{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:44:20Z","timestamp":1793148260974,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Background: Sarcoidosis is a multisystem granulomatous disease with a wide variety of presentations and clinical courses. Cutaneous manifestations and comorbidities associated with sarcoid prognosis remain understudied. Methods: An EPIC query was run for patients age 18+ at the Johns Hopkins Hospital with a diagnosis of sarcoidosis of the skin according to the ICD-10-CM code D86.3. Data were obtained from a population-based sample of 240 patients from 2015 to 2020. Results: A total of 240 patients were included in the cohort study. The mean (SD) age was 43.76 (11.72) years, and 30% of participants were male; 76.25% of patients identified as black, 19.58% as white, and 4.17% as other. The average age of onset in remissive patients was significantly higher than progressive (47 \u00b1 12 vs. 40 \u00b1 10, p = 0.0005); 49% of black patients experienced progressive sarcoid compared to 32.6% of white patients (p = 0.028). Progressive disease was associated with the presence of lupus pernio (aOR = 3.29, 95% CI, 1.60\u20136.77) and at least one autoimmune comorbidity (aOR 6.831, 95% CI 1.819\u201311.843). Conclusions: When controlling for patient demographics, lupus pernio and the presence of at least one autoimmune condition were associated with progressive cutaneous sarcoidosis.<\/jats:p>","DOI":"10.3390\/medicines10100057","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T12:46:13Z","timestamp":1697114773000},"page":"57","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Demographics, Cutaneous Manifestations, and Comorbidities Associated with Progressive Cutaneous Sarcoidosis: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Jonathan","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8625-0083","authenticated-orcid":false,"given":"Erik","family":"Almazan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihad","family":"Alhariri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-1515","authenticated-orcid":false,"given":"Shawn G.","family":"Kwatra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"699.e1","DOI":"10.1016\/j.jaad.2012.02.003","article-title":"Sarcoidosis: A comprehensive review and update for the dermatologist: Part I. Cutaneous disease","volume":"66","author":"Haimovic","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-0037-1604191","article-title":"Sarcoidosis: Evolving Concepts","volume":"38","author":"Grutters","year":"2017","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1164\/ajrccm.164.10.2104046","article-title":"Clinical characteristics of patients in a case control study of sarcoidosis","volume":"164","author":"Baughman","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1378\/chest.14-1120","article-title":"Racial difference in sarcoidosis mortality in the United States","volume":"147","author":"Mirsaeidi","year":"2015","journal-title":"Chest"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S421","DOI":"10.1513\/AnnalsATS.201707-564OT","article-title":"Disease Burden and Variability in Sarcoidosis","volume":"14","author":"Gerke","year":"2017","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.clindermatol.2007.03.004","article-title":"Cutaneous sarcoidosis: Differential diagnosis","volume":"25","author":"McDonnell","year":"2007","journal-title":"Clin. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/2049-6958-8-26","article-title":"Diagnosis of cutaneous sarcoidosis; clinical and the prognostic significance of skin lesions","volume":"8","author":"Yanardag","year":"2013","journal-title":"Multidiscip. Respir. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0954-6111(03)00127-6","article-title":"Cutaneous involvement in sarcoidosis: Analysis of the features in 170 patients","volume":"97","author":"Pamuk","year":"2003","journal-title":"Respir. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1365-2230.2011.04128.x","article-title":"Specific cutaneous lesions in patients with systemic sarcoidosis: Relationship to severity and chronicity of disease","volume":"36","author":"Marcoval","year":"2011","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_10","first-page":"1581","article-title":"Cutaneous sarcoidosis: A dermatologic masquerader","volume":"65","author":"Katta","year":"2002","journal-title":"Am. Fam. Physician"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"121.e1","DOI":"10.1016\/j.jaad.2010.06.068","article-title":"Sarcoidosis: Are there differences in your skin of color patients?","volume":"66","author":"Heath","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2133.1985.tb04859.x","article-title":"Lupus pernio: A clinico-radiological study of thirty-five cases","volume":"112","author":"Spiteri","year":"1985","journal-title":"Br. J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00408-017-0076-4","article-title":"The Burden of Comorbidity and Complexity in Sarcoidosis: Impact of Associated Chronic Diseases","volume":"196","author":"Bosch","year":"2018","journal-title":"Lung"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.hrtlng.2020.03.013","article-title":"Association between Sarcoidosis and Cardiovascular Comorbidity: A Systematic Review and Meta-Analysis","volume":"49","author":"Mahmoud","year":"2020","journal-title":"Heart Lung"},{"key":"ref_15","first-page":"115","article-title":"What comorbidities accompany sarcoidosis? A large cohort (n = 1779) patients analysis","volume":"32","author":"Boros","year":"2015","journal-title":"Sarcoidosis Vasc. Diffus. Lung Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/EDE.0000000000001323","article-title":"Positive Predictive Value of Sarcoidosis Identified in an Administrative Healthcare Registry: A Validation Study","volume":"32","author":"Ceder","year":"2021","journal-title":"Epidemiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/CPM.0000000000000136","article-title":"Refractory Pulmonary Sarcoidosis: Proposal of a Definition and Recommendations for the Diagnostic and Therapeutic Approach","volume":"23","author":"Korsten","year":"2016","journal-title":"Clin. Pulm. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2147\/TCRM.S192922","article-title":"Refractory Sarcoidosis: A Review","volume":"16","author":"Jamilloux","year":"2020","journal-title":"TCRM"},{"key":"ref_19","unstructured":"(2020, October 10). Cutaneous Sarcoidosis in African Americans. Available online: https:\/\/austinpublishinggroup.com\/dermatology\/fulltext\/ajd-v1-id1028.php."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1378\/chest.10-0413","article-title":"Sarcoidosis in black women in the United States: Data from the Black Women\u2019s Health Study","volume":"139","author":"Cozier","year":"2011","journal-title":"Chest"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00408-008-9111-9","article-title":"Racial differences in sarcoidosis granuloma density","volume":"187","author":"Burke","year":"2009","journal-title":"Lung"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ccm.2006.04.002","article-title":"Racial and ethnic disparities in sarcoidosis: From genetics to socioeconomics","volume":"27","author":"Westney","year":"2006","journal-title":"Clin. Chest Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/oxfordjournals.aje.a009096","article-title":"Racial differences in sarcoidosis incidence: A 5-year study in a health maintenance organization","volume":"145","author":"Rybicki","year":"1997","journal-title":"Am. J. Epidemiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1546-0096-6-16","article-title":"Childhood sarcoidosis: A rare but fascinating disorder","volume":"6","author":"Shetty","year":"2008","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5114\/reum.2016.60217","article-title":"Erythema nodosum\u2014Review of the literature","volume":"54","author":"Chowaniec","year":"2016","journal-title":"Reumatologia"},{"key":"ref_26","first-page":"1052","article-title":"Autoimmune Big Data Study Group. Geoepidemiological big data approach to sarcoidosis: Geographical and ethnic determinants","volume":"37","author":"Kostov","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/MCP.0000000000000882","article-title":"The influence of age and sex in sarcoidosis","volume":"28","author":"Singha","year":"2022","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"236905","DOI":"10.1155\/2014\/236905","article-title":"Sarcoidosis: Sex-dependent variations in presentation and management","volume":"2014","author":"Birnbaum","year":"2014","journal-title":"J. Ophthalmol."},{"key":"ref_29","first-page":"119","article-title":"The clinical course of sarcoidosis: Presentation, diagnosis, and treatment in a large white and black cohort in the United States","volume":"29","author":"Judson","year":"2012","journal-title":"Sarcoidosis Vasc. Diffus. Lung Dis."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"(2023, April 12). September 2018\u2014Volume 24\u2014Issue 5: Current Opinion in Pulmonary Medicine. Available online: https:\/\/journals.lww.com\/co-pulmonarymedicine\/fulltext\/2018\/09000\/sarcoidosis_and_autoimmune_diseases__differences.","DOI":"10.1097\/MCP.0000000000000500"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/1346-8138.13654","article-title":"Comorbid autoimmune diseases in patients with sarcoidosis: A nationwide case-control study in Taiwan","volume":"44","author":"Wu","year":"2017","journal-title":"J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1183\/09031936.00224513","article-title":"Rituximab in the treatment of refractory pulmonary sarcoidosis","volume":"43","author":"Sweiss","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"105236","DOI":"10.1016\/j.jbspin.2021.105236","article-title":"Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients","volume":"88","author":"Alguacil","year":"2021","journal-title":"Jt. Bone Spine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1080\/07853890.2022.2063375","article-title":"Comorbidities of Sarcoidosis","volume":"54","author":"Tana","year":"2022","journal-title":"Ann. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.3389\/fimmu.2019.02933","article-title":"Sarcoidosis as an Autoimmune Disease","volume":"10","author":"Starshinova","year":"2020","journal-title":"Front. Immunol."}],"container-title":["Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2305-6320\/10\/10\/57\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:05:29Z","timestamp":1760130329000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2305-6320\/10\/10\/57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["medicines10100057"],"URL":"https:\/\/doi.org\/10.3390\/medicines10100057","relation":{},"ISSN":["2305-6320"],"issn-type":[{"value":"2305-6320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]}}}