":"2006","journal-title":"J. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1111\/j.1528-1167.2007.01198.x","article-title":"Life-Threatening Status Epilepticus Following Gabapentin Administration in a Patient with Benign Adult Familial Myoclonic Epilepsy","volume":"48","author":"Striano","year":"2007","journal-title":"Epilepsia"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3340\/jkns.2008.43.5.237","article-title":"Myoclonus Induced by the Use of Gabapentin","volume":"43","author":"Cho","year":"2008","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/mds.21911","article-title":"Gabapentin-Induced Myoclonus: Case Report","volume":"23","author":"Ege","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.clinthera.2008.09.004","article-title":"A Probable Case of Gabapentin-Related Reversible Hearing Loss in a Patient with Acute Renal Failure","volume":"30","author":"Pierce","year":"2008","journal-title":"Clin. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1002\/mds.22286","article-title":"Pregabalin- and Gabapentin-Associated Myoclonus in a Patient with Chronic Renal Failure","volume":"24","author":"Healy","year":"2009","journal-title":"Mov. Disord."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"342","DOI":"10.5692\/clinicalneurol.49.342","article-title":"Development or worsening of myoclonus associated with gabapentin therapy","volume":"49","author":"Koide","year":"2009","journal-title":"Rinsho Shinkeigaku"},{"key":"ref_39","first-page":"89","article-title":"Drug-Induced Encephalopathy Secondary to Non Renal Dosing of Common Medications in Two Dialysis Patients","volume":"25","author":"Onuigbo","year":"2009","journal-title":"Adv. Perit. Dial."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.4081\/ar.2010.e3","article-title":"Creutzfeldt\u2013Jakob Disease-like Syndrome Induced by Gabapentin Toxicity","volume":"1","author":"Chau","year":"2010","journal-title":"Ageing Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2512\/jspm.5.308","article-title":"Two Cases of Myoclonus Following Administration of Gabapentin for Neuropathic Pain in the End Stage of Malignancy","volume":"5","author":"Honma","year":"2010","journal-title":"Palliat. Care Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.amjmed.2009.09.030","article-title":"Gabapentin Toxicity in Patients with Chronic Kidney Disease: A Preventable Cause of Morbidity","volume":"123","author":"Zand","year":"2010","journal-title":"Am. J. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4093\/jkd.2011.12.3.171","article-title":"A Case of Gabapentin-Induced Myoclonus in a Type 2 Diabetic Patient with End-Stage Renal Disease","volume":"12","author":"Choe","year":"2011","journal-title":"J. Korean Diabetes"},{"key":"ref_44","first-page":"159","article-title":"Provocation of Myoclonic Seizures and Generalized Electroencephalographic Epileptic Patterns in a Patient with Renal Failure and Gabapentin Intoxication","volume":"19","author":"Kampf","year":"2012","journal-title":"Am. J. Case Rep."},{"key":"ref_45","first-page":"512","article-title":"Myoclonus secondary to gabapentin in a patient with chronic renal failure","volume":"52","author":"Montastruc","year":"2011","journal-title":"Rev. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/0971-4065.83744","article-title":"Treatment of Gabapentin-Induced Myoclonus with Continuous Renal Replacement Therapy","volume":"22","author":"Guddati","year":"2012","journal-title":"Indian J. Nephrol."},{"key":"ref_47","first-page":"130","article-title":"Acute renal failure due to gabapentin. A case report and literature","volume":"32","year":"2012","journal-title":"Nefrologia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s40261-013-0080-2","article-title":"Cross-over, Open-Label Trial of the Effects of Gabapentin versus Pregabalin on Painful Peripheral Neuropathy and Health-Related Quality of Life in Haemodialysis Patients","volume":"33","author":"Atalay","year":"2013","journal-title":"Clin. Drug Investig."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"P07.202","DOI":"10.1212\/WNL.80.7_supplement.P07.202","article-title":"Improvement in Cortical Myoclonus in a Patient with VIM Deep Brain Stimulation for Essential Tremor (P07.202)","volume":"80","author":"Kagnoff","year":"2013","journal-title":"Neurology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3810\/pgm.2013.09.2696","article-title":"Asterixis Related to Gabapentin Intake: A Case Report and Review","volume":"125","author":"Wahba","year":"2013","journal-title":"Postgrad. Med."},{"key":"ref_51","first-page":"316","article-title":"Recreational Abuse of Gabapentin and Pregabalin Are Under-Recognized Causes of Hospitalization Related to These Prescription Drugs","volume":"51","author":"Wiegand","year":"2013","journal-title":"Clin. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ebcr.2013.12.002","article-title":"Myoclonus in Renal Failure: Two Cases of Gabapentin Toxicity","volume":"2","author":"Kaufman","year":"2014","journal-title":"Epilepsy Behav. Case Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jfma.2012.06.001","article-title":"Gabapentin-Induced Myoclonus in an Elderly with End-Stage Renal Failure","volume":"113","author":"Shea","year":"2014","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"285","DOI":"10.14740\/jmc2143w","article-title":"Disabling Asterixis Induced By Gabapentin","volume":"6","author":"Clark","year":"2015","journal-title":"J. Med. Cases"},{"key":"ref_55","first-page":"4","article-title":"A Patient with Multiple Myeloma Who Developed Severe Myoclonus after Stem Cell Transplantation","volume":"3","author":"Guner","year":"2015","journal-title":"J. Leuk."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e282","DOI":"10.1016\/j.jns.2015.08.987","article-title":"Gabapentin-Induced Myoclonus: A Case Report","volume":"357","author":"Ozmenoglu","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"S290","DOI":"10.1016\/j.pmrj.2016.07.323","article-title":"Poster 396 Gabapentin-Induced Myoclonus in Spinal Cord Injury","volume":"8","author":"Schnitzer","year":"2016","journal-title":"PM&R"},{"key":"ref_58","first-page":"152","article-title":"Gabapentin Induced Myoclonus in Elderly Patients-More Common than You Think!","volume":"65","author":"Ahmad","year":"2017","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_59","first-page":"232","article-title":"Myoclonus in a Patient with Acute Kidney Injury: A Rare Presentation of Gabapentin Toxicity","volume":"5","author":"Khan","year":"2017","journal-title":"Am. J. Case Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jns.2017.09.019","article-title":"Negative Myoclonus Induced by Gabapentin and Pregabalin: A Case Series and Systematic Literature Review","volume":"382","author":"Kim","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_61","first-page":"S545","article-title":"Myoclonus from Gabapentin Toxicity in the Setting Ofacute Kidney Injury","volume":"32","author":"Zheng","year":"2017","journal-title":"J. Gen. Intern. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"P6.020","DOI":"10.1212\/WNL.90.15_supplement.P6.020","article-title":"Severe Gabapentin Toxicity After Acute Kidney Injury in Hospitalized Patient with Acute Pain (P6.020)","volume":"90","author":"Perez","year":"2018","journal-title":"Neurology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jocn.2018.09.019","article-title":"Gabapentin or Pregabalin Induced Myoclonus: A Case Series and Literature Review","volume":"61","author":"Desai","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1097\/CM9.0000000000000271","article-title":"Reversible Dysphagia Due to Gabapentin-Induced Jaw Myoclonus","volume":"132","author":"Hui","year":"2019","journal-title":"Chin. Med. J."},{"key":"ref_65","unstructured":"(2019). Medsafe Gathering Knowledge from Adverse Reaction Reports: March 2019. Prescr. Update, 40, 22\u201323."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e768","DOI":"10.1097\/MJT.0000000000000942","article-title":"Myoclonus and Altered Mental Status Induced by Single Dose of Gabapentin in a Patient With End-Stage Renal Disease: A Case Report and Literature Review","volume":"26","author":"Yeddi","year":"2019","journal-title":"Am. J. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"7","DOI":"10.15586\/jrenhep.v6i1.104","article-title":"Gabapentin Toxicity and Role of Dialysis: Case Series and Literature Review","volume":"6","author":"Latief","year":"2021","journal-title":"J. Ren. Hepatic Disord."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/jnnp.2006.100222","article-title":"Movement Disorders in Patients Taking Anticonvulsants","volume":"78","author":"Zadikoff","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/mds.27876","article-title":"Parkinsonism Associated with Gabapentinoid Drugs: A Pharmacoepidemiologic Study","volume":"35","author":"Montastruc","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/phar.2761","article-title":"Risk of Parkinsonism and Related Movement Disorders with Gabapentinoids or Tramadol: A Case-Crossover Study","volume":"43","author":"Ri","year":"2023","journal-title":"Pharmacotherapy"},{"key":"ref_71","first-page":"851","article-title":"Choreoathetotic Movements: A Possible Side Effect of Gabapentin","volume":"46","author":"Buetefisch","year":"1996","journal-title":"Neurology"},{"key":"ref_72","first-page":"29","article-title":"Choreoathetosis with Gabapentin","volume":"10","author":"Millichap","year":"1996","journal-title":"Pediatr. Neurol. Briefs"},{"key":"ref_73","first-page":"910","article-title":"Choreoathetosis as a Side Effect of Gabapentin Therapy in Severely Neurologically Impaired Patients","volume":"54","author":"Chudnow","year":"1997","journal-title":"Arch. Neurol."},{"key":"ref_74","first-page":"66","article-title":"Gabapentin-Induced Choreoathetosis","volume":"11","author":"Millichap","year":"1997","journal-title":"Pediatr. Neurol. Briefs"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/00004714-200112000-00018","article-title":"Gabapentin-Related Dyskinesia","volume":"21","author":"Norton","year":"2001","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_76","first-page":"179","article-title":"Choreoathetosis as Side Effect of Gabapentin Therapy in a Patient with Spontaneous Spinal Epidural Hematoma: A Case Report","volume":"35","author":"Lai","year":"2007","journal-title":"Taiwan J. Rehabil. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/mds.21209","article-title":"Dyskinesia Induced by Gabapentin in Idiopathic Parkinson\u2019s Disease","volume":"22","author":"Raju","year":"2007","journal-title":"Mov. Disord."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2710.2008.00882.x","article-title":"Hemichorea Associated with Gabapentin Therapy with Hypoperfusion in Contralateral Basal Ganglion\u2014A Case of a Paraplegic Patient with Neuropathic Pain","volume":"33","author":"Lai","year":"2008","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3346\/jkms.2008.23.3.533","article-title":"A Case of a Patient with Both Chorea and Restless Legs Syndrome","volume":"23","author":"Shin","year":"2008","journal-title":"J. Korean Med. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1590\/S0004-282X2008000100029","article-title":"Chorea Due to Gabapentin Monotherapy in a Not Encephalopatic Patient","volume":"66","author":"Twardowschy","year":"2008","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10067-007-0744-5","article-title":"Chorea as a Side Effect of Gabapentin (Neurontin) in a Patient with Complex Regional Pain Syndrome Type 1","volume":"27","author":"Zesiewicz","year":"2008","journal-title":"Clin. Rheumatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.amjopharm.2009.08.001","article-title":"Chorea Associated with Gabapentin Use in an Elderly Man","volume":"7","author":"Attupurath","year":"2009","journal-title":"Am. J. Geriatr. Pharmacother."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.parkreldis.2008.01.015","article-title":"A Case of Refractory Secondary Paroxysmal Kinesigenic Dyskinesia with High Sensitivity to Phenytoin Monotherapy","volume":"15","author":"Bonakis","year":"2009","journal-title":"Park. Relat. Disord."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.clineuro.2008.11.015","article-title":"Bilateral Ballism Induced by Gabapentin in Idiopatic Parkinson\u2019s Disease","volume":"111","author":"Erol","year":"2009","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4274\/Tnd.63497","article-title":"A Dyskinesia Case Induced by Pramipexole, Pregabalin and Gabapentin After Cardiopulmonary Resuscitation","volume":"19","author":"Aksoy","year":"2013","journal-title":"Turk. J. Neurol."},{"key":"ref_86","first-page":"276","article-title":"Chorea in a Chronic Pain Patient Using Gabapentin","volume":"14","author":"Souzdalnitski","year":"2014","journal-title":"Ochsner J."},{"key":"ref_87","first-page":"769","article-title":"Gabapentin Toxicitypresenting as Choreoathetosis","volume":"12","author":"VanHook","year":"2017","journal-title":"Hosp. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4103\/LJMS.LJMS_44_18","article-title":"Gabapentin-Induced Hemichorea in a Young Female: A Case Report and Literature Review","volume":"2","author":"Rahil","year":"2018","journal-title":"Libyan J. Med. Sci."},{"key":"ref_89","first-page":"e4758","article-title":"Gabapentin-Induced Facial Myoclonus in the Setting of Acute on Chronic Kidney Disease","volume":"11","author":"Hampton","year":"2019","journal-title":"Cureus"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1080\/bij.11.7.537.540","article-title":"Psychomotor Agitation Following Gabapentin Use in Brain Injury","volume":"11","author":"Childers","year":"1997","journal-title":"Brain Inj."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1345\/aph.1Q057","article-title":"Akathisia Induced by Gabapentin Withdrawal","volume":"45","author":"See","year":"2011","journal-title":"Ann. Pharmacother."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"410","DOI":"10.7326\/0003-4819-126-5-199703010-00018","article-title":"Stuttering Caused by Gabapentin","volume":"126","author":"Nissani","year":"1997","journal-title":"Ann. Intern. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3344\/jkps.2004.17.2.275","article-title":"Stuttering during Management of Postherpetic Neuralgia A Case Report","volume":"17","author":"Choi","year":"2004","journal-title":"Korean J. Pain"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3","DOI":"10.37515\/Orthopedics.7616.1102","article-title":"Gabapentin Treatment Resulting in New-Onset Stuttering: A Case Report and Literature Review","volume":"1","author":"Zeldin","year":"2019","journal-title":"J. Orthop. Rehabil. Res."},{"key":"ref_95","first-page":"1215","article-title":"Dystonic movements: A possible secondary effect of gabapentin","volume":"28","author":"Bernal","year":"1999","journal-title":"Rev. Neurol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1001\/archneur.57.4.570","article-title":"Dystonia in a Patient Treated with Propranolol and Gabapentin","volume":"57","author":"Palomeras","year":"2000","journal-title":"Arch. Neurol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1345\/aph.1E503","article-title":"Dystonia Induced by Gabapentin","volume":"39","author":"Pina","year":"2005","journal-title":"Ann. Pharmacother."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/bja\/aem130","article-title":"Prolonged Myotonia and Dystonia after General Anaesthesia in a Patient Taking Gabapentin","volume":"99","author":"Allford","year":"2007","journal-title":"Br. J. Anaesth."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"147","DOI":"10.7713\/ijms.2011.0036","article-title":"Drug-Induced Secondary Dystonia: Clinical Presentation and Management","volume":"2","author":"Lal","year":"2011","journal-title":"Indian J. Med. Spec."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.jemermed.2013.08.024","article-title":"Acute Dystonic Reaction Caused by Gabapentin","volume":"46","author":"Rohman","year":"2014","journal-title":"J. Emerg. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/WNF.0000000000000434","article-title":"Gabapentin-Induced Myokymia: A Case Report","volume":"44","author":"Brown","year":"2021","journal-title":"Clin. Neuropharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1212\/WNL.49.3.739","article-title":"Gabapentin Monotherapy: I. An 8-Day, Double-Blind, Dose-Controlled, Multicenter Study in Hospitalized Patients with Refractory Complex Partial or Secondarily Generalized Seizures. The US Gabapentin Study Group 88\/89","volume":"49","author":"Bergey","year":"1997","journal-title":"Neurology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S1059-1311(97)80029-5","article-title":"Isolated Ataxia as an Idiosyncratic Side-Effect under Gabapentin","volume":"6","author":"Steinhoff","year":"1997","journal-title":"Seizure"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0404.1999.tb00651.x","article-title":"Gabapentin Add-on Treatment: How Many Patients Become Seizure-Free? An Open-Label Multicenter Study","volume":"99","author":"Mayer","year":"1999","journal-title":"Acta Neurol. Scand."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1528-1157.1999.tb00804.x","article-title":"Safety and Tolerability of Gabapentin as Adjunctive Therapy in a Large, Multicenter Study","volume":"40","author":"McLean","year":"1999","journal-title":"Epilepsia"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1055\/s-2007-979219","article-title":"Clinical Experience Using Adjunctive Gabapentin in Treatment-Resistant Bipolar Mixed States","volume":"32","author":"Perugi","year":"1999","journal-title":"Pharmacopsychiatry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0885-3924(00)00181-0","article-title":"Gabapentin vs. Amitriptyline in Painful Diabetic Neuropathy: An Open-Label Pilot Study","volume":"20","author":"Dallocchio","year":"2000","journal-title":"J. Pain Symptom Manag."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00002508-200112000-00002","article-title":"Gabapentin for Neuropathic Pain: Systematic Review of Controlled and Uncontrolled Literature","volume":"17","author":"Mellegers","year":"2001","journal-title":"Clin. J. Pain"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1046\/j.1528-1157.2002.01702.x","article-title":"A Postmarketing Surveillance Study of Gabapentin as Add-on Therapy for 3100 Patients in England","volume":"43","author":"Wilton","year":"2002","journal-title":"Epilepsia"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1081\/CLT-120018265","article-title":"Characterization of Gabapentin Overdose Using a Poison Center Case Series","volume":"41","author":"Shepherd","year":"2003","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"297","DOI":"10.5262\/tndt.2013.1003.10","article-title":"Gabapentin Toxicity in Patients with Chronic Kidney Disease","volume":"22","author":"Karagoz","year":"2013","journal-title":"Nephrol. Dial. Transplant. Turk."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s11011-014-9514-7","article-title":"Asterixis: A Study of 103 Patients","volume":"29","author":"Pal","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"ref_113","first-page":"S597","article-title":"Regardless of Impaired Renal Function, Negative Myoclonus Can Be Induced by Gabapetin and Pregabalin","volume":"34","author":"Kwon","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"5559981","DOI":"10.1155\/2021\/5559981","article-title":"Potential Adverse Consequences of Combination Therapy with Gabapentin and Pregabalin","volume":"2021","author":"Ghayur","year":"2021","journal-title":"Case Rep. Med."},{"key":"ref_115","unstructured":"ClinCalc (2023, June 23). The Top 300 of 2020. Available online: https:\/\/clincalc.com\/DrugStats\/Top300Drugs.aspx."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1528-1167.2009.02042.x","article-title":"Drug Treatment of Epilepsy in the Century of the ILAE: The Second 50 Years, 1959\u20132009","volume":"50","author":"Shorvon","year":"2009","journal-title":"Epilepsia"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1592\/phco.28.12.1443","article-title":"Prioritizing Future Research on Off-Label Prescribing: Results of a Quantitative Evaluation","volume":"28","author":"Walton","year":"2008","journal-title":"Pharmacotherapy"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2147\/RMHP.S168504","article-title":"Gabapentin Use, Abuse, and the US Opioid Epidemic: The Case for Reclassification as a Controlled Substance and the Need for Pharmacovigilance","volume":"11","author":"Peckham","year":"2018","journal-title":"Risk Manag. Healthc. Policy"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01243384","article-title":"Gabapentin Augments Whole Blood Serotonin in Healthy Young Men","volume":"73","author":"Rao","year":"1988","journal-title":"J. Neural Transm."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-2999(96)00682-6","article-title":"The Anticonvulsant Gabapentin Decreases Firing Rates of Substantia Nigra Pars Reticulata Neurons","volume":"316","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"236","DOI":"10.47102\/annals-acadmed.sg.202023","article-title":"The Link Between Amitriptyline and Movement Disorders: Clinical Profile and Outcome","volume":"49","author":"Rissardo","year":"2020","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4103\/bc.bc_77_21","article-title":"Lithium-Associated Movement Disorder: A Literature Review","volume":"8","author":"Rissardo","year":"2022","journal-title":"Brain Circ."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S1474-4422(04)00880-4","article-title":"Myoclonus: Current Concepts and Recent Advances","volume":"3","author":"Caviness","year":"2004","journal-title":"Lancet Neurol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Charlier, B., Coglianese, A., De Rosa, F., de Grazia, U., Operto, F.F., Coppola, G., Filippelli, A., Dal Piaz, F., and Izzo, V. (2021). The Effect of Plasma Protein Binding on the Therapeutic Monitoring of Antiseizure Medications. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13081208"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/clpt.1994.118","article-title":"Pharmacokinetics of Gabapentin in Subjects with Various Degrees of Renal Function","volume":"56","author":"Blum","year":"1994","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"5","DOI":"10.14712\/23362936.2020.1","article-title":"Buspirone-Associated Movement Disorder: A Literature Review","volume":"121","author":"Rissardo","year":"2020","journal-title":"Prague Med. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1212\/WNL.23.11.1234","article-title":"5-Hydroxytryptophan-Induced Myoclonus in Guinea Pigs and the Possible Role of Serotonin in Infantile Myoclonus","volume":"23","author":"Klawans","year":"1973","journal-title":"Neurology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/pr.117.014381","article-title":"Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery","volume":"70","author":"Atkin","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4103\/tcmj.tcmj_74_22","article-title":"Phenytoin-Associated Movement Disorder: A Literature Review","volume":"34","author":"Rissardo","year":"2022","journal-title":"Tzu Chi Med. J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.14712\/23362936.2021.14","article-title":"Valproate-Associated Movement Disorder: A Literature Review","volume":"122","author":"Rissardo","year":"2021","journal-title":"Prague Med. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/WNF.0000000000000395","article-title":"Topiramate-Associated Movement Disorder: Case Series and Literature Review","volume":"43","author":"Rissardo","year":"2020","journal-title":"Clin. Neuropharmacol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1556-4029.2011.01798.x","article-title":"Suicide by Gabapentin Overdose","volume":"56","author":"Middleton","year":"2011","journal-title":"J. Forensic Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/00002826-199012000-00009","article-title":"Acute Dystonic Reaction in Normal Humans Caused by Catecholamine Depletion","volume":"13","author":"McCann","year":"1990","journal-title":"Clin. Neuropharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neubiorev.2016.03.015","article-title":"Serotonergic Perturbations in Dystonia Disorders-a Systematic Review","volume":"65","author":"Smit","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4103\/tcmj.tcmj_13_20","article-title":"Mirtazapine-Associated Movement Disorders: A Literature Review","volume":"32","author":"Rissardo","year":"2020","journal-title":"Tzu Chi Med. J."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/2045125314525433","article-title":"Gabapentin Pharmacotherapy for Antipsychotic-Induced Akathisia: Single-Patient Experiment and Case Report","volume":"4","author":"Sullivan","year":"2014","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00004850-200505000-00011","article-title":"Gabapentin in the Treatment of Antipsychotic-Induced Akathisia in Schizophrenia","volume":"20","author":"Pfeffer","year":"2005","journal-title":"Int. Clin. Psychopharmacol."},{"key":"ref_138","first-page":"479","article-title":"Stuttering: Clinical and Research Update","volume":"62","author":"Perez","year":"2016","journal-title":"Can. Fam. Physician"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0014-2999(83)90425-9","article-title":"Inhibition by GABA, Baclofen and Gabapentin of Dopamine Release from Rabbit Caudate Nucleus: Are There Common or Different Sites of Action?","volume":"94","author":"Reimann","year":"1983","journal-title":"Eur. J. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4103\/bc.bc_57_19","article-title":"Pregabalin-Associated Movement Disorders: A Literature Review","volume":"6","author":"Rissardo","year":"2020","journal-title":"Brain Circ."},{"key":"ref_141","first-page":"240","article-title":"Gabapentin for Treating Acquired Neurogenic Stuttering","volume":"24","author":"Maguire","year":"2012","journal-title":"Ann. Clin. Psychiatry"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s41983-020-00197-w","article-title":"Cinnarizine- and Flunarizine-Associated Movement Disorder: A Literature Review","volume":"56","author":"Rissardo","year":"2020","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00041327-200403000-00032","article-title":"Superior Oblique Myokymia Improved with Gabapentin","volume":"24","author":"Deokule","year":"2004","journal-title":"J. Neuroophthalmol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1600-0404.1998.tb07330.x","article-title":"A Case of Myokymia-Cramp Syndrome Successfully Treated with Gabapentin","volume":"98","author":"Serrao","year":"1998","journal-title":"Acta Neurol. 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