{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:09:33Z","timestamp":1760144973878,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T00:00:00Z","timestamp":1717286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicines"],"abstract":"<jats:p>Background: Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by abnormal and persistent peripheral blood hypereosinophilia (eosinophil count \u2265 1.5 \u00d7 109\/L and \u226510% eosinophils) with duration \u2265 6 months, associated organ damage, and\/or dysfunction attributable to tissue eosinophilic infiltrate of unknown cause. IHES affects different organs such as the heart, lungs, nervous system, and skin, with renal involvement being rare in this condition. Case Presentation: We present a case of a young patient with IHES and immune complex-mediated membranoproliferative glomerulonephritis with nephrotic syndrome, as a rare renal manifestation. We discuss the clinical, analytical, and histopathologic renal and hematologic features, comparing them with other reported cases in the literature.<\/jats:p>","DOI":"10.3390\/medicines11060013","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T03:51:45Z","timestamp":1717386705000},"page":"13","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Unusual Case of Immune Complex-Mediated Membranoproliferative Glomerulonephritis as Renal Manifestation of Idiopathic Hypereosinophilic Syndrome: A Case Report and Literature Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-7231","authenticated-orcid":false,"given":"Michael","family":"Cieza-Terrones","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Cayetano Heredia, Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-2279","authenticated-orcid":false,"given":"Jos\u00e9 C.","family":"De La Flor","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Central Defense Gomez Ulla, 280467 Madrid, Spain"},{"name":"Faculty of Medicine, Alcala de Henares University, 28805 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Requejo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cayetano Heredia, Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Cl\u00ednica Universidad de Navarra, 31008 Navarra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Apaza","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Rey Juan Carlos, 28933 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Rodr\u00edguez-Doy\u00e1g\u00fcez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Guadalajara Center Dialysis, AVERICUM, 19003 Guadalajara, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Zamora","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Universitario General Villalba, 28400 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Asato-Higa","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Department, PATOLOGAS AS SAC, Lima 15082, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rivera-Estrella","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cayetano Heredia, Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Carrasco-Yal\u00e1n","sequence":"additional","affiliation":[{"name":"Postgraduate School, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15081, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jaci.2010.03.035","article-title":"Incidence of myeloproliferative hypereosinophilic syndrome in the United States and an estimate of all hypereosinophilic syndrome incidence","volume":"126","author":"Crane","year":"2010","journal-title":"J. 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